Material Safety Data Sheet
Glyoxal, 40 wt% solution in water
ACC# 01960
Section 1 - Chemical Product and Company Identification |
MSDS Name: Glyoxal, 40 wt% solution in water
Catalog Numbers:
AC156220000, AC156220010, AC156220025, AC156220050, AC156225000, BP1370-500
Synonyms:
Biformal; Diformal; Ethandial; Glyoxylaldehyde.
Company Identification:
Fisher Scientific
1 Reagent Lane
Fair Lawn, NJ 07410
For information, call: 201-796-7100
Emergency Number: 201-796-7100
For CHEMTREC assistance, call: 800-424-9300
For International CHEMTREC assistance, call: 703-527-3887
Section 2 - Composition, Information on Ingredients
|
CAS# |
Chemical Name |
Percent |
EINECS/ELINCS |
7732-18-5 |
Water |
60 | 231-791-2 |
107-22-2 |
Glyoxal |
40 | 203-474-9 |
Section 3 - Hazards Identification
|
EMERGENCY OVERVIEW
Appearance: almost colorless liquid.
Warning! Harmful if inhaled. Possible risks of
irreversible effects. May cause allergic skin reaction. Causes eye
and skin irritation. May cause respiratory tract irritation.
Target Organs: Respiratory system, eyes, skin.
Potential Health Effects
Eye:
Causes eye irritation.
Skin:
Causes skin irritation. May cause skin sensitization, an allergic
reaction, which becomes evident upon re-exposure to this material.
May be harmful if absorbed through the skin.
In a human maximization test for contact allergens, glyoxal rated 5
on a scale of 1 to 5. The induction concentration was 10% glyoxal and
the challenge concentration was 2% glyoxal. Glyoxal is considered to
be a strong human contact sensitizer.
Ingestion:
May cause irritation of the digestive tract. May be harmful if
swallowed.
Inhalation:
Harmful if inhaled. May cause respiratory tract irritation.
Squamous cell metaplasia was observed in the rat larynx after 29 days
of exposure (6 hours/day, 5 days/week) to 2 and 10 mg/m3 of a 40%
glyoxal aerosol.
Chronic:
Prolonged or repeated skin contact may cause dermatitis. Exposure to
high concentrations may cause central nervous system depression.
Possible risk of irreversible effects.
There is insufficient data to classify glyoxal as a human or animal
carcinogen. Glyoxal was found to promote stomach carcinoma in animals
in one study and to be a direct-acting mutagen in bacterial and
mammalian cell assays in extensive testing. NIOSH has noted the
similarity of its mutagenic profile to formaldehyde, acetaldehyde,
and malonaldehyde and has advised concern regarding its carcinogenic
Section 4 - First Aid Measures
|
Eyes:
Immediately flush eyes with plenty of water for at least 15 minutes,
occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Immediately flush skin with plenty of water for at
least 15 minutes while removing contaminated clothing and shoes.
Ingestion:
Do not induce vomiting. Get medical aid.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh
air immediately. If breathing is difficult, give oxygen. Do not use
mouth-to-mouth resuscitation if victim ingested or inhaled the
substance; induce artificial respiration with the aid of a pocket
mask equipped with a one-way valve or other proper respiratory
medical device.
Notes to Physician:
Treat symptomatically and supportively.
Section 5 - Fire Fighting Measures
|
General Information:
As in any fire, wear a self-contained breathing apparatus in
pressure-demand, MSHA/NIOSH (approved or equivalent), and full
protective gear.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or appropriate foam.
Flash Point: > 104 deg C (> 219.20 deg F)
Autoignition Temperature: 285 deg C ( 545.00 deg F)
Explosion Limits, Lower:Not available.
Upper: Not available.
NFPA Rating:
(estimated) Health: 2; Flammability: 1; Instability: 1
Section 6 - Accidental Release Measures
|
General Information: Use proper personal protective equipment as indicated
in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth),
then place in suitable container. Wear a self contained breathing
apparatus and appropriate personal protection. (See Exposure
Controls, Personal Protection section). Provide ventilation. Do not
let this chemical enter the environment.
