Material Safety Data Sheet
Section 1 - Chemical Product and Company Identification
MSDS Name: Propylene Oxide
Propane, 1,2-Epoxy-; 1,2-Ethoxypropane; 1,2-Propylene Oxide; Methyl
Ethylene Oxide; Methyloxirane; 1,2-Epoxypropane.
1 Reagent Lane
Fair Lawn, NJ 07410
For information, call: 201-796-7100
Emergency Number: 201-796-7100
For CHEMTREC assistance, call: 800-424-9300
For International CHEMTREC assistance, call: 703-527-3887
Section 2 - Composition, Information on Ingredients
| 75-56-9||Propylene oxide
|| ca.100 ||200-879-2
Hazard Symbols: T F+
Risk Phrases: 12 20/21/22 36/37/38 45 46
Section 3 - Hazards Identification
Appearance: colorless liquid. Flash Point: -37 deg C.
Danger! Extremely flammable
liquid. May cause reproductive and fetal effects.
Potential cancer hazard. Causes severe eye and skin irritation with
possible burns. Harmful if swallowed. May be harmful if absorbed
through the skin. May cause allergic skin reaction. Causes
respiratory tract irritation.
Target Organs: Central nervous system,
respiratory system, eyes, skin.
Potential Health Effects
Produces irritation, characterized by a burning sensation, redness,
tearing, inflammation, and possible corneal injury.
May cause skin sensitization, an allergic reaction, which becomes
evident upon re-exposure to this material. Causes severe skin
irritation and possible burns. May lead to the formation of
Harmful if swallowed. Causes gastrointestinal irritation with
nausea, vomiting and diarrhea. May cause central nervous system
depression, characterized by excitement, followed by headache,
dizziness, drowsiness, and nausea. Advanced stages may cause
collapse, unconsciousness, coma and possible death due to respiratory
failure. Aspiration of material into the lungs may cause chemical
pneumonitis, which may be fatal.
Inhalation of high concentrations may cause central nervous system
effects characterized by nausea, headache, dizziness, unconsciousness
and coma. Causes respiratory tract irritation. Aspiration may cause
respiratory swelling and pneumonitis. Vapors may cause dizziness or
Prolonged inhalation may cause respiratory tract inflammation and
lung damage. Prolonged or repeated skin contact may cause
dermatitis. May cause cancer according to animal studies. May cause
reproductive and fetal effects. Laboratory experiments have resulted
in mutagenic effects.
May cause heritable genetic damage.
Section 4 - First Aid Measures
Immediately flush eyes with plenty of water for at least 15 minutes,
occasionally lifting the upper and lower eyelids. Get medical aid
Get medical aid immediately. Immediately flush skin with plenty of
water for at least 15 minutes while removing contaminated clothing
and shoes. Wash clothing before reuse.
Do NOT induce vomiting. If victim is conscious and alert, give 2-4
cupfuls of milk or water. Never give anything by mouth to an
unconscious person. Possible aspiration hazard. Get medical aid
Get medical aid immediately. Remove from exposure and move to fresh
air immediately. If breathing is difficult, give oxygen. Do NOT use
mouth-to-mouth resuscitation. If breathing has ceased apply
artificial respiration using oxygen and a suitable mechanical device
such as a bag and a mask.
Notes to Physician:
Persons with kidney disease, chronic respiratory disease, liver
disease, or skin disease may be at increased risk from exposure to
this substance. Treat symptomatically and supportively.
Section 5 - Fire Fighting Measures
Containers can build up pressure if exposed to heat and/or fire. As
in any fire, wear a self-contained breathing apparatus in
pressure-demand, MSHA/NIOSH (approved or equivalent), and full
protective gear. Vapors may form an explosive mixture with air.
