Material Safety Data Sheet

ACC# 42775
Section 1 - Chemical Product and Company Identification
MSDS Name: 1,4-Diazabicyclo[2.2.2]octane
Catalog Numbers: AC112470000, AC112470250, AC112471000, AC112475000
Dabcož4; TED; Triethylenediamine; BACO.
Company Identification:

              Acros Organics N.V.
              One Reagent Lane
              Fair Lawn, NJ 07410
For information in North America, call: 800-ACROS-01
For emergencies in the US, call CHEMTREC: 800-424-9300

Section 2 - Composition, Information on Ingredients

CAS# Chemical Name Percent EINECS/ELINCS
280-57-9 1,4-Diazabicyclo[2.2.2]octane 97 205-999-9

Section 3 - Hazards Identification


Appearance: white solid. Flash Point: 62 deg C.
Danger! Highly flammable. Harmful to aquatic organisms; may cause long-term adverse effects in the aquatic environment. Eye contact may result in permanent eye damage. Harmful if swallowed. Causes eye and skin irritation. Hygroscopic (absorbs moisture from the air).
Target Organs: Kidneys, central nervous system, eyes, skin.

Potential Health Effects
Eye: Causes eye irritation. Risk of serious damage to eyes. A single exposure to TEDA vapor can cause slight swelling of the front part of the eye (cornea). This may result in a "halo" vision effect beginning up to several hours after exposure. Symptoms include hazy, foggy and sometimes blurry vision, and seeing blue halos around lights. Recovery usually occurs within a day. It is not certain what levels of TEDA vapor cause this effect. Minor corneal injury occurred when 0.5 ml of a solution of 5% TEDA in water was applied to rabbit eyes. A 15% solution caused moderate injury, and a 25% solution burned the eyes.
Skin: Causes skin irritation. May be harmful if absorbed through the skin. Definite skin reddening and some death of skin tissue were seen 24 hours after a solution of 25% TEDA in water was applied to rabbit skin. When a solution of 10% TEDA in water was applied to the skin of 5 mice for 2 weeks, 2 of the mice died from bleeding in the prostate gland. Two other mice also had bleeding of the prostate gland but did not die. There was no sign of skin damage .
Ingestion: May cause irritation of the digestive tract. May be harmful if swallowed.
Inhalation: May cause respiratory tract irritation. May be harmful if inhaled. Acute inhalation toxicity was evaluated in guinea pigs exposed to triethylenediamine at a measured concentration of 8.9 ppm for a period of 1 hour. Clinical observations included slight dyspnea and somewhat elevated airway resistance. (Olin Corp.)
Chronic: Prolonged or repeated eye contact may cause conjunctivitis. May cause kidney damage.

Section 4 - First Aid Measures

Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid imme diately.
Skin: Get medical aid immediately. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion: Get medical aid immediately. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation: Get medical aid immediately. Remove from exposure and move to fresh air immediately. If breathing is difficult, give oxygen. Do not use mouth-to-mouth resuscitation if victim ingested or inhaled the substance; induce artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device.
Notes to Physician: Treat symptomatically and supportively.

Section 5 - Fire Fighting Measures

General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Will burn if involved in a fire. Flammable solid.
Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or chemical foam.
Flash Point: 62 deg C ( 143.60 deg F)
Autoignition Temperature: Not available.
Explosion Limits, Lower:Not available.
Upper: Not available.
NFPA Rating: (estimated) Health: 3; Flammability: 2; Instability: 1

Section 6 - Accidental Release Measures

General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks: Vacuum or sweep up material and place into a suitable disposal container. Avoid generating dusty conditions. Remove all sources of ignition. Use a spark-proof tool. Provide ventilation. Do not let this chemical enter the environment.

Section 7 - Handling and Storage

Handling: Minimize dust generation and accumulation. Use spark-proof tools and explosion proof equipment. Do not get in eyes, on skin, or on clothing. Keep away from heat, sparks and flame. Do not ingest or inhale. Use with adequate ventilation.
Storage: Keep away from sources of ignition. Store in a tightly closed container. Store in a dry area. Refrigerator/flammables.

Section 8 - Exposure Controls, Personal Protection

Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate general or local explosion-proof ventilation to keep airborne levels to acceptable levels.
Exposure Limits
Chemical Name ACGIH NIOSH OSHA - Final PELs
1,4-Diazabicyclo[2.2.2]octane none listed none listed none listed

OSHA Vacated PELs: 1,4-Diazabicyclo[2.2.2]octane: No OSHA Vacated PELs are listed for this chemical.
Personal Protective Equipment
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin: Wear appropriate protective gloves to prevent skin exposure.
Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Section 9 - Physical and Chemical Properties

Physical State: Solid
Appearance: white
Odor: ammonia-like
pH: 10.8 (10g/l aq soln)
Vapor Pressure: 2.9 mm Hg @ 50 deg C
Vapor Density: 3.86 (air=1)
Evaporation Rate:Not available.
Viscosity: Not available.
Boiling Point: 174 deg C @ 760 mm Hg
Freezing/Melting Point:155 - 160 deg C
Decomposition Temperature:> 130 deg C
Solubility: 46 g/100ml (26░C)
Specific Gravity/Density:1.1400 g/cm3
Molecular Formula:C6H12N2
Molecular Weight:112.17