Section 7 - Handling and Storage
|
Handling:
Do not get in eyes, on skin, or on clothing. Do not ingest or
inhale. Use only in a chemical fume hood.
Storage:
Store in a tightly closed container. Store in a dry area. Store at
around 20°C.
Section 8 - Exposure Controls, Personal Protection
|
Engineering Controls:
Facilities storing or utilizing this material should be equipped
with an eyewash facility and a safety shower. Use only under a
chemical fume hood.
Exposure Limits
Chemical Name |
ACGIH |
NIOSH |
OSHA - Final PELs |
Water
|
none listed
|
none listed
|
none listed
|
Glyoxal
|
0.1 mg/m3 TWA (inhalable fraction and vapor)
|
none listed
|
none listed
|
OSHA Vacated PELs:
Water:
No OSHA Vacated PELs are listed for this chemical.
Glyoxal:
No OSHA Vacated PELs are listed for this chemical.
Personal Protective Equipment
Eyes:
Wear appropriate protective eyeglasses or chemical
safety goggles as described by OSHA's eye and face
protection regulations in 29 CFR 1910.133 or European
Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin
exposure.
Clothing:
Wear appropriate protective clothing to prevent skin
exposure.
Respirators:
A respiratory protection program that meets OSHA's 29
CFR 1910.134 and ANSI Z88.2 requirements or European
Standard EN 149 must be followed whenever workplace
conditions warrant respirator use.
Section 9 - Physical and Chemical Properties
|
Physical State: Liquid
Appearance: clear - almost colorless
Odor: mild odor - characteristic odor
pH: 2 - 3.5 (400 g/L aq.sol.)
Vapor Pressure: 20.2 hPa @ 20 deg C
Vapor Density: Not available.
Evaporation Rate:Not available.
Viscosity: 8 mPa @ 20 deg C
Boiling Point: 104 deg C @ 760 mmHg
Freezing/Melting Point:-14 deg C
Decomposition Temperature:Not available.
Solubility: Miscible.
Specific Gravity/Density:1.265
Molecular Formula:C2H2O2
Molecular Weight:58.04
Section 10 - Stability and Reactivity
|
Chemical Stability:
Moisture sensitive. May polymerize. Heat sensitive
Conditions to Avoid:
Incompatible materials, exposure to moist air or water, heat.
Incompatibilities with Other Materials:
strong oxidizing agents, strong bases
Hazardous Decomposition Products:
Carbon monoxide, carbon dioxide.
Hazardous Polymerization: May occur.
Section 11 - Toxicological Information
|
RTECS#:
CAS# 7732-18-5:
ZC0110000
CAS# 107-22-2:
MD2625000; MD2650000; MD2700000
LD50/LC50:
CAS# 7732-18-5:
Oral, rat: LD50 =
>90 mL/kg;
.
CAS# 107-22-2:
Dermal, guinea
pig: LD50 = 6600 mg/kg;
Draize
test, rabbit, eye: 20 mg Severe;
Draize test, rabbit, eye: 100 uL/24H
Moderate;
Draize test, rabbit, eye:
100 uL Mild;
Draize test, rabbit,
skin: 500 uL/4H Mild;
Draize test,
rabbit, skin: 10 mg/24H;
Inhalation, rat: LC50 = 2410
mg/m3/4H;
Oral, mouse: LD50 = 400
mg/kg;
Oral, mouse: LD50 = 1280
mg/kg;
Oral, rabbit: LD50 = >3175
mg/kg;
Oral, rat: LD50 = 200
mg/kg;
Oral, rat: LD50 = 200
mg/kg;
Oral, rat: LD50 = 4290
Carcinogenicity:
CAS# 7732-18-5:
Not listed by ACGIH, IARC, NTP, or CA Prop 65.
CAS# 107-22-2:
Not listed by ACGIH, IARC, NTP, or CA Prop 65.
Epidemiology:
No information found
Teratogenicity:
No information found
Reproductive Effects:
No information found
Mutagenicity:
See actual entry in RTECS for complete information.
Neurotoxicity:
No information found
Other Studies:
Section 12 - Ecological Information
|
Ecotoxicity:
No data available.
