Material Safety Data Sheet
L-Methionine

ACC# 00822
Section 1 - Chemical Product and Company Identification

MSDS Name: L-Methionine
Catalog Numbers: AC166160000, AC166160250, AC166161000, BP388-100
Synonyms:
L-2-Amino-4-(methylthio)butyric acid; Met; (S)-2-Amino-4-(methylthio)butanoic acid, an essential amino acid for human development.
Company Identification:

              Fisher Scientific
              1 Reagent Lane
              Fair Lawn, NJ 07410
For information, call:
201-796-7100
Emergency Number:
201-796-7100
For CHEMTREC assistance, call:
800-424-9300
For International CHEMTREC assistance, call:
703-527-3887

Section 2 - Composition, Information on Ingredients

CAS# Chemical Name Percent EINECS/ELINCS
63-68-3 L-Methionine >98 200-562-9

Section 3 - Hazards Identification

EMERGENCY OVERVIEW

Appearance: white solid.
Caution! May cause eye, skin, and respiratory tract irritation.
Target Organs: No data found.


Potential Health Effects
Eye: May cause eye irritation.
Skin: May cause skin irritation.
Ingestion: May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated.
Inhalation: May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
Chronic: Not available.

Section 4 - First Aid Measures


Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin: Get medical aid if irritation develops or persists. Flush skin with plenty of soap and water.
Ingestion: If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid.
Inhalation: Remove from exposure and move to fresh air immediately. Get medical aid if cough or other symptoms appear.
Notes to Physician: Treat symptomatically and supportively.

Section 5 - Fire Fighting Measures


General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Dust from this material can form explosive organic dust cloud.
Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or chemical foam.
Flash Point: 284 deg C ( 543.20 deg F)
Autoignition Temperature: Not available.
Explosion Limits, Lower:Not available.
Upper: Not available.
NFPA Rating: (estimated) Health: 1; Flammability: 1; Instability: 0

Section 6 - Accidental Release Measures


General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks: Vacuum or sweep up material and place into a suitable disposal container. Avoid generating dusty conditions.

Section 7 - Handling and Storage


Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid breathing dust.
Storage: Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Refrigeration has been recommended.

Section 8 - Exposure Controls, Personal Protection


Engineering Controls: Good general ventilation should be sufficient to control airborne levels.
Exposure Limits
Chemical Name ACGIH NIOSH OSHA - Final PELs
L-Methionine none listed none listed none listed

OSHA Vacated PELs: L-Methionine: No OSHA Vacated PELs are listed for this chemical.
Personal Protective Equipment
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin: Wear appropriate protective gloves to prevent skin exposure.
Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Section 9 - Physical and Chemical Properties


Physical State: Solid
Appearance: white
Odor: faint odor
pH: 5.6-6.1 (1% aq soln)
Vapor Pressure: Not available.
Vapor Density: Not available.
Evaporation Rate:Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point:276 - 279 deg C
Decomposition Temperature:276 deg C
Solubility: 56.6 g/L @ 25C
Specific Gravity/Density:Not available.
Molecular Formula:C5H11NO2S
Molecular Weight:149.21

Section 10 - Stability and Reactivity


Chemical Stability: Stable under normal temperatures and pressures.
Conditions to Avoid: Dust generation, excess heat, prolonged exposure to air.
Incompatibilities with Other Materials: Strong oxidizing agents.
Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, oxides of sulfur, carbon dioxide.
Hazardous Polymerization: Will not occur.

Section 11 - Toxicological Information


RTECS#:      
CAS# 63-68-3: PD0457000
LD50/LC50:
CAS# 63-68-3:
     Oral, rat: LD50 = 36 gm/kg;
.

Carcinogenicity:
CAS# 63-68-3: Not listed by ACGIH, IARC, NTP, or CA Prop 65.

Epidemiology: No data available.
Teratogenicity: Embryo or Fetus: Fetotoxicity. Specific Developmental Abnormalities: Musculoskeletal.
Reproductive Effects: Experimental reproductive effects have been observed.
Mutagenicity: No data available.
Neurotoxicity: No data available.
Other Studies:

Section 12 - Ecological Information

No information available.

Section 13 - Disposal Considerations

Chemical waste generators must determine whether a discarded chemical is classified as a hazardous waste. US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3. Additionally, waste generators must consult state and local hazardous waste regulations to ensure complete and accurate classification.
RCRA P-Series: None listed.
RCRA U-Series: None listed.

Section 14 - Transport Information

US DOT Canada TDG
Shipping Name: Not Regulated Not Regulated
Hazard Class:
UN Number:
Packing Group:

Section 15 - Regulatory Information

US FEDERAL

TSCA
     CAS# 63-68-3 is listed on the TSCA inventory.
Health & Safety Reporting List
     None of the chemicals are on the Health & Safety Reporting List.
Chemical Test Rules
     None of the chemicals in this product are under a Chemical Test Rule.
Section 12b
     None of the chemicals are listed under TSCA Section 12b.
TSCA Significant New Use Rule
     None of the chemicals in this material have a SNUR under TSCA.
CERCLA Hazardous Substances and corresponding RQs
     None of the chemicals in this material have an RQ.
SARA Section 302 Extremely Hazardous Substances
     None of the chemicals in this product have a TPQ.
Section 313      No chemicals are reportable under Section 313.
Clean Air Act:
     This material does not contain any hazardous air pollutants.
     This material does not contain any Class 1 Ozone depletors.
     This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
     None of the chemicals in this product are listed as Hazardous Substances under the CWA.
     None of the chemicals in this product are listed as Priority Pollutants under the CWA.
     None of the chemicals in this product are listed as Toxic Pollutants under the CWA.
OSHA:
     None of the chemicals in this product are considered highly hazardous by OSHA.
STATE
     CAS# 63-68-3 is not present on state lists from CA, PA, MN, MA, FL, or NJ.

California Prop 65

California No Significant Risk Level: None of the chemicals in this product are listed.

European/International Regulations

European Labeling in Accordance with EC Directives
Hazard Symbols:
      Not available.
Risk Phrases:


Safety Phrases:

     S 24/25 Avoid contact with skin and eyes.

WGK (Water Danger/Protection)

     CAS# 63-68-3: 0
Canada - DSL/NDSL
     CAS# 63-68-3 is listed on Canada's DSL List.
Canada - WHMIS
     This product has a WHMIS classification of Not controlled..
This product has been classified in accordance with the hazard criteria of the Controlled Products Regulations and the MSDS contains all of the information required by those regulations.
Canadian Ingredient Disclosure List

Section 16 - Additional Information

MSDS Creation Date: 9/02/1997
Revision #6 Date: 6/29/2007

The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no event shall Fisher be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if Fisher has been advised of the possibility of such damages.