Material Safety Data Sheet
Propionic anhydride
ACC# 87839
Section 1 - Chemical Product and Company Identification |
MSDS Name: Propionic anhydride
Catalog Numbers:
AC131520000, AC131520010, AC131520025, AC131522500, AC131525000, AC220100000
AC220100000, AC220100500, AC220105000
Synonyms:
Propanoic anhydride; Propionyl oxide.
Company Identification:
Acros Organics N.V.
One Reagent Lane
Fair Lawn, NJ 07410
For information in North America, call: 800-ACROS-01
For emergencies in the US, call CHEMTREC: 800-424-9300
Section 2 - Composition, Information on Ingredients
|
CAS# |
Chemical Name |
Percent |
EINECS/ELINCS |
123-62-6 |
Propionic anhydride |
98+ | 204-638-2 |
79-09-4 |
Propionic acid |
< 2 | 201-176-3 |
Section 3 - Hazards Identification
|
EMERGENCY OVERVIEW
Appearance: APHA: 20 max liquid. Flash Point: 63 deg C.
Danger! Causes burns by all exposure
routes. Combustible liquid and vapor.
Target Organs: Respiratory system,
gastrointestinal system, eyes, skin.
Potential Health Effects
Eye:
Causes eye burns. Lachrymator (substance which increases the flow
of tears).
Skin:
Causes skin burns. May cause dermatitis. May be harmful if absorbed
through the skin.
Ingestion:
Causes gastrointestinal tract burns. May be harmful if swallowed.
Inhalation:
Causes chemical burns to the respiratory tract. Inhalation may be
fatal as a result of spasm, inflammation, edema of the larynx and
bronchi, chemical pneumonitis and pulmonary edema. May be harmful if
inhaled.
Chronic:
Laboratory experiments have resulted in mutagenic effects.
Section 4 - First Aid Measures
|
Eyes:
Immediately flush eyes with plenty of water for at least 15 minutes,
occasionally lifting the upper and lower eyelids. Get medical aid imme
diately.
Skin:
Get medical aid immediately. Immediately flush skin with plenty of
water for at least 15 minutes while removing contaminated clothing
and shoes.
Ingestion:
Do not induce vomiting. Get medical aid immediately. Call a poison
control center.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh
air immediately. If breathing is difficult, give oxygen. Do not use
mouth-to-mouth resuscitation if victim ingested or inhaled the
substance; induce artificial respiration with the aid of a pocket
mask equipped with a one-way valve or other proper respiratory
medical device.
Notes to Physician:
Treat symptomatically and supportively.
Section 5 - Fire Fighting Measures
|
General Information:
As in any fire, wear a self-contained breathing apparatus in
pressure-demand, MSHA/NIOSH (approved or equivalent), and full
protective gear. Will burn if involved in a fire. Containers may
explode in the heat of a fire. Combustible liquid and vapor.
Extinguishing Media:
Use water spray to cool fire-exposed containers. Use foam, dry
chemical, or carbon dioxide.
Flash Point: 63 deg C ( 145.40 deg F)
Autoignition Temperature: 315 deg C ( 599.00 deg F)
Explosion Limits, Lower:1.3 vol %
Upper: 9.5 vol %
NFPA Rating:
(estimated) Health: 3; Flammability: 2; Instability: 1
Section 6 - Accidental Release Measures
|
General Information: Use proper personal protective equipment as indicated
in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth),
then place in suitable container. Wear a self contained breathing
apparatus and appropriate personal protection. (See Exposure
Controls, Personal Protection section). Remove all sources of
ignition. Use a spark-proof tool. Do not let this chemical enter the
environment.
Section 7 - Handling and Storage
|
Handling:
Use spark-proof tools and explosion proof equipment. Do not get in
eyes, on skin, or on clothing. Keep away from heat, sparks and flame.
Do not ingest or inhale. Use only in a chemical fume hood.
