Section 2 - Composition, Information on Ingredients

CAS#	Chemical Name	Percent	EINECS/ELINCS
108-94-1	Cyclohexanone	98+	203-631-1

Section 3 - Hazards Identification

Appearance: APHA: 10 max liquid. Flash Point: 46 deg C.
Warning! Possible cancer hazard. May cause cancer based on animal data. Flammable liquid and vapor. Harmful if inhaled. Causes eye and skin irritation. May cause respiratory tract irritation. May cause central nervous system effects.
Target Organs: Blood, kidneys, central nervous system, liver, respiratory system, eyes, skin.


Potential Health Effects
Eye: Causes eye irritation. Undiluted cyclohexanone placed in the eyes of rabbits caused marked irritation and some corneal injury.
Skin: Causes skin irritation. May be harmful if absorbed through the skin. Cyclohexanone was not a sensitizer in the guinea pig maximization test and the mouse ear swelling test. There has been one case report of sensitization to cyclohexanone itself in a patient using a PVC adhesive composed of 100% cyclohexanone; patch testing confirmed the sensitization.
Ingestion: May cause irritation of the digestive tract. May be harmful if swallowed. May cause central nervous system effects.
Inhalation: Harmful if inhaled. May cause respiratory tract irritation. May cause central nervous system effects. Cyclohexanone has caused damage to the liver and kidneys in rabbits exposed by inhalation to an airborne concentration of 190 ppm.
Chronic: Possible cancer hazard based on tests with laboratory animals. Prolonged or repeated skin contact may cause dermatitis. May cause liver and kidney damage. Adverse reproductive effects have been reported in animals. Laboratory experiments have resulted in mutagenic effects. Chronic exposure may cause blood effects.

Section 4 - First Aid Measures

Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin: Get medical aid. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion: Do not induce vomiting. Get medical aid.
Inhalation: Get medical aid immediately. Remove from exposure and move to fresh air immediately. If breathing is difficult, give oxygen. Do not use mouth-to-mouth resuscitation if victim ingested or inhaled the substance; induce artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device.
Notes to Physician: Treat symptomatically and supportively.

Section 5 - Fire Fighting Measures

General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Vapors may form an explosive mixture with air. Vapors can travel to a source of ignition and flash back. Will burn if involved in a fire. Containers may explode in the heat of a fire. Flammable liquid and vapor.
Extinguishing Media: Use water spray to cool fire-exposed containers. Use foam, dry chemical, or carbon dioxide. Water may be ineffective.
Flash Point: 46 deg C ( 114.80 deg F)
Autoignition Temperature: 520 deg C ( 968.00 deg F)
Explosion Limits, Lower:1.10 vol %
Upper: 8.10 vol %
NFPA Rating: (estimated) Health: 2; Flammability: 2; Instability: 0

Section 6 - Accidental Release Measures

General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks: Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Wear a self contained breathing apparatus and appropriate personal protection. (See Exposure Controls, Personal Protection section). Remove all sources of ignition. Use a spark-proof tool. Do not let this chemical enter the environment.

Section 7 - Handling and Storage

Handling: Use spark-proof tools and explosion proof equipment. Do not get in eyes, on skin, or on clothing. Take precautionary measures against static discharges. Keep away from heat, sparks and flame. Do not ingest or inhale. Use only in a chemical fume hood.
Storage: Keep away from sources of ignition. Store in a cool, dry place. Store in a tightly closed container. Flammables-area.

Section 8 - Exposure Controls, Personal Protection

Engineering Controls: Use explosion-proof ventilation equipment. Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use only under a chemical fume hood.
Exposure Limits

Chemical Name	ACGIH	NIOSH	OSHA - Final PELs
Cyclohexanone	20 ppm TWA; 50 ppm STEL; Skin - potential significant contribution to overall exposure by the cutaneous r oute	25 ppm TWA; 100 mg/m3 TWA 700 ppm IDLH	50 ppm TWA; 200 mg/m3 TWA

OSHA Vacated PELs: Cyclohexanone: 25 ppm TWA; 100 mg/m3 TWA
Personal Protective Equipment
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin: Wear appropriate protective gloves to prevent skin exposure.
Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Section 9 - Physical and Chemical Properties

Physical State: Liquid
Appearance: clear, colorless - APHA: 10 max
Odor: none reported
pH: Not applicable.
Vapor Pressure: 4.5 mbar @ 20 deg C
Vapor Density: 3.4 (air=1)
Evaporation Rate:Not available.
Viscosity: Not available.
Boiling Point: 155 deg C @ 760 mmHg
Freezing/Melting Point:-47 deg C
Decomposition Temperature:Not available.
Solubility: Slightly soluble.
Specific Gravity/Density:0.947
Molecular Formula:C6H10O
Molecular Weight:98.14

Section 10 - Stability and Reactivity

Chemical Stability: Stable under normal temperatures and pressures.
Conditions to Avoid: Incompatible materials, ignition sources, excess heat.
Incompatibilities with Other Materials: Reducing agents, plastics.
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide.
Hazardous Polymerization: Will not occur.

Section 11 - Toxicological Information

RTECS#:      
CAS# 108-94-1: GW1050000
LD50/LC50:
CAS# 108-94-1:
     Draize test, rabbit, eye: 20 mg Severe;
     Draize test, rabbit, eye: 250 ug/24H Severe;
     Inhalation, mouse: LC50 = 2375 mg/m3;
     Inhalation, rat: LC50 = 8000 ppm/4H;
     Inhalation, rat: LC50 = 19000 mg/m3;
     Oral, mouse: LD50 = 1400 mg/kg;
     Oral, rat: LD50 = 1620 uL/kg;
     Oral, rat: LD50 = 1800 mg/kg;
     Skin, rabbit: LD50 = 1 mL/kg;
.

Carcinogenicity:
CAS# 108-94-1:

• ACGIH: A3 - Confirmed animal carcinogen with unknown relevance to humans
  
• California: Not listed.
  
• NTP: Not listed.
  
• IARC: Not listed.