Material Safety Data Sheet
Glyoxal, 40 wt% solution in water

ACC# 01960
Section 1 - Chemical Product and Company Identification

MSDS Name: Glyoxal, 40 wt% solution in water
Catalog Numbers: AC156220000, AC156220010, AC156220025, AC156220050, AC156225000, BP1370-500
Synonyms:
Biformal; Diformal; Ethandial; Glyoxylaldehyde.
Company Identification:

              Fisher Scientific
              1 Reagent Lane
              Fair Lawn, NJ 07410
For information, call:
201-796-7100
Emergency Number:
201-796-7100
For CHEMTREC assistance, call:
800-424-9300
For International CHEMTREC assistance, call:
703-527-3887

Section 2 - Composition, Information on Ingredients

CAS# Chemical Name Percent EINECS/ELINCS
7732-18-5 Water 60 231-791-2
107-22-2 Glyoxal 40 203-474-9

Section 3 - Hazards Identification

EMERGENCY OVERVIEW

Appearance: almost colorless liquid.
Warning! Harmful if inhaled. Possible risks of irreversible effects. May cause allergic skin reaction. Causes eye and skin irritation. May cause respiratory tract irritation.
Target Organs: Respiratory system, eyes, skin.


Potential Health Effects
Eye: Causes eye irritation.
Skin: Causes skin irritation. May cause skin sensitization, an allergic reaction, which becomes evident upon re-exposure to this material. May be harmful if absorbed through the skin. In a human maximization test for contact allergens, glyoxal rated 5 on a scale of 1 to 5. The induction concentration was 10% glyoxal and the challenge concentration was 2% glyoxal. Glyoxal is considered to be a strong human contact sensitizer.
Ingestion: May cause irritation of the digestive tract. May be harmful if swallowed.
Inhalation: Harmful if inhaled. May cause respiratory tract irritation. Squamous cell metaplasia was observed in the rat larynx after 29 days of exposure (6 hours/day, 5 days/week) to 2 and 10 mg/m3 of a 40% glyoxal aerosol.
Chronic: Prolonged or repeated skin contact may cause dermatitis. Exposure to high concentrations may cause central nervous system depression. Possible risk of irreversible effects. There is insufficient data to classify glyoxal as a human or animal carcinogen. Glyoxal was found to promote stomach carcinoma in animals in one study and to be a direct-acting mutagen in bacterial and mammalian cell assays in extensive testing. NIOSH has noted the similarity of its mutagenic profile to formaldehyde, acetaldehyde, and malonaldehyde and has advised concern regarding its carcinogenic

Section 4 - First Aid Measures


Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin: Get medical aid. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion: Do not induce vomiting. Get medical aid.
Inhalation: Get medical aid immediately. Remove from exposure and move to fresh air immediately. If breathing is difficult, give oxygen. Do not use mouth-to-mouth resuscitation if victim ingested or inhaled the substance; induce artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device.
Notes to Physician: Treat symptomatically and supportively.

Section 5 - Fire Fighting Measures


General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or appropriate foam.
Flash Point: > 104 deg C (> 219.20 deg F)
Autoignition Temperature: 285 deg C ( 545.00 deg F)
Explosion Limits, Lower:Not available.
Upper: Not available.
NFPA Rating: (estimated) Health: 2; Flammability: 1; Instability: 1

Section 6 - Accidental Release Measures


General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks: Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Wear a self contained breathing apparatus and appropriate personal protection. (See Exposure Controls, Personal Protection section). Provide ventilation. Do not let this chemical enter the environment.

Section 7 - Handling and Storage


Handling: Do not get in eyes, on skin, or on clothing. Do not ingest or inhale. Use only in a chemical fume hood.
Storage: Store in a tightly closed container. Store in a dry area. Store at around 20C.

Section 8 - Exposure Controls, Personal Protection


Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use only under a chemical fume hood.
Exposure Limits
Chemical Name ACGIH NIOSH OSHA - Final PELs
Water none listed none listed none listed
Glyoxal 0.1 mg/m3 TWA (inhalable fraction and vapor) none listed none listed

OSHA Vacated PELs: Water: No OSHA Vacated PELs are listed for this chemical. Glyoxal: No OSHA Vacated PELs are listed for this chemical.
Personal Protective Equipment
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin: Wear appropriate protective gloves to prevent skin exposure.
Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators: A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.

Section 9 - Physical and Chemical Properties


Physical State: Liquid
Appearance: clear - almost colorless
Odor: mild odor - characteristic odor
pH: 2 - 3.5 (400 g/L aq.sol.)
Vapor Pressure: 20.2 hPa @ 20 deg C
Vapor Density: Not available.
Evaporation Rate:Not available.
Viscosity: 8 mPa @ 20 deg C
Boiling Point: 104 deg C @ 760 mmHg
Freezing/Melting Point:-14 deg C
Decomposition Temperature:Not available.
Solubility: Miscible.
Specific Gravity/Density:1.265
Molecular Formula:C2H2O2
Molecular Weight:58.04

Section 10 - Stability and Reactivity


Chemical Stability: Moisture sensitive. May polymerize. Heat sensitive
Conditions to Avoid: Incompatible materials, exposure to moist air or water, heat.
Incompatibilities with Other Materials: strong oxidizing agents, strong bases
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide.
Hazardous Polymerization: May occur.

