Material Safety Data Sheet
Ethylene glycol

ACC# 09400
Section 1 - Chemical Product and Company Identification

MSDS Name: Ethylene glycol
Catalog Numbers: AC146750000, AC146750010, AC146750025, AC146750250, AC295530000, AC295530010, AC295530025, AC295530051, AC410010000, AC410010010, AC410010040, AC410010200, S79007, S80005, S800051, S93233, BP230-1, BP230-4, E177-20, E177-4, E178-1, E178-200, E178-4, E178-500, E178J-4, E184-4, S800052, ZZE1785C15
1,2-Dihydroxyethane; 1,2-Ethanediol; Ethylene alcohol; Glycol.
Company Identification:

              Fisher Scientific
              1 Reagent Lane
              Fair Lawn, NJ 07410
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Section 2 - Composition, Information on Ingredients

CAS# Chemical Name Percent EINECS/ELINCS
107-21-1 Ethylene glycol >95 203-473-3

Section 3 - Hazards Identification


Appearance: viscous liquid.
Warning! Causes eye irritation. May be harmful if swallowed. May cause kidney damage. May cause central nervous system effects. Hygroscopic (absorbs moisture from the air).
Target Organs: Kidneys, central nervous system, respiratory system, eyes.

Potential Health Effects
Eye: May cause moderate eye irritation.
Skin: Low hazard for usual industrial handling. A single prolonged skin exposure is not likely to result in the material being absorbed in harmful amounts.
Ingestion: The lethal dose in adult humans for ethylene glycol is about 100 ml (1/3 cup). Swallowing may cause nausea, vomiting or diarrhea. Excessive exposure may cause CNS effects, cardiopulmonary effects (metabolic acidosis), and kidney failure. Toxicity follows 3-stage progression. (1) involves central nervous system effects including paralysis of eye muscles, convulsions, and coma. Metabolic acidosis and cerebral swelling may also occur. (2) involves cardiopulmonary system with symptoms of hypertension, rapid heart beat, and possible cardiac failure. (3) involves severe kidney abnormalities including possible renal failure.
Inhalation: If ethylene glycol is heated or misted in work areas that are poorly ventilated, vapor/mist may accumulate and cause respiratory irritation and symptoms such as headache and nausea. Material has a very low vapor pressure at room temperature, so inhalation exposures are not expected unless material is heated or misted.
Chronic: May cause kidney injury. Repeated excessive exposure to ethylene glycol may cause irritation of the upper respiratory tract. In humans, effects have been reported on the central nervous system, including nystagmus (involuntary, rapid, rhythmic movement of the eyeball).

Section 4 - First Aid Measures

Eyes: In case of contact, immediately flush eyes with plenty of water for a t least 15 minutes. Get medical aid.
Skin: In case of contact, flush skin with plenty of water. Remove contaminated clothing and shoes. Get medical aid if irritation develops and persists. Wash clothing before reuse.
Ingestion: If swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Get medical aid.
Inhalation: If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician: Treat symptomatically and supportively.

Section 5 - Fire Fighting Measures

General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media: Use extinguishing media most appropriate for the surrounding fire.
Flash Point: 111 deg C ( 231.80 deg F)
Autoignition Temperature: 398 deg C ( 748.40 deg F)
Explosion Limits, Lower:3.20 vol %
Upper: 15.30 vol %
NFPA Rating: (estimated) Health: 2; Flammability: 1; Instability: 0

Section 6 - Accidental Release Measures

General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks: Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container.

Section 7 - Handling and Storage

Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Avoid contact with eyes, skin, and clothing. Avoid breathing spray or mist.
Storage: Store in a cool, dry, well-ventilated area away from incompatible substances. Store protected from moisture.

Section 8 - Exposure Controls, Personal Protection

Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits.
Exposure Limits
Chemical Name ACGIH NIOSH OSHA - Final PELs
Ethylene glycol 100 mg/m3 Ceiling (aerosol only) none listed none listed

OSHA Vacated PELs: Ethylene glycol: No OSHA Vacated PELs are listed for this chemical.
Personal Protective Equipment
Eyes: Wear chemical splash goggles.
Skin: Glove protection is not normally required.
Clothing: Protective garments not normally required.
Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Section 9 - Physical and Chemical Properties

Physical State: Liquid
Appearance: clear, colorless - syrupy - viscous
Odor: sweetish odor
pH: Not available.
Vapor Pressure: 0.05 mm Hg @ 20 deg C
Vapor Density: 2.14 (air=1)
Evaporation Rate:Not available.
Viscosity: 21cP @ 20 deg C
Boiling Point: 197 deg C @ 760 mmHg
Freezing/Melting Point:-13 deg C
Decomposition Temperature:Not available.
Solubility: Soluble.
Specific Gravity/Density:1.113 g/ml
Molecular Formula:C2H6O2
Molecular Weight:62.06

Section 10 - Stability and Reactivity

Chemical Stability: Stable at room temperature in closed containers under normal storage and handling conditions. Hygroscopic: absorbs moisture or water from the air.
Conditions to Avoid: Moisture, excess heat.
Incompatibilities with Other Materials: Strong oxidizing agents, strong acids, isocyanates, aliphatic amines, caustics.
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide.
Hazardous Polymerization: Will not occur.