Fish toxicity: Brachidanio rerio LC50:760 mg/l (48 h)Daphnia
toxicity: Daphnia magna EC50:430 mg/l (24 h)Bacteria toxicity:
Pseudomonas putida EC50:134 mg/l (16 h)
Environmental:
Biodegradability: >80% (Method OECD 302 B, 28 d)DOC = 176.8 mgC/lCOD
= 342 mgO2/g
Physical:
No information available.
Other:
Do not empty into drains.
Section 13 - Disposal Considerations
|
Chemical waste generators must determine whether a discarded chemical is classified
as a hazardous waste.
US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3.
Additionally, waste generators must consult state and local hazardous waste regulations to
ensure complete and accurate classification.
RCRA P-Series: None listed.
RCRA U-Series: None listed.
Section 14 - Transport Information
|
|
US DOT |
Canada TDG |
Shipping Name: |
TOXIC LIQUIDS, ORGANIC, N.O.S. (GLYOXAL) |
Not Regulated |
Hazard Class: |
6.1 |
|
UN Number: |
UN2810 |
|
Packing Group: |
III |
|
Section 15 - Regulatory Information
|
US FEDERAL
TSCA
CAS# 7732-18-5 is listed on the TSCA inventory.
CAS# 107-22-2 is listed on the TSCA inventory.
Health & Safety Reporting List
None of the chemicals are on the Health & Safety Reporting List.
Chemical Test Rules
None of the chemicals in this product are under a Chemical Test Rule.
Section 12b
None of the chemicals are listed under TSCA Section 12b.
TSCA Significant New Use Rule
None of the chemicals in this material have a SNUR under TSCA.
CERCLA Hazardous Substances and corresponding RQs
None of the chemicals in this material have an RQ.
SARA Section 302 Extremely Hazardous Substances
None of the chemicals in this product have a TPQ.
SARA Codes
CAS # 107-22-2: immediate.
Section 313
No chemicals are reportable under Section 313.
Clean Air Act:
This material does not contain any hazardous air pollutants.
This material does not contain any Class 1 Ozone depletors.
This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
None of the chemicals in this product
are listed as Hazardous Substances under the CWA.
None of the chemicals in this
product are listed as Priority Pollutants under the CWA.
None of the chemicals in this
product are listed as Toxic Pollutants under the CWA.
OSHA:
None of the chemicals in this product
are considered highly hazardous by OSHA.
STATE
CAS# 7732-18-5 is not present on
state lists from CA, PA, MN, MA, FL, or NJ.
CAS# 107-22-2 is not present on
state lists from CA, PA, MN, MA, FL, or NJ.
California Prop 65
California No Significant Risk Level:
None of the chemicals in this product are listed.
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols:
XN
Risk Phrases:
R 36/38 Irritating to eyes and skin.
R 43 May cause sensitization by skin contact.
R 20 Harmful by inhalation.
R 68 Possible risk of irreversible effects.
Safety Phrases:
S 36/37 Wear suitable protective clothing and gloves.
WGK (Water Danger/Protection)
CAS# 7732-18-5: No information available.
CAS# 107-22-2: 1
Canada - DSL/NDSL
CAS# 7732-18-5 is listed on Canada's DSL List.
CAS# 107-22-2 is listed on Canada's DSL List.
Canada - WHMIS
This product has a WHMIS classification of D2B, D1B.
This product has been classified in accordance with the hazard
criteria of the Controlled Products Regulations and the MSDS
contains all of the information required by those regulations.
Canadian Ingredient Disclosure List
CAS# 107-22-2 is listed on the Canadian Ingredient Disclosure List.
Section 16 - Additional Information
|
MSDS Creation Date: 3/16/1998
Revision #8 Date: 4/10/2008
The information above is believed to be accurate and represents the best
information currently available to us. However, we make no warranty of
merchantability or any other warranty, express or implied, with respect to
such information, and we assume no liability resulting from its use. Users
should make their own investigations to determine the suitability of the
information for their particular purposes. In no event shall Fisher be liable
for any claims, losses, or damages of any third party or for lost profits
or any special, indirect, incidental, consequential or exemplary
damages, howsoever arising, even if Fisher has been advised of
the possibility of such damages.