Material Safety Data Sheet
Bouin's fixative
ACC# 89489
Section 1 - Chemical Product and Company Identification |
MSDS Name: Bouin's fixative
Catalog Numbers:
23-005-69, 57008
Synonyms:
None.
Company Identification:
Fisher Diagnostics
Fisher Scientific Company, LLC
8365 Valley Pike
Middletown, VA 22645-0307
For information, call: 800-524-0294
Emergency Number: 800-524-0294
For CHEMTREC assistance, call: 800-424-9300
For International CHEMTREC assistance, call: 703-527-3887
Section 2 - Composition, Information on Ingredients
|
CAS# |
Chemical Name |
Percent |
EINECS/ELINCS |
7732-18-5 | Deionized water |
<80 | 231-791-2 |
50-00-0 | Formaldehyde |
<10 | 200-001-8 |
64-19-7 | Acetic acid |
5 | 200-580-7 |
67-56-1 | Methyl alcohol |
<4 | 200-659-6 |
88-89-1 | Picric acid |
<1 | 201-865-9 |
Section 3 - Hazards Identification
|
EMERGENCY OVERVIEW
Appearance: clear to yellow liquid.
Danger! Causes eye and skin burns. Contains
formaldehyde which can cause cancer. Harmful if swallowed, inhaled,
or absorbed through the skin. May cause allergic respiratory and
skin reaction. May cause severe respiratory tract irritation with
possible burns. May cause severe digestive tract irritation with
possible burns. May cause reproductive and fetal effects.
Target Organs: Lungs, respiratory system, eyes,
skin.
Potential Health Effects
Eye:
Causes eye burns. May cause chemical conjunctivitis and corneal
damage.
Inhalation, ingestion, or skin absorption of methanol can cause signif
icant distrubances in vision, including blindness.
Skin:
Causes skin burns. May cause skin sensitization, an allergic
reaction, which becomes evident upon re-exposure to this material.
May cause skin rash (in milder cases), and cold and clammy skin with
cyanosis or pale color.
Ingestion:
May cause severe and permanent damage to the digestive tract. Causes
gastrointestinal tract burns. May cause perforation of the digestive
tract. May cause systemic effects.
Inhalation:
May cause asthmatic attacks due to allergic sensitization of the
respiratory tract. Causes chemical burns to the respiratory tract.
Aspiration may lead to pulmonary edema. May cause systemic effects.
Inhalation at high concentrations may cause CNS depression and
asphixiation.
Chronic:
Contains formaldehyde which can cause cancer in humans. There is
sufficient evidence that formaldehyde causes nasopharyngeal cancer in
humans, a rare cancer in developed countries. There is limited
evidence that formaldehyde causes cancer of the nasal cavity and
paranasal sinuses and strong but not sufficient evidence for
leukemia. Methanol has produced fetotoxicity in rats and
teratogenicity in mice exposed by inhalation to high concentrations
that did not produce significant maternal toxicity.
Section 4 - First Aid Measures
|
Eyes:
Get medical aid immediately. Do NOT allow victim to rub eyes or keep
eyes closed. Extensive irrigation with water is required (at least 30
minutes).
Skin:
Get medical aid immediately. Immediately flush skin with plenty of
water for at least 15 minutes while removing contaminated clothing
and shoes. Wash clothing before reuse. Destroy contaminated shoes.
Ingestion:
Do not induce vomiting. If victim is conscious and alert, give 2-4
cupfuls of milk or water. Never give anything by mouth to an
unconscious person. Get medical aid immediately.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh
air immediately. If breathing is difficult, give oxygen. Do NOT use
mouth-to-mouth resuscitation. If breathing has ceased apply
artificial respiration using oxygen and a suitable mechanical device
such as a bag and a mask.
Notes to Physician:
Treat symptomatically and supportively.
Section 5 - Fire Fighting Measures
|
General Information:
Containers can build up pressure if exposed to heat and/or fire. As
in any fire, wear a self-contained breathing apparatus in
pressure-demand, MSHA/NIOSH (approved or equivalent), and full
protective gear. During a fire, irritating and highly toxic gases may
be generated by thermal decomposition or combustion. Use water spray
to keep fire-exposed containers cool. Vapors may be heavier than
air. They can spread along the ground and collect in low or confined
areas. Non-combustible, substance itself does not burn but may
decompose upon heating to produce irritating, corrosive and/or toxic
fumes.
Extinguishing Media:
Use water spray to cool fire-exposed containers. Substance is
noncombustible; use agent most appropriate to extinguish surrounding
fire. Do NOT use straight streams of water.
