Material Safety Data Sheet
Propionic anhydride

ACC# 87839
Section 1 - Chemical Product and Company Identification
MSDS Name: Propionic anhydride
Catalog Numbers: AC131520000, AC131520010, AC131520025, AC131522500, AC131525000, AC220100000 AC220100000, AC220100500, AC220105000
Propanoic anhydride; Propionyl oxide.
Company Identification:

              Acros Organics N.V.
              One Reagent Lane
              Fair Lawn, NJ 07410
For information in North America, call: 800-ACROS-01
For emergencies in the US, call CHEMTREC: 800-424-9300

Section 2 - Composition, Information on Ingredients

CAS# Chemical Name Percent EINECS/ELINCS
123-62-6 Propionic anhydride 98+ 204-638-2
79-09-4 Propionic acid < 2 201-176-3

Section 3 - Hazards Identification


Appearance: APHA: 20 max liquid. Flash Point: 63 deg C.
Danger! Causes burns by all exposure routes. Combustible liquid and vapor.
Target Organs: Respiratory system, gastrointestinal system, eyes, skin.

Potential Health Effects
Eye: Causes eye burns. Lachrymator (substance which increases the flow of tears).
Skin: Causes skin burns. May cause dermatitis. May be harmful if absorbed through the skin.
Ingestion: Causes gastrointestinal tract burns. May be harmful if swallowed.
Inhalation: Causes chemical burns to the respiratory tract. Inhalation may be fatal as a result of spasm, inflammation, edema of the larynx and bronchi, chemical pneumonitis and pulmonary edema. May be harmful if inhaled.
Chronic: Laboratory experiments have resulted in mutagenic effects.

Section 4 - First Aid Measures

Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid imme diately.
Skin: Get medical aid immediately. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion: Do not induce vomiting. Get medical aid immediately. Call a poison control center.
Inhalation: Get medical aid immediately. Remove from exposure and move to fresh air immediately. If breathing is difficult, give oxygen. Do not use mouth-to-mouth resuscitation if victim ingested or inhaled the substance; induce artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device.
Notes to Physician: Treat symptomatically and supportively.

Section 5 - Fire Fighting Measures

General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Will burn if involved in a fire. Containers may explode in the heat of a fire. Combustible liquid and vapor.
Extinguishing Media: Use water spray to cool fire-exposed containers. Use foam, dry chemical, or carbon dioxide.
Flash Point: 63 deg C ( 145.40 deg F)
Autoignition Temperature: 315 deg C ( 599.00 deg F)
Explosion Limits, Lower:1.3 vol %
Upper: 9.5 vol %
NFPA Rating: (estimated) Health: 3; Flammability: 2; Instability: 1

Section 6 - Accidental Release Measures

General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks: Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Wear a self contained breathing apparatus and appropriate personal protection. (See Exposure Controls, Personal Protection section). Remove all sources of ignition. Use a spark-proof tool. Do not let this chemical enter the environment.

Section 7 - Handling and Storage

Handling: Use spark-proof tools and explosion proof equipment. Do not get in eyes, on skin, or on clothing. Keep away from heat, sparks and flame. Do not ingest or inhale. Use only in a chemical fume hood.
Storage: Keep away from sources of ignition. Store in a cool, dry place. Store in a tightly closed container. Corrosives area.

Section 8 - Exposure Controls, Personal Protection

Engineering Controls: Use explosion-proof ventilation equipment. Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use only under a chemical fume hood.
Exposure Limits
Chemical Name ACGIH NIOSH OSHA - Final PELs
Propionic anhydride none listed none listed none listed
Propionic acid 10 ppm TWA 10 ppm TWA; 30 mg/m3 TWA none listed

OSHA Vacated PELs: Propionic anhydride: No OSHA Vacated PELs are listed for this chemical. Propionic acid: 10 ppm TWA; 30 mg/m3 TWA
Personal Protective Equipment
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin: Wear appropriate protective gloves to prevent skin exposure.
Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators: A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.

Section 9 - Physical and Chemical Properties

Physical State: Liquid
Appearance: clear, colorless - APHA: 20 max
Odor: pungent odor
pH: 3 (100 g/L aq.sol.)
Vapor Pressure: 1.3 mbar @ 20 deg C
Vapor Density: Not available.
Evaporation Rate:Not available.
Viscosity: 1.144 cP @ 20 deg C
Boiling Point: 167 - 170 deg C @ 760 mmHg
Freezing/Melting Point:-42 deg C
Decomposition Temperature:Not available.
Solubility: Hydrolysis.
Specific Gravity/Density:1.015
Molecular Formula:C6H10O3
Molecular Weight:130.14

Section 10 - Stability and Reactivity

Chemical Stability: Moisture sensitive.
Conditions to Avoid: Incompatible materials, ignition sources, excess heat, exposure to moist air or water.
Incompatibilities with Other Materials: Strong oxidizing agents, reducing agents, acids, bases, alcohols, amines.
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide.
Hazardous Polymerization: Has not been reported.

