Material Safety Data Sheet
Acetylsalicylic acid
ACC# 00300
Section 1 - Chemical Product and Company Identification |
MSDS Name: Acetylsalicylic acid
Catalog Numbers:
AC158180000, AC158180500, AC158185000, AC385760000
Synonyms:
2-Acetoxybenzoic acid; Aspirin.
Company Identification:
Acros Organics N.V.
One Reagent Lane
Fair Lawn, NJ 07410
For information in North America, call: 800-ACROS-01
For emergencies in the US, call CHEMTREC: 800-424-9300
Section 2 - Composition, Information on Ingredients
|
CAS# |
Chemical Name |
Percent |
EINECS/ELINCS |
50-78-2 |
Acetylsalicylic acid |
99 | 200-064-1 |
Section 3 - Hazards Identification
|
EMERGENCY OVERVIEW
Appearance: white powder.
Warning! Toxic if swallowed. Causes eye, skin, and
respiratory tract irritation. Hygroscopic (absorbs moisture from the
air).
Target Organs: Blood, respiratory system, eyes,
skin.
Potential Health Effects
Eye:
Causes eye irritation.
Skin:
Causes skin irritation. May be harmful if absorbed through the skin.
Ingestion:
May cause irritation of the digestive tract. May cause liver and
kidney damage. Ingestion may cause high blood pressure, labored
breathing, unsteady gait, lung edema, and coma. Human systemic
effects include acute renal failure, acute tubular necrosis, cough,
diarrhea, dyspnea (labored breathing), headache, hypermitility,
nausea, vomiting, ulceration or bleeding from stomach. Toxic if
swallowed.
Inhibits platelet aggregation affecting bleeding time. High or
repeated exposure may cause headache, dizziness, depression and
irritability. If an allergic response develops, later exposures to
even very small amounts can cause hives, difficulty breathing, and/or
rapid drop in blood pressure.
Inhalation:
Causes respiratory tract irritation. Aspiration may lead to
pulmonary edema. May be harmful if inhaled.
Chronic:
Prolonged or repeated skin contact may cause dermatitis.
Whether or not acetaylsalicylic acid (aspirin) is a human teratogen
is controversial. There is no conclusive evidence that salicylates
are teratogenic in
Section 4 - First Aid Measures
|
Eyes:
Immediately flush eyes with plenty of water for at least 15 minutes,
occasionally lifting the upper and lower eyelids. Get medical aid imme
diately.
Skin:
Get medical aid. Immediately flush skin with plenty of water for at
least 15 minutes while removing contaminated clothing and shoes.
Ingestion:
Do not induce vomiting. Get medical aid immediately. Call a poison
control center.
Inhalation:
Remove from exposure and move to fresh air immediately. If breathing
is difficult, give oxygen. Get medical aid. Do not use mouth-to-mouth
resuscitation if victim ingested or inhaled the substance; induce
artificial respiration with the aid of a pocket mask equipped with a
one-way valve or other proper respiratory medical device.
Notes to Physician:
Treat symptomatically and supportively.
Section 5 - Fire Fighting Measures
|
General Information:
As in any fire, wear a self-contained breathing apparatus in
pressure-demand, MSHA/NIOSH (approved or equivalent), and full
protective gear. Dangerous fire hazard in the form of dust when
exposed to heat or flame.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or appropriate foam.
Flash Point: 250 deg C ( 482.00 deg F)
Autoignition Temperature: 500 deg C ( 932.00 deg F)
Explosion Limits, Lower:Not available.
Upper: Not available.
NFPA Rating:
(estimated) Health: 2; Flammability: 1; Instability: 1
Section 6 - Accidental Release Measures
|
General Information: Use proper personal protective equipment as indicated
in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal
container. Avoid generating dusty conditions. Provide ventilation. Do
not let this chemical enter the environment.
