Material Safety Data Sheet
Section 1 - Chemical Product and Company Identification
MSDS Name: Hydrazine anhydrous
AC411745000, AC611195000, BP1200-100, O3106-500
1 Reagent Lane
Fair Lawn, NJ 07410
For information, call: 201-796-7100
Emergency Number: 201-796-7100
For CHEMTREC assistance, call: 800-424-9300
For International CHEMTREC assistance, call: 703-527-3887
Section 2 - Composition, Information on Ingredients
|| >95 ||206-114-9
Section 3 - Hazards Identification
Appearance: colorless liquid. Flash Point: 38 deg C.
Danger! Strong reducing agent. Fire and explosion
risk in contact with oxidizing agents. May be fatal if absorbed
through the skin. Causes eye and skin burns. Causes digestive and
respiratory tract burns. Flammable liquid and
vapor. Harmful if inhaled or swallowed. May cause
allergic skin reaction. Cancer suspect agent. May cause blood
abnormalities. May cause liver and kidney damage.
Target Organs: Blood, kidneys, liver.
Potential Health Effects
May cause irreversible eye injury. Exposure to the vapors or
liquid may cause temporary blindness. Causes severe eye irritation
May be fatal if absorbed through the skin. Prolonged and/or repeated
contact may cause irritation and/or dermatitis. May cause skin
sensitization, an allergic reaction, which becomes evident upon
re-exposure to this material. Contact with liquid is corrosive and
causes severe burns and ulceration. Contact with the skin may
Harmful if swallowed. Causes gastrointestinal irritation with
nausea, vomiting and diarrhea. May cause liver and kidney damage.
Causes digestive tract burns with immediate pain, swelling of the
throat, convulsions, and possible coma. Exposure may cause anemia
and other blood abnormalities.
Harmful if inhaled. Irritation may lead to chemical pneumonitis and
pulmonary edema. May cause liver and kidney damage. Causes severe
irritation of upper respiratory tract with coughing, burns,
breathing difficulty, and possible coma. Vapors may cause dizziness,
nausea, itching, burning, and swelling of the eyes.
Repeated inhalation may cause chronic bronchitis. May cause cancer
according to animal studies. Repeated exposure may cause
sensitization dermatitis. May cause reproductive and fetal effects.
Section 4 - First Aid Measures
Immediately flush eyes with plenty of water for at least 15 minutes,
occasionally lifting the upper and lower eyelids. Get medical aid imme
diately. Do NOT allow victim to rub eyes or keep eyes closed.
Get medical aid immediately. Immediately flush skin with plenty of
water for at least 15 minutes while removing contaminated clothing
and shoes. Discard contaminated clothing in a manner which limits
Do not induce vomiting. If victim is conscious and alert, give 2-4
cupfuls of milk or water. Never give anything by mouth to an
unconscious person. Get medical aid immediately.
Get medical aid immediately. Remove from exposure and move to fresh
air immediately. If breathing is difficult, give oxygen. Do NOT use
mouth-to-mouth resuscitation. If breathing has ceased apply
artificial respiration using oxygen and a suitable mechanical device
such as a bag and a mask.
Notes to Physician:
Treat symptomatically and supportively.
Section 5 - Fire Fighting Measures
As in any fire, wear a self-contained breathing apparatus in
pressure-demand, MSHA/NIOSH (approved or equivalent), and full
protective gear. Vapors can travel to a source of ignition and flash
back. Use water spray to keep fire-exposed containers cool. Flammable
liquid and vapor. Autoignition temperature varies based upon contact
surface. Vapors may be heavier than air. They can spread along the
ground and collect in low or confined areas. May be ignited by heat,
sparks, and flame. Vapors may form an explosive mixture with air.
Containers may explode when heated.
For large fires, use water spray, fog, or alcohol-resistant foam.
