Material Safety Data Sheet
Carnoy's Solution
ACC# 45410
Section 1 - Chemical Product and Company Identification |
MSDS Name: Carnoy's Solution
Catalog Numbers:
S79954, S799541
Synonyms:
None.
Company Identification:
Fisher Scientific
1 Reagent Lane
Fair Lawn, NJ 07410
For information, call: 201-796-7100
Emergency Number: 201-796-7100
For CHEMTREC assistance, call: 800-424-9300
For International CHEMTREC assistance, call: 703-527-3887
Section 2 - Composition, Information on Ingredients
|
CAS# |
Chemical Name |
Percent |
EINECS/ELINCS |
64-17-5 |
Ethyl alcohol |
54.42 | 200-578-6 |
67-66-3 |
Chloroform |
30.0 | 200-663-8 |
64-19-7 |
Acetic acid |
10.0 | 200-580-7 |
141-78-6 |
Ethyl acetate |
3.0 | 205-500-4 |
67-56-1 |
Methyl alcohol |
2.1 | 200-659-6 |
|
Aliphatic Hydrocarbons |
0.48 | unlisted |
Section 3 - Hazards Identification
|
EMERGENCY OVERVIEW
Appearance: colorless liquid. Flash Point: 8.3 deg C.
Danger! Causes eye, skin, and respiratory tract
irritation. Flammable liquid and vapor.
This substance has caused adverse reproductive and fetal effects in
humans. Aspiration hazard if swallowed. Can enter lungs and cause
damage. May cause central nervous system depression. May cause
cancer based on animal studies. May cause cardiac disturbances. May
cause liver, kidney and heart damage. May cause blindness if
swallowed.
Target Organs: Kidneys, heart, central nervous
system, liver, eyes.
Potential Health Effects
Eye:
Causes severe eye irritation. May cause painful sensitization to
light. May cause chemical conjunctivitis and corneal damage.
Skin:
Causes moderate skin irritation. May be absorbed through the skin.
Ingestion:
May be fatal or cause blindness if swallowed. May cause
gastrointestinal irritation with nausea, vomiting and diarrhea. May
cause systemic toxicity with acidosis. May cause central nervous
system depression, characterized by excitement, followed by headache,
dizziness, drowsiness, and nausea. Advanced stages may cause
collapse, unconsciousness, coma and possible death due to respiratory
failure. May cause cardiac disturbances. Aspiration of material into
the lungs may cause chemical pneumonitis, which may be fatal.
Inhalation:
Inhalation of high concentrations may cause central nervous system
effects characterized by nausea, headache, dizziness, unconsciousness
and coma. Causes respiratory tract irritation. May cause cardiac
sensitization and possible failure. May cause narcotic effects in
high concentration. Vapors may cause dizziness or suffocation.
Chronic:
Prolonged or repeated skin contact may cause defatting and
dermatitis. Repeated exposure may cause erosion of teeth. Toxicity
may be increased by exposure to alcohol, steroids, and ketones.
Animal studies have reported fetal losses, delays in fetal
development, and cleft palate. Laboratory experiments have resulted
in mutagenic effects. Animal studies have reported the development of
tumors. Prolonged exposure may cause liver, kidney, and heart damage.
Section 4 - First Aid Measures
|
Eyes:
Immediately flush eyes with plenty of water for at least 15 minutes,
occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Immediately flush skin with plenty of water for at
least 15 minutes while removing contaminated clothing and shoes.
Wash clothing before reuse.
Ingestion:
Do not induce vomiting. If victim is conscious and alert, give 2-4
cupfuls of milk or water. Never give anything by mouth to an
unconscious person. Possible aspiration hazard. Get medical aid
immediately.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh
air immediately. If breathing is difficult, give oxygen. Do NOT use
mouth-to-mouth resuscitation. If breathing has ceased apply
artificial respiration using oxygen and a suitable mechanical device
such as a bag and a mask.
Notes to Physician:
Causes cardiac sensitization to endogenous catelcholamines which may
lead to cardiac arrhythmias. Do NOT use adrenergic agents such as
epinephrine or pseudoepinephrine. Treat symptomatically and
supportively. Persons with skin or eye disorders or liver, kidney,
chronic respiratory diseases, or central and peripheral nervous sytem
diseases may be at increased risk from exposure to this substance.
