Material Safety Data Sheet
4-Hydroxy-3-nitrobenzenearsonic acid, 98%

ACC# 20540
Section 1 - Chemical Product and Company Identification
MSDS Name: 4-Hydroxy-3-nitrobenzenearsonic acid, 98%
Catalog Numbers: AC121660000, AC121660050, AC121660250, AC121665000
Synonyms: 4-Hydroxy-3-nitrophenylarsonic acid; Roxarsone; 3-Nitro-4-hydroxyphenylarsonic acid; nitrophenolarsonic acid.
Company Identification:
              Acros Organics N.V.
              One Reagent Lane
              Fair Lawn, NJ 07410
For information in North America, call: 800-ACROS-01
For emergencies in the US, call CHEMTREC: 800-424-9300

Section 2 - Composition, Information on Ingredients

CAS# Chemical Name Percent EINECS/ELINCS
121-19-7 4-Hydroxy-3-nitrobenzenearsonic acid 98 204-453-7

Section 3 - Hazards Identification

EMERGENCY OVERVIEW

Appearance: beige crystalline powder.
Warning! Harmful if swallowed. Harmful if inhaled. May be harmful if absorbed through the skin. May cause eye and skin irritation. May cause respiratory tract irritation. The toxicological properties of this material have not been fully investigated.
Target Organs: Kidneys, liver, lungs, nervous system, pancreas, skin.


Potential Health Effects
Eye: May cause eye irritation.
Skin: May cause skin irritation. May be harmful if absorbed through the skin. The toxicological properties of this material have not been fully investigated.
Ingestion: Harmful if swallowed. All soluble arsenic (As) compounds are considered to be poisonous to humans. Inorganic arsenic is more toxic than organic arsenic. Organic arsenic is excreted more rapidly than inorganic arsenic. Arsenic 5+ is excreted more rapidly than arsenic 3+.
Inhalation: Harmful if inhaled. May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
Chronic: Prolonged or repeated skin contact may cause irritation. May cause liver and kidney damage. May cause digestive tract disturbances. NTP Chemical Status Report concludes that under the conditions of the 2-year feed studies, there was equivocal evidence of carcinogenic activity of roxarsone for male rats, as indicated by a marginally increased incidence of benign tumors of the pancreas There was no evidence of carcinogenic activity for female rats. There was no evidence of carcinogenic activity for male or female mice fed diets containing 100 or 200 ppm roxarsone for 2 years.

Section 4 - First Aid Measures


Eyes: In case of contact, immediately flush eyes with plenty of water for a t least 15 minutes. Get medical aid.
Skin: In case of contact, immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid immediately. Wash clothing before reuse.
Ingestion: If swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Get medical aid.
Inhalation: If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician: Treat symptomatically and supportively.

Section 5 - Fire Fighting Measures


General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. This material in sufficient quantity and reduced particle size is capable of creating a dust explosion.
Extinguishing Media: Use water spray to cool fire-exposed containers. Use water spray, dry chemical, carbon dioxide, or chemical foam.
Flash Point: Not available.
Autoignition Temperature: Not available.
Explosion Limits, Lower:Not available.
Upper: Not available.
NFPA Rating: (estimated) Health: 2; Flammability: 1; Instability: 0

Section 6 - Accidental Release Measures


General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks: Vacuum or sweep up material and place into a suitable disposal container. Avoid generating dusty conditions. Provide ventilation. Evacuate unnecessary personnel.

Section 7 - Handling and Storage


Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Use only with adequate ventilation. Avoid breathing dust.
Storage: Store in a cool, dry place. Store in a tightly closed container.

Section 8 - Exposure Controls, Personal Protection


Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits
Chemical Name ACGIH NIOSH OSHA - Final PELs
4-Hydroxy-3-nitrobenzenearsonic acid none listed none listed 0.5 mg/m3 TWA (as As) (listed under Arsenic organic compounds).

OSHA Vacated PELs: 4-Hydroxy-3-nitrobenzenearsonic acid: No OSHA Vacated PELs are listed for this chemical.
Personal Protective Equipment
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin: Wear appropriate protective gloves to prevent skin exposure.
Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Section 9 - Physical and Chemical Properties


Physical State: Crystalline powder
Appearance: brown - beige
Odor: aromatic odor
pH: Not available.
Vapor Pressure: Not available.
Vapor Density: Not available.
Evaporation Rate:Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point:> 300 deg C
Decomposition Temperature:Not available.
Solubility: slightly soluble in cold water
Specific Gravity/Density:Not available.
Molecular Formula:C6H6AsNO6
Molecular Weight:263.03

Section 10 - Stability and Reactivity


Chemical Stability: Stable. May be sensitive to light and elevated temperatures on long-term storage. It puffs up and deflagrates (burns rapidly with intense heat and sparks being given off) on heating.
Conditions to Avoid: Excess heat.
Incompatibilities with Other Materials: Strong oxidizing agents, strong acids.
Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, carbon dioxide, oxides of arsenic.
Hazardous Polymerization: Will not occur.