Section 11 - Toxicological Information

CAS# 107-21-1: KW2975000
CAS# 107-21-1:
     Draize test, rabbit, eye: 500 mg/24H Mild;
     Draize test, rabbit, eye: 100 mg/1H Mild;
     Draize test, rabbit, eye: 0.012 ppm/3D;
     Draize test, rabbit, eye: 1440 mg/6H Moderate;
     Oral, mouse: LD50 = 5500 mg/kg;
     Oral, rat: LD50 = 4700 mg/kg;
     Skin, rabbit: LD50 = 9530 uL/kg;
Ethylene glycol is more acutely toxic for humans than for laboratory animals by ingestion. The single oral lethal dose for humans has been estimated at 1.4 ml/kg (1.56 g/kg) or about 100 ml (111 g) for an adult.
CAS# 107-21-1: Not listed by ACGIH, IARC, NTP, or CA Prop 65.

Epidemiology: No data available.
Teratogenicity: An expert panel convened by the NTP's Center for the Evaluation of Risks to Human Reproduction concluded 2/13/03 that developmental and reproductive risks stemming from exposure to the chemicals propylene glycol and ethylene glycol are negligible.
Reproductive Effects: No data available.
Mutagenicity: No data available.
Neurotoxicity: No data available.
Other Studies:

Section 12 - Ecological Information

Ecotoxicity: Fish: Rainbow trout: LC50 = 41000 mg/L; 96 Hr.; Unspecified
Fish: Bluegill/Sunfish: LC50 = 27500-41000 mg/L; 96 Hr.; Unspecified
Fish: Goldfish: LC50 = 27500-41000 mg/L; 96 Hr.; Unspecified
Water flea Phytobacterium phosphoreum: LC50 = 46300 mg/L; 48 Hr.; Unspecified

Section 13 - Disposal Considerations

Chemical waste generators must determine whether a discarded chemical is classified as a hazardous waste. US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3. Additionally, waste generators must consult state and local hazardous waste regulations to ensure complete and accurate classification.
RCRA P-Series: None listed.
RCRA U-Series: None listed.

Section 14 - Transport Information

Shipping Name: Not regulated Not Regulated
Hazard Class:
UN Number:
Packing Group:

Section 15 - Regulatory Information


     CAS# 107-21-1 is listed on the TSCA inventory.
Health & Safety Reporting List
     None of the chemicals are on the Health & Safety Reporting List.
Chemical Test Rules
     None of the chemicals in this product are under a Chemical Test Rule.
Section 12b
     None of the chemicals are listed under TSCA Section 12b.
TSCA Significant New Use Rule
     None of the chemicals in this material have a SNUR under TSCA.
CERCLA Hazardous Substances and corresponding RQs
     CAS# 107-21-1: 5000 lb final RQ; 2270 kg final RQ
SARA Section 302 Extremely Hazardous Substances
     None of the chemicals in this product have a TPQ.
SARA Codes
     CAS # 107-21-1: immediate, delayed.
Section 313
     This material contains Ethylene glycol (CAS# 107-21-1, >95%),which is subject to the reporting requirements of Section 313 of SARA Title III and 40 CFR Part 373.
Clean Air Act:
     CAS# 107-21-1 is listed as a hazardous air pollutant (HAP).
     This material does not contain any Class 1 Ozone depletors.
     This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
     None of the chemicals in this product are listed as Hazardous Substances under the CWA.
     None of the chemicals in this product are listed as Priority Pollutants under the CWA.
     None of the chemicals in this product are listed as Toxic Pollutants under the CWA.
     None of the chemicals in this product are considered highly hazardous by OSHA.
     CAS# 107-21-1 can be found on the following state right to know lists: California, New Jersey, Pennsylvania, Minnesota, Massachusetts.

California Prop 65

California No Significant Risk Level: None of the chemicals in this product are listed.

European/International Regulations

European Labeling in Accordance with EC Directives
Hazard Symbols:
Risk Phrases:

     R 22 Harmful if swallowed.

Safety Phrases:

WGK (Water Danger/Protection)

     CAS# 107-21-1: 0
Canada - DSL/NDSL
     CAS# 107-21-1 is listed on Canada's DSL List.
Canada - WHMIS
     This product has a WHMIS classification of D2B.
This product has been classified in accordance with the hazard criteria of the Controlled Products Regulations and the MSDS contains all of the information required by those regulations.
Canadian Ingredient Disclosure List
     CAS# 107-21-1 is listed on the Canadian Ingredient Disclosure List.

Section 16 - Additional Information

MSDS Creation Date: 5/12/1999
Revision #9 Date: 6/29/2007

The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no event shall Fisher be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if Fisher has been advised of the possibility of such damages.