Material Safety Data Sheet
Tetrahydrofuran, 99.5+%, for spectroscopy.
Section 1 - Chemical Product and Company Identification
MSDS Name: Tetrahydrofuran, 99.5+%, for spectroscopy.
AC222160000, AC222160010, AC222162500, AC222165000, AC268290000,
AC268290010, AC268290025, AC268290040, AC268295000, AC610100040,
AC610450010, AC610451000, AC610921000, BP1140-1, BP11401LC, NC9058040,
NC9234867, NC9326115, T397RS-200ASME, T400RS-50, T421-1, T421RS-19,
T421RS19, T421RS50, T422-1, T422RS-200, T422RS-50, T422RS200, T424-4,
T425-1, T425-4, T425N219, T425RS-115, T425RS-28, T425RS-50, T425RS115,
T425RS19, T425SK-1, T425SK-4, T425SS-115, T425SS-19, T425SS-200, T425SS-50,
T427-1, T427-4, T427POP200, T427RS-200, T427RS115, T427RS200, T427RS28,
T427SK-4, T427SS115, T427SS19, T427SS200, T427SS28, T427SS50
Diethylene oxide; 1,4-Epoxybutane; Tetramethylene oxide; THF;
1 Reagent Lane
Fair Lawn, NJ 07410
For information, call: 201-796-7100
Emergency Number: 201-796-7100
For CHEMTREC assistance, call: 800-424-9300
For International CHEMTREC assistance, call: 703-527-3887
Section 2 - Composition, Information on Ingredients
|| 99.5+ ||203-726-8
Section 3 - Hazards Identification
Appearance: colorless liquid. Flash Point: -14 deg C.
Danger! Highly flammable. Causes eye and
respiratory tract irritation. May form explosive peroxides.
Hygroscopic (absorbs moisture from the air).
Target Organs: Kidneys, central nervous system,
liver, respiratory system, eyes, skin.
Potential Health Effects
Contact with eyes may cause severe irritation, and possible eye
burns. Vapors may cause eye irritation.
Damage may be permanent.
Causes skin irritation. May be absorbed through the skin. If
absorbed, causes symptoms similar to those of inhalation.
THF is not a skin sensitizer in animals.
May cause gastrointestinal irritation with nausea, vomiting and
diarrhea. May cause central nervous system depression.
Inhalation of high concentrations may cause central nervous system
effects characterized by nausea, headache, dizziness, unconsciousness
and coma. Vapors may cause dizziness or suffocation. Inhalation may
cause coughing, difficulty breathing and loss of consciousness.
Causes irritation of the mucous membrane and upper respiratory tract.
Inhalation of tetrahydrofuran vapors may cause abnormal liver
function as detected by laboratory tests. (Dupont)
Prolonged or repeated eye contact may cause conjunctivitis.
Prolonged or repeated skin contact may cause defatting and
dermatitis. May cause liver and kidney damage. May cause lung damage.
Narcotic in high concentrations.
Data show carcinogenic activity in the liver and kidneys of
laboratory animals. The kidney tumors were by a mechanism that has no
relevance in humans.
Section 4 - First Aid Measures
In case of contact, immediately flush eyes with plenty of water for a
t least 15 minutes. Get medical aid immediately.
In case of contact, flush skin with plenty of water. Remove
contaminated clothing and shoes. Get medical aid if irritation
develops and persists. Wash clothing before reuse.
If swallowed, do not induce vomiting unless directed to do so by
medical personnel. Never give anything by mouth to an unconscious
person. Get medical aid.
If inhaled, remove to fresh air. If not breathing, give artificial
respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
Treat symptomatically and supportively. Persons with skin problems
or liver, kidney, lung, or blood diseases may be at increased risk
from exposure to this substance.
Section 5 - Fire Fighting Measures
As in any fire, wear a self-contained breathing apparatus in
pressure-demand, MSHA/NIOSH (approved or equivalent), and full
protective gear. Use water spray to keep fire-exposed containers
cool. Forms peroxides of unknown stability. Extremely flammable
liquid and vapor. Vapor may cause flash fire. Vapors are heavier than
air and may travel to a source of ignition and flash back. Vapors can
spread along the ground and collect in low or confined areas.
Water may be ineffective. In case of fire, use carbon dioxide, dry
chemical powder or appropriate foam.