Section 7 - Handling and Storage
|
Handling:
Use with adequate ventilation. Minimize dust generation and
accumulation. Do not get in eyes, on skin, or on clothing. Do not
ingest or inhale.
Storage:
Store in a cool, dry place. Store in a tightly closed container.
Section 8 - Exposure Controls, Personal Protection
|
Engineering Controls:
Facilities storing or utilizing this material should be equipped
with an eyewash facility and a safety shower. Use adequate
ventilation to keep airborne concentrations low.
Exposure Limits
Chemical Name |
ACGIH |
NIOSH |
OSHA - Final PELs |
Acetylsalicylic acid
|
5 mg/m3 TWA
|
5 mg/m3 TWA
|
none listed
|
OSHA Vacated PELs:
Acetylsalicylic acid:
5 mg/m3 TWA
Personal Protective Equipment
Eyes:
Wear appropriate protective eyeglasses or chemical
safety goggles as described by OSHA's eye and face
protection regulations in 29 CFR 1910.133 or European
Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin
exposure.
Clothing:
Wear appropriate protective clothing to prevent skin
exposure.
Respirators:
Follow the OSHA respirator regulations found in 29
CFR 1910.134 or European Standard EN 149. Use a
NIOSH/MSHA or European Standard EN 149 approved
respirator if exposure limits are exceeded or if
irritation or other symptoms are experienced.
Section 9 - Physical and Chemical Properties
|
Physical State: Powder
Appearance: white
Odor: odorless
pH: 3.5 (2.5 g/L (20°C))
Vapor Pressure: 0.000003 mm Hg @ 25 deg C
Vapor Density: Not available.
Evaporation Rate:Not applicable.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point:136 - 140 deg C
Decomposition Temperature:140 deg C
Solubility: 3.3 g/L (20°C)
Specific Gravity/Density:1.350
Molecular Formula:C9H8O4
Molecular Weight:180.16
Section 10 - Stability and Reactivity
|
Chemical Stability:
Hygroscopic: absorbs moisture or water from the air.
Conditions to Avoid:
Incompatible materials, dust generation, exposure to moist air or
water.
Incompatibilities with Other Materials:
Strong oxidizing agents, strong acids, strong bases, alkalis.
Hazardous Decomposition Products:
Carbon monoxide, carbon dioxide.
Hazardous Polymerization: Will not occur.
Section 11 - Toxicological Information
|
RTECS#:
CAS# 50-78-2:
VO0700000
LD50/LC50:
CAS# 50-78-2:
Oral, mouse: LD50 =
250 mg/kg;
Oral, rabbit: LD50 =
1010 mg/kg;
Oral, rat: LD50 = 200
mg/kg;
.
Human oral LD50 estimated at 357 mg/kg. Other references state that
a 10 g dose (143 mg/kg) may be fatal in humans.
Carcinogenicity:
CAS# 50-78-2:
Not listed by ACGIH, IARC, NTP, or CA Prop 65.
Epidemiology:
Epidemiological evidence has suggested the possibility of
an association between the use of aspirin in the treatment
of fever in children with chickenpox or influenza virus
infections and the development of Reye's Syndrome.
Teratogenicity:
Teratogenic effects have occurred in experimental
animals.Whether or not aspirin is a human teratogen is
controversial. Some studies have linked prenatal aspirin
exposure with cardiac effects, but it has not been
confirmed by other studies. The possibility of a weak
teratogenic effect has not been conclusively ruled out
however.
Reproductive Effects:
See actual entry in RTECS for complete information.
Mutagenicity:
Aspirin induced chromosome aberrations in cultured human
fibrolasts.Mutagenic effects have occurred in experimental
animals.
Neurotoxicity:
No information found
Other Studies:
Section 12 - Ecological Information
|
Ecotoxicity:
Fish: Leuciscus idus: >1000 mg/L; 48H; LC50Daphnia: Daphnia: 168
mg/L; 24H; EC50Bacteria: Phytobacterium phosphoreum: 26 mg/L;
5M; EC50
No data available.
