Material Safety Data Sheet
MSDS Name: Acetone cyanohydrin
Section 1 - Chemical Product and Company Identification
Acros Organics N.V.
One Reagent Lane
Fair Lawn, NJ 07410
For information in North America, call: 800-ACROS-01
For emergencies in the US, call CHEMTREC: 800-424-9300
Section 2 - Composition, Information on Ingredients
|| > 98 ||200-909-4
Section 3 - Hazards Identification
Appearance: colorless liquid. Flash Point: 73.8 deg C.
Danger! May be fatal if absorbed through the skin.
Harmful or fatal if swallowed. Combustible liquid and
vapor. May cause eye and skin irritation. May cause
respiratory and digestive tract irritation. May cause central nervous
system depression. May cause liver and kidney damage. Metabolized to
cyanide in the body, which may cause headache, dizziness, weakness,
unconsciousness, convulsions, coma and possible death.
Target Organs: Kidneys, central nervous system,
Potential Health Effects
May cause eye irritation. May cause chemical conjunctivitis and
May be fatal if absorbed through the skin. May be metabolized to
cyanide which in turn acts by inhibiting cytochrome oxidase impairing
cellular respiration. May cause irritation and dermatitis. May cause
cyanosis of the extremities.
May be fatal if swallowed. May cause gastrointestinal irritation
with nausea, vomiting and diarrhea. May cause liver and kidney
damage. Metabolism may release cyanide, which may result in
headache, dizziness, weakness, collapse, unconsciousness and
possible death. Human fatalities have been reported from acute
poisoning. Ingestion may result in symptoms similar to cyanide
poisoning which is characterized by asphyxiation.
May cause respiratory tract irritation. May cause liver and kidney
damage. Aspiration may lead to pulmonary edema. May be metabolized to
cyanide which in turns act by inhibiting cytochrome oxidase impairing
cellular respiration. Inhalation may result in symptoms similar to
cyanide poisoning which include tachypnea, hyperpnea (abnormally
rapid or deep breathing), and dyspnea (labored breathing) followed
rapidly by respiratory depression. Pulmonary edema may occur.
Inhalation at high concentrations may cause CNS depression and
May cause liver and kidney damage. May be metabolized to cyanide
which in turn acts by inhibiting cytochrome oxidase impairing
Section 4 - First Aid Measures
Immediately flush eyes with plenty of water for at least 15 minutes,
occasionally lifting the upper and lower eyelids. Get medical aid imme
Flush skin with plenty of water for at least 15 minutes while
removing contaminated clothing and shoes. Discard contaminated
clothing in a manner which limits further exposure. SPEEDY ACTION IS
Do not induce vomiting. If victim is conscious and alert, give 2-4
cupfuls of milk or water. Never give anything by mouth to an
unconscious person. Get medical aid immediately.
Get medical aid immediately. Remove from exposure and move to fresh
air immediately. If not breathing, give artificial respiration. If
breathing is difficult, give oxygen. Do NOT use mouth-to-mouth
resuscitation. If breathing has ceased apply artificial respiration
using oxygen and a suitable mechanical device such as a bag and a
Notes to Physician:
Treat symptomatically and supportively.
Section 5 - Fire Fighting Measures
As in any fire, wear a self-contained breathing apparatus in
pressure-demand, MSHA/NIOSH (approved or equivalent), and full
protective gear. Use water spray to keep fire-exposed containers
cool. Water may be ineffective. Material is lighter than water and a
fire may be spread by the use of water. Combustible liquid. Vapors
may be heavier than air. They can spread along the ground and
collect in low or confined areas. Containers may explode when
In case of fire, use water, dry chemical, chemical foam, or
alcohol-resistant foam. Use water spray to cool fire-exposed
containers. Water may be ineffective.
Flash Point: 73.8 deg C ( 164.84 deg F)
Autoignition Temperature: 688 deg C ( 1,270.40 deg F)
Explosion Limits, Lower:2.2
(estimated) Health: 4; Flammability: 1; Instability: 2
Section 6 - Accidental Release Measures
General Information: Use proper personal protective equipment as indicated
in Section 8.
Absorb spill with inert material (e.g. vermiculite, sand or earth),
then place in suitable container. Avoid runoff into storm sewers and
ditches which lead to waterways. Clean up spills immediately,
observing precautions in the Protective Equipment section. Remove all
sources of ignition. Use a spark-proof tool. Provide ventilation.
Section 7 - Handling and Storage
Wash thoroughly after handling. Wash hands before eating. Remove
contaminated clothing and wash before reuse. Use only in a
well-ventilated area. Empty containers retain product residue,
(liquid and/or vapor), and can be dangerous. Keep container tightly
closed. Keep away from heat, sparks and flame. Do not get on skin or
in eyes. Do not ingest or inhale. Do not pressurize, cut, weld,
braze, solder, drill, grind, or expose empty containers to heat,
sparks or open flames.
Keep away from heat, sparks, and flame. Keep away from sources of
ignition. Store in a cool, dry place. Store in a tightly closed
container. Store in a cool, dry, well-ventilated area away from
Section 8 - Exposure Controls, Personal Protection
Facilities storing or utilizing this material should be equipped
with an eyewash facility and a safety shower. Use adequate
ventilation to keep airborne concentrations low.
||OSHA - Final PELs|
Skin - potential significant contribution to overall exposure by the cutaneous r oute; 5 mg/m3 Ceiling (as CN)
OSHA Vacated PELs:
No OSHA Vacated PELs are listed for this chemical.