Activated charcoal does not reduce ethanol absorption.
Antidote:
Ethanol may inhibit methanol metabolism.
Section 5 - Fire Fighting Measures
|
General Information:
Ethanol may inhibit methanol metabolism. As in any fire, wear a
self-contained breathing apparatus in pressure-demand, MSHA/NIOSH
(approved or equivalent), and full protective gear. Vapors may form
an explosive mixture with air. Vapors can travel to a source of
ignition and flash back. May burn with invisible flame. Will burn if
involved in a fire. Flammable Liquid. Can release vapors that form
explosive mixtures at temperatures above the flashpoint. Use water
spray to keep fire-exposed containers cool. Containers may explode in
the heat of a fire. Vapors may be heavier than air. They can spread
along the ground and collect in low or confined areas. May be
ignited by heat, sparks, and flame. Vapors may form an explosive
mixture with air.
Extinguishing Media:
For small fires, use dry chemical, carbon dioxide, water spray or
alcohol-resistant foam. For large fires, use water spray, fog, or
alcohol-resistant foam. Water may be ineffective. Do NOT use
straight streams of water. Cool containers with flooding quantities
of water until well after fire is out.
Flash Point: 8.3 deg C ( 46.94 deg F)
Autoignition Temperature: 362.8 deg C ( 685.04 deg F)
Explosion Limits, Lower:3 vol %
Upper: 19 vol %
NFPA Rating:
(estimated) Health: 1; Flammability: 3; Instability: 0
Section 6 - Accidental Release Measures
|
General Information: Use proper personal protective equipment as indicated
in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth),
then place in suitable container. Clean up spills immediately,
observing precautions in the Protective Equipment section. Remove all
sources of ignition. Use a spark-proof tool. Provide ventilation. A
vapor suppressing foam may be used to reduce vapors. Water spray may
reduce vapor but may not prevent ignition in closed spaces.
Section 7 - Handling and Storage
|
Handling:
Wash thoroughly after handling. Remove contaminated clothing and
wash before reuse. Use only in a well-ventilated area. Ground and
bond containers when transferring material. Use spark-proof tools and
explosion proof equipment. Avoid contact with eyes, skin, and
clothing. Empty containers retain product residue, (liquid and/or
vapor), and can be dangerous. Keep container tightly closed. Keep
away from heat, sparks and flame. Do not ingest or inhale. Do not
pressurize, cut, weld, braze, solder, drill, grind, or expose empty
containers to heat, sparks or open flames.
Storage:
Keep away from heat, sparks, and flame. Keep away from sources of
ignition. Do not store in direct sunlight. Store in a tightly closed
container. Keep from contact with oxidizing materials. Store in a
cool, dry, well-ventilated area away from incompatible substances.
Flammables-area. Do not store near perchlorates, peroxides, chromic
acid or nitric acid.
Section 8 - Exposure Controls, Personal Protection
|
Engineering Controls:
Use explosion-proof ventilation equipment. Facilities storing or
utilizing this material should be equipped with an eyewash facility
and a safety shower. Use adequate general or local exhaust
ventilation to keep airborne concentrations below the permissible
exposure limits.
Exposure Limits
Chemical Name |
ACGIH |
NIOSH |
OSHA - Final PELs |
Ethyl alcohol
|
1000 ppm TWA
|
1000 ppm TWA; 1900 mg/m3 TWA 3300 ppm IDLH
|
1000 ppm TWA; 1900 mg/m3 TWA
|
Chloroform
|
10 ppm TWA
|
500 ppm IDLH
|
50 ppm Ceiling; 240 mg/m3 Ceiling
|
Acetic acid
|
10 ppm TWA; 15 ppm STEL
|
10 ppm TWA; 25 mg/m3 TWA 50 ppm IDLH
|
10 ppm TWA; 25 mg/m3 TWA
|
Ethyl acetate
|
400 ppm TWA
|
400 ppm TWA; 1400 mg/m3 TWA 2000 ppm IDLH
|
400 ppm TWA; 1400 mg/m3 TWA
|
Methyl alcohol
|
200 ppm TWA; 250 ppm STEL; Skin - potential significant contribution to overall exposure by the cutaneous r oute
|
200 ppm TWA; 260 mg/m3 TWA 6000 ppm IDLH
|
200 ppm TWA; 260 mg/m3 TWA
|
Aliphatic Hydrocarbons
|
none listed
|
none listed
|
none listed
|
OSHA Vacated PELs:
Ethyl alcohol:
1000 ppm TWA; 1900 mg/m3 TWA
Chloroform:
2 ppm TWA; 9.78 mg/m3 TWA
Acetic acid:
10 ppm TWA; 25 mg/m3 TWA
Ethyl acetate:
400 ppm TWA; 1400 mg/m3 TWA
Methyl alcohol:
200 ppm TWA; 260 mg/m3 TWA
Aliphatic Hydrocarbons:
No OSHA Vacated PELs are listed for this chemical.