Environmental:
No information available.
Physical:
No information available.
Other:
Do not empty into drains. Readily biodegradable.
Section 13 - Disposal Considerations
|
Chemical waste generators must determine whether a discarded chemical is classified
as a hazardous waste.
US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3.
Additionally, waste generators must consult state and local hazardous waste regulations to
ensure complete and accurate classification.
RCRA P-Series: None listed.
RCRA U-Series: None listed.
Section 14 - Transport Information
|
|
US DOT |
Canada TDG |
Shipping Name: |
TOXIC SOLID, ORGANIC, N.O.S. |
TOXIC SOLID, ORGANIC, N.O.S. |
Hazard Class: |
6.1 |
6.1 |
UN Number: |
UN2811 |
UN2811 |
Packing Group: |
III |
III |
Section 15 - Regulatory Information
|
US FEDERAL
TSCA
CAS# 50-78-2 is listed on the TSCA inventory.
Health & Safety Reporting List
None of the chemicals are on the Health & Safety Reporting List.
Chemical Test Rules
None of the chemicals in this product are under a Chemical Test Rule.
Section 12b
None of the chemicals are listed under TSCA Section 12b.
TSCA Significant New Use Rule
None of the chemicals in this material have a SNUR under TSCA.
CERCLA Hazardous Substances and corresponding RQs
None of the chemicals in this material have an RQ.
SARA Section 302 Extremely Hazardous Substances
None of the chemicals in this product have a TPQ.
Section 313
No chemicals are reportable under Section 313.
Clean Air Act:
This material does not contain any hazardous air pollutants.
This material does not contain any Class 1 Ozone depletors.
This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
None of the chemicals in this product
are listed as Hazardous Substances under the CWA.
None of the chemicals in this
product are listed as Priority Pollutants under the CWA.
None of the chemicals in this
product are listed as Toxic Pollutants under the CWA.
OSHA:
None of the chemicals in this product
are considered highly hazardous by OSHA.
STATE
CAS# 50-78-2 can be found on the
following state right to know lists: California, New Jersey,
Pennsylvania, Minnesota, Massachusetts.
California Prop 65
The following statement(s) is(are) made in order to comply with
the California Safe Drinking Water Act:
WARNING: This product contains Acetylsalicylic acid, a chemical
known to the state of California to cause female reproductive
toxicity.
California No Significant Risk Level:
None of the chemicals in this product are listed.
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols:
T
Risk Phrases:
R 25 Toxic if swallowed.
R 36/37/38 Irritating to eyes, respiratory system and skin.
Safety Phrases:
S 26 In case of contact with eyes, rinse immediately with plenty of
water and seek medical advice.
S 37/39 Wear suitable gloves and eye/face protection.
S 45 In case of accident or if you feel unwell, seek medical advice
immediately (show the label where possible).
WGK (Water Danger/Protection)
CAS# 50-78-2: 1
Canada - DSL/NDSL
CAS# 50-78-2 is listed on Canada's DSL List.
Canada - WHMIS
This product has a WHMIS classification of D1B, D2B.
This product has been classified in accordance with the hazard
criteria of the Controlled Products Regulations and the MSDS
contains all of the information required by those regulations.
Canadian Ingredient Disclosure List
Section 16 - Additional Information
|
MSDS Creation Date: 12/12/1997
Revision #11 Date: 2/08/2008
The information above is believed to be accurate and represents the best
information currently available to us. However, we make no warranty of
merchantability or any other warranty, express or implied, with respect to
such information, and we assume no liability resulting from its use. Users
should make their own investigations to determine the suitability of the
information for their particular purposes. In no event shall Fisher be liable
for any claims, losses, or damages of any third party or for lost profits
or any special, indirect, incidental, consequential or exemplary
damages, howsoever arising, even if Fisher has been advised of
the possibility of such damages.