Material Safety Data Sheet
Section 1 - Chemical Product and Company Identification
MSDS Name: Benzene
AC167660000, AC167660010, AC167660025, AC167660250, AC167665000,
AC168650250, AC295330000, AC295330010, AC295330025, AC295330250,
AC296880000, AC296880010, AC296880025, AC296880250, AC610230010,
AC610231000, AC611001000, B243-4, B245-4, B245-500, B411-1, B411-4, B412-1,
Benzol; Cyclohexatriene; Phenyl hydride.
1 Reagent Lane
Fair Lawn, NJ 07410
For information, call: 201-796-7100
Emergency Number: 201-796-7100
For CHEMTREC assistance, call: 800-424-9300
For International CHEMTREC assistance, call: 703-527-3887
Section 2 - Composition, Information on Ingredients
|| > 99 ||200-753-7
Section 3 - Hazards Identification
Appearance: clear colorless liquid. Flash Point: -11 deg C.
Danger! Extremely flammable liquid and vapor.
Vapor may cause flash fire. Harmful if swallowed, inhaled, or
absorbed through the skin. Causes eye, skin, and respiratory tract
irritation. Contains benzene. Benzene can cause cancer. Aspiration
hazard if swallowed. Can enter lungs and cause damage. May cause
blood abnormalities. May cause central nervous system effects.
Target Organs: Blood, central nervous system,
respiratory system, eyes, bone marrow, immune system, skin.
Potential Health Effects
Causes eye irritation.
Causes skin irritation. Harmful if absorbed through the skin.
Prolonged and/or repeated contact may cause defatting of the skin
May cause central nervous system depression, characterized by
excitement, followed by headache, dizziness, drowsiness, and nausea.
Advanced stages may cause collapse, unconsciousness, coma and
possible death due to respiratory failure. May cause effects similar
to those for inhalation exposure. Aspiration of material into the
lungs may cause chemical pneumonitis, which may be fatal.
Causes respiratory tract irritation. May cause drowsiness,
unconsciousness, and central nervous system depression. Exposure may
lead to irreversible bone marrow injury. Exposure may lead to
Potential symptoms of overexposure by inhalation are dizziness,
headache, vomiting, visual disturbances, staggering gait, hilarity,
fatigue, and other symptoms of CNS depression.
May cause bone marrow abnormalities with damage to blood forming
tissues. May cause anemia and other blood cell abnormalities. Chronic
exposure to benzene has been associated with an increased incidence
of leukemia and multiple myeloma (tumor composed of cells of the type
normally found in the bone marrow). Immunodepressive effects have
been reported. This substance has caused adverse reproductive and
fetal effects in laboratory animals.
Section 4 - First Aid Measures
In case of contact, immediately flush eyes with plenty of water for a
t least 15 minutes. Get medical aid.
In case of contact, flush skin with plenty of water. Remove
contaminated clothing and shoes. Get medical aid if irritation
develops and persists. Wash clothing before reuse.
Potential for aspiration if swallowed. Get medical aid immediately.
Do not induce vomiting unless directed to do so by medical
personnel. Never give anything by mouth to an unconscious person. If
vomiting occurs naturally, have victim lean forward.
If inhaled, remove to fresh air. If not breathing, give artificial
respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
Treat symptomatically and supportively.
Section 5 - Fire Fighting Measures
As in any fire, wear a self-contained breathing apparatus in
pressure-demand, MSHA/NIOSH (approved or equivalent), and full
protective gear. Use water spray to keep fire-exposed containers
cool. Extremely flammable liquid and vapor. Vapor may cause flash
fire. Approach fire from upwind to avoid hazardous vapors and toxic
decomposition products. Vapors are heavier than air and may travel to
a source of ignition and flash back. Vapors can spread along the
ground and collect in low or confined areas. This liquid floats on
water and may travel to a source of ignition and spread fire. May
accumulate static electricity.
Use water spray, dry chemical, carbon dioxide, or appropriate foam.