Personal Protective Equipment
Wear appropriate protective eyeglasses or chemical
safety goggles as described by OSHA's eye and face
protection regulations in 29 CFR 1910.133 or European
Wear appropriate protective gloves to prevent skin
Wear appropriate protective clothing to prevent skin
Follow the OSHA respirator regulations found in 29
CFR 1910.134 or European Standard EN 149. Use a
NIOSH/MSHA or European Standard EN 149 approved
respirator if exposure limits are exceeded or if
irritation or other symptoms are experienced.
Section 9 - Physical and Chemical Properties
Physical State: Liquid
pH: Not available.
Vapor Pressure: 1 mbar @ 20 C
Vapor Density: 2.93
Evaporation Rate:Not available.
Viscosity: Not available.
Boiling Point: 69 deg C
Freezing/Melting Point:-19 deg C
Decomposition Temperature:Not available.
Solubility: Freely Soluble.
Section 10 - Stability and Reactivity
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials, ignition sources, excess heat.
Incompatibilities with Other Materials:
Hazardous Decomposition Products:
Hydrogen cyanide, carbon monoxide, irritating and toxic fumes and
gases, carbon dioxide.
Hazardous Polymerization: Has not been reported.
Section 11 - Toxicological Information
Dermal, guinea pig:
LD50 = 150 mg/kg;
LD50 = 1898 ug/kg;
LD50 = 13500 ug/kg;
LD50 = 18650 ug/kg;
LD50 = 17 uL/kg;
Not listed by ACGIH, IARC, NTP, or CA Prop 65.
Considered to be an experimental teratogen.
Teratogenic effects have occurred in experimental animals.
No information found
No information found
No information found
Section 12 - Ecological Information
No data available.
No information available.
Terrestrial: If acetone cyanohydrin is released to soil, it will be
expected to rapidly dissociate. Aquatic: If acetone cyanohydrin is
released to water, it will be expected to rapidly dissociate.
Atmospheric: Expected to exist almost entirely in the vapor phase
based upon a reported vapor pressure of 0.80 mm Hg at 20 deg C. It
will be susceptible to photooxidation via vapor phase reaction with
photochemically produced hydroxyl radicals. Half-life approximately
Not expected to biodegrade or bioconcentrate.
For more information, see "HANDBOOK OF ENVIRONMENTAL FATE AND
Section 13 - Disposal Considerations
Chemical waste generators must determine whether a discarded chemical is classified
as a hazardous waste.
US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3.
Additionally, waste generators must consult state and local hazardous waste regulations to
ensure complete and accurate classification.
RCRA P-Series: CAS# 75-86-5: waste number
RCRA U-Series: None listed.
Section 14 - Transport Information
||ACETONE CYANOHYDRIN, STABILIZED
Section 15 - Regulatory Information
CAS# 75-86-5 is listed on the TSCA inventory.
Health & Safety Reporting List
CAS# 75-86-5: Effective 3/7/86, Sunset 12/19/95
Chemical Test Rules
None of the chemicals in this product are under a Chemical Test Rule.
None of the chemicals are listed under TSCA Section 12b.
TSCA Significant New Use Rule
None of the chemicals in this material have a SNUR under TSCA.
CERCLA Hazardous Substances and corresponding RQs
CAS# 75-86-5: 10 lb final RQ; 4.54 kg final RQ
SARA Section 302 Extremely Hazardous Substances
CAS# 75-86-5: 1000 lb TPQ
This material contains Acetone
cyanohydrin (CAS# 75-86-5, > 98%),which is subject to the reporting
requirements of Section 313 of SARA Title III and 40 CFR Part 373.
Clean Air Act:
This material does not contain any hazardous air pollutants.
This material does not contain any Class 1 Ozone depletors.
This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
CAS# 75-86-5 is listed as a Hazardous Substance under the CWA.
None of the chemicals in this
product are listed as Priority Pollutants under the CWA.
None of the chemicals in this
product are listed as Toxic Pollutants under the CWA.
None of the chemicals in this product
are considered highly hazardous by OSHA.
CAS# 75-86-5 can be found on the
following state right to know lists: California, New Jersey,
Pennsylvania, Minnesota, Massachusetts.
California Prop 65
California No Significant Risk Level:
None of the chemicals in this product are listed.
European Labeling in Accordance with EC Directives
R 26/27/28 Very toxic by inhalation, in contact with skin and if
R 50 Very toxic to aquatic organisms.
S 27 Take off immediately all contaminated clothing.
S 45 In case of accident or if you feel unwell, seek medical advice
immediately (show the label where possible).
S 7/9 Keep container tightly closed and in a well-ventilated place.
S 61 Avoid release to the environment. Refer to special instructions
/safety data sheets.
WGK (Water Danger/Protection)
CAS# 75-86-5: 3
Canada - DSL/NDSL
CAS# 75-86-5 is listed on Canada's DSL List.
Canada - WHMIS
This product has a WHMIS classification of D1A, D2A, D2B, B3.
This product has been classified in accordance with the hazard
criteria of the Controlled Products Regulations and the MSDS
contains all of the information required by those regulations.
Canadian Ingredient Disclosure List
CAS# 75-86-5 is listed on the Canadian Ingredient Disclosure List.
Section 16 - Additional Information
MSDS Creation Date: 8/24/1997
Revision #6 Date: 3/04/2004
The information above is believed to be accurate and represents the best
information currently available to us. However, we make no warranty of
merchantability or any other warranty, express or implied, with respect to
such information, and we assume no liability resulting from its use. Users
should make their own investigations to determine the suitability of the
information for their particular purposes. In no event shall Fisher be liable
for any claims, losses, or damages of any third party or for lost profits
or any special, indirect, incidental, consequential or exemplary
damages, howsoever arising, even if Fisher has been advised of
the possibility of such damages.