Flash Point: Not available.
Autoignition Temperature: Not available.
Explosion Limits, Lower:Not available.
Upper: Not available.
NFPA Rating:
(estimated) Health: 3; Flammability: 1; Instability: 0
Section 6 - Accidental Release Measures
|
General Information: Use proper personal protective equipment as indicated
in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth),
then place in suitable container. Avoid runoff into storm sewers and
ditches which lead to waterways. Clean up spills immediately,
observing precautions in the Protective Equipment section. Provide
ventilation.
Section 7 - Handling and Storage
|
Handling:
Wash thoroughly after handling. Remove contaminated clothing and
wash before reuse. Do not breathe dust, vapor, mist, or gas. Do not
get in eyes, on skin, or on clothing. Keep container tightly closed.
Discard contaminated shoes. Use only with adequate ventilation.
Storage:
Keep container closed when not in use. Store in a cool, dry,
well-ventilated area away from incompatible substances. Corrosives
area.
Section 8 - Exposure Controls, Personal Protection
|
Engineering Controls:
Facilities storing or utilizing this material should be equipped
with an eyewash facility and a safety shower. Use adequate general or
local exhaust ventilation to keep airborne concentrations below the
permissible exposure limits. See 29CFR 1910.1048 for regulatory
requirements pertaining to all occupational exposures to
formaldehyde, i.e., from formaldehyde gas, its solutions, and
materials that release formaldehyde.
Exposure Limits
Chemical Name |
ACGIH |
NIOSH |
OSHA - Final PELs |
Deionized water | none listed |
none listed
|
none listed
|
Formaldehyde | 0.3 ppm Ceiling |
0.016 ppm TWA 20 ppm IDLH
|
0.75 ppm TWA; 2 ppm STEL; 0.5 ppm Action Level (Irritant and potential cancer ha zard - see 29 CFR 1910.1048)
|
Acetic acid | 10 ppm TWA; 15 ppm STEL |
10 ppm TWA; 25 mg/m3 TWA 50 ppm IDLH
|
10 ppm TWA; 25 mg/m3 TWA
|
Methyl alcohol | 200 ppm TWA; 250 ppm STEL; skin - potential for cutaneous absorption |
200 ppm TWA; 260 mg/m3 TWA 6000 ppm IDLH
|
200 ppm TWA; 260 mg/m3 TWA
|
Picric acid | 0.1 mg/m3 TWA |
0.1 mg/m3 TWA 75 mg/m3 IDLH
|
0.1 mg/m3 TWA
|
OSHA Vacated PELs:
Deionized water:
No OSHA Vacated PELs are listed for this chemical.
Formaldehyde:
3 ppm TWA (unless specified in 1910.1048)
Acetic acid:
10 ppm TWA; 25 mg/m3 TWA
Methyl alcohol:
200 ppm TWA; 260 mg/m3 TWA
Picric acid:
0.1 mg/m3 TWA
Personal Protective Equipment
Eyes:
Wear chemical goggles.
Skin:
Wear appropriate protective gloves to prevent skin
exposure.
Clothing:
Wear appropriate protective clothing to prevent skin
exposure.
Respirators:
A respiratory protection program that meets OSHA's 29
CFR 1910.134 and ANSI Z88.2 requirements or European
Standard EN 149 must be followed whenever workplace
conditions warrant a respirator's use.
Section 9 - Physical and Chemical Properties
|
Physical State: Liquid
Appearance: clear to yellow
Odor: formaldehyde
pH: Not available.
Vapor Pressure: Not available.
Vapor Density: >1.0
Evaporation Rate:Not available.
Viscosity: Not available.
Boiling Point: 102 deg C
Freezing/Melting Point:> 0 deg C
Decomposition Temperature:Not available.
Solubility: Soluble.
Specific Gravity/Density:>1.000
Molecular Formula:Solution
Molecular Weight:Not available.
Section 10 - Stability and Reactivity
|
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Ignition sources, oxidizers, confined spaces.
Incompatibilities with Other Materials:
Strong oxidizing agents.
Hazardous Decomposition Products:
Carbon monoxide, irritating and toxic fumes and gases, carbon
dioxide, formaldehyde.
Hazardous Polymerization: Has not been reported.
