Material Safety Data Sheet
Arsenic(V) oxide

ACC# 02088
Section 1 - Chemical Product and Company Identification
MSDS Name: Arsenic(V) oxide
Catalog Numbers: AC192500000, AC192500250, AC366310000, AC366310050, AC366310250
Synonyms: Arsenic pentoxide; Diarsenic pentaoxide; Arsenic acid anhydride; Arsenic anhydride.
Company Identification:
              Acros Organics N.V.
              One Reagent Lane
              Fair Lawn, NJ 07410
For information in North America, call: 800-ACROS-01
For emergencies in the US, call CHEMTREC: 800-424-9300

Section 2 - Composition, Information on Ingredients

CAS# Chemical Name Percent EINECS/ELINCS
1303-28-2 Arsenic(V) oxide >99.9 215-116-9

Section 3 - Hazards Identification

EMERGENCY OVERVIEW

Appearance: white solid.
Danger! May be fatal if swallowed. Contains inorganic arsenic. Harmful if inhaled. Causes eye, skin, and respiratory tract irritation. Cancer hazard. May cause nervous system effects. May cause fetal effects.
Target Organs: Liver, lungs, nervous system, skin.


Potential Health Effects
Eye: May cause eye irritation. May result in corneal injury.
Skin: May cause skin irritation. May cause skin sensitization, an allergic reaction, which becomes evident upon re-exposure to this material.
Ingestion: May cause liver damage. Can cause nervous system damage. Ingestion of arsenical compounds may cause burning of the lips, throat constriction, swallowing difficulties, severe abdominal pain, severe nausea, projectile vomiting, and profuse diarrhea. All soluble arsenic (As) compounds are considered to be poisonous to humans. Inorganic arsenic is more toxic than organic arsenic. Organic arsenic is excreted more rapidly than inorganic arsenic. Arsenic 5+ is excreted more rapidly than arsenic 3+. Arsenic inhibits enzymes required for cellular respiration and also competes with phosphorus for incorporation into ATP, depleting cellular energy stores and leading to cell death.
Inhalation: Causes respiratory tract irritation. May cause effects similar to those described for ingestion. Inhalation of arsenic compounds may lead to irritation of the respiratory tract and to possible nasal perforation.
Chronic: Chronic ingestion is characterized by weakness, anorexia, gastrointestinal disturbances, impairment of cognitive function, peripheral neuropathy, and skin disorders. Chronic ingestion may cause fetal effects. Inorganic arsenic compounds may cause skin and lung cancers in humans. Based on a case report of one family with chronic exposure, the spectrum of toxic effects from arsenic pentoxide may include skin rashes, nosebleeds, easy bruising, hair loss, headaches, malaise, and grand mal seizures. Because of mixed exposures, these eeffects cannot be attributed solely to arsenic

Section 4 - First Aid Measures


Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.
Skin: Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops or persists.
Ingestion: Call a poison control center. If swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Get medical aid.
Inhalation: Get medical aid immediately. Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Notes to Physician: Treat symptomatically and supportively.

Section 5 - Fire Fighting Measures


General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media: Use water spray to cool fire-exposed containers.
Flash Point: Not available.
Autoignition Temperature: Not available.
Explosion Limits, Lower:Not available.
Upper: Not available.
NFPA Rating: (estimated) Health: 3; Flammability: 0; Instability: 0

Section 6 - Accidental Release Measures


General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks: Vacuum or sweep up material and place into a suitable disposal container. Avoid generating dusty conditions. Provide ventilation.

Section 7 - Handling and Storage


Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Do not get in eyes, on skin, or on clothing. Do not ingest or inhale. Use only with adequate ventilation or respiratory protection.
Storage: Poison room locked.

Section 8 - Exposure Controls, Personal Protection


Engineering Controls: Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits. See 29CFR 1910.1018 for regulatory requirements pertaining to all occupational exposures to inorganic arsenic.
Exposure Limits
Chemical Name ACGIH NIOSH OSHA - Final PELs
Arsenic(V) oxide 0.01 mg/m3 TWA (as As) (listed under Arsenic, inorganic compounds). 5 mg/m3 IDLH (as As) (listed under Arsenic, inorganic compounds). 10 ęg/m3 TWA (as As) (listed under Arsenic, inorganic compounds).5 ęg/m3 Action Level (as As); 10 ęg/m3 TWA (as As, Cancer hazard - see 29 CFR 19 10.1018, except Arsine) (listed under Arsenic, inorga nic compounds).

OSHA Vacated PELs: Arsenic(V) oxide: No OSHA Vacated PELs are listed for this chemical.
Personal Protective Equipment
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin: Wear appropriate protective gloves to prevent skin exposure.
Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Section 9 - Physical and Chemical Properties


Physical State: Solid
Appearance: white
Odor: odorless
pH: acidic in soln
Vapor Pressure: Not available.
Vapor Density: Not available.
Evaporation Rate:Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point:315 deg C (dec)
Decomposition Temperature:315 deg C
Solubility: Soluble.
Specific Gravity/Density:Not available.
Molecular Formula:As2O5
Molecular Weight:229.84

Section 10 - Stability and Reactivity


Chemical Stability: Stable under normal temperatures and pressures.
Conditions to Avoid: Excess heat, moist air.
Incompatibilities with Other Materials: Acids, aluminum, halogens, zinc, rubidium carbide.
Hazardous Decomposition Products: Oxides of arsenic.
Hazardous Polymerization: Has not been reported.

