Material Safety Data Sheet
Arsenic Trioxide

ACC# 02070
Section 1 - Chemical Product and Company Identification

MSDS Name: Arsenic Trioxide
Catalog Numbers: A59I-100, A889-60
Arsenic Oxide; Arsenic Sesquioxide; Arsenous Oxide; Arsenous Acid Anhydride; Arsenous Acid
Company Identification:

              Fisher Scientific
              1 Reagent Lane
              Fair Lawn, NJ 07410
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Section 2 - Composition, Information on Ingredients

CAS# Chemical Name Percent EINECS/ELINCS
1327-53-3 Arsenic trioxide 100.0 215-481-4

Section 3 - Hazards Identification


Appearance: white solid.
Danger! May be fatal if swallowed. Poison! Contains inorganic arsenic. Harmful if inhaled. Cancer hazard. Causes eye and skin irritation. May cause severe respiratory and digestive tract irritation with possible burns. May cause blood abnormalities. May cause lung damage. May cause central nervous system effects. May cause cardiac disturbances. May cause liver and kidney damage. This substance has caused adverse reproductive and fetal effects in animals.
Target Organs: Kidneys, central nervous system, liver, lungs, cardiovascular system, red blood cells, skin.

Potential Health Effects
Eye: Contact produces irritation, tearing, and burning pain. May cause conjunctivitis.
Skin: Causes irritation with burning pain, itching, and redness. May cause dermatitis. Exposure to arsenic compounds may produce hyperpigmentation of the skin and hyperkeratoses of plantar and palmar surfaces as well as both primary irritation and sensitization types.
Ingestion: May be fatal if swallowed. Causes severe digestive tract burns with abdominal pain, vomiting, and possible death. May cause hemorrhaging of the digestive tract. Ingestion of arsenical compounds may cause burning of the lips, throat constriction, swallowing difficulties, severe abdominal pain, severe nausea, projectile vomiting, and profuse diarrhea. Ingestion of arsenic compounds can produce convulsions, coma, and possibly death within 24 hours.
Inhalation: May cause severe irritation of the respiratory tract with sore throat, coughing, shortness of breath and delayed lung edema. Inhalation of arsenic compounds may lead to irritation of the respiratory tract and to possible nasal perforation. Long-term exposure to arsenic compounds may produce impairment of peripheral circulation.
Chronic: May cause liver and kidney damage. Chronic inhalation may cause nasal septum ulceration and perforation. May cause anemia and other blood cell abnormalities. Chronic skin effects include: cracking, thickening, pigmentation, and drying of the skin. Arsenic trioxide can cause cancer in humans. Other long term effects include: anemia, liver and kidney damage. Chronic exposure to arsenical dust may cause shortness of breath, nausea, chest pains, and garlic odor.

Section 4 - First Aid Measures

Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion: Call a poison control center. If swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Get medical aid.
Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Do NOT use mouth-to-mouth resuscitation.
Notes to Physician: Treat symptomatically and supportively.

Section 5 - Fire Fighting Measures

General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use extinguishing media appropriate to the surrounding fire. Substance is noncombustible.
Extinguishing Media: Substance is noncombustible; use agent most appropriate to extinguish surrounding fire. Do NOT get water inside containers.
Flash Point: Not applicable.
Autoignition Temperature: Not applicable.
Explosion Limits, Lower:Not available.
Upper: Not available.
NFPA Rating: (estimated) Health: 3; Flammability: 0; Instability: 0

Section 6 - Accidental Release Measures

General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks: Vacuum or sweep up material and place into a suitable disposal container. Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions. Provide ventilation. Do not get water inside containers.

Section 7 - Handling and Storage

Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation. Do not allow contact with water. Use only with adequate ventilation or respiratory protection.
Storage: Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Do not store in metal containers.

Section 8 - Exposure Controls, Personal Protection

Engineering Controls: Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits. See 29CFR 1910.1018 for regulatory requirements pertaining to all occupational exposures to inorganic arsenic.
Exposure Limits
Chemical Name ACGIH NIOSH OSHA - Final PELs
Arsenic trioxide 0.01 mg/m3 TWA (as As) (listed under Arsenic, inorganic compounds). 5 mg/m3 IDLH (as As) (listed under Arsenic, inorganic compounds). 10 ęg/m3 TWA (as As) (listed under Arsenic, inorganic compounds).5 ęg/m3 Action Level (as As); 10 ęg/m3 TWA (as As, Cancer hazard - see 29 CFR 19 10.1018, except Arsine) (listed under Arsenic, inorga nic compounds).

OSHA Vacated PELs: Arsenic trioxide: No OSHA Vacated PELs are listed for this chemical.
Personal Protective Equipment
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin: Wear appropriate gloves to prevent skin exposure.
Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Section 9 - Physical and Chemical Properties

Physical State: Solid
Appearance: white
Odor: odorless
pH: Not available.
Vapor Pressure: 66 mm Hg @ 312C
Vapor Density: Not available.
Evaporation Rate:Negligible.
Viscosity: Not available.
Boiling Point: 465 deg C
Freezing/Melting Point:312 deg C
Decomposition Temperature:Not available.
Solubility: 3.7% in water.
Specific Gravity/Density: 3.738
Molecular Formula:As2O3
Molecular Weight:197.8414

Section 10 - Stability and Reactivity

Chemical Stability: Stable under normal temperatures and pressures.
Conditions to Avoid: Dust generation, moisture, metals, excess heat.
Incompatibilities with Other Materials: Incompatible with chlorine trifluoride, fluorine, hydrogen fluoride, oxygen difluoride, and sodium chlorate. Can generate arsine, which is an extremely poisonous gas, when arsenic compounds contact acid, alkalies, or water in the presence of an active metal (zinc, aluminum, magnesium, manganese, sodium, iron, etc).
Hazardous Decomposition Products: Excess heat, oxides of arsenic, arsine.
Hazardous Polymerization: Has not been reported.