Personal Protective Equipment
Eyes:
Wear appropriate protective eyeglasses or chemical
safety goggles as described by OSHA's eye and face
protection regulations in 29 CFR 1910.133 or European
Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin
exposure.
Clothing:
Wear appropriate protective clothing to prevent skin
exposure.
Respirators:
A respiratory protection program that meets OSHA's 29
CFR 1910.134 and ANSI Z88.2 requirements or European
Standard EN 149 must be followed whenever workplace
conditions warrant respirator use.
Section 9 - Physical and Chemical Properties
|
Physical State: Liquid
Appearance: colorless
Odor: acetic odor
pH: Acidic.
Vapor Pressure: 100 mm Hg
Vapor Density: 4.12 (Air=1)
Evaporation Rate:11.6
Viscosity: Not available.
Boiling Point: 118 deg C
Freezing/Melting Point:-65 deg C
Decomposition Temperature:Not available.
Solubility: Soluble in water.
Specific Gravity/Density:1.0
Molecular Formula:Mixture
Molecular Weight:Not available.
Section 10 - Stability and Reactivity
|
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Light, ignition sources, excess heat.
Incompatibilities with Other Materials:
Metals, strong oxidizing agents, acids, alkali metals, aluminum,
ammonia, fluorine, hydrazine, magnesium, peroxides, potassium,
lithium, sodium, acids (mineral, non-oxidizing, e.g. hydrochloric
acid, hydrofluoric acid, muriatic acid, phosphoric acid), acid
anhydrides, calcium hypochlorite, dinitrogen tetraoxide, sodium +
methanol, chromyl chloride, nitrosyl perchlorate, bromine
pentafluoride, perchloric acid, silver nitrate, mercuric nitrate,
potassium tert-butoxide, magnesium perchlorate, acid chlorides,
platinum, uranium hexafluoride, silver oxide, iodine heptafluoride,
acetyl bromide, disulfuryl difluoride, tetrachlorosilane + water,
acetyl chloride, nitrogen tetroxide, permanganic acid, ruthenium
(VIII) oxide, uranyl perchlorate, acetone + alkali, disilane,
perchloric acid + phosphorus pentoxide, sodium methylate,
triisopropylphosphine, sodium methoxide + methanol, potassium
dioxide.
Hazardous Decomposition Products:
Hydrogen chloride, carbon monoxide, irritating and toxic fumes and
gases, carbon dioxide, chlorine, phosgene gas.
Hazardous Polymerization: Will not occur.
Section 11 - Toxicological Information
|
RTECS#:
CAS# 64-17-5:
KQ6300000
CAS# 67-66-3:
FS9100000
CAS# 64-19-7:
AF1225000
CAS# 141-78-6:
AH5425000
CAS# 67-56-1:
PC1400000
CAS# unlisted.
LD50/LC50:
CAS# 64-17-5:
Draize test, rabbit,
eye: 500 mg Severe;
Draize test,
rabbit, eye: 500 mg/24H Mild;
Draize test, rabbit, skin: 20 mg/24H
Moderate;
Inhalation, mouse: LC50 =
39 gm/m3/4H;
Inhalation, rat: LC50
= 20000 ppm/10H;
Oral, mouse: LD50
= 3450 mg/kg;
Oral, rabbit: LD50 =
6300 mg/kg;
Oral, rat: LD50 = 7060
mg/kg;
Oral, rat: LD50 = 9000
mg/kg;
.
