Material Safety Data Sheet
Morpholine

ACC# 15200
Section 1 - Chemical Product and Company Identification

MSDS Name: Morpholine
Catalog Numbers: AC158680000, AC158680010, AC158680025, AC158680050, AC415160000, AC415160030, AC415160050, 41516-5000, M263-1
Synonyms:
1-Oxa-4-azacyclohexane; Tetrahydro-2H-1,4-oxazine.
Company Identification:

              Fisher Scientific
              1 Reagent Lane
              Fair Lawn, NJ 07410
For information, call:
201-796-7100
Emergency Number:
201-796-7100
For CHEMTREC assistance, call:
800-424-9300
For International CHEMTREC assistance, call:
703-527-3887

Section 2 - Composition, Information on Ingredients

CAS# Chemical Name Percent EINECS/ELINCS
110-91-8 Morpholine 99+ 203-815-1

Section 3 - Hazards Identification

EMERGENCY OVERVIEW

Appearance: APHA: 15 max liquid. Flash Point: 32 deg C.
Danger! Causes burns by all exposure routes. Flammable liquid and vapor. Harmful if swallowed, inhaled, or absorbed through the skin. Hygroscopic (absorbs moisture from the air).
Target Organs: Blood, kidneys, central nervous system, liver, spleen, lungs, respiratory system, eyes, skin.


Potential Health Effects
Eye: Causes eye burns. Lachrymator (substance which increases the flow of tears).
Skin: Harmful if absorbed through the skin. Causes skin burns.
Ingestion: Harmful if swallowed. Causes gastrointestinal tract burns. Possible aspiration hazard. May cause lung damage.
Inhalation: Harmful if inhaled. Causes chemical burns to the respiratory tract.
Chronic: May cause liver and kidney damage. Repeated exposure may cause damage to the spleen. Chronic inhalation can cause pneumoconiosis. Adverse reproductive effects have been reported in animals. Laboratory experiments have resulted in mutagenic effects. Chronic exposure may cause blood effects. Exposure to high concentrations may cause central nervous system depression. Animal studies have reported the development of tumors.

Section 4 - First Aid Measures


Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid imme diately.
Skin: Get medical aid immediately. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion: Potential for aspiration if swallowed. Get medical aid immediately. Do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. If vomiting occurs naturally, have victim lean forward.
Inhalation: Get medical aid immediately. Remove from exposure and move to fresh air immediately. If breathing is difficult, give oxygen. Do not use mouth-to-mouth resuscitation if victim ingested or inhaled the substance; induce artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device.
Notes to Physician: Treat symptomatically and supportively.

Section 5 - Fire Fighting Measures


General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Vapors may form an explosive mixture with air. Vapors can travel to a source of ignition and flash back. Will burn if involved in a fire. Containers may explode in the heat of a fire. Flammable liquid and vapor.
Extinguishing Media: Use water spray to cool fire-exposed containers. Use foam, dry chemical, or carbon dioxide.
Flash Point: 32 deg C ( 89.60 deg F)
Autoignition Temperature: 255 deg C ( 491.00 deg F)
Explosion Limits, Lower:2 vol %
Upper: 11.2 vol %
NFPA Rating: (estimated) Health: 3; Flammability: 3; Instability: 1

Section 6 - Accidental Release Measures


General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks: Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Wear a self contained breathing apparatus and appropriate personal protection. (See Exposure Controls, Personal Protection section). Remove all sources of ignition. Use a spark-proof tool. Do not let this chemical enter the environment.

Section 7 - Handling and Storage


Handling: Use spark-proof tools and explosion proof equipment. Do not get in eyes, on skin, or on clothing. Take precautionary measures against static discharges. Keep away from heat, sparks and flame. Do not ingest or inhale. Use only in a chemical fume hood.
Storage: Keep away from sources of ignition. Store in a cool, dry place. Store in a tightly closed container. Flammables-area.

Section 8 - Exposure Controls, Personal Protection


Engineering Controls: Use explosion-proof ventilation equipment. Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use only under a chemical fume hood.
Exposure Limits
Chemical Name ACGIH NIOSH OSHA - Final PELs
Morpholine 20 ppm TWA; Skin - potential significant contribution to overall exposure by the cutaneous r oute 20 ppm TWA; 70 mg/m3 TWA 1400 ppm IDLH (10% LEL) 20 ppm TWA; 70 mg/m3 TWA

OSHA Vacated PELs: Morpholine: 20 ppm TWA; 70 mg/m3 TWA
Personal Protective Equipment
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin: Wear appropriate protective gloves to prevent skin exposure.
Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators: A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.

Section 9 - Physical and Chemical Properties


Physical State: Liquid
Appearance: APHA: 15 max
Odor: characteristic odor
pH: Not available.
Vapor Pressure: 11 mbar @ 20 deg C
Vapor Density: 3.0 (air=1)
Evaporation Rate:Not available.
Viscosity: 2.23 cP @ 20 deg C
Boiling Point: 126 - 130 deg C @ 760 mmHg
Freezing/Melting Point:-5 deg C
Decomposition Temperature:Not available.
Solubility: Miscible.
Specific Gravity/Density:0.990
Molecular Formula:C4H9NO
Molecular Weight:87.12

Section 10 - Stability and Reactivity


Chemical Stability: Hygroscopic: absorbs moisture or water from the air.
Conditions to Avoid: Incompatible materials, ignition sources, excess heat, exposure to moist air or water.
Incompatibilities with Other Materials: Acids, strong oxidizing agents, aluminum, nitriles (e.g. acetonitrile, methyl cyanide).
Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, carbon dioxide, ammonia.
Hazardous Polymerization: Has not been reported.