Section 11 - Toxicological Information


RTECS#:      
CAS# 1303-28-2: CG2275000
LD50/LC50:
CAS# 1303-28-2:
     Oral, mouse: LD50 = 55 mg/kg;
     Oral, rat: LD50 = 8 mg/kg;
.

Carcinogenicity:
CAS# 1303-28-2:


Epidemiology: No data available.
Teratogenicity: No data available.
Reproductive Effects: No data available.
Mutagenicity: No data available.
Neurotoxicity: No data available.
Other Studies:

Section 12 - Ecological Information


Ecotoxicity: No data available. No information available.
Environmental: No information available.
Physical: No information available.
Other: Used in wood preservatives, weed control, and as fungicide.

Section 13 - Disposal Considerations

Chemical waste generators must determine whether a discarded chemical is classified as a hazardous waste. US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3. Additionally, waste generators must consult state and local hazardous waste regulations to ensure complete and accurate classification.
RCRA P-Series: CAS# 1303-28-2: waste number P011.
RCRA U-Series: None listed.

Section 14 - Transport Information

US DOT Canada TDG
Shipping Name: DOT regulated - small quantity provisions apply (see 49CFR173.4) ARSENIC PENTOXIDE
Hazard Class: 6.1
UN Number: UN1559
Packing Group: II

Section 15 - Regulatory Information

US FEDERAL
TSCA
     CAS# 1303-28-2 is listed on the TSCA inventory.
Health & Safety Reporting List
     None of the chemicals are on the Health & Safety Reporting List.
Chemical Test Rules
     None of the chemicals in this product are under a Chemical Test Rule.
Section 12b
     None of the chemicals are listed under TSCA Section 12b.
TSCA Significant New Use Rule
     None of the chemicals in this material have a SNUR under TSCA.
CERCLA Hazardous Substances and corresponding RQs
     CAS# 1303-28-2: 1 lb final RQ; 0.454 kg final RQ
SARA Section 302 Extremely Hazardous Substances
     CAS# 1303-28-2: 100 lb lower threshold TPQ; 10000 lb upper threshold T      PQ
Section 313
     This material contains Arsenic(V) oxide (listed as Arsenic, inorganic compounds), >99.9%, (CAS# 1303-28-2) which is subject to the reporting requirements of Section 313 of SARA Title III and 40 CFR Part 373.
Clean Air Act:
     CAS# 1303-28-2 (listed as Arsenic, inorganic compounds) is listed as a      hazardous air pollutant (HAP).
     This material does not contain any Class 1 Ozone depletors.
     This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
CAS# 1303-28-2 is listed as a Hazardous Substance under the CWA.
     None of the chemicals in this product are listed as Priority Pollutants under the CWA. CAS# 1303-28-2 is listed as a Toxic Pollutant under the Clean Water Act.
OSHA:
     None of the chemicals in this product are considered highly hazardous by OSHA.
STATE
     CAS# 1303-28-2 can be found on the following state right to know lists: California, New Jersey, Pennsylvania, Minnesota, (listed as Arsenic, inorganic compounds), Massachusetts.

California Prop 65
The following statement(s) is(are) made in order to comply with the California Safe Drinking Water Act:
WARNING: This product contains Arsenic(V) oxide, listed as `Arsenic, inorganic compounds', a chemical known to the state of California to cause cancer. WARNING: This product contains Arsenic(V) oxide, listed as `Arsenic (inorganic oxides)', a chemical known to the state of California to cause developmental reproductive toxicity.
California No Significant Risk Level: None of the chemicals in this product are listed.

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols:
     T N
Risk Phrases:
     R 23/25 Toxic by inhalation and if swallowed.
     R 45 May cause cancer.
     R 50/53 Very toxic to aquatic organisms, may cause long-term
     adverse effects in the aquatic environment.

Safety Phrases:
     S 45 In case of accident or if you feel unwell, seek medical advice
     immediately (show the label where possible).
     S 53 Avoid exposure - obtain special instructions before use.
     S 60 This material and its container must be disposed of as hazardou
     s waste.
     S 61 Avoid release to the environment. Refer to special instructions
     /safety data sheets.

WGK (Water Danger/Protection)
     CAS# 1303-28-2: 3
Canada - DSL/NDSL
     CAS# 1303-28-2 is listed on Canada's DSL List.
Canada - WHMIS
     This product has a WHMIS classification of D2A, D1A.
This product has been classified in accordance with the hazard criteria of the Controlled Products Regulations and the MSDS contains all of the information required by those regulations.
Canadian Ingredient Disclosure List
     CAS# 1303-28-2 is listed on the Canadian Ingredient Disclosure List.

Section 16 - Additional Information

MSDS Creation Date: 9/02/1997
Revision #5 Date: 11/20/2008

The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no event shall Fisher be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if Fisher has been advised of the possibility of such damages.