Section 11 - Toxicological Information

CAS# 123-62-6: UF9100000      
CAS# 79-09-4: UE5950000
CAS# 123-62-6:
     Dermal, guinea pig: LD50 = 1 mL/kg;
     Oral, rat: LD50 = 2360 mg/kg;
     Skin, rabbit: LD50 = 10 mL/kg;

CAS# 79-09-4:
     Draize test, rabbit, eye: 990 ug Severe;
     Oral, rat: LD50 = 2600 mg/kg;
     Skin, rabbit: LD50 = 500 uL/kg;

CAS# 123-62-6: Not listed by ACGIH, IARC, NTP, or CA Prop 65.
CAS# 79-09-4: Not listed by ACGIH, IARC, NTP, or CA Prop 65.

Epidemiology: No information found
Teratogenicity: No information found
Reproductive Effects: No information found
Mutagenicity: Mutagenic effects have occurred in humans.
Neurotoxicity: No information found
Other Studies:

Section 12 - Ecological Information

Ecotoxicity: No data available. No information available.
Environmental: No information available.
Physical: No information available.
Other: Do not empty into drains.

Section 13 - Disposal Considerations

Chemical waste generators must determine whether a discarded chemical is classified as a hazardous waste. US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3. Additionally, waste generators must consult state and local hazardous waste regulations to ensure complete and accurate classification.
RCRA P-Series: None listed.
RCRA U-Series: None listed.

Section 14 - Transport Information

Hazard Class: 8 8
UN Number: UN2496 UN2496
Packing Group: III III

Section 15 - Regulatory Information


     CAS# 123-62-6 is listed on the TSCA inventory.
     CAS# 79-09-4 is listed on the TSCA inventory.
Health & Safety Reporting List
     None of the chemicals are on the Health & Safety Reporting List.
Chemical Test Rules
     None of the chemicals in this product are under a Chemical Test Rule.
Section 12b
     None of the chemicals are listed under TSCA Section 12b.
TSCA Significant New Use Rule
     None of the chemicals in this material have a SNUR under TSCA.
CERCLA Hazardous Substances and corresponding RQs
     CAS# 123-62-6: 5000 lb final RQ; 2270 kg final RQ      CAS# 79-09-4: 5000 lb final RQ; 2270 kg final RQ
SARA Section 302 Extremely Hazardous Substances
     None of the chemicals in this product have a TPQ.
SARA Codes
     CAS # 123-62-6: immediate, fire, reactive.
     CAS # 79-09-4: immediate, fire.
Section 313      No chemicals are reportable under Section 313.
Clean Air Act:
     This material does not contain any hazardous air pollutants.
     This material does not contain any Class 1 Ozone depletors.
     This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
CAS# 123-62-6 is listed as a Hazardous Substance under the CWA. CAS# 79-09-4 is listed as a Hazardous Substance under the CWA.
     None of the chemicals in this product are listed as Priority Pollutants under the CWA.
     None of the chemicals in this product are listed as Toxic Pollutants under the CWA.
     None of the chemicals in this product are considered highly hazardous by OSHA.
     CAS# 123-62-6 can be found on the following state right to know lists: California, New Jersey, Pennsylvania, Massachusetts.
     CAS# 79-09-4 can be found on the following state right to know lists: California, New Jersey, Pennsylvania, Minnesota, Massachusetts.

California Prop 65

California No Significant Risk Level: None of the chemicals in this product are listed.

European/International Regulations

European Labeling in Accordance with EC Directives
Hazard Symbols:
Risk Phrases:

     R 34 Causes burns.

Safety Phrases:

     S 26 In case of contact with eyes, rinse immediately with plenty of
     water and seek medical advice.
     S 45 In case of accident or if you feel unwell, seek medical advice
     immediately (show the label where possible).

WGK (Water Danger/Protection)

     CAS# 123-62-6: 1
     CAS# 79-09-4: 1
Canada - DSL/NDSL
     CAS# 123-62-6 is listed on Canada's DSL List.
     CAS# 79-09-4 is listed on Canada's DSL List.
Canada - WHMIS
     This product has a WHMIS classification of E, B3.
This product has been classified in accordance with the hazard criteria of the Controlled Products Regulations and the MSDS contains all of the information required by those regulations.
Canadian Ingredient Disclosure List
     CAS# 123-62-6 is listed on the Canadian Ingredient Disclosure List.
     CAS# 79-09-4 is listed on the Canadian Ingredient Disclosure List.

Section 16 - Additional Information

MSDS Creation Date: 11/14/1997
Revision #5 Date: 3/20/2008

The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no event shall Fisher be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if Fisher has been advised of the possibility of such damages.