Storage:
Keep away from sources of ignition. Store in a cool, dry place.
Store in a tightly closed container. Corrosives area.
Section 8 - Exposure Controls, Personal Protection
|
Engineering Controls:
Use explosion-proof ventilation equipment. Facilities storing or
utilizing this material should be equipped with an eyewash facility
and a safety shower. Use only under a chemical fume hood.
Exposure Limits
Chemical Name |
ACGIH |
NIOSH |
OSHA - Final PELs |
Propionic anhydride
|
none listed
|
none listed
|
none listed
|
Propionic acid
|
10 ppm TWA
|
10 ppm TWA; 30 mg/m3 TWA
|
none listed
|
OSHA Vacated PELs:
Propionic anhydride:
No OSHA Vacated PELs are listed for this chemical.
Propionic acid:
10 ppm TWA; 30 mg/m3 TWA
Personal Protective Equipment
Eyes:
Wear appropriate protective eyeglasses or chemical
safety goggles as described by OSHA's eye and face
protection regulations in 29 CFR 1910.133 or European
Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin
exposure.
Clothing:
Wear appropriate protective clothing to prevent skin
exposure.
Respirators:
A respiratory protection program that meets OSHA's 29
CFR 1910.134 and ANSI Z88.2 requirements or European
Standard EN 149 must be followed whenever workplace
conditions warrant respirator use.
Section 9 - Physical and Chemical Properties
|
Physical State: Liquid
Appearance: clear, colorless - APHA: 20 max
Odor: pungent odor
pH: 3 (100 g/L aq.sol.)
Vapor Pressure: 1.3 mbar @ 20 deg C
Vapor Density: Not available.
Evaporation Rate:Not available.
Viscosity: 1.144 cP @ 20 deg C
Boiling Point: 167 - 170 deg C @ 760 mmHg
Freezing/Melting Point:-42 deg C
Decomposition Temperature:Not available.
Solubility: Hydrolysis.
Specific Gravity/Density:1.015
Molecular Formula:C6H10O3
Molecular Weight:130.14
Section 10 - Stability and Reactivity
|
Chemical Stability:
Moisture sensitive.
Conditions to Avoid:
Incompatible materials, ignition sources, excess heat, exposure to
moist air or water.
Incompatibilities with Other Materials:
Strong oxidizing agents, reducing agents, acids, bases, alcohols,
amines.
Hazardous Decomposition Products:
Carbon monoxide, carbon dioxide.
Hazardous Polymerization: Has not been reported.
Section 11 - Toxicological Information
|
RTECS#:
CAS# 123-62-6:
UF9100000
CAS# 79-09-4:
UE5950000
LD50/LC50:
CAS# 123-62-6:
Dermal, guinea pig:
LD50 = 1 mL/kg;
Oral, rat: LD50 =
2360 mg/kg;
Skin, rabbit: LD50 = 10
mL/kg;
.
CAS# 79-09-4:
Draize test,
rabbit, eye: 990 ug Severe;
Oral,
rat: LD50 = 2600 mg/kg;
Skin,
rabbit: LD50 = 500 uL/kg;
.
Carcinogenicity:
CAS# 123-62-6:
Not listed by ACGIH, IARC, NTP, or CA Prop 65.
CAS# 79-09-4:
Not listed by ACGIH, IARC, NTP, or CA Prop 65.
Epidemiology:
No information found
Teratogenicity:
No information found
Reproductive Effects:
No information found
Mutagenicity:
Mutagenic effects have occurred in humans.
Neurotoxicity:
No information found
Other Studies:
Section 12 - Ecological Information
|
Ecotoxicity:
No data available.
No information available.
Environmental:
No information available.
Physical:
No information available.
Other:
Do not empty into drains.
Section 13 - Disposal Considerations
|
Chemical waste generators must determine whether a discarded chemical is classified
as a hazardous waste.
US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3.
Additionally, waste generators must consult state and local hazardous waste regulations to
ensure complete and accurate classification.
