Material Safety Data Sheet
Ethylenediamine Tetraacetic Acid
Section 1 - Chemical Product and Company Identification
MSDS Name: Ethylenediamine Tetraacetic Acid
S80007, S80007-1, BP118-500, E478-1, E478-10, E478-500, S80008MF
Acetic acid, (ethylenedinitrilo)tetra-; 3,6-Diazaoctanedioic acid,
3,6-bis(carboxymethyl)-; Edetic acid; EDTA; EDTA (chelating agent);
EDTA acid; Endrate;
Ethylenediaminetetraacetic acid; Ethylenediamine
1 Reagent Lane
Fair Lawn, NJ 07410
For information, call: 201-796-7100
Emergency Number: 201-796-7100
For CHEMTREC assistance, call: 800-424-9300
For International CHEMTREC assistance, call: 703-527-3887
Section 2 - Composition, Information on Ingredients
Ethylenediamine tetraacetic acid
|| >99 ||200-449-4
Section 3 - Hazards Identification
Appearance: colorless to white crystals.
Warning! Causes respiratory tract irritation.
Causes eye and skin irritation. May cause kidney damage. May cause
reproductive and fetal effects.
Target Organs: Kidneys, eyes, skin.
Potential Health Effects
Causes eye irritation. Causes redness and pain.
Causes skin irritation. Causes redness and pain.
May cause gastrointestinal irritation with nausea, vomiting and
diarrhea. Ingestion of large amounts can cause hypocalcemic tetany
due to formation of calcium complexes. Exposure may cause kidney
injury, muscle cramps, bone-marrow depression, and a generalized
Ingestion of large quantities may cause appreciable systemic toxicity
involving blood chemistry changes due to chelation properties.
Causes irritation of the mucous membrane and upper respiratory
May cause reproductive and fetal effects. Laboratory experiments
have resulted in mutagenic effects. Chronic exposure may cause kidney
Section 4 - First Aid Measures
Immediately flush eyes with plenty of water for at least 15 minutes,
occasionally lifting the upper and lower eyelids. Get medical aid.
Get medical aid. Immediately flush skin with plenty of water for at
least 15 minutes while removing contaminated clothing and shoes.
Wash clothing before reuse.
Never give anything by mouth to an unconscious person. Get medical
aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and
drink 2-4 cupfuls of milk or water.
Remove from exposure and move to fresh air immediately. If not
breathing, give artificial respiration. If breathing is difficult,
give oxygen. Get medical aid.
Notes to Physician:
Treat symptomatically and supportively.
Section 5 - Fire Fighting Measures
As in any fire, wear a self-contained breathing apparatus in
pressure-demand, MSHA/NIOSH (approved or equivalent), and full
protective gear. Dusts at sufficient concentrations can form
explosive mixtures with air. During a fire, irritating and highly
toxic gases may be generated by thermal decomposition or combustion.
Use water spray, dry chemical, carbon dioxide, or appropriate foam.
Flash Point: Not applicable.
Autoignition Temperature: Not applicable.
Explosion Limits, Lower:Not available.
Upper: Not available.
(estimated) Health: 2; Flammability: 1; Instability: 0
Section 6 - Accidental Release Measures
General Information: Use proper personal protective equipment as indicated
in Section 8.
Vacuum or sweep up material and place into a suitable disposal
container. Avoid runoff into storm sewers and ditches which lead to
waterways. Clean up spills immediately, observing precautions in the
Protective Equipment section. Avoid generating dusty conditions.
Section 7 - Handling and Storage
Wash thoroughly after handling. Remove contaminated clothing and
wash before reuse. Use with adequate ventilation. Minimize dust
generation and accumulation. Avoid contact with skin and eyes. Keep
container tightly closed. Avoid breathing dust.
Do not store in direct sunlight. Store in a tightly closed
container. Store in a cool, dry, well-ventilated area away from
Section 8 - Exposure Controls, Personal Protection
Facilities storing or utilizing this material should be equipped
with an eyewash facility and a safety shower. Use adequate
ventilation to keep airborne concentrations low.
||OSHA - Final PELs|
|Ethylenediamine tetraacetic acid
OSHA Vacated PELs:
Ethylenediamine tetraacetic acid:
No OSHA Vacated PELs are listed for this chemical.
Personal Protective Equipment
Wear appropriate protective eyeglasses or chemical
safety goggles as described by OSHA's eye and face
protection regulations in 29 CFR 1910.133 or European
Wear appropriate protective gloves to prevent skin
Wear appropriate protective clothing to prevent skin
A respiratory protection program that meets OSHA's 29
CFR 1910.134 and ANSI Z88.2 requirements or European
Standard EN 149 must be followed whenever workplace
conditions warrant respirator use.
Section 9 - Physical and Chemical Properties
Physical State: Crystals
Appearance: colorless to white
pH: Not available.
Vapor Pressure: Negligible.
Vapor Density: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point:220 deg C
Decomposition Temperature:240 deg C
Solubility: Slightly soluble.
Specific Gravity/Density:0.86 @ 20C
Section 10 - Stability and Reactivity
Stable at room temperature in closed containers under normal storage
and handling conditions. Decarboxylates above 150C.
Conditions to Avoid:
Dust generation, excess heat.
Incompatibilities with Other Materials:
Strong oxidizing agents, strong bases, aluminum, copper, copper
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, irritating and toxic fumes and
gases, carbon dioxide.
Hazardous Polymerization: Will not occur.
Section 11 - Toxicological Information
Oral, mouse: LD50 =
Not listed by ACGIH, IARC, NTP, or CA Prop 65.
No information available.