Flash Point: -11 deg C ( 12.20 deg F)
Autoignition Temperature: 498 deg C ( 928.40 deg F)
Explosion Limits, Lower:1.3 vol %
Upper: 7.1 vol %
(estimated) Health: 2; Flammability: 3; Instability: 0
Section 6 - Accidental Release Measures
General Information: Use proper personal protective equipment as indicated
in Section 8.
Absorb spill with inert material (e.g. vermiculite, sand or earth),
then place in suitable container. Avoid runoff into storm sewers and
ditches which lead to waterways. Remove all sources of ignition.
Provide ventilation. Approach spill from upwind. Use water spray to
cool and disperse vapors, protect personnel, and dilute spills to
form nonflammable mixtures.
Section 7 - Handling and Storage
Wash thoroughly after handling. Remove contaminated clothing and
wash before reuse. Ground and bond containers when transferring
material. Avoid contact with eyes, skin, and clothing. Empty
containers retain product residue, (liquid and/or vapor), and can be
dangerous. Take precautionary measures against static discharges.
Keep container tightly closed. Do not pressurize, cut, weld, braze,
solder, drill, grind, or expose empty containers to heat, sparks or
open flames. Use only with adequate ventilation. Keep away from heat,
sparks and flame. Avoid breathing vapor.
Keep away from sources of ignition. Store in a tightly closed
container. Keep from contact with oxidizing materials. Store in a
cool, dry, well-ventilated area away from incompatible substances.
Section 8 - Exposure Controls, Personal Protection
Use process enclosure, local exhaust ventilation, or other
engineering controls to control airborne levels below recommended
exposure limits. Use explosion-proof ventilation equipment.
Facilities storing or utilizing this material should be equipped with
an eyewash facility and a safety shower. See 29CFR 1910.1028 for the
regulatory requirements for the control of employee exposure to
||OSHA - Final PELs|
0.5 ppm TWA; 2.5 ppm STEL; Skin - potential significant contribution to overall exposure by the cutaneous r oute
0.1 ppm TWA 500 ppm IDLH
1 ppm TWA; 10 ppm TWA (applies to industry segments exempt from the benzene stan dard at 29 CFR 1910.1028); 25 ppm Ceiling (applies to industry segments exempt from the 1 ppm TWA and 5 ppm STEL of th
e benzene standard); 0.5 ppm Action Level; 1 ppm TWA; 5 ppm STEL (Cancer hazard, Flammable - see 29 C FR 1910.1028)
OSHA Vacated PELs:
10 ppm TWA (unless specified in 1910.1028)
Personal Protective Equipment
Wear chemical splash goggles.
Wear appropriate protective gloves to prevent skin
Wear appropriate protective clothing to prevent skin
A respiratory protection program that meets OSHA's 29
CFR 1910.134 and ANSI Z88.2 requirements or European
Standard EN 149 must be followed whenever workplace
conditions warrant respirator use.
Section 9 - Physical and Chemical Properties
Physical State: Liquid
Appearance: clear colorless
Odor: sweetish odor - aromatic odor
pH: Not applicable.
Vapor Pressure: 75 mm Hg @ 20 deg C
Vapor Density: 2.8 (air=1)
Evaporation Rate:Not available.
Viscosity: 0.647mPa @ 20 deg C
Boiling Point: 80.1 deg C
Freezing/Melting Point:5.5 deg C
Decomposition Temperature:Not available.
Solubility: 0.180 g/100 ml @ 25°C
Specific Gravity/Density:0.8765 @ 20°C
Section 10 - Stability and Reactivity
Stable under normal temperatures and pressures.
Conditions to Avoid:
Ignition sources, excess heat, confined spaces.
Incompatibilities with Other Materials:
Strong oxidizing agents.
Hazardous Decomposition Products:
Carbon monoxide, carbon dioxide.
Hazardous Polymerization: Has not been reported.
