Material Safety Data Sheet
Trifluoroacetic anhydride
ACC# 24055
Section 1 - Chemical Product and Company Identification |
MSDS Name: Trifluoroacetic anhydride
Catalog Numbers:
AC147810000, AC147812500, 14781-0250, 14781-1000, 14781-5000, O4903-100
Synonyms:
Hexafluoroacetic Anhydride; Perfluoroacetic Anhydride;
Trifluoroacetyl Anhydride; Bis(Trifluoroacetic) Anhydride.
Company Identification:
Fisher Scientific
1 Reagent Lane
Fair Lawn, NJ 07410
For information, call: 201-796-7100
Emergency Number: 201-796-7100
For CHEMTREC assistance, call: 800-424-9300
For International CHEMTREC assistance, call: 703-527-3887
Section 2 - Composition, Information on Ingredients
|
CAS# |
Chemical Name |
Percent |
EINECS/ELINCS |
407-25-0 |
Trifluoroacetic anhydride |
100 | 206-982-9 |
Section 3 - Hazards Identification
|
EMERGENCY OVERVIEW
Appearance: colorless clear liquid.
Danger! Harmful to aquatic organisms; may cause
long-term adverse effects in the aquatic environment. Causes severe
eye and skin burns. Causes severe digestive and respiratory tract
burns. Water-Reactive.
Target Organs: Respiratory system, eyes, skin.
Potential Health Effects
Eye:
Causes severe eye burns. Contact may cause ulceration of the
conjunctiva and cornea. May cause blindness.
Skin:
Causes skin burns. May cause deep, penetrating ulcers of the skin.
Ingestion:
May cause corrosion and permanent tissue destruction of the
esophagus and digestive tract.
Inhalation:
May cause ulceration and perforation of the nasal septum if inhaled
in excessive quantities. May cause burns to the respiratory tract.
Inhalation may be fatal as a result of spasm, inflammation, edema of
the larynx and bronchi, chemical pneumonitis and pulmonary edema.
Chronic:
Repeated inhalation may cause chronic bronchitis.
Section 4 - First Aid Measures
|
Eyes:
Immediately flush eyes with plenty of water for at least 15 minutes,
occasionally lifting the upper and lower eyelids. Get medical aid imme
diately. Do NOT allow victim to rub eyes or keep eyes closed.
Skin:
Get medical aid immediately. Immediately flush skin with plenty of
water for at least 15 minutes while removing contaminated clothing
and shoes.
Ingestion:
Do not induce vomiting. If victim is conscious and alert, give 2-4
cupfuls of milk or water. Never give anything by mouth to an
unconscious person. Get medical aid immediately.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh
air immediately. If breathing is difficult, give oxygen. Do NOT use
mouth-to-mouth resuscitation. If breathing has ceased apply
artificial respiration using oxygen and a suitable mechanical device
such as a bag and a mask.
Notes to Physician:
Treat symptomatically and supportively.
Section 5 - Fire Fighting Measures
|
General Information:
As in any fire, wear a self-contained breathing apparatus in
pressure-demand, MSHA/NIOSH (approved or equivalent), and full
protective gear. During a fire, irritating and highly toxic gases
may be generated by thermal decomposition or combustion. May react
violently or explosively on contact with water.
Extinguishing Media:
In case of fire, use carbon dioxide, dry chemical powder or
appropriate foam.
Flash Point: Not available.
Autoignition Temperature: Not available.
Explosion Limits, Lower:Not available.
Upper: Not available.
NFPA Rating:
(estimated) Health: 3; Flammability: 0; Instability: 1
Section 6 - Accidental Release Measures
|
General Information: Use proper personal protective equipment as indicated
in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth),
then place in suitable container. Avoid runoff into storm sewers and
ditches which lead to waterways. Clean up spills immediately,
observing precautions in the Protective Equipment section. Provide
ventilation.
Section 7 - Handling and Storage
|
Handling:
Wash thoroughly after handling. Remove contaminated clothing and
wash before reuse. Do not get in eyes, on skin, or on clothing. Do
not ingest or inhale. Use only in a chemical fume hood. Discard
contaminated shoes.
Storage:
Store in a cool, dry place. Keep containers tightly closed.
Section 8 - Exposure Controls, Personal Protection
|
Engineering Controls:
Facilities storing or utilizing this material should be equipped
with an eyewash facility and a safety shower. Use adequate
ventilation to keep airborne concentrations low.
Exposure Limits
Chemical Name |
ACGIH |
NIOSH |
OSHA - Final PELs |
Trifluoroacetic anhydride
|
none listed
|
none listed
|
none listed
|
OSHA Vacated PELs:
Trifluoroacetic anhydride:
No OSHA Vacated PELs are listed for this chemical.
Personal Protective Equipment
Eyes:
Wear appropriate protective eyeglasses or chemical
safety goggles as described by OSHA's eye and face
protection regulations in 29 CFR 1910.133 or European
Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin
exposure.
Clothing:
Wear appropriate protective clothing to prevent skin
exposure.
Respirators:
A respiratory protection program that meets OSHA's 29
CFR 1910.134 and ANSI Z88.2 requirements or European
Standard EN 149 must be followed whenever workplace
conditions warrant respirator use.
Section 9 - Physical and Chemical Properties
|
Physical State: Clear liquid
Appearance: colorless
Odor: pungent odor
pH: 1 (1.05% @ 20°C)
Vapor Pressure: 141 mbar @ 20 deg C
Vapor Density: Not available.
Evaporation Rate:Not available.
