Material Safety Data Sheet
Phenolphthalein Solution 1%
ACC# 45376
Section 1 - Chemical Product and Company Identification |
MSDS Name: Phenolphthalein Solution 1%
Catalog Numbers:
SP62-1, SP62-500
Synonyms:
Phenolphthalein Indicator Solution
Company Identification:
Fisher Scientific
1 Reagent Lane
Fair Lawn, NJ 07410
For information, call: 201-796-7100
Emergency Number: 201-796-7100
For CHEMTREC assistance, call: 800-424-9300
For International CHEMTREC assistance, call: 703-527-3887
Section 2 - Composition, Information on Ingredients
|
CAS# |
Chemical Name |
Percent |
EINECS/ELINCS |
67-63-0 |
Isopropyl alcohol |
99 | 200-661-7 |
77-09-8 |
Phenolphthalein |
1 | 201-004-7 |
Section 3 - Hazards Identification
|
EMERGENCY OVERVIEW
Appearance: colorless liquid. Flash Point: 12 deg C.
Warning! Flammable liquid and
vapor. Causes eye, skin, and respiratory tract
irritation. May cause allergic skin reaction. May cause central
nervous system depression. May cause cancer based on animal studies.
May form explosive peroxides. May cause kidney damage. May cause
reproductive and fetal effects.
Target Organs: Kidneys, central nervous system.
Potential Health Effects
Eye:
Produces irritation, characterized by a burning sensation, redness,
tearing, inflammation, and possible corneal injury.
Skin:
May cause skin sensitization, an allergic reaction, which becomes
evident upon re-exposure to this material. Prolonged and/or repeated
contact may cause defatting of the skin and dermatitis. May cause
irritation with pain and stinging, especially if the skin is abraded.
Ingestion:
May cause gastrointestinal irritation with nausea, vomiting and
diarrhea. May cause kidney damage. May cause central nervous system
depression, characterized by excitement, followed by headache,
dizziness, drowsiness, and nausea. Advanced stages may cause
collapse, unconsciousness, coma and possible death due to respiratory
failure.
Inhalation:
Inhalation of high concentrations may cause central nervous system
effects characterized by nausea, headache, dizziness, unconsciousness
and coma. Inhalation of vapor may cause respiratory tract irritation.
Chronic:
Possible cancer hazard based on tests with laboratory animals.
Prolonged or repeated skin contact may cause defatting and
dermatitis. May cause kidney injury. May cause allergic skin
reaction in some individuals.
Section 4 - First Aid Measures
|
Eyes:
Immediately flush eyes with plenty of water for at least 15 minutes,
occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Flush skin with plenty of water for at least 15 minutes while
removing contaminated clothing and shoes. Get medical aid if
irritation develops or persists.
Ingestion:
Do not induce vomiting. If victim is conscious and alert, give 2-4
cupfuls of milk or water. Never give anything by mouth to an
unconscious person. Get medical aid immediately.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh
air immediately. If not breathing, give artificial respiration. If
breathing is difficult, give oxygen. Do NOT use mouth-to-mouth
resuscitation.
Notes to Physician:
Treat symptomatically and supportively.
Section 5 - Fire Fighting Measures
|
General Information:
As in any fire, wear a self-contained breathing apparatus in
pressure-demand, MSHA/NIOSH (approved or equivalent), and full
protective gear. Vapors can travel to a source of ignition and flash
back. Use water spray to keep fire-exposed containers cool.
Containers may explode in the heat of a fire. This chemical poses an
explosion hazard. May form explosive peroxides. Vapors may be
heavier than air. They can spread along the ground and collect in
low or confined areas.
Extinguishing Media:
For small fires, use dry chemical, carbon dioxide, water spray or
alcohol-resistant foam. Water may be ineffective. For large fires,
use water spray, fog or alcohol-resistant foam. Do NOT use straight
streams of water. Cool containers with flooding quantities of water
until well after fire is out.
Flash Point: 12 deg C ( 53.60 deg F)
Autoignition Temperature: 398.9 deg C ( 750.02 deg F)
Explosion Limits, Lower:2.0
Upper: 12.7
NFPA Rating:
(estimated) Health: 1; Flammability: 3; Instability: 0
Section 6 - Accidental Release Measures
|
General Information: Use proper personal protective equipment as indicated
in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth),
then place in suitable container. Avoid runoff into storm sewers and
ditches which lead to waterways. Clean up spills immediately,
observing precautions in the Protective Equipment section. Scoop up
with a nonsparking tool, then place into a suitable container for
disposal. Remove all sources of ignition. Provide ventilation.
Section 7 - Handling and Storage
|
Handling:
Wash thoroughly after handling. Wash thoroughly after handling.
Remove contaminated clothing and wash before reuse. Use with
adequate ventilation. Use spark-proof tools and explosion proof
equipment. Avoid contact with eyes, skin, and clothing. Empty
containers retain product residue, (liquid and/or vapor), and can be
dangerous. Keep container tightly closed. Avoid ingestion and
inhalation. Do not pressurize, cut, weld, braze, solder, drill,
grind, or expose empty containers to heat, sparks or open flames.
