Material Safety Data Sheet
Tetramisole hydrochloride, 99+%
ACC# 32094
Section 1 - Chemical Product and Company Identification |
MSDS Name: Tetramisole hydrochloride, 99+%
Catalog Numbers:
AC187860000, AC187860100
Synonyms:
DL-2,3,5,6-Tetrahydro-6-phenylimidazo[2,1-b]thiazole hydrochloride;
(+-)-2,3,5,6-Tetrahycro-6-phenylimidazo (2,1-b)thiazole
monohydrochloride; Tatramisole; DL-Tetramisole hydrochloride;
Tetramisol hydrochloride
Company Identification:
Acros Organics N.V.
One Reagent Lane
Fair Lawn, NJ 07410
For information in North America, call: 800-ACROS-01
For emergencies in the US, call CHEMTREC: 800-424-9300
Section 2 - Composition, Information on Ingredients
|
CAS# |
Chemical Name |
Percent |
EINECS/ELINCS |
5086-74-8 |
Tetramisole hydrochloride |
99+ | 225-799-5 |
Section 3 - Hazards Identification
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EMERGENCY OVERVIEW
Appearance: white crystals.
Caution! Causes eye and skin irritation. May be
harmful if swallowed. May cause dermatitis.
Target Organs: No data found.
Potential Health Effects
Eye:
Causes eye irritation. May cause chemical conjunctivitis.
Skin:
Causes skin irritation. The toxicological properties of this
material have not been fully investigated.
Ingestion:
Harmful if swallowed. The toxicological properties of this substance
have not been fully investigated. Causes gastrointestinal tract
irritation.
Systemic exposure may cause skin dermatitis.
Inhalation:
The toxicological properties of this substance have not been fully
investigated. Causes irritation of the mucous membrane and upper
respiratory tract.
Chronic:
No information found.
Section 4 - First Aid Measures
|
Eyes:
Immediately flush eyes with plenty of water for at least 15 minutes,
occasionally lifting the upper and lower eyelids. Get medical aid imme
diately.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15
minutes while removing contaminated clothing and shoes.
Ingestion:
Never give anything by mouth to an unconscious person. Get medical
aid immediately. Do NOT induce vomiting. If conscious and alert,
rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not
breathing, give artificial respiration. If breathing is difficult,
give oxygen. Get medical aid.
Notes to Physician:
Treat symptomatically and supportively.
Section 5 - Fire Fighting Measures
|
General Information:
As in any fire, wear a self-contained breathing apparatus in
pressure-demand, MSHA/NIOSH (approved or equivalent), and full
protective gear. During a fire, irritating and highly toxic gases
may be generated by thermal decomposition or combustion.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or appropriate foam.
Flash Point: Not applicable.
Autoignition Temperature: 500 deg C ( 932.00 deg F)
Explosion Limits, Lower:Not available.
Upper: Not available.
NFPA Rating:
(estimated) Health: 2; Flammability: 0; Instability: 0
Section 6 - Accidental Release Measures
|
General Information: Use proper personal protective equipment as indicated
in Section 8.
Spills/Leaks:
Wash area with soap and water. Clean up spills immediately,
observing precautions in the Protective Equipment section. Sweep up,
then place into a suitable container for disposal. Provide
ventilation.
Section 7 - Handling and Storage
|
Handling:
Wash thoroughly after handling. Remove contaminated clothing and
wash before reuse. Do not get in eyes, on skin, or on clothing. Do
not ingest or inhale. Use only in a chemical fume hood.
Storage:
Keep containers tightly closed. Store in a cool, dry area away from
incompatible substances.
Section 8 - Exposure Controls, Personal Protection
|
Engineering Controls:
Facilities storing or utilizing this material should be equipped
with an eyewash facility and a safety shower. Use adequate
ventilation to keep airborne concentrations low.
Exposure Limits
Chemical Name |
ACGIH |
NIOSH |
OSHA - Final PELs |
Tetramisole hydrochloride
|
none listed
|
none listed
|
none listed
|
OSHA Vacated PELs:
Tetramisole hydrochloride:
No OSHA Vacated PELs are listed for this chemical.
Personal Protective Equipment
Eyes:
Wear safety glasses and chemical goggles if splashing
is possible.
Skin:
Wear appropriate protective gloves and clothing to
prevent skin exposure.
Clothing:
Wear appropriate protective clothing to minimize
contact with skin.
Respirators:
A respiratory protection program that meets OSHA's 29
CFR 1910.134 and ANSI Z88.2 requirements or European
Standard EN 149 must be followed whenever workplace
conditions warrant respirator use.
Section 9 - Physical and Chemical Properties
|
Physical State: Crystals
Appearance: white
Odor: None reported.
pH: Not available.