Section 11 - Toxicological Information
|
RTECS#:
CAS# 7732-18-5: ZC0110000
CAS# 50-00-0: LP8925000
CAS# 64-19-7: AF1225000
CAS# 67-56-1: PC1400000
CAS# 88-89-1: TJ7875000
LD50/LC50:
CAS# 7732-18-5:
Oral, rat: LD50 = >90 mL/kg;
CAS# 50-00-0:
Draize test, rabbit, eye: 750 ug/24H
Severe;
Draize test, rabbit, eye: 750 ug Severe;
Draize test,
rabbit, eye: 10 mg Severe;
Draize test, rabbit, eye: 37%
Severe;
Draize test, rabbit, skin: 2 mg/24H Severe;
Draize
test, rabbit, skin: 50 mg/24H Moderate;
Inhalation, mouse: LC50 =
454 mg/m3/4H;
Inhalation, mouse: LC50 = 505 mg/m3/2H;
Inhalation, rat: LC50 = 203 mg/m3;
Inhalation, rat: LC50 = 578
mg/m3/2H;
Inhalation, rat: LC50 = 250 ppm/2H;
Oral, mouse:
LD50 = 42 mg/kg;
Oral, mouse: LD50 = 385 mg/kg;
Oral, mouse:
LD50 = 500 mg/kg;
Oral, rat: LD50 = 100 mg/kg;
Oral, rat:
LD50 = 500 mg/kg;
Skin, rabbit: LD50 = 270 uL/kg;
Skin,
rabbit: LD50 = 270 mg/kg;
CAS# 64-19-7:
Draize test, rabbit, skin: 50 mg/24H Mild;
Inhalation, mouse: LC50 = 5620 ppm/1H;
Oral, rat: LD50 = 3310
mg/kg;
Skin, rabbit: LD50 = 1060 uL/kg;
CAS# 67-56-1:
Draize test, rabbit, eye: 40 mg Moderate;
Draize test, rabbit, eye: 100 mg/24H Moderate;
Draize test,
rabbit, skin: 20 mg/24H Moderate;
Inhalation, rabbit: LC50 =
81000 mg/m3/14H;
Inhalation, rat: LC50 = 64000 ppm/4H;
Oral,
mouse: LD50 = 7300 mg/kg;
Oral, rabbit: LD50 = 14200 mg/kg;
Oral, rat: LD50 = 5600 mg/kg;
Skin, rabbit: LD50 = 15800
mg/kg;
CAS# 88-89-1:
Oral, rat: LD50 = 200 mg/kg;
Carcinogenicity:
CAS# 7732-18-5:
Not listed by ACGIH, IARC, NTP, or CA Prop 65.
CAS# 50-00-0:
ACGIH: A2 - Suspected Human Carcinogen
California: carcinogen, initial date 1/1/88 (gas)
NTP: Suspect carcinogen
IARC: Group 2A carcinogen
CAS# 64-19-7:
Not listed by ACGIH, IARC, NTP, or CA Prop 65.
CAS# 67-56-1:
Not listed by ACGIH, IARC, NTP, or CA Prop 65.
CAS# 88-89-1:
Not listed by ACGIH, IARC, NTP, or CA Prop 65.
Epidemiology:
No data available.
Teratogenicity:
No data available.
Reproductive Effects:
No data available.
Neurotoxicity:
No data available.
Mutagenicity:
No data available.
Other Studies:
The hazards associated with formaldehyde may be seen in thi
s product. See actual entry in RTECS for complete in
formation.
Section 12 - Ecological Information
|
No information available.
Section 13 - Disposal Considerations
|
Chemical waste generators must determine whether a discarded chemical is classified
as a hazardous waste.
US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3.
Additionally, waste generators must consult state and local hazardous waste regulations to
ensure complete and accurate classification.
RCRA P-Series: None listed.
RCRA U-Series: CAS# 50-00-0: waste number
U122. CAS# 67-56-1: waste number U154 (Ignitable
waste).
Section 14 - Transport Information
|
|
US DOT |
Canada TDG |
Shipping Name: |
CORROSIVE LIQUID, ACIDIC, ORGANIC, N.O.S. |
CORROSIVE LIQUID, ACIDIC, ORGANIC, |
Hazard Class: |
8 |
8 |
UN Number: |
UN3265 |
UN3265 |
Packing Group: |
III |
III |
Section 15 - Regulatory Information
|
US FEDERAL
TSCA
CAS# 7732-18-5 is listed on the TSCA inventory.
CAS# 50-00-0 is listed on the TSCA inventory.
CAS# 64-19-7 is listed on the TSCA inventory.
CAS# 67-56-1 is listed on the TSCA inventory.
CAS# 88-89-1 is listed on the TSCA inventory.
Health & Safety Reporting List
None of the chemicals are on the Health & Safety Reporting List.
Chemical Test Rules
None of the chemicals in this product are under a Chemical Test Rule.
Section 12b
None of the chemicals are listed under TSCA Section 12b.