Vapors can travel to a source of ignition and flash back. Extremely
flammable. Material will readily ignite at room temperature. Use
water spray to keep fire-exposed containers cool. Containers may
explode in the heat of a fire. Liquid will float and may reignite on
the surface of water. May polymerize explosively when involved in a
For small fires, use dry chemical, carbon dioxide, water spray or
alcohol-resistant foam. For large fires, use water spray, fog, or
alcohol-resistant foam. Use water spray to cool fire-exposed
containers. Water may be ineffective. Do NOT use straight streams of
Flash Point: -37 deg C ( -34.60 deg F)
Autoignition Temperature: 449 deg C ( 840.20 deg F)
Explosion Limits, Lower:2.3 vol %
Upper: 36.0 vol %
(estimated) Health: 3; Flammability: 4; Instability: 2
Section 6 - Accidental Release Measures
General Information: Use proper personal protective equipment as indicated
in Section 8.
Absorb spill with inert material (e.g. vermiculite, sand or earth),
then place in suitable container. Avoid runoff into storm sewers and
ditches which lead to waterways. Clean up spills immediately,
observing precautions in the Protective Equipment section. Remove all
sources of ignition. Use a spark-proof tool. Provide ventilation. A
vapor suppressing foam may be used to reduce vapors.
Section 7 - Handling and Storage
Wash thoroughly after handling. Remove contaminated clothing and
wash before reuse. Use only in a well-ventilated area. Ground and
bond containers when transferring material. Empty containers retain
product residue, (liquid and/or vapor), and can be dangerous. Avoid
contact with heat, sparks and flame. Do not get on skin or in eyes.
Do not ingest or inhale. Prevent build up of vapors to explosive
concentration. This product may be under pressure; cool before
opening. Do not pressurize, cut, weld, braze, solder, drill, grind,
or expose empty containers to heat, sparks or open flames.
Keep away from heat, sparks, and flame. Keep away from sources of
ignition. Store in a tightly closed container. Store in a cool, dry,
well-ventilated area away from incompatible substances.
Section 8 - Exposure Controls, Personal Protection
Use explosion-proof ventilation equipment. Facilities storing or
utilizing this material should be equipped with an eyewash facility
and a safety shower. Use adequate general or local exhaust
ventilation to keep airborne concentrations below the permissible
||OSHA - Final PELs|
|Propylene oxide||2 ppm TWA
|| 400 ppm IDLH||100 ppm TWA; 240 mg/m3 TWA
OSHA Vacated PELs:
20 ppm TWA; 50 mg/m3 TWA
Personal Protective Equipment
Wear appropriate protective eyeglasses or chemical
safety goggles as described by OSHA's eye and face
protection regulations in 29 CFR 1910.133 or European
Wear appropriate protective gloves to prevent skin
Wear appropriate protective clothing to prevent skin
A respiratory protection program that meets OSHA's 29
CFR 1910.134 and ANSI Z88.2 requirements or European
Standard EN 149 must be followed whenever workplace
conditions warrant a respirator's use.
Section 9 - Physical and Chemical Properties
Physical State: Liquid
Odor: alcohol-like - ethereal odor
Vapor Pressure: 400 mm Hg @ 17.8 deg C
Vapor Density: 2.0 (Air=1)
Evaporation Rate:Not available.
Viscosity: 0.28 cP @ 25 deg C
Boiling Point: 35 deg C
Freezing/Melting Point:-112 deg C
Decomposition Temperature:Not available.
Specific Gravity/Density:0.8304 @ 20/20°C
Section 10 - Stability and Reactivity
Stable under normal temperatures and pressures. May polymerize.
Conditions to Avoid:
High temperatures, incompatible materials, ignition sources, excess
Incompatibilities with Other Materials:
Oxidizing agents, strong acids, copper, copper alloys, iron, nitric
acid, peroxides, sodium hydroxide, sulfuric acid, oxygen, caustics
(e.g. ammonia, ammonium hydroxide, calcium hydroxide, potassium
hydroxide, sodium hydroxide), chlorosulfonic acid, oleum,
hydrochloric acid, hydrofluoric acid, alkalis, ammonium hydroxide,
aluminum chloride, epoxy resin, ethylene oxide + polyhydric alcohol,
anhydrous metal chloride.
Hazardous Decomposition Products:
Carbon monoxide, irritating and toxic fumes and gases, carbon
Hazardous Polymerization: Will occur.
