Material Safety Data Sheet
Section 1 - Chemical Product and Company Identification
MSDS Name: Arsenic Trioxide
Arsenic Oxide; Arsenic Sesquioxide; Arsenous Oxide; Arsenous Acid
Anhydride; Arsenous Acid
1 Reagent Lane
Fair Lawn, NJ 07410
For information, call: 201-796-7100
Emergency Number: 201-796-7100
For CHEMTREC assistance, call: 800-424-9300
For International CHEMTREC assistance, call: 703-527-3887
Section 2 - Composition, Information on Ingredients
|| 100.0 ||215-481-4
Section 3 - Hazards Identification
Appearance: white solid.
Danger! May be fatal if swallowed. Poison!
Contains inorganic arsenic. Harmful if inhaled. Cancer hazard. Causes
eye and skin irritation. May cause severe respiratory and digestive
tract irritation with possible burns. May cause blood abnormalities.
May cause lung damage. May cause central nervous system effects. May
cause cardiac disturbances. May cause liver and kidney damage. This
substance has caused adverse reproductive and fetal effects in
Target Organs: Kidneys, central nervous system,
liver, lungs, cardiovascular system, red blood cells, skin.
Potential Health Effects
Contact produces irritation, tearing, and burning pain. May cause
Causes irritation with burning pain, itching, and redness. May cause
dermatitis. Exposure to arsenic compounds may produce
hyperpigmentation of the skin and hyperkeratoses of plantar and
palmar surfaces as well as both primary irritation and sensitization
May be fatal if swallowed. Causes severe digestive tract burns with
abdominal pain, vomiting, and possible death. May cause hemorrhaging
of the digestive tract. Ingestion of arsenical compounds may cause
burning of the lips, throat constriction, swallowing difficulties,
severe abdominal pain, severe nausea, projectile vomiting, and
profuse diarrhea. Ingestion of arsenic compounds can produce
convulsions, coma, and possibly death within 24 hours.
May cause severe irritation of the respiratory tract with sore
throat, coughing, shortness of breath and delayed lung edema.
Inhalation of arsenic compounds may lead to irritation of the
respiratory tract and to possible nasal perforation. Long-term
exposure to arsenic compounds may produce impairment of peripheral
May cause liver and kidney damage. Chronic inhalation may cause
nasal septum ulceration and perforation. May cause anemia and other
blood cell abnormalities. Chronic skin effects include: cracking,
thickening, pigmentation, and drying of the skin. Arsenic trioxide
can cause cancer in humans. Other long term effects include: anemia,
liver and kidney damage. Chronic exposure to arsenical dust may cause
shortness of breath, nausea, chest pains, and garlic odor.
Section 4 - First Aid Measures
Flush eyes with plenty of water for at least 15 minutes, occasionally
lifting the upper and lower eyelids. Get medical aid.
Get medical aid. Flush skin with plenty of water for at least 15
minutes while removing contaminated clothing and shoes. Wash clothing
Call a poison control center. If swallowed, do not induce vomiting
unless directed to do so by medical personnel. Never give anything by
mouth to an unconscious person. Get medical aid.
Remove from exposure and move to fresh air immediately. If not
breathing, give artificial respiration. If breathing is difficult,
give oxygen. Get medical aid. Do NOT use mouth-to-mouth
Notes to Physician:
Treat symptomatically and supportively.
Section 5 - Fire Fighting Measures
As in any fire, wear a self-contained breathing apparatus in
pressure-demand, MSHA/NIOSH (approved or equivalent), and full
protective gear. During a fire, irritating and highly toxic gases
may be generated by thermal decomposition or combustion. Use
extinguishing media appropriate to the surrounding fire. Substance is
Substance is noncombustible; use agent most appropriate to
extinguish surrounding fire. Do NOT get water inside containers.
Flash Point: Not applicable.
Autoignition Temperature: Not applicable.
Explosion Limits, Lower:Not available.
Upper: Not available.
(estimated) Health: 3; Flammability: 0; Instability: 0
Section 6 - Accidental Release Measures
General Information: Use proper personal protective equipment as indicated
in Section 8.
Vacuum or sweep up material and place into a suitable disposal
container. Avoid runoff into storm sewers and ditches which lead to
waterways. Clean up spills immediately, observing precautions in the
Protective Equipment section. Avoid generating dusty conditions.
