Section 2 - Composition, Information on Ingredients

CAS#	Chemical Name	Percent	EINECS/ELINCS
1327-53-3	Arsenic trioxide	100.0	215-481-4

Section 3 - Hazards Identification

Appearance: white solid.
Danger! May be fatal if swallowed. Poison! Contains inorganic arsenic. Harmful if inhaled. Cancer hazard. Causes eye and skin irritation. May cause severe respiratory and digestive tract irritation with possible burns. May cause blood abnormalities. May cause lung damage. May cause central nervous system effects. May cause cardiac disturbances. May cause liver and kidney damage. This substance has caused adverse reproductive and fetal effects in animals.
Target Organs: Kidneys, central nervous system, liver, lungs, cardiovascular system, red blood cells, skin.


Potential Health Effects
Eye: Contact produces irritation, tearing, and burning pain. May cause conjunctivitis.
Skin: Causes irritation with burning pain, itching, and redness. May cause dermatitis. Exposure to arsenic compounds may produce hyperpigmentation of the skin and hyperkeratoses of plantar and palmar surfaces as well as both primary irritation and sensitization types.
Ingestion: May be fatal if swallowed. Causes severe digestive tract burns with abdominal pain, vomiting, and possible death. May cause hemorrhaging of the digestive tract. Ingestion of arsenical compounds may cause burning of the lips, throat constriction, swallowing difficulties, severe abdominal pain, severe nausea, projectile vomiting, and profuse diarrhea. Ingestion of arsenic compounds can produce convulsions, coma, and possibly death within 24 hours.
Inhalation: May cause severe irritation of the respiratory tract with sore throat, coughing, shortness of breath and delayed lung edema. Inhalation of arsenic compounds may lead to irritation of the respiratory tract and to possible nasal perforation. Long-term exposure to arsenic compounds may produce impairment of peripheral circulation.
Chronic: May cause liver and kidney damage. Chronic inhalation may cause nasal septum ulceration and perforation. May cause anemia and other blood cell abnormalities. Chronic skin effects include: cracking, thickening, pigmentation, and drying of the skin. Arsenic trioxide can cause cancer in humans. Other long term effects include: anemia, liver and kidney damage. Chronic exposure to arsenical dust may cause shortness of breath, nausea, chest pains, and garlic odor.

Section 4 - First Aid Measures

Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion: Call a poison control center. If swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Get medical aid.
Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Do NOT use mouth-to-mouth resuscitation.
Notes to Physician: Treat symptomatically and supportively.

Section 5 - Fire Fighting Measures

General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use extinguishing media appropriate to the surrounding fire. Substance is noncombustible.
Extinguishing Media: Substance is noncombustible; use agent most appropriate to extinguish surrounding fire. Do NOT get water inside containers.
Flash Point: Not applicable.
Autoignition Temperature: Not applicable.
Explosion Limits, Lower:Not available.
Upper: Not available.
NFPA Rating: (estimated) Health: 3; Flammability: 0; Instability: 0

Section 6 - Accidental Release Measures

General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks: Vacuum or sweep up material and place into a suitable disposal container. Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions. Provide ventilation. Do not get water inside containers.

Section 7 - Handling and Storage

Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation. Do not allow contact with water. Use only with adequate ventilation or respiratory protection.
Storage: Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Do not store in metal containers.

Section 8 - Exposure Controls, Personal Protection

Engineering Controls: Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits. See 29CFR 1910.1018 for regulatory requirements pertaining to all occupational exposures to inorganic arsenic.
Exposure Limits

Chemical Name	ACGIH	NIOSH	OSHA - Final PELs
Arsenic trioxide	0.01 mg/m3 TWA (as As) (listed under Arsenic, inorganic compounds).	5 mg/m3 IDLH (as As) (listed under Arsenic, inorganic compounds).	10 ęg/m3 TWA (as As) (listed under Arsenic, inorganic compounds).5 ęg/m3 Action Level (as As); 10 ęg/m3 TWA (as As, Cancer hazard - see 29 CFR 19 10.1018, except Arsine) (listed under Arsenic, inorga nic compounds).

OSHA Vacated PELs: Arsenic trioxide: No OSHA Vacated PELs are listed for this chemical.
Personal Protective Equipment
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin: Wear appropriate gloves to prevent skin exposure.
Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Section 9 - Physical and Chemical Properties

Physical State: Solid
Appearance: white
Odor: odorless
pH: Not available.
Vapor Pressure: 66 mm Hg @ 312C
Vapor Density: Not available.
Evaporation Rate:Negligible.
Viscosity: Not available.
Boiling Point: 465 deg C
Freezing/Melting Point:312 deg C
Decomposition Temperature:Not available.
Solubility: 3.7% in water.
Specific Gravity/Density: 3.738
Molecular Formula:As2O3
Molecular Weight:197.8414

Section 10 - Stability and Reactivity

Chemical Stability: Stable under normal temperatures and pressures.
Conditions to Avoid: Dust generation, moisture, metals, excess heat.
Incompatibilities with Other Materials: Incompatible with chlorine trifluoride, fluorine, hydrogen fluoride, oxygen difluoride, and sodium chlorate. Can generate arsine, which is an extremely poisonous gas, when arsenic compounds contact acid, alkalies, or water in the presence of an active metal (zinc, aluminum, magnesium, manganese, sodium, iron, etc).
Hazardous Decomposition Products: Excess heat, oxides of arsenic, arsine.
Hazardous Polymerization: Has not been reported.

Section 11 - Toxicological Information

RTECS#:      
CAS# 1327-53-3: CG3325000
LD50/LC50:
CAS# 1327-53-3:
     Oral, mouse: LD50 = 20 mg/kg;
     Oral, rabbit: LD50 = 20190 ug/kg;
     Oral, rat: LD50 = 10 mg/kg;
.

Carcinogenicity:
CAS# 1327-53-3:

• ACGIH: A1 - Confirmed Human Carcinogen (listed as 'Arsenic, inorganic compounds').
  
• California: carcinogen, initial date 2/27/87 (listed as Arsenic, inorganic compounds).
  
• NTP: Known carcinogen (listed as Arsenic, inorganic compounds).
  
• IARC: Group 1 carcinogen