Section 11 - Toxicological Information
CAS# 75-56-9: TZ2975000
Draize test, rabbit, eye: 20 mg Severe;
test, rabbit, eye: 20 mg/24H Moderate;
Draize test, rabbit, skin:
50 mg/6M Severe;
Inhalation, mouse: LC50 = 1740 ppm/4H;
Inhalation, rat: LC50 = 4000 ppm/4H;
Oral, mouse: LD50 = 440
Oral, rat: LD50 = 380 mg/kg;
Skin, rabbit: LD50 =
ACGIH: A3 - Animal Carcinogen
California: carcinogen; initial date 10/1/88
NIOSH: potential occupational carcinogen
NTP: Suspect carcinogen
OSHA: Possible Select carcinogen
IARC: Group 2B carcinogen
Oral, rat: TDLo = 10798 mg/kg/2Y-I (Tumorigenic - Carcinogen
ic by RTECS criteria - Gastrointestinal - tumors.; Inhal
ation, mouse: TCLo = 400 ppm/6H/2Y-I (Tumorigenic - Carcin
ogenic by RTECS criteria - Sense Organs and Special Sens
es (Olfaction) - tumors).; Subcutaneous, mouse
: TDLo = 272 mg/kg/95W-I (Tumorigenic - Carcinogen
ic by RTECS criteria - Blood - lymphoma, including
Hodgkin's disease and tumors at site of application).
Inhalation, rat: TCLo = 500 ppm/7H (female 7-16 day(s) after
conception) Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus) and Specific Developmental Abnormalities -
musculoskeletal system.; Inhalation, rat: TCLo = 500 ppm/7H (female
1-16 day(s) after conception) Specific Developmental Abnormalities -
craniofacial (including nose and tongue).;
Inhalation, rat: TCLo = 500 ppm/7H (female 15 day(s) pre-matingand
female 1-16 day(s) after conception) Fertility - pre-implantation
mortality (e.g. reduction in number of implants per female; total
number of implants per corpora lutea) and Fertility - litter size
(e.g. # fetuses per litter; measured before birth). Reproductive -
Fertility - other measures of fertility
No information available.
Cytogenetic Analysis: Human, Lymphocyte = 1850 ug/L.; Sister
Chromatid Exchange: Human, Lymphocyte = 25000 ppm.
Standard Draize Test: Administration into the eye (rabbit)
= 20 mg/24H (Moderate). Standard Draize Test: Administ
ration into the eye (rabbit) = 20 mg (Severe). Standard Drai
ze Test: Administration onto the skin = 50 mg/6 min (Sever
Section 12 - Ecological Information
Fish: Goldfish: LC50 = 170 mg/L; 24 Hr; Unspecified
Bluegill/Sunfish: TLm = 215 mg/L; 96 Hr; Static bioassay @ 24°C
If released to soil, propylene oxide is expected to be susceptible to
leaching and chemical hydrolysis in moist soils. It is expected to
evaporate relatively rapidly from dry soil surfaces; evaporation
from wet soils may also occur, but at a rate diminished by leaching.
If released to water, propylene oxide will hydrolyze. Volatilization
of propylene oxide from the aquatic environment may be an important
If released to the atmosphere, propylene oxide will react in the
vapor phase with photochemically produced hydroxyl radicals with an
estimated half-life of approximately 30 days. Atmospheric removal by
rainfall may occur. Adsorption to sediment, bioconcentration in
aquatic organisms and reaction with photochemically produced hydroxyl
radicals in water are not expected to be environmentally important
No information available.
No information available.
Section 13 - Disposal Considerations
Chemical waste generators must determine whether a discarded chemical is classified
as a hazardous waste.
US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3.
Additionally, waste generators must consult state and local hazardous waste regulations to
ensure complete and accurate classification.
RCRA P-Series: None listed.
RCRA U-Series: None listed.
Section 14 - Transport Information
||No information available.
Section 15 - Regulatory Information
CAS# 75-56-9 is listed on the TSCA inventory.
