Section 2 - Composition, Information on Ingredients

CAS#	Chemical Name	Percent	EINECS/ELINCS
2206-26-0	Acetonitrile-d3	>99	218-616-5

Section 3 - Hazards Identification

Not available. Appearance: colorless clear liquid. Flash Point: 2 deg C.
Not available.
Target Organs: Kidneys, heart, central nervous system, liver, lungs, respiratory system, gastrointestinal system, cardiovascular system, red blood cells, skin.


Potential Health Effects
Eye: Causes eye irritation.
Skin: Causes skin irritation. Harmful if absorbed through the skin. May cause dermatitis.
Ingestion: Harmful if swallowed. May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May cause methemoglobinemia, cyanosis (bluish discoloration of skin due to deficient oxygenation of the blood), convulsions, and death. May cause effects similar to those for inhalation exposure. May cause central nervous system depression.
Inhalation: Harmful if inhaled. May cause methemoglobinemia, cyanosis (bluish discoloration of skin due to deficient oxygenation of the blood), convulsions, tachycardia, dyspnea (labored breathing), and death. Causes irritation of mucous membrane. Aspiration may lead to pulmonary edema. Vapors may cause dizziness or suffocation. Causes upper respiratory tract irritation. Inhalation may lead to dizziness, weakness, and drowsiness, leading to stupor, unconsciousness, and even death. Inhalation may lead to hematemesis, convulsions, shock, coma, and possible death.
Chronic: Prolonged or repeated skin contact may cause dermatitis. Chronic inhalation and ingestion may cause effects similar to those of acute inhalation and ingestion. May cause liver and kidney damage. May be metabolized to cyanide which in turn acts by inhibiting cytochrome oxidase impairing cellular respiration. Chronic exposure may cause dizziness, dry throat, sleepiness, anorexia, and nausea.

Section 4 - First Aid Measures

Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid imme diately.
Skin: Get medical aid immediately. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion: Induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
Inhalation: Get medical aid immediately. Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Notes to Physician: Exposure should be treated as a cyanide poisoning. Effects may be delayed. May be partially metabolized to cyanide in the body. For methemoglobinemia, administer oxygen alone or with Methylene Blue depending on the methemoglobin concentration in the blood.
Antidote: Always have a cyanide antidote kit on hand when working with cyanide compounds. Get medical advice to use. The combination of sodium thiosulfate and hydroxycobalamin has been used as an effective antidote.

Section 5 - Fire Fighting Measures

General Information: The combination of sodium thiosulfate and hydroxycobalamin has been used as an effective antidote. As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Water runoff can cause environmental damage. Dike and collect water used to fight fire. Vapors may form an explosive mixture with air. Vapors can travel to a source of ignition and flash back. Will burn if involved in a fire. Flammable liquid and vapor. Vapors may be heavier than air. They can spread along the ground and collect in low or confined areas. Containers may explode when heated.
Extinguishing Media: Use water spray to cool fire-exposed containers. Use foam, dry chemical, or carbon dioxide.
Flash Point: 2 deg C ( 35.60 deg F)
Autoignition Temperature: 525 deg C ( 977.00 deg F)
Explosion Limits, Lower:3 Vol %
Upper: 16 Vol %
NFPA Rating: (estimated) Health: 2; Flammability: 3; Instability: 0

Section 6 - Accidental Release Measures

General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks: Avoid runoff into storm sewers and ditches which lead to waterways. Remove all sources of ignition. Absorb spill using an absorbent, non-combustible material such as earth, sand, or vermiculite. Do not use combustible materials such as sawdust. Use a spark-proof tool. Provide ventilation.

Section 7 - Handling and Storage

Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Ground and bond containers when transferring material. Use spark-proof tools and explosion proof equipment. Do not breathe dust, mist, or vapor. Do not get in eyes, on skin, or on clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Take precautionary measures against static discharges. Keep away from heat, sparks and flame. Do not ingest or inhale. Use and store under nitrogen. Use only in a chemical fume hood. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.
Storage: Keep away from sources of ignition. Store in a cool, dry place. Store in a tightly closed container. Keep from contact with oxidizing materials. Flammables-area. Store protected from moisture. Store under nitrogen.

Section 8 - Exposure Controls, Personal Protection

Engineering Controls: Use explosion-proof ventilation equipment. Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits

Chemical Name	ACGIH	NIOSH	OSHA - Final PELs
Acetonitrile-d3	none listed	none listed	none listed

OSHA Vacated PELs: Acetonitrile-d3: No OSHA Vacated PELs are listed for this chemical.
Personal Protective Equipment
Eyes: Wear chemical splash goggles.
Skin: Wear appropriate protective gloves to prevent skin exposure.
Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Section 9 - Physical and Chemical Properties