Flash Point: -14 deg C ( 6.80 deg F)
Autoignition Temperature: 321 deg C ( 609.80 deg F)
Explosion Limits, Lower:2.0 vol %
Upper: 11.8 vol %
(estimated) Health: 2; Flammability: 3; Instability: 1
Section 6 - Accidental Release Measures
General Information: Use proper personal protective equipment as indicated
in Section 8.
Absorb spill with inert material (e.g. vermiculite, sand or earth),
then place in suitable container. Use water spray to dilute spill to
a non-flammable mixture. Avoid runoff into storm sewers and ditches
which lead to waterways. Remove all sources of ignition. Use a
spark-proof tool. Isolate area and deny entry. Provide ventilation.
A vapor suppressing foam may be used to reduce vapors.
Section 7 - Handling and Storage
Wash thoroughly after handling. Remove contaminated clothing and
wash before reuse. Ground and bond containers when transferring
material. Empty containers retain product residue, (liquid and/or
vapor), and can be dangerous. Take precautionary measures against
static discharges. Keep container tightly closed. Do not pressurize,
cut, weld, braze, solder, drill, grind, or expose empty containers
to heat, sparks or open flames. Use only with adequate ventilation.
Keep away from heat, sparks and flame. Avoid breathing vapor or mist.
Do not get in eyes. Avoid contact with skin and clothing.
Keep away from heat, sparks, and flame. Store in a cool place in the
original container and protect from sunlight. Keep under a nitrogen
blanket. Keep from contact with oxidizing materials. Flammables-area.
Store protected from moisture. Containers should be dated when opened
and tested periodically for the presence of peroxides. Should
crystals form in a peroxidizable liquid, peroxidation may have
occurred and the product should be considered extremely dangerous.
In this instance, the container should only be opened remotely by
professionals. All peroxidizable substances should be stored away
from heat and light and be protected from ignition sources.
Section 8 - Exposure Controls, Personal Protection
Use explosion-proof ventilation equipment. Facilities storing or
utilizing this material should be equipped with an eyewash facility
and a safety shower. Use adequate general or local exhaust
ventilation to keep airborne concentrations below the permissible
||OSHA - Final PELs|
50 ppm TWA; 100 ppm STEL; Skin - potential significant contribution to overall exposure by the cutaneous r oute
200 ppm TWA; 590 mg/m3 TWA 2000 ppm IDLH
200 ppm TWA; 590 mg/m3 TWA
OSHA Vacated PELs:
200 ppm TWA; 590 mg/m3 TWA
Personal Protective Equipment
Wear appropriate protective eyeglasses or chemical
safety goggles as described by OSHA's eye and face
protection regulations in 29 CFR 1910.133 or European
Wear appropriate protective gloves to prevent skin
Wear appropriate protective clothing to prevent skin
A respiratory protection program that meets OSHA's 29
CFR 1910.134 and ANSI Z88.2 requirements or European
Standard EN 149 must be followed whenever workplace
conditions warrant respirator use.
Section 9 - Physical and Chemical Properties
Physical State: liquid
pH: ~7 (in aq soln)
Vapor Pressure: 145 mm Hg @ 20 deg C
Vapor Density: 2.5 (air = 1)
Evaporation Rate:>1 (Butyl Acetate = 1)
Viscosity: 0.48 cP @ 20C
Boiling Point: 66 deg C
Freezing/Melting Point:-108.5 deg C
Decomposition Temperature:Not available.
Section 10 - Stability and Reactivity
Under normal storage conditions, peroxidizable compounds can form
and accumulate peroxides which may explode when subjected to heat or
shock. This material is most hazardous when peroxide levels are
concentrated by distillation or evaporation. THF should never be
distilled to dryness.
Conditions to Avoid:
Light, ignition sources, moisture, excess heat, evaporating to near
dryness, confined spaces.
Incompatibilities with Other Materials:
Strong oxidizing agents, strong acids, oxygen, bromine, metal
halides, lithium tetrahydroaluminate, borane, sodium aluminum
hydride, sodium tetrahydroaluminate, caustic alkalis.
Hazardous Decomposition Products:
Carbon monoxide, carbon dioxide.
Hazardous Polymerization: May occur.
Section 11 - Toxicological Information
LC50 = 21000 ppm/3H;
LD50 = 1650 mg/kg;
- ACGIH: A3 - Confirmed animal carcinogen with unknown relevance to humans
- California: Not listed.
- NTP: Not listed.
- IARC: Not listed.
No information found
Animal data show developmental effects only at exposure
levels producing other toxic effects in the adult animal.