Embryo or Fetus: Stunted fetus, oral-rat
TDLo=7632mg/kg.Specific developmental abnormalities:
cardiovascular, craniofacial, musculoskeletal, respiratory,
and urogenital, oral-rat TDLo=7632mg/kg.
Fertility: Post-implantation mortality, oral-rat
Cytogenetic Analysis: intraperitoneal-mouse 50mmol/L. DNA
Inhibition: hamster fibroblast 500ug/L, rabbit kidney
250umol/L.EDTA leads to morphological changes of chromatin
& chromosome structure in plant & animal cells.A weak
induction of gene mutations has been reported.
No information available.
Section 12 - Ecological Information
Fish: Channel catfish: LC50 = 129-159 mg/L; 96Hr;
UnspecifiedFish: Rainbow trout: LC50 = 340 mg/L; 24Hr;
UnspecifiedFish: Bluegill/Sunfish: LC50 = 129-159 mg/L; 96Hr;
UnspecifiedFish: Fathead Minnow: 100% Lethal = 750 ppm; 96 Hr;
Static bioassayWater flea Daphnia: LC50 > 100 ppm; 96 Hr; Static
If released to soil, EDTA is expected to complex with trace metals
and alkaline earth metals present in the soil, thereby causing an
increase in the total solubility of the metals. EDTA may eventually
predominate as the Fe(III) chelate in acidic soils and as the Ca
chelate in alkaline soils. Biodegradation of EDTA in aerobic soils is
the dominant removal mechanism, although biodegradation in anaerobic
soils is negligible. glycine. EDTA is not expected to bioaccumulate
in aquatic organisms, adsorb to suspended solids or sediments or
volatilize from water surfaces.
EDTA and its chelates are expected to leach readily through soil and
significant volatilization from soil is not expected. If released to
water, EDTA is expected to complex with trace metals and alkaline
earth metals. Biodegradation of EDTA is expected to take place
relatively slowly under aerobic conditions and to be negligible
under anaerobic conditions. Cometabolism has been suggested as the
mechanism for EDTA biodegradation. EDTA may react with
photochemically generated hydroxyl radicals (half-life 229 days) and
it may photodegrade.
Compounds identified as possible biodegradation products of the
ammonium ferric chelate of EDTA are as follows: ethylenediamine
triacetic acid (ED3A), iminodiacetic acid (IDA), N,N-ethylenediamine
diacetic acid (N,N-EDDA), N,N'-EDDA, ethylenediamine monoacetic acid
(EDMA), nitrilotriacetic acid (NTA) and glycine. The following
photodegradation products of Fe(III)-EDTA have been identified:
carbon monoxide, formaldehyde, ED3A, N,N-EDDA, N,N'-EDDA, IDA, EDMA
Section 13 - Disposal Considerations
Chemical waste generators must determine whether a discarded chemical is classified
as a hazardous waste.
US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3.
Additionally, waste generators must consult state and local hazardous waste regulations to
ensure complete and accurate classification.
RCRA P-Series: None listed.
RCRA U-Series: None listed.
Section 14 - Transport Information
||Not regulated as a hazardous material
||No information available.
Section 15 - Regulatory Information
CAS# 60-00-4 is listed on the TSCA inventory.
Health & Safety Reporting List
None of the chemicals are on the Health & Safety Reporting List.
Chemical Test Rules
None of the chemicals in this product are under a Chemical Test Rule.
None of the chemicals are listed under TSCA Section 12b.
TSCA Significant New Use Rule
None of the chemicals in this material have a SNUR under TSCA.
CERCLA Hazardous Substances and corresponding RQs
CAS# 60-00-4: 5000 lb final RQ; 2270 kg final RQ
SARA Section 302 Extremely Hazardous Substances
None of the chemicals in this product have a TPQ.
No chemicals are reportable under Section 313.
Clean Air Act:
This material does not contain any hazardous air pollutants.
This material does not contain any Class 1 Ozone depletors.
This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
CAS# 60-00-4 is listed as a Hazardous Substance under the CWA.
None of the chemicals in this
product are listed as Priority Pollutants under the CWA.
None of the chemicals in this
product are listed as Toxic Pollutants under the CWA.
None of the chemicals in this product
are considered highly hazardous by OSHA.
CAS# 60-00-4 can be found on the
following state right to know lists: California, New Jersey,
California Prop 65
California No Significant Risk Level:
None of the chemicals in this product are listed.
European Labeling in Accordance with EC Directives
R 36/37/38 Irritating to eyes, respiratory system and skin.
S 26 In case of contact with eyes, rinse immediately with plenty of
water and seek medical advice.
S 37/39 Wear suitable gloves and eye/face protection.
WGK (Water Danger/Protection)
CAS# 60-00-4: 2
Canada - DSL/NDSL
CAS# 60-00-4 is listed on Canada's DSL List.
Canada - WHMIS
This product has a WHMIS classification of D2B.
This product has been classified in accordance with the hazard
criteria of the Controlled Products Regulations and the MSDS
contains all of the information required by those regulations.
Canadian Ingredient Disclosure List
Section 16 - Additional Information
MSDS Creation Date: 6/01/1999
Revision #5 Date: 6/29/2007
The information above is believed to be accurate and represents the best
information currently available to us. However, we make no warranty of
merchantability or any other warranty, express or implied, with respect to
such information, and we assume no liability resulting from its use. Users
should make their own investigations to determine the suitability of the
information for their particular purposes. In no event shall Fisher be liable
for any claims, losses, or damages of any third party or for lost profits
or any special, indirect, incidental, consequential or exemplary
damages, howsoever arising, even if Fisher has been advised of
the possibility of such damages.