Provide ventilation. Do not get water inside containers.
Section 7 - Handling and Storage
Wash thoroughly after handling. Remove contaminated clothing and
wash before reuse. Minimize dust generation and accumulation. Avoid
contact with eyes, skin, and clothing. Avoid ingestion and
inhalation. Do not allow contact with water. Use only with adequate
ventilation or respiratory protection.
Store in a tightly closed container. Store in a cool, dry,
well-ventilated area away from incompatible substances. Do not store
in metal containers.
Section 8 - Exposure Controls, Personal Protection
Use adequate general or local exhaust ventilation to keep airborne
concentrations below the permissible exposure limits. See 29CFR
1910.1018 for regulatory requirements pertaining to all occupational
exposures to inorganic arsenic.
||OSHA - Final PELs|
0.01 mg/m3 TWA (as As) (listed under Arsenic, inorganic compounds).
5 mg/m3 IDLH (as As) (listed under Arsenic, inorganic compounds).
10 ęg/m3 TWA (as As) (listed under Arsenic, inorganic compounds).5 ęg/m3 Action Level (as As); 10 ęg/m3 TWA (as As, Cancer hazard - see 29 CFR 19 10.1018, except Arsine) (listed under Arsenic, inorga
OSHA Vacated PELs:
No OSHA Vacated PELs are listed for this chemical.
Personal Protective Equipment
Wear appropriate protective eyeglasses or chemical
safety goggles as described by OSHA's eye and face
protection regulations in 29 CFR 1910.133 or European
Wear appropriate gloves to prevent skin exposure.
Wear appropriate protective clothing to prevent skin
Follow the OSHA respirator regulations found in 29
CFR 1910.134 or European Standard EN 149. Use a
NIOSH/MSHA or European Standard EN 149 approved
respirator if exposure limits are exceeded or if
irritation or other symptoms are experienced.
Section 9 - Physical and Chemical Properties
Physical State: Solid
pH: Not available.
Vapor Pressure: 66 mm Hg @ 312C
Vapor Density: Not available.
Viscosity: Not available.
Boiling Point: 465 deg C
Freezing/Melting Point:312 deg C
Decomposition Temperature:Not available.
Solubility: 3.7% in water.
Specific Gravity/Density: 3.738
Section 10 - Stability and Reactivity
Stable under normal temperatures and pressures.
Conditions to Avoid:
Dust generation, moisture, metals, excess heat.
Incompatibilities with Other Materials:
Incompatible with chlorine trifluoride, fluorine, hydrogen fluoride,
oxygen difluoride, and sodium chlorate. Can generate arsine, which
is an extremely poisonous gas, when arsenic compounds contact acid,
alkalies, or water in the presence of an active metal (zinc,
aluminum, magnesium, manganese, sodium, iron, etc).
Hazardous Decomposition Products:
Excess heat, oxides of arsenic, arsine.
Hazardous Polymerization: Has not been reported.
Section 11 - Toxicological Information
Oral, mouse: LD50
= 20 mg/kg;
Oral, rabbit: LD50 =
Oral, rat: LD50 = 10
- ACGIH: A1 - Confirmed Human Carcinogen (listed as 'Arsenic, inorganic compounds').
- California: carcinogen, initial date 2/27/87 (listed as Arsenic, inorganic compounds).
- NTP: Known carcinogen (listed as Arsenic, inorganic compounds).
- IARC: Group 1 carcinogen
In a large number of studies, exposure to inorganic arsenic
compounds in drugs, food, and water as well as in an
occupational setting have been causally associated with
the developmental of cancer, primarily of the skin and
Teratogenic effects, including exencephaly, skeletal
defects, and genitourinay system defects, of arsenic
compounds administered intravenously or intraperitoneally t
high doses have been demonstrated in hamsters, rats and
May cause reproductive effects.
No information available.
No information available.
Section 12 - Ecological Information
Water flea Daphnia: LC50 = 0.038 mg/L; 24 Hr.;
UnspecifiedBacteria: Phytobacterium phosphoreum: EC50 =
31.43-73.73 mg/L; 5,15,30 minutes; Microtox test
No data available.