Section 11 - Toxicological Information
Dermal, guinea pig:
LD50 = >9400 uL/kg;
rabbit, eye: 88 mg Moderate;
test, rabbit, eye: 2 mg/24H Severe;
Draize test, rabbit, skin: 20 mg/24H
Inhalation, mouse: LC50
= 9980 ppm;
LC50 = 24 mL/kg/2H;
rat: LC50 = 10000 ppm/7H;
Inhalation, rat: LC50 = 34
Inhalation, rat: LC50 =
Oral, mouse: LD50 =
Oral, rat: LD50 = 930
Oral, rat: LD50 = 1
Oral, rat: LD50 = 1800
Benzene is considered very toxic; probable human oral lethal dose
would be 50-500 mg/kg. Human inhalation of approximately 20,000 ppm
(2% in air) was fatal in 5-10 minutes.While percutaneous absorption
of liquid benzene through intact human skin can be limited (e.g.,
0.05% of the applied dose), the absorbed dose via direct dermal
contact combined with that received from body surface exposure to
benzene in workplace air is such that a substantial fraction (20-40%)
of the total exposure is due to skin absorption.
- ACGIH: A1 - Confirmed Human Carcinogen
- California: carcinogen, initial date 2/27/87
- NTP: Known carcinogen
- IARC: Group 1 carcinogen
IARC has concluded that epidemiological studies have
established the relationship between benzene exposure and
the development of acute myelogenous leukemia, and that
there is sufficient evidence that benzene is carcinogenic
Inhalation, rat: TCLO = 50 ppm/24H (female 7-14 day(s)
after conception) Effects on Embryo or Fetus -
extra-embryonic structures (e.g., placenta, umbilical cord)
and Effects on Embryo or Fetus - fetotoxicity (except
death, e.g., stunted fetus).; Inhalation,mouse: TCLo = 5
ppm (female 6-15 day(s) after conception) Effects on
Embryo or Fetus - cytological changes (including somatic
cell genetic material) and Specific Developmental
Abnormalities - blood and lymphatic systems (including
spleen and marrow).
Inhalation, rat: TCLO = 670 mg/m3/24H (female 15 day(s)
pre-mating and female 1-22 day(s) after conception) female
fertility index (e.g. # females pregnant per # sperm
positive females; # females pregnant per # females mated).;
Oral, mouse: TDLo = 12 gm/kg (female 6-15 day(s) after
conception) Fertility - post-implantation mortality (e.g.
dead and/or resorbed implants per total number of
DNA Inhibition: Human, Leukocyte = 2200 umol/L.; DNA
Inhibition: Human, HeLa cell = 2200 umol/L.; Mutation Test
Systems - not otherwise specified: Human, Lymphocyte = 5
umol/L.; Cytogenetic Analysis: Inhalation, Human = 125
ppm/1Y.; Cytogenetic Analysis: Human, Leukocyte = 1
mmol/L/72H.; Cytogenetic Analysis: Human, Lymphocyte = 1
See actual entry in RTECS for complete information.
Section 12 - Ecological Information
Fish: Mosquito Fish: TLm = 395 mg/L; 24 Hr; UnspecifiedFish:
Goldfish: LC50 =46 mg/L; 24 Hr; Modified ASTM D 1345Fish:
Fathead Minnow: LC50 = 15.1 mg/L; 96 Hr; Flow-through at 25°C (pH
7.9-8.0)Fish: Rainbow trout: LC50 = 5.3 mg/L; 96 Hr;
Flow-through at 25°C (pH 7.9-8.0)Fish: Bluegill/Sunfish: LD50 =
20 mg/L; 24-48 Hr; Unspecified
If benzene is released to soil, it will be subject to rapid
volatilization near the surface and that which does not evaporate
will be highly to very highly mobile in the soil and may leach to
groundwater. If benzene is released to water, it will be subject to
rapid volatilization. It will not be expected to significantly adsorb
to sediment, bioconcentrate in aquatic organisms or hydrolyze. It may
be subject to biodegradation.
If benzene is released to the atmosphere, it will exist predominantly
in the vapor phase. Gas-phase benzene will not be subject to direct
photolysis but it will react with photochemically produced hydroxyl
radicals with a half-life of 13.4 days. The reaction time in polluted
atmospheres which contain nitrogen oxides or sulfur dioxide is
accelerated with the half-life being reported as 4-6 hours. Benzene
is fairly soluble in water and is removed from the atmosphere in
Products of photooxidation include phenol, nitrophenols,
nitrobenzene, formic acid, and peroxyacetyl nitrate.