Section 10 - Stability and Reactivity

Chemical Stability: Hygroscopic: absorbs moisture or water from the air.
Conditions to Avoid: Incompatible materials, ignition sources, dust generation, excess heat, exposure to moist air or water.
Incompatibilities with Other Materials: Strong acids, strong oxidizing agents, peroxides, hypochlorite.
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, nitrogen oxides (NOx) and ammonia (NH3), nitric acid.
Hazardous Polymerization: Will not occur.

Section 11 - Toxicological Information

CAS# 280-57-9: HM0354200
CAS# 280-57-9:
     Draize test, rabbit, eye: 25 mg Moderate;
     Oral, rabbit: LD50 = 1100 mg/kg;
     Oral, rat: LD50 = 1700 mg/kg;

CAS# 280-57-9: Not listed by ACGIH, IARC, NTP, or CA Prop 65.

Epidemiology: No information found
Teratogenicity: No information found
Reproductive Effects: No information found
Mutagenicity: No information found
Neurotoxicity: TEDA may cause neurological effects as indicated by transient experimental effects on blood pressure in dogs.
Other Studies:

Section 12 - Ecological Information

Ecotoxicity: No data available. No information available.
Environmental: No information available.
Physical: No information available.
Other: Do not empty into drains.

Section 13 - Disposal Considerations

Chemical waste generators must determine whether a discarded chemical is classified as a hazardous waste. US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3. Additionally, waste generators must consult state and local hazardous waste regulations to ensure complete and accurate classification.
RCRA P-Series: None listed.
RCRA U-Series: None listed.

Section 14 - Transport Information

Shipping Name: FLAMMABLE SOLIDS, CORROSIVE, ORGANIC, N.O.S. Flammable Solid, Organic, N.O.S. (1,4 DIAZABICYCLO(2.2.2)
Hazard Class: 4.1 4.1
UN Number: UN2925 UN1325
Packing Group: III III
Additional Info:OCTANE)

Section 15 - Regulatory Information


     CAS# 280-57-9 is listed on the TSCA inventory.
Health & Safety Reporting List
     None of the chemicals are on the Health & Safety Reporting List.
Chemical Test Rules
     None of the chemicals in this product are under a Chemical Test Rule.
Section 12b
     None of the chemicals are listed under TSCA Section 12b.
TSCA Significant New Use Rule
     None of the chemicals in this material have a SNUR under TSCA.
CERCLA Hazardous Substances and corresponding RQs
     None of the chemicals in this material have an RQ.
SARA Section 302 Extremely Hazardous Substances
     None of the chemicals in this product have a TPQ.
SARA Codes
     CAS # 280-57-9: immediate, fire.
Section 313      No chemicals are reportable under Section 313.
Clean Air Act:
     This material does not contain any hazardous air pollutants.
     This material does not contain any Class 1 Ozone depletors.
     This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
     None of the chemicals in this product are listed as Hazardous Substances under the CWA.
     None of the chemicals in this product are listed as Priority Pollutants under the CWA.
     None of the chemicals in this product are listed as Toxic Pollutants under the CWA.
     None of the chemicals in this product are considered highly hazardous by OSHA.
     CAS# 280-57-9 can be found on the following state right to know lists: New Jersey.

California Prop 65

California No Significant Risk Level: None of the chemicals in this product are listed.

European/International Regulations

European Labeling in Accordance with EC Directives
Hazard Symbols:
     XN F
Risk Phrases:

     R 11 Highly flammable.
     R 22 Harmful if swallowed.
     R 36/38 Irritating to eyes and skin.
     R 41 Risk of serious damage to eyes.
     R 52/53 Harmful to aquatic organisms, may cause long-term adverse
     effects in the aquatic environment.

Safety Phrases:

     S 16 Keep away from sources of ignition - No smoking.
     S 26 In case of contact with eyes, rinse immediately with plenty of
     water and seek medical advice.
     S 3 Keep in a cool place.
     S 37/39 Wear suitable gloves and eye/face protection.

WGK (Water Danger/Protection)

     CAS# 280-57-9: 2
Canada - DSL/NDSL
     CAS# 280-57-9 is listed on Canada's DSL List.
Canada - WHMIS
     This product has a WHMIS classification of B4, E, D1B, D2B.
This product has been classified in accordance with the hazard criteria of the Controlled Products Regulations and the MSDS contains all of the information required by those regulations.
Canadian Ingredient Disclosure List
     CAS# 280-57-9 is listed on the Canadian Ingredient Disclosure List.

Section 16 - Additional Information

MSDS Creation Date: 8/18/1998
Revision #9 Date: 5/27/2008

The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no event shall Fisher be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if Fisher has been advised of the possibility of such damages.