Viscosity: Not available.
Boiling Point: 39.1 deg C @ 760 mmHg
Freezing/Melting Point:-63.5 deg C
Decomposition Temperature:Not available.
Solubility: Hydrolysis.
Specific Gravity/Density: 1.510
Molecular Formula:C4F6O3
Molecular Weight:210.03
Section 10 - Stability and Reactivity
|
Chemical Stability:
Hygroscopic: absorbs moisture or water from the air. Reacts with
water.
Conditions to Avoid:
Incompatible materials.
Incompatibilities with Other Materials:
Water, metals, strong oxidizing agents, strong acids, strong bases,
alcohols, alkali metals.
Hazardous Decomposition Products:
Carbon monoxide, carbon dioxide, hydrogen fluoride gas.
Hazardous Polymerization: Will not occur.
Section 11 - Toxicological Information
|
RTECS#:
CAS# 407-25-0:
AJ9800000
LD50/LC50:
CAS# 407-25-0:
Draize test,
rabbit, eye: 5 mg/24H Severe;
Draize test, rabbit, skin: 750 ug/24H
Severe;
.
Carcinogenicity:
CAS# 407-25-0:
Not listed by ACGIH, IARC, NTP, or CA Prop 65.
Epidemiology:
No information found
Teratogenicity:
No information found
Reproductive Effects:
No information found
Mutagenicity:
No information found
Neurotoxicity:
No information found
Other Studies:
Section 12 - Ecological Information
|
No information available.
Section 13 - Disposal Considerations
|
Chemical waste generators must determine whether a discarded chemical is classified
as a hazardous waste.
US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3.
Additionally, waste generators must consult state and local hazardous waste regulations to
ensure complete and accurate classification.
RCRA P-Series: None listed.
RCRA U-Series: None listed.
Section 14 - Transport Information
|
|
US DOT |
Canada TDG |
Shipping Name: |
CORROSIVE LIQUID, ACIDIC, ORGANIC, N.O.S (TRIFLUOROACETIC ANHYDRIDE) |
CORROSIVE LIQUID, ACIDIC, ORGANIC, N.O.S (TRIFLUOROACETIC ANHYDRIDE) |
Hazard Class: |
8 |
8 |
UN Number: |
UN3265 |
UN3265 |
Packing Group: |
I |
I |
Section 15 - Regulatory Information
|
US FEDERAL
TSCA
CAS# 407-25-0 is listed on the TSCA inventory.
Health & Safety Reporting List
None of the chemicals are on the Health & Safety Reporting List.
Chemical Test Rules
None of the chemicals in this product are under a Chemical Test Rule.
Section 12b
None of the chemicals are listed under TSCA Section 12b.
TSCA Significant New Use Rule
None of the chemicals in this material have a SNUR under TSCA.
CERCLA Hazardous Substances and corresponding RQs
None of the chemicals in this material have an RQ.
SARA Section 302 Extremely Hazardous Substances
None of the chemicals in this product have a TPQ.
SARA Codes
CAS # 407-25-0: immediate.
Section 313
No chemicals are reportable under Section 313.
Clean Air Act:
This material does not contain any hazardous air pollutants.
This material does not contain any Class 1 Ozone depletors.
This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
None of the chemicals in this product
are listed as Hazardous Substances under the CWA.
None of the chemicals in this
product are listed as Priority Pollutants under the CWA.
None of the chemicals in this
product are listed as Toxic Pollutants under the CWA.
OSHA:
None of the chemicals in this product
are considered highly hazardous by OSHA.
STATE
CAS# 407-25-0 is not present on
state lists from CA, PA, MN, MA, FL, or NJ.
California Prop 65
California No Significant Risk Level:
None of the chemicals in this product are listed.
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols:
C
Risk Phrases:
R 14 Reacts violently with water.
R 35 Causes severe burns.
R 20 Harmful by inhalation.
R 52/53 Harmful to aquatic organisms, may cause long-term adverse
effects in the aquatic environment.
Safety Phrases:
S 26 In case of contact with eyes, rinse immediately with plenty of
water and seek medical advice.
S 27 Take off immediately all contaminated clothing.
S 45 In case of accident or if you feel unwell, seek medical advice
immediately (show the label where possible).
S 8 Keep container dry.
S 9 Keep container in a well-ventilated place.
S 28A After contact with skin, wash immediately with plenty of water
.
S 61 Avoid release to the environment. Refer to special instructions
/safety data sheets.
WGK (Water Danger/Protection)
CAS# 407-25-0: 1
Canada - DSL/NDSL
CAS# 407-25-0 is listed on Canada's DSL List.
Canada - WHMIS
This product has a WHMIS classification of D3, D1B, B6.
This product has been classified in accordance with the hazard
criteria of the Controlled Products Regulations and the MSDS
contains all of the information required by those regulations.
Canadian Ingredient Disclosure List
CAS# 407-25-0 is listed on the Canadian Ingredient Disclosure List.
Section 16 - Additional Information
|
MSDS Creation Date: 12/12/1997
Revision #5 Date: 11/20/2008
The information above is believed to be accurate and represents the best
information currently available to us. However, we make no warranty of
merchantability or any other warranty, express or implied, with respect to
such information, and we assume no liability resulting from its use. Users
should make their own investigations to determine the suitability of the
information for their particular purposes. In no event shall Fisher be liable
for any claims, losses, or damages of any third party or for lost profits
or any special, indirect, incidental, consequential or exemplary
damages, howsoever arising, even if Fisher has been advised of
the possibility of such damages.