RCRA P-Series: None listed.
RCRA U-Series: None listed.
Section 14 - Transport Information
|
|
US DOT |
Canada TDG |
Shipping Name: |
PROPIONIC ANHYDRIDE |
PROPIONIC ANHYDRIDE |
Hazard Class: |
8 |
8 |
UN Number: |
UN2496 |
UN2496 |
Packing Group: |
III |
III |
Section 15 - Regulatory Information
|
US FEDERAL
TSCA
CAS# 123-62-6 is listed on the TSCA inventory.
CAS# 79-09-4 is listed on the TSCA inventory.
Health & Safety Reporting List
None of the chemicals are on the Health & Safety Reporting List.
Chemical Test Rules
None of the chemicals in this product are under a Chemical Test Rule.
Section 12b
None of the chemicals are listed under TSCA Section 12b.
TSCA Significant New Use Rule
None of the chemicals in this material have a SNUR under TSCA.
CERCLA Hazardous Substances and corresponding RQs
CAS# 123-62-6: 5000 lb final RQ; 2270 kg final RQ
CAS# 79-09-4: 5000 lb final RQ; 2270 kg final RQ
SARA Section 302 Extremely Hazardous Substances
None of the chemicals in this product have a TPQ.
SARA Codes
CAS # 123-62-6: immediate, fire, reactive.
CAS # 79-09-4: immediate, fire.
Section 313
No chemicals are reportable under Section 313.
Clean Air Act:
This material does not contain any hazardous air pollutants.
This material does not contain any Class 1 Ozone depletors.
This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
CAS# 123-62-6 is listed as a Hazardous Substance under the CWA.
CAS# 79-09-4 is listed as a Hazardous Substance under the CWA.
None of the chemicals in this
product are listed as Priority Pollutants under the CWA.
None of the chemicals in this
product are listed as Toxic Pollutants under the CWA.
OSHA:
None of the chemicals in this product
are considered highly hazardous by OSHA.
STATE
CAS# 123-62-6 can be found on the
following state right to know lists: California, New Jersey,
Pennsylvania, Massachusetts.
CAS# 79-09-4 can be found on the
following state right to know lists: California, New Jersey,
Pennsylvania, Minnesota, Massachusetts.
California Prop 65
California No Significant Risk Level:
None of the chemicals in this product are listed.
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols:
C
Risk Phrases:
R 34 Causes burns.
Safety Phrases:
S 26 In case of contact with eyes, rinse immediately with plenty of
water and seek medical advice.
S 45 In case of accident or if you feel unwell, seek medical advice
immediately (show the label where possible).
WGK (Water Danger/Protection)
CAS# 123-62-6: 1
CAS# 79-09-4: 1
Canada - DSL/NDSL
CAS# 123-62-6 is listed on Canada's DSL List.
CAS# 79-09-4 is listed on Canada's DSL List.
Canada - WHMIS
This product has a WHMIS classification of E, B3.
This product has been classified in accordance with the hazard
criteria of the Controlled Products Regulations and the MSDS
contains all of the information required by those regulations.
Canadian Ingredient Disclosure List
CAS# 123-62-6 is listed on the Canadian Ingredient Disclosure List.
CAS# 79-09-4 is listed on the Canadian Ingredient Disclosure List.
Section 16 - Additional Information
|
MSDS Creation Date: 11/14/1997
Revision #5 Date: 3/20/2008
The information above is believed to be accurate and represents the best
information currently available to us. However, we make no warranty of
merchantability or any other warranty, express or implied, with respect to
such information, and we assume no liability resulting from its use. Users
should make their own investigations to determine the suitability of the
information for their particular purposes. In no event shall Fisher be liable
for any claims, losses, or damages of any third party or for lost profits
or any special, indirect, incidental, consequential or exemplary
damages, howsoever arising, even if Fisher has been advised of
the possibility of such damages.