Physical State: Clear liquid
Appearance: colorless
Odor: aromatic odor - sweetish odor
pH: Not available.
Vapor Pressure: 97mbar @20 deg C
Vapor Density: 1.42 (Air=1)
Evaporation Rate:5.79 (Butyl acetate=1)
Viscosity: 0.39 cP @20 deg C
Boiling Point: 79 - 81 deg C @760mmHg
Freezing/Melting Point:-46 deg C
Decomposition Temperature:Not available.
Solubility: Miscible.
Specific Gravity/Density:0.844
Molecular Formula:C2D3N
Molecular Weight:44.07

Section 10 - Stability and Reactivity

Chemical Stability: Stable under normal temperatures and pressures.
Conditions to Avoid: Incompatible materials, ignition sources, excess heat, exposure to moist air or water.
Incompatibilities with Other Materials: Oxidizing agents, reducing agents, acids, bases, alkali metals, nitric acid, perchlorates, sulfuric acid, chlorosulfonic acid, oleum, dinitrogen tetraoxide, indium, iodine, sulfur trioxide.
Hazardous Decomposition Products: Hydrogen cyanide, nitrogen oxides, carbon monoxide, carbon dioxide.
Hazardous Polymerization: Will not occur.

Section 11 - Toxicological Information

RTECS#:      
CAS# 2206-26-0 unlisted.
LD50/LC50:
Not available.

Carcinogenicity:
CAS# 2206-26-0: Not listed by ACGIH, IARC, NTP, or CA Prop 65.

Epidemiology: No information available.
Teratogenicity: Embryo or Fetus: stunted fetus, ihl-ham TCLo=8000 ppm/1H.Specific Developmental Abnormalities: musculoskeletal, orl-ham TCLo:300 mg/kg.
Reproductive Effects: Fertility: post-implantation mortality, orl-ham TDLo=400 mg/kg and ihl-ham TCLo=5000 ppm/1H.
Mutagenicity: sln-smc 47600 ppm
Neurotoxicity: No information available.
Other Studies:

Section 12 - Ecological Information

Ecotoxicity: No data available. No information available.
Environmental: No information available.
Physical: No information available.
Other: This chemical is not likely to bioconcentrate. Biodegradable. Do not empty into drains.

Section 13 - Disposal Considerations

Chemical waste generators must determine whether a discarded chemical is classified as a hazardous waste. US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3. Additionally, waste generators must consult state and local hazardous waste regulations to ensure complete and accurate classification.
RCRA P-Series: None listed.
RCRA U-Series: None listed.

Section 14 - Transport Information

	US DOT	Canada TDG
Shipping Name:	ACETONITRILE	ACETONITRILE
Hazard Class:	3	3
UN Number:	UN1648	UN1648
Packing Group:	II	II

Section 15 - Regulatory Information

US FEDERAL

TSCA
     CAS# 2206-26-0 is not listed on the TSCA inventory. It is for research and development use only.
Health & Safety Reporting List
     None of the chemicals are on the Health & Safety Reporting List.
Chemical Test Rules
     None of the chemicals in this product are under a Chemical Test Rule.
Section 12b
     None of the chemicals are listed under TSCA Section 12b.
TSCA Significant New Use Rule
     None of the chemicals in this material have a SNUR under TSCA.
CERCLA Hazardous Substances and corresponding RQs
     None of the chemicals in this material have an RQ.
SARA Section 302 Extremely Hazardous Substances
     None of the chemicals in this product have a TPQ.
Section 313      No chemicals are reportable under Section 313.
Clean Air Act:
     This material does not contain any hazardous air pollutants.
     This material does not contain any Class 1 Ozone depletors.
     This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
     None of the chemicals in this product are listed as Hazardous Substances under the CWA.
     None of the chemicals in this product are listed as Priority Pollutants under the CWA.
     None of the chemicals in this product are listed as Toxic Pollutants under the CWA.
OSHA:
     None of the chemicals in this product are considered highly hazardous by OSHA.
STATE
     CAS# 2206-26-0 is not present on state lists from CA, PA, MN, MA, FL, or NJ.

California Prop 65

California No Significant Risk Level: None of the chemicals in this product are listed.

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols:
     XN F
Risk Phrases:
     R 11 Highly flammable.
     R 20/21/22 Harmful by inhalation, in contact with skin and if
     swallowed.
     R 36 Irritating to eyes.

Safety Phrases:
     S 16 Keep away from sources of ignition - No smoking.
     S 36/37 Wear suitable protective clothing and gloves.

WGK (Water Danger/Protection)
     CAS# 2206-26-0: No information available.
Canada - DSL/NDSL
None of the chemicals in this product are listed on the DSL or NDSL list.
Canada - WHMIS
     This product has a WHMIS classification of B2, D2B.
This product has been classified in accordance with the hazard criteria of the Controlled Products Regulations and the MSDS contains all of the information required by those regulations.
Canadian Ingredient Disclosure List

Section 16 - Additional Information

MSDS Creation Date: 8/25/1998
Revision #5 Date: 11/20/2008

The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no event shall Fisher be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if Fisher has been advised of the possibility of such damages.