Section 11 - Toxicological Information


RTECS#:      
CAS# 121-19-7: CY5250000
LD50/LC50:
CAS# 121-19-7:
     Oral, mouse: LD50 = 244 mg/kg;
     Oral, rat: LD50 = 81 mg/kg;
.
Oral, dog: LD50 = 50 mg/kg; Oral, chicken: LD50 = 110 mg/kg; Oral, turkey: LD50 = 61 mg/kg.
Carcinogenicity:
CAS# 121-19-7:


Epidemiology: Inorganic arsenic is a proven human carcinogen after long-term oral intake, as well as after inhalation.Epidemiological studies have demonstrated evidence of a causal relationship between environmental, occupational, and medicinal exposure of humans to inorganic arsenic and cancer of the skin and lungs.
Teratogenicity: No information found
Reproductive Effects: No information found
Mutagenicity: Mutation:msc-mus-lym 400 mg/L
Neurotoxicity: No information found
Other Studies:

Section 12 - Ecological Information


Ecotoxicity: No data available. No information available.
Environmental: No information available.
Physical: No information available.
Other: Arsenic is moderately toxic for fish and aquatic invertebrates but highly toxic for some algal species. There is field evidence of arsenic affecting aquatic ecosystems.

Section 13 - Disposal Considerations

Chemical waste generators must determine whether a discarded chemical is classified as a hazardous waste. US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3. Additionally, waste generators must consult state and local hazardous waste regulations to ensure complete and accurate classification.
RCRA P-Series: None listed.
RCRA U-Series: None listed.

Section 14 - Transport Information

US DOT Canada TDG
Shipping Name: ORGANOARSENIC COMPOUND, SOLID, N.O.S. (4-Hydroxy-3-nitrobenzenearsonic acid) ORGANOARSENIC COMPOUND, SOLID, N.O.S. (4-Hydroxy-3-nitrobenzenearsonic acid)
Hazard Class: 6.1 6.1
UN Number: UN3465 UN3465
Packing Group: III III

Section 15 - Regulatory Information

US FEDERAL
TSCA
     CAS# 121-19-7 is listed on the TSCA inventory.
Health & Safety Reporting List
     None of the chemicals are on the Health & Safety Reporting List.
Chemical Test Rules
     None of the chemicals in this product are under a Chemical Test Rule.
Section 12b
     None of the chemicals are listed under TSCA Section 12b.
TSCA Significant New Use Rule
     None of the chemicals in this material have a SNUR under TSCA.
CERCLA Hazardous Substances and corresponding RQs
     None of the chemicals in this material have an RQ.
SARA Section 302 Extremely Hazardous Substances
     None of the chemicals in this product have a TPQ.
Section 313
     This material contains 4-Hydroxy-3-nitrobenzenearsonic acid (listed as Arsenic organic compounds), 98%, (CAS# 121-19-7) which is subject to the reporting requirements of Section 313 of SARA Title III and 40 CFR Part 373.
Clean Air Act:
     This material does not contain any hazardous air pollutants.
     This material does not contain any Class 1 Ozone depletors.
     This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
     None of the chemicals in this product are listed as Hazardous Substances under the CWA.
     None of the chemicals in this product are listed as Priority Pollutants under the CWA. CAS# 121-19-7 is listed as a Toxic Pollutant under the Clean Water Act.
OSHA:
     None of the chemicals in this product are considered highly hazardous by OSHA.
STATE
     CAS# 121-19-7 can be found on the following state right to know lists: California, (listed as Arsenic compounds, n.o.s.), New Jersey, (listed as Arsenic compounds, n.o.s.), Pennsylvania, (listed as Arsenic compounds, n.o.s.), Minnesota, (listed as Arsenic organic compounds).

California Prop 65

California No Significant Risk Level: None of the chemicals in this product are listed.

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols:
     T N
Risk Phrases:
     R 23/25 Toxic by inhalation and if swallowed.
     R 50/53 Very toxic to aquatic organisms, may cause long-term
     adverse effects in the aquatic environment.

Safety Phrases:
     S 20/21 When using do not eat, drink or smoke.
     S 45 In case of accident or if you feel unwell, seek medical advice
     immediately (show the label where possible).
     S 60 This material and its container must be disposed of as hazardou
     s waste.
     S 28A After contact with skin, wash immediately with plenty of water
     .
     S 61 Avoid release to the environment. Refer to special instructions
     /safety data sheets.

WGK (Water Danger/Protection)
     CAS# 121-19-7: No information available.
Canada - DSL/NDSL
     CAS# 121-19-7 is listed on Canada's DSL List.
Canada - WHMIS
     This product has a WHMIS classification of D1B, D2B.
This product has been classified in accordance with the hazard criteria of the Controlled Products Regulations and the MSDS contains all of the information required by those regulations.
Canadian Ingredient Disclosure List
     CAS# 121-19-7 is not listed on the Canadian Ingredient Disclosure List.

Section 16 - Additional Information

MSDS Creation Date: 9/02/1997
Revision #5 Date: 1/08/2007

The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no event shall Fisher be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if Fisher has been advised of the possibility of such damages.