Section 2 - Composition, Information on Ingredients

CAS#	Chemical Name	Percent	EINECS/ELINCS
109-99-9	Tetrahydrofuran	99+	203-726-8
128-37-0	Butylated hydroxytoluene	0.025	204-881-4

Section 3 - Hazards Identification

Appearance: APHA: 10 max liquid. Flash Point: -21 deg C.
Danger! Flammable liquid and vapor. Possible cancer hazard. May cause cancer based on animal data. Harmful if swallowed. Causes eye, skin, and respiratory tract irritation. May form explosive peroxides. May cause central nervous system effects. Hygroscopic (absorbs moisture from the air).
Target Organs: Blood, kidneys, central nervous system, liver, spleen, respiratory system, eyes, skin.


Potential Health Effects
Eye: Causes severe eye irritation. Contact may cause ulceration of the conjunctiva and cornea. Damage may be permanent.
Skin: Causes skin irritation. May be harmful if absorbed through the skin. THF is not a skin sensitizer in animals.
Ingestion: Harmful if swallowed. May cause gastrointestinal irritation with nausea, vomiting and diarrhea.
Inhalation: Inhalation of high concentrations may cause central nervous system effects characterized by nausea, headache, dizziness, unconsciousness and coma. Causes respiratory tract irritation. May be harmful if inhaled. Inhalation of tetrahydrofuran vapors may cause abnormal liver function as detected by laboratory tests. (Dupont)
Chronic: Prolonged or repeated eye contact may cause conjunctivitis. Prolonged or repeated skin contact may cause defatting and dermatitis. May cause liver and kidney damage. Repeated exposure may cause damage to the spleen. Adverse reproductive effects have been reported in animals. Chronic exposure may cause blood effects. Animal studies have reported the development of tumors. Data show carcinogenic activity in the liver and kidneys of laboratory animals. The kidney tumors were by a mechanism that has no relevance in humans.

Section 4 - First Aid Measures

Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid imme diately.
Skin: Get medical aid. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion: Do not induce vomiting. Get medical aid immediately. Call a poison control center.
Inhalation: Remove from exposure and move to fresh air immediately. If breathing is difficult, give oxygen. Get medical aid. Do not use mouth-to-mouth resuscitation if victim ingested or inhaled the substance; induce artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device.
Notes to Physician: Treat symptomatically and supportively.

Section 5 - Fire Fighting Measures

General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Vapors may form an explosive mixture with air. Vapors can travel to a source of ignition and flash back. Will burn if involved in a fire. Containers may explode in the heat of a fire. Flammable liquid and vapor. May form explosive peroxides.
Extinguishing Media: Use water spray to cool fire-exposed containers. Use foam, dry chemical, or carbon dioxide. Water may be ineffective.
Flash Point: -21 deg C ( -5.80 deg F)
Autoignition Temperature: 215 deg C ( 419.00 deg F)
Explosion Limits, Lower:1.5 vol %
Upper: 12.0 vol %
NFPA Rating: (estimated) Health: 2; Flammability: 3; Instability: 1

Section 6 - Accidental Release Measures

General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks: Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Use water spray to dilute spill to a non-flammable mixture. Wear a self contained breathing apparatus and appropriate personal protection. (See Exposure Controls, Personal Protection section). Remove all sources of ignition. Use a spark-proof tool. Do not let this chemical enter the environment.

Section 7 - Handling and Storage

Handling: Use spark-proof tools and explosion proof equipment. Do not get in eyes, on skin, or on clothing. Take precautionary measures against static discharges. Keep away from heat, sparks and flame. Do not ingest or inhale. Container should be opened by a technically qualified person. Use only in a chemical fume hood. Prevent build up of vapors to explosive concentration. If peroxide formation is suspected, do not open or move container.
Storage: Store in a cool, dry place. Store in a tightly closed container. Flammables-area. Containers should be dated when opened and tested periodically for the presence of peroxides. Should crystals form in a peroxidizable liquid, peroxidation may have occurred and the product should be considered extremely dangerous. In this instance, the container should only be opened remotely by professionals. All peroxidizable substances should be stored away from heat and light and be protected from ignition sources. May form explosive peroxides on prolonged storage.

Section 8 - Exposure Controls, Personal Protection

Engineering Controls: Use explosion-proof ventilation equipment. Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use only under a chemical fume hood.
Exposure Limits

Chemical Name	ACGIH	NIOSH	OSHA - Final PELs
Tetrahydrofuran	50 ppm TWA; 100 ppm STEL; Skin - potential significant contribution to overall exposure by the cutaneous r oute	200 ppm TWA; 590 mg/m3 TWA 2000 ppm IDLH (10% LEL)	200 ppm TWA; 590 mg/m3 TWA
Butylated hydroxytoluene	2 mg/m3 TWA (inhalable fraction and vapor)	10 mg/m3 TWA	none listed

OSHA Vacated PELs: Tetrahydrofuran: 200 ppm TWA; 590 mg/m3 TWA Butylated hydroxytoluene: 10 mg/m3 TWA
Personal Protective Equipment
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin: Wear appropriate protective gloves to prevent skin exposure.
Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators: A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.

Section 9 - Physical and Chemical Properties

Physical State: liquid
Appearance: clear, colorless - APHA: 10 max
Odor: fruity odor
pH: Not available.
Vapor Pressure: 200 mbar @ 20 deg C
Vapor Density: 2.5 (air = 1)
Evaporation Rate:>1 (Butyl Acetate = 1)
Viscosity: 0.55 cP @ 20 deg C
Boiling Point: 66 deg C @ 760 mmHg
Freezing/Melting Point:-108.4 deg C
Decomposition Temperature:Not available.
Solubility: Soluble.
Specific Gravity/Density:0.888
Molecular Formula:C4H8O
Molecular Weight:72.11

Section 10 - Stability and Reactivity

Chemical Stability: May form explosive peroxides. Hygroscopic: absorbs moisture or water from the air.
Conditions to Avoid: Incompatible materials, light, ignition sources, exposure to moist air or water, prolonged exposure to air, loss of inhibitor, heat.
Incompatibilities with Other Materials: Caustics (e.g. ammonia, ammonium hydroxide, calcium hydroxide, potassium hydroxide, sodium hydroxide), oxidizing agents (strong, e.g. bromine, hydrogen peroxide, nitrogen dioxide, potassium nitrate), metal halides.
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide.
Hazardous Polymerization: May occur.

Section 11 - Toxicological Information

RTECS#:      
CAS# 109-99-9: LU5950000      
CAS# 128-37-0: GO7875000
LD50/LC50:
CAS# 109-99-9:
     Inhalation, rat: LC50 = 21000 ppm/3H;
     Oral, rat: LD50 = 1650 mg/kg;
.

CAS# 128-37-0:
     Draize test, rabbit, eye: 100 mg/24H Moderate;
     Draize test, rabbit, skin: 500 mg/48H Moderate;
     Oral, mouse: LD50 = 650 mg/kg;
     Oral, mouse: LD50 = 1040 mg/kg;
     Oral, rabbit: LD50 = 2100 mg/kg;
     Oral, rat: LD50 = 890 mg/kg;
.

Carcinogenicity:
CAS# 109-99-9:

• ACGIH: A3 - Confirmed animal carcinogen with unknown relevance to humans
  
• California: Not listed.
  
• NTP: Not listed.
  
• IARC: Not listed.