Storage:
Keep away from heat, sparks, and flame. Keep away from sources of
ignition. Keep container closed when not in use. Keep from contact
with oxidizing materials. Store in a cool, dry, well-ventilated area
away from incompatible substances. Flammables-area.
Section 8 - Exposure Controls, Personal Protection
|
Engineering Controls:
Good general ventilation should be sufficient to control airborne
levels. Facilities storing or utilizing this material should be
equipped with an eyewash facility and a safety shower.
Exposure Limits
Chemical Name |
ACGIH |
NIOSH |
OSHA - Final PELs |
Isopropyl alcohol
|
200 ppm TWA; 400 ppm STEL
|
400 ppm TWA; 980 mg/m3 TWA 2000 ppm IDLH (10% LEL)
|
400 ppm TWA; 980 mg/m3 TWA
|
Phenolphthalein
|
none listed
|
none listed
|
none listed
|
OSHA Vacated PELs:
Isopropyl alcohol:
400 ppm TWA; 980 mg/m3 TWA
Phenolphthalein:
No OSHA Vacated PELs are listed for this chemical.
Personal Protective Equipment
Eyes:
Wear appropriate protective eyeglasses or chemical
safety goggles as described by OSHA's eye and face
protection regulations in 29 CFR 1910.133 or European
Standard EN166.
Skin:
Nitrile or Neoprene gloves are recommended.
Clothing:
Wear appropriate protective clothing to prevent skin
exposure.
Respirators:
Follow the OSHA respirator regulations found in 29
CFR 1910.134 or European Standard EN 149. Use a
NIOSH/MSHA or European Standard EN 149 approved
respirator if exposure limits are exceeded or if
irritation or other symptoms are experienced.
Section 9 - Physical and Chemical Properties
|
Physical State: Liquid
Appearance: colorless
Odor: alcohol-like
pH: Not available.
Vapor Pressure: 40 mm Hg
Vapor Density: 2.1
Evaporation Rate:2.88 (Butyl Acetate=1)
Viscosity: Not available.
Boiling Point: 83 deg C
Freezing/Melting Point:-89 deg C
Decomposition Temperature:Not available.
Solubility: Soluble in water.
Specific Gravity/Density:0.7855
Molecular Formula:Mixture
Molecular Weight:Not available.
Section 10 - Stability and Reactivity
|
Chemical Stability:
Stable. This material may be sensitive to peroxide formation.
Conditions to Avoid:
This material may be sensitive to peroxide formation., incompatible
materials, ignition sources, excess heat.
Incompatibilities with Other Materials:
Oxidizing agents, Isopropanol is susceptible to autoxidation and
therefore should be classified as peroxidizable..
Hazardous Decomposition Products:
Carbon monoxide, carbon dioxide, acrid smoke and fumes.
Hazardous Polymerization: Will not occur.
Section 11 - Toxicological Information
|
RTECS#:
CAS# 67-63-0:
NT8050000
CAS# 77-09-8:
SM8380000
LD50/LC50:
CAS# 67-63-0:
Draize test, rabbit,
eye: 100 mg Severe;
Draize test,
rabbit, eye: 10 mg Moderate;
Draize test, rabbit, eye: 100 mg/24H
Moderate;
Draize test, rabbit,
skin: 500 mg Mild;
Inhalation,
mouse: LC50 = 53000 mg/m3;
Inhalation, rat: LC50 = 16000
ppm/8H;
Inhalation, rat: LC50 =
72600 mg/m3;
Oral, mouse: LD50 =
3600 mg/kg;
Oral, mouse: LD50 =
3600 mg/kg;
Oral, rabbit: LD50 =
6410 mg/kg;
Oral, rat: LD50 = 5045
mg/kg;
Oral, rat: LD50 = 5000
mg/kg;
Skin, rabbit: LD50 = 12800
CAS# 77-09-8:
.
Carcinogenicity:
CAS# 67-63-0:
Not listed by ACGIH, IARC, NTP, or CA Prop 65.
CAS# 77-09-8:
- ACGIH:
Not listed.
- California:
carcinogen, initial date 5/15/98
- NTP:
Suspect carcinogen
- IARC:
Group 2B carcinogen
Epidemiology:
The NTP reported that there was clear evidence of
carcinogenic activity in male rats based on the markedly
increased incidences of benign pheochromocytoma of the
adrenal medulla and others. There was clear evidence in
mice based on the increased incidences of histiocytic
sarcoma and malignant lymphoma of thymic origin. There was
also clear evidence in female mice based on the increased
incidences of histiocytic sarcoma, malignant lymphomas,
and benign sex-cord stromal tumors of the ovary.
Teratogenicity:
No information available.
Reproductive Effects:
No information available.
Mutagenicity:
Significant increases in chromosomal aberrations were
observed after treament of cultured Chinese hamster ovary
cells with phenolphthalein in the presence of S9.
Frequencies of micronucleated erythrocytes were noted in
male and female feeding studies.
Neurotoxicity:
No information available.