Animal testing for reproductive effects shows no change in
THF has not produced genetic damage in mammalian cell
cultures or in animals. It has not been tested for its
ability to cause permanent genetic damage in reproductive
cells of mammals (not tested for heritable genetic
No information found
Section 12 - Ecological Information
Fish: Fathead Minnow: LC50 = 2160 mg/L; 96 Hr; Flow through bioassay
(pH 7.5)Water flea Daphnia: EC50 =5930 mg/L; 24 Hr;
Tetrahydrofuran is not expected to adsorb to suspended matter in the
water based on its measured Koc values. This compound should
volatilize from water surfaces. An estimated BCF value of 1 suggests
that tetrahydrofuran will not bioconcentrate in aquatic organisms.
If released to the atmosphere, tetrahydrofuran will exist solely in
the vapor phase and is degraded in the atmosphere by reaction with
photochemically-produced hydroxyl radicals and nitrate radicals with
half-lives of about 1 and 3 days, respectively. Measured Koc values
of 23 and 18 indicate that tetrahydrofuran will have very high
mobility in soil.
No information available.
Do not empty into drains.
Section 13 - Disposal Considerations
Chemical waste generators must determine whether a discarded chemical is classified
as a hazardous waste.
US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3.
Additionally, waste generators must consult state and local hazardous waste regulations to
ensure complete and accurate classification.
RCRA P-Series: None listed.
CAS# 109-99-9: waste
number U213 (Ignitable waste).
Section 14 - Transport Information
|Additional Info:||FLASHPOINT -21 C|
Section 15 - Regulatory Information
CAS# 109-99-9 is listed on the TSCA inventory.
Health & Safety Reporting List
None of the chemicals are on the Health & Safety Reporting List.
Chemical Test Rules
CAS# 109-99-9: 40 CFR 799.5000; 40 CFR 799.5115
CAS# 109-99-9: Section 4, 1 % de minimus concentration
TSCA Significant New Use Rule
None of the chemicals in this material have a SNUR under TSCA.
CERCLA Hazardous Substances and corresponding RQs
CAS# 109-99-9: 1000 lb final RQ; 454 kg final RQ
SARA Section 302 Extremely Hazardous Substances
None of the chemicals in this product have a TPQ.
CAS # 109-99-9: immediate, fire, reactive.
No chemicals are reportable under Section 313.
Clean Air Act:
This material does not contain any hazardous air pollutants.
This material does not contain any Class 1 Ozone depletors.
This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
None of the chemicals in this product
are listed as Hazardous Substances under the CWA.
None of the chemicals in this
product are listed as Priority Pollutants under the CWA.
None of the chemicals in this
product are listed as Toxic Pollutants under the CWA.
None of the chemicals in this product
are considered highly hazardous by OSHA.
CAS# 109-99-9 can be found on the
following state right to know lists: California, New Jersey,
Pennsylvania, Minnesota, Massachusetts.
California Prop 65
California No Significant Risk Level:
None of the chemicals in this product are listed.
European Labeling in Accordance with EC Directives
R 11 Highly flammable.
R 19 May form explosive peroxides.
R 36/37 Irritating to eyes and respiratory system.
S 16 Keep away from sources of ignition - No smoking.
S 29 Do not empty into drains.
S 33 Take precautionary measures against static discharges.
WGK (Water Danger/Protection)
CAS# 109-99-9: 1
Canada - DSL/NDSL
CAS# 109-99-9 is listed on Canada's DSL List.
Canada - WHMIS
This product has a WHMIS classification of B2, D2B.
This product has been classified in accordance with the hazard
criteria of the Controlled Products Regulations and the MSDS
contains all of the information required by those regulations.
Canadian Ingredient Disclosure List
CAS# 109-99-9 is listed on the Canadian Ingredient Disclosure List.
Section 16 - Additional Information
MSDS Creation Date: 7/15/1999
Revision #9 Date: 6/29/2007
The information above is believed to be accurate and represents the best
information currently available to us. However, we make no warranty of
merchantability or any other warranty, express or implied, with respect to
such information, and we assume no liability resulting from its use. Users
should make their own investigations to determine the suitability of the
information for their particular purposes. In no event shall Fisher be liable
for any claims, losses, or damages of any third party or for lost profits
or any special, indirect, incidental, consequential or exemplary
damages, howsoever arising, even if Fisher has been advised of
the possibility of such damages.