Use water spray to cool fire-exposed containers. Do NOT get water
inside containers. For small fires, use dry chemical, carbon
dioxide, or water spray. Cool containers with flooding quantities of
water until well after fire is out.
Flash Point: 38 deg C ( 100.40 deg F)
Autoignition Temperature: 270 deg C ( 518.00 deg F)
Explosion Limits, Lower:2.9%
(estimated) Health: 3; Flammability: 3; Instability: 3
Section 6 - Accidental Release Measures
General Information: Use proper personal protective equipment as indicated
in Section 8.
Remove all sources of ignition. Absorb spill using an absorbent,
non-combustible material such as earth, sand, or vermiculite. Do not
use combustible materials such as sawdust. Do not get water inside
containers. Approach spill from upwind. Use water spray to cool and
disperse vapors, protect personnel, and dilute spills to form
nonflammable mixtures. Control runoff and isolate discharged material
for proper disposal.
Section 7 - Handling and Storage
Wash thoroughly after handling. Remove contaminated clothing and
wash before reuse. Ground and bond containers when transferring
material. Use spark-proof tools and explosion proof equipment. Do not
get in eyes, on skin, or on clothing. Empty containers retain product
residue, (liquid and/or vapor), and can be dangerous. Keep container
tightly closed. Do not ingest or inhale. Do not pressurize, cut,
weld, braze, solder, drill, grind, or expose empty containers to
heat, sparks or open flames. Keep away from heat, sparks and flame.
Use only with adequate ventilation or respiratory protection.
Keep away from heat, sparks, and flame. Keep away from sources of
ignition. Do not store in direct sunlight. Store in a cool, dry,
well-ventilated area away from incompatible substances.
Flammables-area. Storage under a nitrogen blanket has been
recommended. Isolate from oxidizing materials and acids.
Section 8 - Exposure Controls, Personal Protection
Facilities storing or utilizing this material should be equipped
with an eyewash facility and a safety shower. Use adequate general or
local explosion-proof ventilation to keep airborne levels to
||OSHA - Final PELs|
0.01 ppm TWA; Skin - potential significant contribution to overall exposure by the cutaneous r oute
50 ppm IDLH
1 ppm TWA; 1.3 mg/m3 TWA
OSHA Vacated PELs:
0.1 ppm TWA; 0.1 mg/m3 TWA
Personal Protective Equipment
Wear chemical splash goggles and face shield.
Wear appropriate protective gloves to prevent skin
Wear appropriate protective clothing to prevent skin
Follow the OSHA respirator regulations found in 29
CFR 1910.134 or European Standard EN 149. Use a
NIOSH/MSHA or European Standard EN 149 approved
respirator if exposure limits are exceeded or if
irritation or other symptoms are experienced.
Section 9 - Physical and Chemical Properties
Physical State: Liquid
Odor: strong odor - ammonia-like
pH: Not available.
Vapor Pressure: 10 mm Hg @ 20 deg C
Vapor Density: 1.1 (air=1)
Evaporation Rate:Not available.
Boiling Point: 113 deg C
Freezing/Melting Point:1.4 deg C
Decomposition Temperature:Not available.
Specific Gravity/Density:1.01 (water=1)
Section 10 - Stability and Reactivity
Conditions to Avoid:
Light, ignition sources, moisture, temperatures above 150°C.
Incompatibilities with Other Materials:
Substance is highly reactive reducing agent. Incompatible with
oxidizing agents (including air), acids, and some metal oxides and
metals. Substance may spontaneously ignite in air when in contact
with porous materials. Ignites on contact with dinitrogen oxide and
tetroxide, hydrogen peroxide, tetryl, and nitric acid. Explodes on
contact with dicyanofurazan, n-halomides, potassium, silver
compounds, sodium hydroxide, titanium compounds, and trioxygen
difluoride. Explosive compounds may result from contact with air,
chloromethylnitrobenzene, lithium perchlorate, metal salts, methanol
+ nitromethane, sodium , and sodium perchlorate. Also incompatible
with barium oxide or calcium oxide, benzeneseleninic acid or
anhydride, calcium, carbon dioxide + stainless steel,
1-chloro-2,4-dinitrobenzene, cotton waste + heavy metals,
(difluoroamino)difluoroacetonitrile, iodine pentoxide, rust,
ruthenium(III) oxide, thiocarbonyl azide thiocyanate,
Hazardous Decomposition Products:
Oxides of nitrogen, ammonia and/or derivatives.