Section 11 - Toxicological Information


RTECS#:      
CAS# 110-91-8: QD6475000
LD50/LC50:
CAS# 110-91-8:
     Draize test, rabbit, eye: 2 mg Severe;
     Draize test, rabbit, skin: 995 mg/24H Severe;
     Inhalation, mouse: LC50 = 1320 mg/m3/2H;
     Inhalation, rat: LC50 = 8000 ppm/8H;
     Oral, mouse: LD50 = 525 mg/kg;
     Oral, rat: LD50 = 1450 mg/kg;
     Skin, rabbit: LD50 = 500 uL/kg;
.

Carcinogenicity:
CAS# 110-91-8: Not listed by ACGIH, IARC, NTP, or CA Prop 65.

Epidemiology: Tumorigenic effects have been reported in experimental animals.
Teratogenicity: No information found
Reproductive Effects: Adverse reproductive effects have occurred in experimental animals.
Mutagenicity: Mutagenic effects have occurred in experimental animals.
Neurotoxicity: No information found
Other Studies:

Section 12 - Ecological Information


Ecotoxicity: Water flea Daphnia: LC50=100.0-119.0mg/L; 24 Hr.; UnspecifiedFish: Bluegill/Sunfish: LC50=350.0mg/L; 96 Hr.; Static conditions, 18-22CBacteria: Phytobacterium phosphoreum: EC50=37mg/L; 30min.; Microtox test No data available.
Environmental: No information available.
Physical: No information available.
Other: Do not empty into drains.

Section 13 - Disposal Considerations

Chemical waste generators must determine whether a discarded chemical is classified as a hazardous waste. US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3. Additionally, waste generators must consult state and local hazardous waste regulations to ensure complete and accurate classification.
RCRA P-Series: None listed.
RCRA U-Series: None listed.

Section 14 - Transport Information

US DOT Canada TDG
Shipping Name: MORPHOLINE MORPHOLINE
Hazard Class: 8 8
UN Number: UN2054 UN2054
Packing Group: I I

Section 15 - Regulatory Information

US FEDERAL

TSCA
     CAS# 110-91-8 is listed on the TSCA inventory.
Health & Safety Reporting List
     None of the chemicals are on the Health & Safety Reporting List.
Chemical Test Rules
     None of the chemicals in this product are under a Chemical Test Rule.
Section 12b
     None of the chemicals are listed under TSCA Section 12b.
TSCA Significant New Use Rule
     None of the chemicals in this material have a SNUR under TSCA.
CERCLA Hazardous Substances and corresponding RQs
     None of the chemicals in this material have an RQ.
SARA Section 302 Extremely Hazardous Substances
     None of the chemicals in this product have a TPQ.
SARA Codes
     CAS # 110-91-8: immediate, delayed, fire.
Section 313      No chemicals are reportable under Section 313.
Clean Air Act:
     This material does not contain any hazardous air pollutants.
     This material does not contain any Class 1 Ozone depletors.
     This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
     None of the chemicals in this product are listed as Hazardous Substances under the CWA.
     None of the chemicals in this product are listed as Priority Pollutants under the CWA.
     None of the chemicals in this product are listed as Toxic Pollutants under the CWA.
OSHA:
     None of the chemicals in this product are considered highly hazardous by OSHA.
STATE
     CAS# 110-91-8 can be found on the following state right to know lists: California, New Jersey, Pennsylvania, Minnesota, Massachusetts.

California Prop 65

California No Significant Risk Level: None of the chemicals in this product are listed.

European/International Regulations

European Labeling in Accordance with EC Directives
Hazard Symbols:
     C
Risk Phrases:

     R 10 Flammable.
     R 20/21/22 Harmful by inhalation, in contact with skin and if
     swallowed.
     R 34 Causes burns.

Safety Phrases:

     S 23 Do not inhale gas/fumes/vapour/spray.
     S 36 Wear suitable protective clothing.
     S 45 In case of accident or if you feel unwell, seek medical advice
     immediately (show the label where possible).

WGK (Water Danger/Protection)

     CAS# 110-91-8: 2
Canada - DSL/NDSL
     CAS# 110-91-8 is listed on Canada's DSL List.
Canada - WHMIS
     This product has a WHMIS classification of B2, D1B, E.
This product has been classified in accordance with the hazard criteria of the Controlled Products Regulations and the MSDS contains all of the information required by those regulations.
Canadian Ingredient Disclosure List
     CAS# 110-91-8 is listed on the Canadian Ingredient Disclosure List.

Section 16 - Additional Information

MSDS Creation Date: 6/04/1999
Revision #13 Date: 3/07/2008

The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no event shall Fisher be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if Fisher has been advised of the possibility of such damages.