Material Safety Data Sheet
Section 1 - Chemical Product and Company Identification
MSDS Name: Diethylene Glycol
2,2'-Oxydiethanol; Diethylene glycol; Diglycol; Dihydroxydiethyl
ether; 2,2'-Dihydroxyethyl ether; Ethylene diglycol;
3-Oxa-1,5-pentanediol; Bis(2-hydroxyethyl)ether; DEG.
1 Reagent Lane
Fair Lawn, NJ 07410
For information, call: 201-796-7100
Emergency Number: 201-796-7100
For CHEMTREC assistance, call: 800-424-9300
For International CHEMTREC assistance, call: 703-527-3887
Section 2 - Composition, Information on Ingredients
|| 100.0 ||203-872-2
Section 3 - Hazards Identification
Appearance: colorless viscous liquid.
Caution! May cause eye and skin irritation. May be
harmful if swallowed. May cause central nervous system depression.
May cause kidney damage. Hygroscopic (absorbs moisture from the
Target Organs: Kidneys, central nervous system,
Potential Health Effects
May cause mild eye irritation.
May cause mild skin irritation. May be absorbed through the skin.
Passage of diethylene glycol into the body through the skin is
possible, but it is unlikely that this would result in harmful
effects during safe handling and use.
May cause liver and kidney damage. May cause central nervous system
depression, characterized by excitement, followed by headache,
dizziness, drowsiness, and nausea. Advanced stages may cause
collapse, unconsciousness, coma and possible death due to respiratory
failure. Human fatalities have been reported from acute poisoning.
May cause respiratory tract irritation. May be harmful if inhaled.
Inhalation of heated or misted form may cause pulmonary edema.
Adverse reproductive effects have been reported in animals. A long
term rat feeding study showed that 1% diethylene glycol in the diet
over a 2-year period resulted in slight growth depression, a few
calcium oxalate bladder stones, minimal kidney damage, and
occasional liver damage. At 4% dietary level, there was increased
mortality, a marked depression of growth rate, bladder stones, severe
kidney damage, and moderate liver damage. In addition, bladder tumors
appeared rather frequently.
Section 4 - First Aid Measures
Flush eyes with plenty of water for at least 15 minutes, occasionally
lifting the upper and lower eyelids. Get medical aid.
Get medical aid. Immediately flush skin with plenty of water for at
least 15 minutes while removing contaminated clothing and shoes.
Wash clothing before reuse.
If victim is conscious and alert, give 2-4 cupfuls of milk or water.
Never give anything by mouth to an unconscious person. Get medical
Remove from exposure and move to fresh air immediately. If not
breathing, give artificial respiration. If breathing is difficult,
give oxygen. Get medical aid.
Notes to Physician:
Treatment options include ipecac/lavage, activated charcoal,
cathartics--admisitered within two hours of ingestion. Hemodialysis
should be considered in severe intoxication.
Section 5 - Fire Fighting Measures
As in any fire, wear a self-contained breathing apparatus in
pressure-demand, MSHA/NIOSH (approved or equivalent), and full
protective gear. During a fire, irritating and highly toxic gases
may be generated by thermal decomposition or combustion. Use water
spray to keep fire-exposed containers cool.
Water or foam may cause frothing. Alcohol foam, water fog, carbon
dioxide, dry chemical.
Flash Point: 124 deg C ( 255.20 deg F)
Autoignition Temperature: 224 deg C ( 435.20 deg F)
Explosion Limits, Lower:Not available.
Upper: Not available.
(estimated) Health: 1; Flammability: 1; Instability: 0
Section 6 - Accidental Release Measures
General Information: Use proper personal protective equipment as indicated
in Section 8.
Absorb spill with inert material (e.g. vermiculite, sand or earth),
then place in suitable container. Clean up spills immediately,
observing precautions in the Protective Equipment section. Provide
Section 7 - Handling and Storage
Wash thoroughly after handling. Use with adequate ventilation. Avoid
breathing vapors from heated material. Avoid contact with eyes, skin,
and clothing. Keep container tightly closed. Wash clothing before
reuse. Avoid breathing spray or mist.
Store in a cool, dry, well-ventilated area away from incompatible
substances. Keep containers tightly closed. Store protected from
Section 8 - Exposure Controls, Personal Protection
Good general ventilation should be sufficient to control airborne
||OSHA - Final PELs|
OSHA Vacated PELs:
No OSHA Vacated PELs are listed for this chemical.
Personal Protective Equipment
Wear appropriate protective eyeglasses or chemical
safety goggles as described by OSHA's eye and face
protection regulations in 29 CFR 1910.133 or European
Wear appropriate protective gloves to prevent skin
Wear appropriate protective clothing to minimize
contact with skin.
A respiratory protection program that meets OSHA's 29
CFR 1910.134 and ANSI Z88.2 requirements or European
Standard EN 149 must be followed whenever workplace
conditions warrant respirator use.
Section 9 - Physical and Chemical Properties
Physical State: Viscous liquid
Odor: practically odorless
pH: Not available.
Vapor Pressure: 0.01 mm Hg @ 30 deg C
Vapor Density: 3.66 (Air=1)
Evaporation Rate:< 0.001
Viscosity: 0.30 cP @ 25 deg C
Boiling Point: 245 deg C
Freezing/Melting Point:-10 deg C
Decomposition Temperature:Not available.
Section 10 - Stability and Reactivity
Stable under normal temperatures and pressures.
Conditions to Avoid:
Excess heat, exposure to moist air or water.
Incompatibilities with Other Materials:
Strong oxidizing agents, strong acids, strong bases.