Terrestrial: Half-life in soil 6.5 years. Aquatic: Tends to
bioaccumulate. Will biodegrade to arsine and will bioconcentrate.
No information available.
No information available.
Section 13 - Disposal Considerations
Chemical waste generators must determine whether a discarded chemical is classified
as a hazardous waste.
US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3.
Additionally, waste generators must consult state and local hazardous waste regulations to
ensure complete and accurate classification.
RCRA P-Series: CAS# 1327-53-3: waste number
RCRA U-Series: None listed.
Section 14 - Transport Information
||No information available.
Section 15 - Regulatory Information
CAS# 1327-53-3 is listed on the TSCA inventory.
Health & Safety Reporting List
None of the chemicals are on the Health & Safety Reporting List.
Chemical Test Rules
None of the chemicals in this product are under a Chemical Test Rule.
None of the chemicals are listed under TSCA Section 12b.
TSCA Significant New Use Rule
None of the chemicals in this material have a SNUR under TSCA.
CERCLA Hazardous Substances and corresponding RQs
CAS# 1327-53-3: 1 lb final RQ; 0.454 kg final RQ
SARA Section 302 Extremely Hazardous Substances
CAS# 1327-53-3: 100 lb lower threshold TPQ; 10000 lb upper threshold T
CAS # 1327-53-3: immediate, delayed.
This material contains Arsenic
trioxide (listed as Arsenic, inorganic compounds), 100.0%, (CAS#
1327-53-3) which is subject to the reporting requirements of Section
313 of SARA Title III and 40 CFR Part 373.
Clean Air Act:
CAS# 1327-53-3 (listed as Arsenic, inorganic compounds) is listed as a
hazardous air pollutant (HAP).
This material does not contain any Class 1 Ozone depletors.
This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
CAS# 1327-53-3 is listed as a Hazardous Substance under the CWA.
None of the chemicals in this
product are listed as Priority Pollutants under the CWA.
CAS# 1327-53-3 is listed as a Toxic Pollutant under the Clean Water
None of the chemicals in this product
are considered highly hazardous by OSHA.
CAS# 1327-53-3 can be found on the
following state right to know lists: California, New Jersey,
Pennsylvania, Minnesota, (listed as Arsenic, inorganic compounds),
California Prop 65
The following statement(s) is(are) made in order to comply with
the California Safe Drinking Water Act:
WARNING: This product contains Arsenic trioxide, listed as `Arsenic,
inorganic compounds', a chemical known to the state of California to
WARNING: This product contains Arsenic trioxide, listed as `Arsenic
(inorganic oxides)', a chemical known to the state of California to
cause developmental reproductive toxicity.
California No Significant Risk Level:
None of the chemicals in this product are listed.
European Labeling in Accordance with EC Directives
R 28 Very toxic if swallowed.
R 34 Causes burns.
R 45 May cause cancer.
R 50/53 Very toxic to aquatic organisms, may cause long-term
adverse effects in the aquatic environment.
S 45 In case of accident or if you feel unwell, seek medical advice
immediately (show the label where possible).
S 53 Avoid exposure - obtain special instructions before use.
S 60 This material and its container must be disposed of as hazardou
S 61 Avoid release to the environment. Refer to special instructions
/safety data sheets.
WGK (Water Danger/Protection)
CAS# 1327-53-3: 3
Canada - DSL/NDSL
CAS# 1327-53-3 is listed on Canada's DSL List.
Canada - WHMIS
This product has a WHMIS classification of D1A, D2A.
This product has been classified in accordance with the hazard
criteria of the Controlled Products Regulations and the MSDS
contains all of the information required by those regulations.
Canadian Ingredient Disclosure List
CAS# 1327-53-3 is listed on the Canadian Ingredient Disclosure List.
Section 16 - Additional Information
MSDS Creation Date: 6/21/1999
Revision #7 Date: 11/20/2008
The information above is believed to be accurate and represents the best
information currently available to us. However, we make no warranty of
merchantability or any other warranty, express or implied, with respect to
such information, and we assume no liability resulting from its use. Users
should make their own investigations to determine the suitability of the
information for their particular purposes. In no event shall Fisher be liable
for any claims, losses, or damages of any third party or for lost profits
or any special, indirect, incidental, consequential or exemplary
damages, howsoever arising, even if Fisher has been advised of
the possibility of such damages.