Section 11 - Toxicological Information

CAS# 1327-53-3: CG3325000
CAS# 1327-53-3:
     Oral, mouse: LD50 = 20 mg/kg;
     Oral, rabbit: LD50 = 20190 ug/kg;
     Oral, rat: LD50 = 10 mg/kg;

CAS# 1327-53-3:

Epidemiology: In a large number of studies, exposure to inorganic arsenic compounds in drugs, food, and water as well as in an occupational setting have been causally associated with the developmental of cancer, primarily of the skin and lungs.
Teratogenicity: Teratogenic effects, including exencephaly, skeletal defects, and genitourinay system defects, of arsenic compounds administered intravenously or intraperitoneally t high doses have been demonstrated in hamsters, rats and mice.
Reproductive Effects: May cause reproductive effects.
Mutagenicity: No information available.
Neurotoxicity: No information available.
Other Studies:

Section 12 - Ecological Information

Ecotoxicity: Water flea Daphnia: LC50 = 0.038 mg/L; 24 Hr.; UnspecifiedBacteria: Phytobacterium phosphoreum: EC50 = 31.43-73.73 mg/L; 5,15,30 minutes; Microtox test No data available.
Environmental: Terrestrial: Half-life in soil 6.5 years. Aquatic: Tends to bioaccumulate. Will biodegrade to arsine and will bioconcentrate.
Physical: No information available.
Other: No information available.

Section 13 - Disposal Considerations

Chemical waste generators must determine whether a discarded chemical is classified as a hazardous waste. US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3. Additionally, waste generators must consult state and local hazardous waste regulations to ensure complete and accurate classification.
RCRA P-Series: CAS# 1327-53-3: waste number P012.
RCRA U-Series: None listed.

Section 14 - Transport Information

Shipping Name: ARSENIC TRIOXIDE No information available.
Hazard Class: 6.1
UN Number: UN1561
Packing Group: II

Section 15 - Regulatory Information


     CAS# 1327-53-3 is listed on the TSCA inventory.
Health & Safety Reporting List
     None of the chemicals are on the Health & Safety Reporting List.
Chemical Test Rules
     None of the chemicals in this product are under a Chemical Test Rule.
Section 12b
     None of the chemicals are listed under TSCA Section 12b.
TSCA Significant New Use Rule
     None of the chemicals in this material have a SNUR under TSCA.
CERCLA Hazardous Substances and corresponding RQs
     CAS# 1327-53-3: 1 lb final RQ; 0.454 kg final RQ
SARA Section 302 Extremely Hazardous Substances
     CAS# 1327-53-3: 100 lb lower threshold TPQ; 10000 lb upper threshold T      PQ
SARA Codes
     CAS # 1327-53-3: immediate, delayed.
Section 313
     This material contains Arsenic trioxide (listed as Arsenic, inorganic compounds), 100.0%, (CAS# 1327-53-3) which is subject to the reporting requirements of Section 313 of SARA Title III and 40 CFR Part 373.
Clean Air Act:
     CAS# 1327-53-3 (listed as Arsenic, inorganic compounds) is listed as a      hazardous air pollutant (HAP).
     This material does not contain any Class 1 Ozone depletors.
     This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
CAS# 1327-53-3 is listed as a Hazardous Substance under the CWA.
     None of the chemicals in this product are listed as Priority Pollutants under the CWA. CAS# 1327-53-3 is listed as a Toxic Pollutant under the Clean Water Act.
     None of the chemicals in this product are considered highly hazardous by OSHA.
     CAS# 1327-53-3 can be found on the following state right to know lists: California, New Jersey, Pennsylvania, Minnesota, (listed as Arsenic, inorganic compounds), Massachusetts.

California Prop 65
The following statement(s) is(are) made in order to comply with the California Safe Drinking Water Act:
WARNING: This product contains Arsenic trioxide, listed as `Arsenic, inorganic compounds', a chemical known to the state of California to cause cancer. WARNING: This product contains Arsenic trioxide, listed as `Arsenic (inorganic oxides)', a chemical known to the state of California to cause developmental reproductive toxicity.
California No Significant Risk Level: None of the chemicals in this product are listed.

European/International Regulations

European Labeling in Accordance with EC Directives
Hazard Symbols:
     T+ N
Risk Phrases:

     R 28 Very toxic if swallowed.
     R 34 Causes burns.
     R 45 May cause cancer.
     R 50/53 Very toxic to aquatic organisms, may cause long-term
     adverse effects in the aquatic environment.

Safety Phrases:

     S 45 In case of accident or if you feel unwell, seek medical advice
     immediately (show the label where possible).
     S 53 Avoid exposure - obtain special instructions before use.
     S 60 This material and its container must be disposed of as hazardou
     s waste.
     S 61 Avoid release to the environment. Refer to special instructions
     /safety data sheets.

WGK (Water Danger/Protection)

     CAS# 1327-53-3: 3
Canada - DSL/NDSL
     CAS# 1327-53-3 is listed on Canada's DSL List.
Canada - WHMIS
     This product has a WHMIS classification of D1A, D2A.
This product has been classified in accordance with the hazard criteria of the Controlled Products Regulations and the MSDS contains all of the information required by those regulations.
Canadian Ingredient Disclosure List
     CAS# 1327-53-3 is listed on the Canadian Ingredient Disclosure List.

Section 16 - Additional Information

MSDS Creation Date: 6/21/1999
Revision #7 Date: 11/20/2008

The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no event shall Fisher be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if Fisher has been advised of the possibility of such damages.