Hazardous Decomposition Products:
Carbon monoxide, carbon dioxide.
Hazardous Polymerization: Will not occur.
Section 11 - Toxicological Information
rabbit, eye: 50 mg Mild;
test, rabbit, skin: 500 mg Mild;
Oral, mouse: LD50 = 23700 mg/kg;
Oral, mouse: LD50 = 2300 mg/kg;
Oral, rabbit: LD50 = 4400 mg/kg;
Oral, rat: LD50 = 12565 mg/kg;
Oral, rat: LD50 = 12000 mg/kg;
Skin, rabbit: LD50 = 11890
Oral, human: LDLo = 1000 mg/kg.
Not listed by ACGIH, IARC, NTP, or CA Prop 65.
The major hazard from diethylene glycol occurs following
the ingestion of relatively large single doses...105
fatalities among 353 people who ingested a solution of
sulfanilamide in an aqueous mixture containing 72%
diethylene glycol. The symptomsincluded nausea, dizziness,
and pain in the kidney region. In a few days, oliguria
(reduced urination) and anuria (complete suppression of
urination), with death resulting from uremic poisoning
(kidney failure) followed.Diethylene glycol-contaminated
acetaminophen elixirs were the cause of at least 30 deaths
from renal failure in Haitian children in June 1996.
Delayed neurological effects including lethargy, 6th nerve
palsy, dilated pupils, optic neuritis & cerebralatrophy
occurred in a 71/2-year-old girl poisoned in this
Oral, rat: TDLo = 50 gm/kg (Female 1-20 days after
Oral, rat: TDLo = 76420 mg/kg (Female 6-15 days after
conception--Effects on embryo and fetus).; Oral, mouse:
TDLo = 334 gm/kg (Multigeneration--Materal and embryonic
No information found
Rats and mice exposed to diethylene glycol at 5 mg/m3 for
3-7 months showed structural changes in CNS and endocrine
and internal organs along with other pathological effects.
Section 12 - Ecological Information
Fish: Fathead Minnow: LC50 = >100.0 mg/L; 96 Hr.; Static
ConditionWater flea Daphnia: LC50 = 0.3-1.0 mg/L; 96 Hr.; Static
ConditionBacteria: Phytobacterium phosphoreum: EC50 = 228 mg/L;
15 minutes; Microtox test
No data available.
Estimated Koc value = 1. This value suggests that 2-Hydroxyethyl
ether will have high mobility and be expected to biodegrade quickly
in soil. It will not be expected to adsorb to suspended solids and
No information found.
Estimated BCF value = 0.05. This value indicates that this product
will exhibit low bioconcentration in aquatic organisms.
Biodegradation is expected to be an important fate process in water.
2-Hydroxyethyl ether will exits primarily as a vapor in the ambient
Section 13 - Disposal Considerations
Chemical waste generators must determine whether a discarded chemical is classified
as a hazardous waste.
US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3.
Additionally, waste generators must consult state and local hazardous waste regulations to
ensure complete and accurate classification.
RCRA P-Series: None listed.
RCRA U-Series: None listed.
Section 14 - Transport Information
||Not regulated as a hazardous material
||No information available.
Section 15 - Regulatory Information
CAS# 111-46-6 is listed on the TSCA inventory.
Health & Safety Reporting List
None of the chemicals are on the Health & Safety Reporting List.
Chemical Test Rules
None of the chemicals in this product are under a Chemical Test Rule.
None of the chemicals are listed under TSCA Section 12b.
TSCA Significant New Use Rule
None of the chemicals in this material have a SNUR under TSCA.
CERCLA Hazardous Substances and corresponding RQs
None of the chemicals in this material have an RQ.
SARA Section 302 Extremely Hazardous Substances
None of the chemicals in this product have a TPQ.
CAS # 111-46-6: immediate, delayed.
No chemicals are reportable under Section 313.
Clean Air Act:
This material does not contain any hazardous air pollutants.
This material does not contain any Class 1 Ozone depletors.
This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
None of the chemicals in this product
are listed as Hazardous Substances under the CWA.
None of the chemicals in this
product are listed as Priority Pollutants under the CWA.
None of the chemicals in this
product are listed as Toxic Pollutants under the CWA.
None of the chemicals in this product
are considered highly hazardous by OSHA.
CAS# 111-46-6 can be found on the
following state right to know lists: Pennsylvania, Minnesota.
California Prop 65
California No Significant Risk Level:
None of the chemicals in this product are listed.
European Labeling in Accordance with EC Directives
R 22 Harmful if swallowed.
S 46 If swallowed, seek medical advice immediately and show this con
tainer or label.
WGK (Water Danger/Protection)
CAS# 111-46-6: 1
Canada - DSL/NDSL
CAS# 111-46-6 is listed on Canada's DSL List.
Canada - WHMIS
This product has a WHMIS classification of D2A.
This product has been classified in accordance with the hazard
criteria of the Controlled Products Regulations and the MSDS
contains all of the information required by those regulations.
Canadian Ingredient Disclosure List
Section 16 - Additional Information
MSDS Creation Date: 6/08/1999
Revision #8 Date: 11/20/2008
The information above is believed to be accurate and represents the best
information currently available to us. However, we make no warranty of
merchantability or any other warranty, express or implied, with respect to
such information, and we assume no liability resulting from its use. Users
should make their own investigations to determine the suitability of the
information for their particular purposes. In no event shall Fisher be liable
for any claims, losses, or damages of any third party or for lost profits
or any special, indirect, incidental, consequential or exemplary
damages, howsoever arising, even if Fisher has been advised of
the possibility of such damages.