Section 11 - Toxicological Information


RTECS#:      
CAS# 7732-18-5: ZC0110000      
CAS# 107-22-2: MD2625000; MD2650000; MD2700000
LD50/LC50:
CAS# 7732-18-5:
     Oral, rat: LD50 = >90 mL/kg;
.

CAS# 107-22-2:
     Dermal, guinea pig: LD50 = 6600 mg/kg;
     Draize test, rabbit, eye: 20 mg Severe;
     Draize test, rabbit, eye: 100 uL/24H Moderate;
     Draize test, rabbit, eye: 100 uL Mild;
     Draize test, rabbit, skin: 500 uL/4H Mild;
     Draize test, rabbit, skin: 10 mg/24H;
     Inhalation, rat: LC50 = 2410 mg/m3/4H;
     Oral, mouse: LD50 = 400 mg/kg;
     Oral, mouse: LD50 = 1280 mg/kg;
     Oral, rabbit: LD50 = >3175 mg/kg;
     Oral, rat: LD50 = 200 mg/kg;
     Oral, rat: LD50 = 200 mg/kg;
     Oral, rat: LD50 = 4290
Carcinogenicity:
CAS# 7732-18-5: Not listed by ACGIH, IARC, NTP, or CA Prop 65.
CAS# 107-22-2: Not listed by ACGIH, IARC, NTP, or CA Prop 65.

Epidemiology: No information found
Teratogenicity: No information found
Reproductive Effects: No information found
Mutagenicity: See actual entry in RTECS for complete information.
Neurotoxicity: No information found
Other Studies:

Section 12 - Ecological Information


Ecotoxicity: No data available. Fish toxicity: Brachidanio rerio LC50:760 mg/l (48 h)Daphnia toxicity: Daphnia magna EC50:430 mg/l (24 h)Bacteria toxicity: Pseudomonas putida EC50:134 mg/l (16 h)
Environmental: Biodegradability: >80% (Method OECD 302 B, 28 d)DOC = 176.8 mgC/lCOD = 342 mgO2/g
Physical: No information available.
Other: Do not empty into drains.

Section 13 - Disposal Considerations

Chemical waste generators must determine whether a discarded chemical is classified as a hazardous waste. US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3. Additionally, waste generators must consult state and local hazardous waste regulations to ensure complete and accurate classification.
RCRA P-Series: None listed.
RCRA U-Series: None listed.

Section 14 - Transport Information

US DOT Canada TDG
Shipping Name: TOXIC LIQUIDS, ORGANIC, N.O.S. (GLYOXAL) Not Regulated
Hazard Class: 6.1
UN Number: UN2810
Packing Group: III

Section 15 - Regulatory Information

US FEDERAL

TSCA
     CAS# 7732-18-5 is listed on the TSCA inventory.
     CAS# 107-22-2 is listed on the TSCA inventory.
Health & Safety Reporting List
     None of the chemicals are on the Health & Safety Reporting List.
Chemical Test Rules
     None of the chemicals in this product are under a Chemical Test Rule.
Section 12b
     None of the chemicals are listed under TSCA Section 12b.
TSCA Significant New Use Rule
     None of the chemicals in this material have a SNUR under TSCA.
CERCLA Hazardous Substances and corresponding RQs
     None of the chemicals in this material have an RQ.
SARA Section 302 Extremely Hazardous Substances
     None of the chemicals in this product have a TPQ.
SARA Codes
     CAS # 107-22-2: immediate.
Section 313      No chemicals are reportable under Section 313.
Clean Air Act:
     This material does not contain any hazardous air pollutants.
     This material does not contain any Class 1 Ozone depletors.
     This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
     None of the chemicals in this product are listed as Hazardous Substances under the CWA.
     None of the chemicals in this product are listed as Priority Pollutants under the CWA.
     None of the chemicals in this product are listed as Toxic Pollutants under the CWA.
OSHA:
     None of the chemicals in this product are considered highly hazardous by OSHA.
STATE
     CAS# 7732-18-5 is not present on state lists from CA, PA, MN, MA, FL, or NJ.
     CAS# 107-22-2 is not present on state lists from CA, PA, MN, MA, FL, or NJ.

California Prop 65

California No Significant Risk Level: None of the chemicals in this product are listed.

European/International Regulations

European Labeling in Accordance with EC Directives
Hazard Symbols:
     XN
Risk Phrases:

     R 36/38 Irritating to eyes and skin.
     R 43 May cause sensitization by skin contact.
     R 20 Harmful by inhalation.
     R 68 Possible risk of irreversible effects.

Safety Phrases:

     S 36/37 Wear suitable protective clothing and gloves.

WGK (Water Danger/Protection)

     CAS# 7732-18-5: No information available.
     CAS# 107-22-2: 1
Canada - DSL/NDSL
     CAS# 7732-18-5 is listed on Canada's DSL List.
     CAS# 107-22-2 is listed on Canada's DSL List.
Canada - WHMIS
     This product has a WHMIS classification of D2B, D1B.
This product has been classified in accordance with the hazard criteria of the Controlled Products Regulations and the MSDS contains all of the information required by those regulations.
Canadian Ingredient Disclosure List
     CAS# 107-22-2 is listed on the Canadian Ingredient Disclosure List.

Section 16 - Additional Information

MSDS Creation Date: 3/16/1998
Revision #8 Date: 4/10/2008

The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no event shall Fisher be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if Fisher has been advised of the possibility of such damages.