Vapor Pressure: Not available.
Vapor Density: Not available.
Evaporation Rate:Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point:266.00 - 267.00 deg C
Decomposition Temperature:Not available.
Solubility: 210 g/l (20°C)
Specific Gravity/Density:Not available.
Molecular Formula:C11H12N2S.HCl
Molecular Weight:240.76
Section 10 - Stability and Reactivity
|
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials, strong oxidants.
Incompatibilities with Other Materials:
Strong oxidizing agents.
Hazardous Decomposition Products:
Hydrogen chloride, nitrogen oxides, carbon monoxide, oxides of
sulfur, carbon dioxide.
Hazardous Polymerization: Has not been reported.
Section 11 - Toxicological Information
|
RTECS#:
CAS# 5086-74-8:
NJ5950000
LD50/LC50:
CAS# 5086-74-8:
Oral, mouse: LD50
= 210 mg/kg;
Oral, rat: LD50 = 480
mg/kg;
.
Oral, Human: TDLo=2 mg/kg
Carcinogenicity:
CAS# 5086-74-8:
Not listed by ACGIH, IARC, NTP, or CA Prop 65.
Epidemiology:
No information found
Teratogenicity:
No information found
Reproductive Effects:
No information found
Mutagenicity:
No information found
Neurotoxicity:
No information found
Other Studies:
Section 12 - Ecological Information
|
Ecotoxicity:
No data available.
No information available.
Environmental:
No data available.
Physical:
No data available.
Other:
None.
Section 13 - Disposal Considerations
|
Chemical waste generators must determine whether a discarded chemical is classified
as a hazardous waste.
US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3.
Additionally, waste generators must consult state and local hazardous waste regulations to
ensure complete and accurate classification.
RCRA P-Series: None listed.
RCRA U-Series: None listed.
Section 14 - Transport Information
|
|
US DOT |
Canada TDG |
Shipping Name: |
Not regulated as a hazardous material |
No information available. |
Hazard Class: |
|
|
UN Number: |
|
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Packing Group: |
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Section 15 - Regulatory Information
|
US FEDERAL
TSCA
CAS# 5086-74-8 is not listed on the TSCA inventory.
It is for research and development use only.
Health & Safety Reporting List
None of the chemicals are on the Health & Safety Reporting List.
Chemical Test Rules
None of the chemicals in this product are under a Chemical Test Rule.
Section 12b
None of the chemicals are listed under TSCA Section 12b.
TSCA Significant New Use Rule
None of the chemicals in this material have a SNUR under TSCA.
CERCLA Hazardous Substances and corresponding RQs
None of the chemicals in this material have an RQ.
SARA Section 302 Extremely Hazardous Substances
None of the chemicals in this product have a TPQ.
Section 313
No chemicals are reportable under Section 313.
Clean Air Act:
This material does not contain any hazardous air pollutants.
This material does not contain any Class 1 Ozone depletors.
This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
None of the chemicals in this product
are listed as Hazardous Substances under the CWA.
None of the chemicals in this
product are listed as Priority Pollutants under the CWA.
None of the chemicals in this
product are listed as Toxic Pollutants under the CWA.
OSHA:
None of the chemicals in this product
are considered highly hazardous by OSHA.
STATE
CAS# 5086-74-8 is not present on
state lists from CA, PA, MN, MA, FL, or NJ.
California Prop 65
California No Significant Risk Level:
None of the chemicals in this product are listed.
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols:
XN
Risk Phrases:
R 22 Harmful if swallowed.
Safety Phrases:
S 38 In case of insufficient ventilation, wear suitable respiratory
equipment.
S 28B After contact with skin, wash immediately with plenty of water
and soap.
WGK (Water Danger/Protection)
CAS# 5086-74-8: No information available.
Canada - DSL/NDSL
None of the chemicals in this product are listed on the DSL or NDSL list.
Canada - WHMIS
This product has a WHMIS classification of D1B.
This product has been classified in accordance with the hazard
criteria of the Controlled Products Regulations and the MSDS
contains all of the information required by those regulations.
Canadian Ingredient Disclosure List
Section 16 - Additional Information
|
MSDS Creation Date: 7/14/1999
Revision #4 Date: 11/20/2008
The information above is believed to be accurate and represents the best
information currently available to us. However, we make no warranty of
merchantability or any other warranty, express or implied, with respect to
such information, and we assume no liability resulting from its use. Users
should make their own investigations to determine the suitability of the
information for their particular purposes. In no event shall Fisher be liable
for any claims, losses, or damages of any third party or for lost profits
or any special, indirect, incidental, consequential or exemplary
damages, howsoever arising, even if Fisher has been advised of
the possibility of such damages.