No information available.
Section 13 - Disposal Considerations
Chemical waste generators must determine whether a discarded chemical is classified
as a hazardous waste.
US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3.
Additionally, waste generators must consult state and local hazardous waste regulations to
ensure complete and accurate classification.
RCRA P-Series: None listed.
CAS# 71-43-2: waste
number U019 (Ignitable waste, Toxic waste).
Section 14 - Transport Information
|Additional Info:||FLASHPOINT -11 C|
Section 15 - Regulatory Information
CAS# 71-43-2 is listed on the TSCA inventory.
Health & Safety Reporting List
None of the chemicals are on the Health & Safety Reporting List.
Chemical Test Rules
None of the chemicals in this product are under a Chemical Test Rule.
None of the chemicals are listed under TSCA Section 12b.
TSCA Significant New Use Rule
None of the chemicals in this material have a SNUR under TSCA.
CERCLA Hazardous Substances and corresponding RQs
CAS# 71-43-2: 10 lb final RQ (received an adjusted RQ of 10 lbs based on potential carcinogeni
SARA Section 302 Extremely Hazardous Substances
None of the chemicals in this product have a TPQ.
CAS # 71-43-2: immediate, delayed, fire.
This material contains Benzene
(CAS# 71-43-2, > 99%),which is subject to the reporting requirements
of Section 313 of SARA Title III and 40 CFR Part 373.
Clean Air Act:
CAS# 71-43-2 is listed as a hazardous air pollutant (HAP).
This material does not contain any Class 1 Ozone depletors.
This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
CAS# 71-43-2 is listed as a Hazardous Substance under the CWA.
CAS# 71-43-2 is listed as a Priority Pollutant under the Clean Water
CAS# 71-43-2 is listed as a Toxic Pollutant under the Clean Water
None of the chemicals in this product
are considered highly hazardous by OSHA.
CAS# 71-43-2 can be found on the
following state right to know lists: California, New Jersey,
Pennsylvania, Minnesota, Massachusetts.
California Prop 65
The following statement(s) is(are) made in order to comply with
the California Safe Drinking Water Act:
WARNING: This product contains Benzene, a chemical known to the
state of California to cause cancer.
WARNING: This product contains Benzene, a chemical known to the
state of California to cause male reproductive toxicity.
California No Significant Risk Level:
CAS# 71-43-2: 6.4 æg/day NSRL (oral); 13 æg/day NSRL (inhalation)
European Labeling in Accordance with EC Directives
R 11 Highly flammable.
R 36/38 Irritating to eyes and skin.
R 45 May cause cancer.
R 46 May cause heritable genetic damage.
R 48/23/24/25 Toxic : danger of serious damage to health by
prolonged exposure through inhalation, contact with skin and if
R 65 Harmful: may cause lung damage if swallowed.
S 45 In case of accident or if you feel unwell, seek medical advice
immediately (show the label where possible).
S 53 Avoid exposure - obtain special instructions before use.
WGK (Water Danger/Protection)
CAS# 71-43-2: 3
Canada - DSL/NDSL
CAS# 71-43-2 is listed on Canada's DSL List.
Canada - WHMIS
This product has a WHMIS classification of B2, D2A, D2B.
This product has been classified in accordance with the hazard
criteria of the Controlled Products Regulations and the MSDS
contains all of the information required by those regulations.
Canadian Ingredient Disclosure List
CAS# 71-43-2 is listed on the Canadian Ingredient Disclosure List.
Section 16 - Additional Information
MSDS Creation Date: 6/11/1999
Revision #8 Date: 9/11/2008
The information above is believed to be accurate and represents the best
information currently available to us. However, we make no warranty of
merchantability or any other warranty, express or implied, with respect to
such information, and we assume no liability resulting from its use. Users
should make their own investigations to determine the suitability of the
information for their particular purposes. In no event shall Fisher be liable
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or any special, indirect, incidental, consequential or exemplary
damages, howsoever arising, even if Fisher has been advised of
the possibility of such damages.