Material Safety Data Sheet

ACC# 23010
Section 1 - Chemical Product and Company Identification

MSDS Name: Tetrahydrofuran
Catalog Numbers: AC164240000, AC164240010, AC164240025, AC164240050, AC164240250, AC176630000, AC176630010, AC176630025, AC176630050, AC176630100, AC176630200, AC176630250, AC176635000, AC181500000, AC326970000, AC326970010, AC326970025, AC326971000, AC326972500, AC348450000, AC348450010, AC348450025, AC348451000, AC348455000, 18150-0010, 18150-2500, 61090-0010, 61090-1000, 61091-1000, BP2623-100, BP2624100, NC9684113, NC9687969, NC9708997, NC9966538, T397-1, T397-20, T397-200, T397-4, T397-4LC, T397-500, T397RB19, T397RB200, T397RS-200, T397RS50, T397SK-4, T400-20, T400-4, T400-500
Company Identification:

              Fisher Scientific
              1 Reagent Lane
              Fair Lawn, NJ 07410
For information, call:
Emergency Number:
For CHEMTREC assistance, call:
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Section 2 - Composition, Information on Ingredients

CAS# Chemical Name Percent EINECS/ELINCS
109-99-9 Tetrahydrofuran 99+ 203-726-8
128-37-0 Butylated hydroxytoluene 0.025 204-881-4

Section 3 - Hazards Identification


Appearance: APHA: 10 max liquid. Flash Point: -21 deg C.
Danger! Flammable liquid and vapor. Possible cancer hazard. May cause cancer based on animal data. Harmful if swallowed. Causes eye, skin, and respiratory tract irritation. May form explosive peroxides. May cause central nervous system effects. Hygroscopic (absorbs moisture from the air).
Target Organs: Blood, kidneys, central nervous system, liver, spleen, respiratory system, eyes, skin.

Potential Health Effects
Eye: Causes severe eye irritation. Contact may cause ulceration of the conjunctiva and cornea. Damage may be permanent.
Skin: Causes skin irritation. May be harmful if absorbed through the skin. THF is not a skin sensitizer in animals.
Ingestion: Harmful if swallowed. May cause gastrointestinal irritation with nausea, vomiting and diarrhea.
Inhalation: Inhalation of high concentrations may cause central nervous system effects characterized by nausea, headache, dizziness, unconsciousness and coma. Causes respiratory tract irritation. May be harmful if inhaled. Inhalation of tetrahydrofuran vapors may cause abnormal liver function as detected by laboratory tests. (Dupont)
Chronic: Prolonged or repeated eye contact may cause conjunctivitis. Prolonged or repeated skin contact may cause defatting and dermatitis. May cause liver and kidney damage. Repeated exposure may cause damage to the spleen. Adverse reproductive effects have been reported in animals. Chronic exposure may cause blood effects. Animal studies have reported the development of tumors. Data show carcinogenic activity in the liver and kidneys of laboratory animals. The kidney tumors were by a mechanism that has no relevance in humans.

Section 4 - First Aid Measures

Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid imme diately.
Skin: Get medical aid. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion: Do not induce vomiting. Get medical aid immediately. Call a poison control center.
Inhalation: Remove from exposure and move to fresh air immediately. If breathing is difficult, give oxygen. Get medical aid. Do not use mouth-to-mouth resuscitation if victim ingested or inhaled the substance; induce artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device.
Notes to Physician: Treat symptomatically and supportively.

Section 5 - Fire Fighting Measures

General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Vapors may form an explosive mixture with air. Vapors can travel to a source of ignition and flash back. Will burn if involved in a fire. Containers may explode in the heat of a fire. Flammable liquid and vapor. May form explosive peroxides.
Extinguishing Media: Use water spray to cool fire-exposed containers. Use foam, dry chemical, or carbon dioxide. Water may be ineffective.
Flash Point: -21 deg C ( -5.80 deg F)
Autoignition Temperature: 215 deg C ( 419.00 deg F)
Explosion Limits, Lower:1.5 vol %
Upper: 12.0 vol %
NFPA Rating: (estimated) Health: 2; Flammability: 3; Instability: 1

Section 6 - Accidental Release Measures

General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks: Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Use water spray to dilute spill to a non-flammable mixture. Wear a self contained breathing apparatus and appropriate personal protection. (See Exposure Controls, Personal Protection section). Remove all sources of ignition. Use a spark-proof tool. Do not let this chemical enter the environment.