Hazardous Polymerization: Has not been reported.
Section 11 - Toxicological Information
Dermal, guinea pig:
LD50 = 190 mg/kg;
mouse: LC50 = 252 ppm/4H;
Inhalation, mouse: LC50 = 1000
Inhalation, mouse: LC50
= 320 mg/m3/4H;
LC50 = 570 ppm/4H;
LC50 = 130 mg/m3/2H;
LD50 = 59 mg/kg;
Oral, mouse: LD50
= 59 mg/kg;
Oral, rat: LD50 = 60
Oral, rat: LD50 = 60
Skin, rabbit: LD50 = 91
- ACGIH: A3 - Confirmed animal carcinogen with unknown relevance to humans
- California: carcinogen, initial date 1/1/88
- NTP: Suspect carcinogen
- IARC: Group 2B carcinogen
This substance has shown a high tumor-generating potential
in multiple studies. Hydrazine has been classified as
carcinogenic in many rodent studies following long-term
administration. The major target tissues include: liver,
lungs, and respiratory tract. Please refer to Patty's
Industrial Hygiene and Toxicology for specific information.
Substance is listed by CA Proposition 65. IARC has
determined that there is sufficient evidence of
carcinogenicity to animals and inadequate evidence for
Effects on Newborn: Viability index, subcutaneous-rat
TDLo=80mg/kg Embryo or Fetus: Death and Fetotoxicity,
inhalation-rat TCLo= 1mg/m3/24H. Specific Developmental
Abnormalities: Central nervous
Post-implantation mortality, inhalation-rat TCLo=4mg/m3/2H.
Maternal Effects: Ovaries/Fallopian tubes.Inhalation,
ratTCLo=5ppm/6H; Paternal Effects: Testes/Sperm
DNA Damage: hamster oral 15mg/kg, rat liver 3mmol/L. DNA
Inhibition: mouse oral 200mg/kg, rat oral 60mg/kg.
Unscheduled DNA Synthesis: hamster ovary 250ug/L, rat oral
60mg/kg, rat lung 250ug/L.Oncogenic Transformation: human
liver 80ug/L, human cell types 35mg/L.
No information available.
Section 12 - Ecological Information
No data available.
Rainbow trout (fresh water) 146ppm/0.5H (Lethal) Guppy (hard water):
LC50 = 3.85mg/L/96H Guppy (soft water): LC50 = 0.61mg/L/96HBluegill
sunfish: LC50 = 1.08mg/L/96H
Biodegradation is not expected to be significant when large amounts
of hydrazine are released due to the high microbial toxicity of
hydrazine; at lower concentrations, however, hydrazine biodegradation
could be important. Volatilization of hydrazine should not be
important from moist soil surfaces given an estimated Henry's Law
constant of 6.1X10-7 atm-cu m/mole, calculated from experimental
values for vapor pressure and water solubility.
No information available.
Bioconcentration in guppies was studied using a hydrazine
concentration in water of 0.5 ug/g. After 96 hours, the concentration
of hydrazine in guppies was about 144 ug/g. These values give a
bioconcentration factor of 316. An estimated BCF value of 0.01 was
calculated for hydrazine, using a measured log Kow of -2.07(2) and a
recommended regression-derived equation. According to a
classification scheme, these BCF values suggest that bioconcentration
in aquatic organisms may be high, as for guppies; however, based on
this compound's values for log Kow and water solubility, the
Section 13 - Disposal Considerations
Chemical waste generators must determine whether a discarded chemical is classified
as a hazardous waste.