TSCA Significant New Use Rule
None of the chemicals in this material have a SNUR under TSCA.
SARA
CERCLA Hazardous Substances and corresponding RQs
CAS# 50-00-0: 100 lb final RQ; 45.4 kg final RQ
CAS# 64-19-7: 5000 lb final RQ; 2270 kg final RQ
CAS# 67-56-1: 5000 lb final RQ; 2270 kg final RQ
SARA Section 302 Extremely Hazardous Substances
CAS# 50-00-0: 500 lb TPQ
SARA Codes
CAS # 50-00-0: acute, chronic.
CAS # 64-19-7: acute, chronic, flammable.
CAS # 67-56-1: acute, flammable.
CAS # 88-89-1: acute, chronic, flammable, sudden release of pressure, reactive.
Section 313
This material contains Formaldehyde (CAS# 50-00-0, 10%),which is
subject to the reporting requirements of Section 313 of SARA Title
III and 40 CFR Part 373.
This material contains Methyl alcohol (CAS# 67-56-1, 4%),which is
subject to the reporting requirements of Section 313 of SARA Title
III and 40 CFR Part 373.
This chemical is not at a high enough concentration to be reportable
under Section 313.
Clean Air Act:
CAS# 50-00-0 is listed as a hazardous air pollutant (HAP).
CAS# 67-56-1 is listed as a hazardous air pollutant (HAP).
This material does not contain any Class 1 Ozone depletors.
This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
CAS# 50-00-0 is listed as a Hazardous Substance under the CWA.
CAS# 64-19-7 is listed as a Hazardous Substance under the CWA.
None of the chemicals in this product are listed as Priority
Pollutants under the CWA.
None of the chemicals in this product are listed as Toxic Pollutants
under the CWA.
OSHA:
CAS# 50-00-0 is considered highly hazardous by OSHA.
STATE
CAS# 7732-18-5 is not present on state lists from CA, PA, MN, MA,
FL, or NJ.
CAS# 50-00-0 can be found on the following state right to know
lists: California, New Jersey, Pennsylvania, Minnesota,
Massachusetts.
CAS# 64-19-7 can be found on the following state right to know
lists: California, New Jersey, Pennsylvania, Minnesota,
Massachusetts.
CAS# 67-56-1 can be found on the following state right to know
lists: California, New Jersey, Pennsylvania, Minnesota,
Massachusetts.
CAS# 88-89-1 can be found on the following state right to know
lists: California, New Jersey, Pennsylvania, Minnesota,
Massachusetts.
WARNING: This product contains Formaldehyde, a chemical known to the
state of California to cause cancer.
California No Significant Risk Level:
CAS# 50-00-0: 40 ęg/day NSRL
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols:
C
Risk Phrases:
R 20/21/22 Harmful by inhalation, in contact with skin and if
swallowed.
R 34 Causes burns.
R 45 May cause cancer.
Safety Phrases:
S 16 Keep away from sources of ignition - No smoking.
WGK (Water Danger/Protection)
CAS# 7732-18-5: No information available.
CAS# 50-00-0: 2
CAS# 64-19-7: 1
CAS# 67-56-1: 1
CAS# 88-89-1: 2
Canada - DSL/NDSL
CAS# 7732-18-5 is listed on Canada's DSL List.
CAS# 50-00-0 is listed on Canada's DSL List.
CAS# 64-19-7 is listed on Canada's DSL List.
CAS# 67-56-1 is listed on Canada's DSL List.
CAS# 88-89-1 is listed on Canada's DSL List.
Canada - WHMIS
This product has a WHMIS classification of E, D1B.
Canadian Ingredient Disclosure List
CAS# 50-00-0 is listed on the Canadian Ingredient Disclosure List.
CAS# 64-19-7 is listed on the Canadian Ingredient Disclosure List.
CAS# 67-56-1 is listed on the Canadian Ingredient Disclosure List.
CAS# 88-89-1 is listed on the Canadian Ingredient Disclosure List.
Section 16 - Additional Information
|
MSDS Creation Date: 7/12/1999
Revision #8 Date: 8/19/2003
The information above is believed to be accurate and represents the best
information currently available to us. However, we make no warranty of
merchantability or any other warranty, express or implied, with respect to
such information, and we assume no liability resulting from its use. Users
should make their own investigations to determine the suitability of the
information for their particular purposes. In no event shall Fisher be liable
for any claims, losses, or damages of any third party or for lost profits
or any special, indirect, incidental, consequential or exemplary
damages, howsoever arising, even if Fisher has been advised of
the possibility of such damages.