Section 7 - Handling and Storage

Handling: Use spark-proof tools and explosion proof equipment. Do not get in eyes, on skin, or on clothing. Take precautionary measures against static discharges. Keep away from heat, sparks and flame. Do not ingest or inhale. Container should be opened by a technically qualified person. Use only in a chemical fume hood. Prevent build up of vapors to explosive concentration. If peroxide formation is suspected, do not open or move container.
Storage: Store in a cool, dry place. Store in a tightly closed container. Flammables-area. Containers should be dated when opened and tested periodically for the presence of peroxides. Should crystals form in a peroxidizable liquid, peroxidation may have occurred and the product should be considered extremely dangerous. In this instance, the container should only be opened remotely by professionals. All peroxidizable substances should be stored away from heat and light and be protected from ignition sources. May form explosive peroxides on prolonged storage.

Section 8 - Exposure Controls, Personal Protection

Engineering Controls: Use explosion-proof ventilation equipment. Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use only under a chemical fume hood.
Exposure Limits
Chemical Name ACGIH NIOSH OSHA - Final PELs
Tetrahydrofuran 50 ppm TWA; 100 ppm STEL; Skin - potential significant contribution to overall exposure by the cutaneous r oute 200 ppm TWA; 590 mg/m3 TWA 2000 ppm IDLH (10% LEL) 200 ppm TWA; 590 mg/m3 TWA
Butylated hydroxytoluene 2 mg/m3 TWA (inhalable fraction and vapor) 10 mg/m3 TWA none listed

OSHA Vacated PELs: Tetrahydrofuran: 200 ppm TWA; 590 mg/m3 TWA Butylated hydroxytoluene: 10 mg/m3 TWA
Personal Protective Equipment
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin: Wear appropriate protective gloves to prevent skin exposure.
Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators: A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.

Section 9 - Physical and Chemical Properties

Physical State: liquid
Appearance: clear, colorless - APHA: 10 max
Odor: fruity odor
pH: Not available.
Vapor Pressure: 200 mbar @ 20 deg C
Vapor Density: 2.5 (air = 1)
Evaporation Rate:>1 (Butyl Acetate = 1)
Viscosity: 0.55 cP @ 20 deg C
Boiling Point: 66 deg C @ 760 mmHg
Freezing/Melting Point:-108.4 deg C
Decomposition Temperature:Not available.
Solubility: Soluble.
Specific Gravity/Density:0.888
Molecular Formula:C4H8O
Molecular Weight:72.11

Section 10 - Stability and Reactivity

Chemical Stability: May form explosive peroxides. Hygroscopic: absorbs moisture or water from the air.
Conditions to Avoid: Incompatible materials, light, ignition sources, exposure to moist air or water, prolonged exposure to air, loss of inhibitor, heat.
Incompatibilities with Other Materials: Caustics (e.g. ammonia, ammonium hydroxide, calcium hydroxide, potassium hydroxide, sodium hydroxide), oxidizing agents (strong, e.g. bromine, hydrogen peroxide, nitrogen dioxide, potassium nitrate), metal halides.
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide.
Hazardous Polymerization: May occur.

Section 11 - Toxicological Information

CAS# 109-99-9: LU5950000      
CAS# 128-37-0: GO7875000
CAS# 109-99-9:
     Inhalation, rat: LC50 = 21000 ppm/3H;
     Oral, rat: LD50 = 1650 mg/kg;

CAS# 128-37-0:
     Draize test, rabbit, eye: 100 mg/24H Moderate;
     Draize test, rabbit, skin: 500 mg/48H Moderate;
     Oral, mouse: LD50 = 650 mg/kg;
     Oral, mouse: LD50 = 1040 mg/kg;
     Oral, rabbit: LD50 = 2100 mg/kg;
     Oral, rat: LD50 = 890 mg/kg;

CAS# 109-99-9:

CAS# 128-37-0: Not listed by ACGIH, IARC, NTP, or CA Prop 65.