US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3.
Additionally, waste generators must consult state and local hazardous waste regulations to
ensure complete and accurate classification.
RCRA P-Series: None listed.
CAS# 302-01-2: waste
number U133 (Reactive waste, Toxic waste).
Section 14 - Transport Information
Section 15 - Regulatory Information
CAS# 302-01-2 is listed on the TSCA inventory.
Health & Safety Reporting List
None of the chemicals are on the Health & Safety Reporting List.
Chemical Test Rules
None of the chemicals in this product are under a Chemical Test Rule.
None of the chemicals are listed under TSCA Section 12b.
TSCA Significant New Use Rule
None of the chemicals in this material have a SNUR under TSCA.
CERCLA Hazardous Substances and corresponding RQs
CAS# 302-01-2: 1 lb final RQ; 0.454 kg final RQ
SARA Section 302 Extremely Hazardous Substances
CAS# 302-01-2: 1000 lb TPQ
CAS # 302-01-2: immediate, delayed, fire, reactive.
This material contains Hydrazine
(CAS# 302-01-2, >95%),which is subject to the reporting requirements
of Section 313 of SARA Title III and 40 CFR Part 373.
Clean Air Act:
CAS# 302-01-2 is listed as a hazardous air pollutant (HAP).
This material does not contain any Class 1 Ozone depletors.
This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
None of the chemicals in this product
are listed as Hazardous Substances under the CWA.
None of the chemicals in this
product are listed as Priority Pollutants under the CWA.
None of the chemicals in this
product are listed as Toxic Pollutants under the CWA.
None of the chemicals in this product
are considered highly hazardous by OSHA.
CAS# 302-01-2 can be found on the
following state right to know lists: California, New Jersey,
Pennsylvania, Minnesota, Massachusetts.
California Prop 65
The following statement(s) is(are) made in order to comply with
the California Safe Drinking Water Act:
WARNING: This product contains Hydrazine, a chemical known to the
state of California to cause cancer.
California No Significant Risk Level:
CAS# 302-01-2: 0.04 æg/day NSRL
European Labeling in Accordance with EC Directives
T C N
R 10 Flammable.
R 23/24/25 Toxic by inhalation, in contact with skin and if
R 34 Causes burns.
R 43 May cause sensitization by skin contact.
R 45 May cause cancer.
R 50/53 Very toxic to aquatic organisms, may cause long-term
adverse effects in the aquatic environment.
S 45 In case of accident or if you feel unwell, seek medical advice
immediately (show the label where possible).
S 53 Avoid exposure - obtain special instructions before use.
S 60 This material and its container must be disposed of as hazardou
S 61 Avoid release to the environment. Refer to special instructions
/safety data sheets.
WGK (Water Danger/Protection)
CAS# 302-01-2: 3
Canada - DSL/NDSL
CAS# 302-01-2 is listed on Canada's DSL List.
Canada - WHMIS
This product has a WHMIS classification of E, B2, D1B.
This product has been classified in accordance with the hazard
criteria of the Controlled Products Regulations and the MSDS
contains all of the information required by those regulations.
Canadian Ingredient Disclosure List
CAS# 302-01-2 is listed on the Canadian Ingredient Disclosure List.
Section 16 - Additional Information
MSDS Creation Date: 7/01/1999
Revision #7 Date: 6/29/2007
The information above is believed to be accurate and represents the best
information currently available to us. However, we make no warranty of
merchantability or any other warranty, express or implied, with respect to
such information, and we assume no liability resulting from its use. Users
should make their own investigations to determine the suitability of the
information for their particular purposes. In no event shall Fisher be liable
for any claims, losses, or damages of any third party or for lost profits
or any special, indirect, incidental, consequential or exemplary
damages, howsoever arising, even if Fisher has been advised of
the possibility of such damages.