Other Studies:
Section 12 - Ecological Information
|
Ecotoxicity:
No data available.
Cas# 67-63-0:LC50 (96Hr.) Fathead Minnow = 94900-10400 mg/L;
Flow-through conditionLC50 (96 Hr.) Fathead Minnow = 61200-65500
mg/L;Flow-through condition.
Environmental:
Cas# 67-63-0: TERRESTRIAL FATE: When spilled on soil, isopropanol
will both evaporate quickly and leach into the ground due to its high
vapor pressure and low adsorption to soil. Degradation in soil and
groundwater has not been determined. If soil degradation is not
rapid, it is apt to leach into the groundwater. AQUATIC FATE: When
released into water, isopropyl alcohol will volatilize (estimated
half-life approximately 5.4 days) and may biodegrade. Although it is
readily degradable in a number of laboratory tests, no data on its
degradability in natural waters.
Physical:
Cas# 67-63-0: ATMOSPHERIC FATE: When released into the atmosphere,
isopropanol will photodegrade with an estimated half-life ranging
from one to several days. Due to its solubility in water, rainout
may be significant.
Other:
No information available.
Section 13 - Disposal Considerations
|
Chemical waste generators must determine whether a discarded chemical is classified
as a hazardous waste.
US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3.
Additionally, waste generators must consult state and local hazardous waste regulations to
ensure complete and accurate classification.
RCRA P-Series: None listed.
RCRA U-Series: None listed.
Section 14 - Transport Information
|
|
US DOT |
Canada TDG |
Shipping Name: |
ISOPROPANOL |
ISOPROPANOL |
Hazard Class: |
3 |
3 |
UN Number: |
UN1219 |
UN1219 |
Packing Group: |
II |
II |
Section 15 - Regulatory Information
|
US FEDERAL
TSCA
CAS# 67-63-0 is listed on the TSCA inventory.
CAS# 77-09-8 is listed on the TSCA inventory.
Health & Safety Reporting List
CAS# 67-63-0: Effective 12/15/86, Sunset 12/15/96
Chemical Test Rules
CAS# 67-63-0: 40 CFR 799.2325
Section 12b
None of the chemicals are listed under TSCA Section 12b.
TSCA Significant New Use Rule
None of the chemicals in this material have a SNUR under TSCA.
CERCLA Hazardous Substances and corresponding RQs
None of the chemicals in this material have an RQ.
SARA Section 302 Extremely Hazardous Substances
None of the chemicals in this product have a TPQ.
SARA Codes
CAS # 67-63-0: immediate, delayed, fire.
CAS # 77-09-8: immediate.
Section 313
This material contains Isopropyl
alcohol (CAS# 67-63-0, 99%),which is subject to the reporting
requirements of Section 313 of SARA Title III and 40 CFR Part 373.
Clean Air Act:
This material does not contain any hazardous air pollutants.
This material does not contain any Class 1 Ozone depletors.
This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
None of the chemicals in this product
are listed as Hazardous Substances under the CWA.
None of the chemicals in this
product are listed as Priority Pollutants under the CWA.
None of the chemicals in this
product are listed as Toxic Pollutants under the CWA.
OSHA:
None of the chemicals in this product
are considered highly hazardous by OSHA.
STATE
CAS# 67-63-0 can be found on the
following state right to know lists: California, New Jersey,
Pennsylvania, Minnesota, Massachusetts.
CAS# 77-09-8 is not present on
state lists from CA, PA, MN, MA, FL, or NJ.
California Prop 65
WARNING: This product contains Phenolphthalein, a chemical known to
the state of California to cause cancer.
California No Significant Risk Level:
None of the chemicals in this product are listed.
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols:
F
Risk Phrases:
R 11 Highly flammable.
Safety Phrases:
S 16 Keep away from sources of ignition - No smoking.
S 24/25 Avoid contact with skin and eyes.
WGK (Water Danger/Protection)
CAS# 67-63-0: 1
CAS# 77-09-8: 1
Canada - DSL/NDSL
CAS# 67-63-0 is listed on Canada's DSL List.
CAS# 77-09-8 is listed on Canada's DSL List.
Canada - WHMIS
This product has a WHMIS classification of B2, D2B.
This product has been classified in accordance with the hazard
criteria of the Controlled Products Regulations and the MSDS
contains all of the information required by those regulations.
Canadian Ingredient Disclosure List
CAS# 67-63-0 is listed on the Canadian Ingredient Disclosure List.
Section 16 - Additional Information
|
MSDS Creation Date: 7/27/1999
Revision #7 Date: 2/15/2008
The information above is believed to be accurate and represents the best
information currently available to us. However, we make no warranty of
merchantability or any other warranty, express or implied, with respect to
such information, and we assume no liability resulting from its use. Users
should make their own investigations to determine the suitability of the
information for their particular purposes. In no event shall Fisher be liable
for any claims, losses, or damages of any third party or for lost profits
or any special, indirect, incidental, consequential or exemplary
damages, howsoever arising, even if Fisher has been advised of
the possibility of such damages.