Epidemiology: ACGIH has labeled this substance as a confirmed animal carcinogen.Tumorigenic effects have been reported in experimental animals.
Teratogenicity: Teratogenic effects have occurred in experimental animals.
Reproductive Effects: Adverse reproductive effects have occurred in experimental animals.
Mutagenicity: Mutation in microorganisms:See actual entry in RTECS for complete information.
Neurotoxicity: No information found
Other Studies:

Section 12 - Ecological Information

Ecotoxicity: Fish: Fathead Minnow: LC50 = 2160 mg/L; 96 Hr; Flow through bioassay (pH 7.5)Water flea Daphnia: EC50 =5930 mg/L; 24 Hr; Tetrahydrofuran is not expected to adsorb to suspended matter in the water based on its measured Koc values. This compound should volatilize from water surfaces. An estimated BCF value of 1 suggests that tetrahydrofuran will not bioconcentrate in aquatic organisms.
Environmental: If released to the atmosphere, tetrahydrofuran will exist solely in the vapor phase and is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals and nitrate radicals with half-lives of about 1 and 3 days, respectively. Measured Koc values of 23 and 18 indicate that tetrahydrofuran will have very high mobility in soil.
Physical: No information available.
Other: Do not empty into drains.

Section 13 - Disposal Considerations

Chemical waste generators must determine whether a discarded chemical is classified as a hazardous waste. US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3. Additionally, waste generators must consult state and local hazardous waste regulations to ensure complete and accurate classification.
RCRA P-Series: None listed.
RCRA U-Series:
CAS# 109-99-9: waste number U213 (Ignitable waste).

Section 14 - Transport Information

Hazard Class: 3 3
UN Number: UN2056 UN2056
Packing Group: II II
Additional Info:FLASH POINT -21C

Section 15 - Regulatory Information


     CAS# 109-99-9 is listed on the TSCA inventory.
     CAS# 128-37-0 is listed on the TSCA inventory.
Health & Safety Reporting List
     None of the chemicals are on the Health & Safety Reporting List.
Chemical Test Rules
     CAS# 109-99-9: 40 CFR 799.5000; 40 CFR 799.5115
Section 12b
     CAS# 109-99-9: Section 4, 1 % de minimus concentration
TSCA Significant New Use Rule
     None of the chemicals in this material have a SNUR under TSCA.
CERCLA Hazardous Substances and corresponding RQs
     CAS# 109-99-9: 1000 lb final RQ; 454 kg final RQ
SARA Section 302 Extremely Hazardous Substances
     None of the chemicals in this product have a TPQ.
SARA Codes
     CAS # 109-99-9: immediate, fire, reactive.
     CAS # 128-37-0: immediate.
Section 313      No chemicals are reportable under Section 313.
Clean Air Act:
     This material does not contain any hazardous air pollutants.
     This material does not contain any Class 1 Ozone depletors.
     This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
     None of the chemicals in this product are listed as Hazardous Substances under the CWA.
     None of the chemicals in this product are listed as Priority Pollutants under the CWA.
     None of the chemicals in this product are listed as Toxic Pollutants under the CWA.
     None of the chemicals in this product are considered highly hazardous by OSHA.
     CAS# 109-99-9 can be found on the following state right to know lists: California, New Jersey, Pennsylvania, Minnesota, Massachusetts.
     CAS# 128-37-0 can be found on the following state right to know lists: California, New Jersey, Pennsylvania, Minnesota, Massachusetts.

California Prop 65

California No Significant Risk Level: None of the chemicals in this product are listed.

European/International Regulations

European Labeling in Accordance with EC Directives
Hazard Symbols:
     XI F
Risk Phrases:

     R 11 Highly flammable.
     R 19 May form explosive peroxides.
     R 36/37 Irritating to eyes and respiratory system.

Safety Phrases:

     S 16 Keep away from sources of ignition - No smoking.
     S 29 Do not empty into drains.
     S 33 Take precautionary measures against static discharges.

WGK (Water Danger/Protection)

     CAS# 109-99-9: 1
     CAS# 128-37-0: 1
Canada - DSL/NDSL
     CAS# 109-99-9 is listed on Canada's DSL List.
     CAS# 128-37-0 is listed on Canada's DSL List.
Canada - WHMIS
     This product has a WHMIS classification of B2, D2B.
This product has been classified in accordance with the hazard criteria of the Controlled Products Regulations and the MSDS contains all of the information required by those regulations.
Canadian Ingredient Disclosure List
     CAS# 109-99-9 is listed on the Canadian Ingredient Disclosure List.
     CAS# 128-37-0 is listed on the Canadian Ingredient Disclosure List.

Section 16 - Additional Information

MSDS Creation Date: 5/28/1999
Revision #10 Date: 7/23/2008

The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no event shall Fisher be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if Fisher has been advised of the possibility of such damages.