Health & Safety Reporting List
CAS# 75-56-9: Effective Date: 10/4/82; Sunset Date: 10/4/92
Chemical Test Rules
None of the chemicals in this product are under a Chemical Test Rule.
None of the chemicals are listed under TSCA Section 12b.
TSCA Significant New Use Rule
None of the chemicals in this material have a SNUR under TSCA.
CERCLA Hazardous Substances and corresponding RQs
CAS# 75-56-9: 100 lb final RQ; 45.4 kg final RQ
SARA Section 302 Extremely Hazardous Substances
CAS# 75-56-9: 10,000 lb TPQ
CAS # 75-56-9: acute, chronic, flammable, reactive.
This material contains Propylene oxide (CAS# 75-56-9, 100%),which is
subject to the reporting requirements of Section 313 of SARA Title
III and 40 CFR Part 373.
Clean Air Act:
CAS# 75-56-9 is listed as a hazardous air pollutant (HAP).
This material does not contain any Class 1 Ozone depletors.
This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
CAS# 75-56-9 is listed as a Hazardous Substance under the CWA.
None of the chemicals in this product are listed as Priority
Pollutants under the CWA.
None of the chemicals in this product are listed as Toxic Pollutants
under the CWA.
None of the chemicals in this product are considered highly hazardous
CAS# 75-56-9 can be found on the following state right to know
lists: California, New Jersey, Pennsylvania, Minnesota,
The following statement(s) is(are) made in order to comply with
the California Safe Drinking Water Act:
WARNING: This product contains Propylene oxide, a chemical known to
the state of California to cause cancer.
California No Significant Risk Level:
None of the chemicals in this product are listed.
European Labeling in Accordance with EC Directives
R 12 Extremely flammable.
R 20/21/22 Harmful by inhalation, in contact with
skin and if swallowed.
R 36/37/38 Irritating to eyes, respiratory system
R 45 May cause cancer.
R 46 May cause heritable genetic damage.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
S 53 Avoid exposure - obtain special instructions
WGK (Water Danger/Protection)
CAS# 75-56-9: 2
Canada - DSL/NDSL
CAS# 75-56-9 is listed on Canada's DSL List.
Canada - WHMIS
This product has a WHMIS classification of B2, D1B, D2A.
Canadian Ingredient Disclosure List
CAS# 75-56-9 is listed on the Canadian Ingredient Disclosure List.
CAS# 75-56-9: OEL-AUSTRALIA:TWA 20 ppm (50 mg/m3);Carcinogen OEL-BE
LGIUM:TWA 20 ppm (48 mg/m3) OEL-DENMARK:TWA 5 ppm (12 mg/m3);Skin;Car
cinogen OEL-FINLAND:TWA 5 ppm (12 mg/m3);Carcinogen OEL-FRANCE:TWA 2
0 ppm (50 mg/m3) OEL-GERMANY;Carcinogen OEL-THE NETHERLANDS:TWA 100
ppm (240 mg/m3) OEL-THE PHILIPPINES:TWA 100 ppm (240 mg/m3) OEL-RUSS
IA:STEL 1 mg/m3;Skin OEL-SWEDEN:TWA 5 ppm (12 mg/m3);STEL 10 ppm (25
mg/m3) OEL-SWITZERLAND:TWA 2.5 ppm (6 mg/m3);Carcinogen OEL-TURKEY:T
WA 100 ppm (240 mg/m3) OEL-UNITED KINGDOM:TWA 20 ppm (50 mg/m3);STEL
100 ppm OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL
IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGI TLV
Section 16 - Additional Information
MSDS Creation Date: 7/01/1999
Revision #5 Date: 7/23/2002
The information above is believed to be accurate and represents the best
information currently available to us. However, we make no warranty of
merchantability or any other warranty, express or implied, with respect to
such information, and we assume no liability resulting from its use. Users
should make their own investigations to determine the suitability of the
information for their particular purposes. In no event shall Fisher be liable
for any claims, losses, or damages of any third party or for lost profits
or any special, indirect, incidental, consequential or exemplary
damages, howsoever arising, even if Fisher has been advised of
the possibility of such damages.