CAS# 67-66-3:
Draize test,
rabbit, eye: 148 mg;
Draize test,
rabbit, eye: 20 mg/24H Moderate;
Draize test, rabbit, skin: 500 mg/24H
Mild;
Inhalation, mouse: LC50 =
17200 mg/m3/2H;
Inhalation, mouse:
LC50 = 6000 mg/m3/6H;
Inhalation,
rat: LC50 = 47702 mg/m3/4H;
Inhalation, rat: LC50 = 6000
mg/m3/6H;
Oral, mouse: LD50 = 36
mg/kg;
Oral, rat: LD50 = 695
mg/kg;
Oral, rat: LD50 = 1250
mg/kg;
Skin, rabbit: LD50 = >20
gm/kg;
.
CAS# 64-19-7:
Draize test,
rabbit, skin: 50 mg/24H Mild;
Inhalation, mouse: LC50 = 5620
ppm/1H;
Oral, rat: LD50 = 3310
mg/kg;
Skin, rabbit: LD50 = 1060
uL/kg;
.
CAS# 141-78-6:
Inhalation,
mouse: LC50 = 45 gm/m3/2H;
Inhalation, rat: LC50 = 200 gm/m3;
Oral, mouse: LD50 = 4100 mg/kg;
Oral, rabbit: LD50 = 4935 mg/kg;
Oral, rat: LD50 = 5620 mg/kg;
Skin, rabbit: LD50 = >20
mL/kg;
.
CAS# 67-56-1:
Draize test,
rabbit, eye: 40 mg Moderate;
Draize
test, rabbit, eye: 100 mg/24H Moderate;
Draize test, rabbit, skin: 20 mg/24H
Moderate;
Inhalation, rabbit: LC50
= 81000 mg/m3/14H;
Inhalation, rat:
LC50 = 64000 ppm/4H;
Oral, mouse:
LD50 = 7300 mg/kg;
Oral, rabbit:
LD50 = 14200 mg/kg;
Oral, rat:
LD50 = 5600 mg/kg;
Skin, rabbit:
LD50 = 15800 mg/kg;
.
CAS# :
.
Carcinogenicity:
CAS# 64-17-5:
Not listed by ACGIH, IARC, NTP, or CA Prop 65.
CAS# 67-66-3:
- ACGIH:
A3 - Confirmed animal carcinogen with unknown relevance to humans
- California:
carcinogen, initial date 10/1/87
- NTP:
Suspect carcinogen
- IARC:
Group 2B carcinogen
CAS# 64-19-7:
Not listed by ACGIH, IARC, NTP, or CA Prop 65.
CAS# 141-78-6:
Not listed by ACGIH, IARC, NTP, or CA Prop 65.
CAS# 67-56-1:
Not listed by ACGIH, IARC, NTP, or CA Prop 65.
CAS# :
Not listed by ACGIH, IARC, NTP, or CA Prop 65.
Epidemiology:
Prenatal exposure to ethanol is associated with a distinct
pattern of congenital malformations that have collectively
been termed the "fetal alcohol syndrome".Methanol has been
shown to produce fetotoxicity in the embryo or fetus of
laboratory animals. Specific developmental abnormalities
include cardiovascular, musculoskeletal, and urogenital
systems.Ethanol has been shown to produce fetotoxicity in
the embryo or fetus of laboratory animals.
Teratogenicity:
CAS# 64-17-5: Oral, Human - woman: TDLo = 41 gm/kg (female
41 week(s) after conception) Effects on Newborn - Apgar
score (human only) and Effects on Newborn - other neonatal
measures or effects and Effects on Newborn - drug
dependence.
Reproductive Effects:
CAS# 64-17-5: Intrauterine, Human - woman: TDLo = 200 mg/kg
(female 5 day(s) pre-mating) Fertility - female fertility
index (e.g. # females pregnant per # sperm positive
females; # females pregnant per # females mated).
Mutagenicity:
CAS# 64-17-5: DNA Inhibition: Human, Lymphocyte = 220
mmol/L.; Cytogenetic Analysis: Human, Lymphocyte = 1160
gm/L.; Cytogenetic Analysis: Human, Fibroblast = 12000
ppm.; Cytogenetic Analysis: Human, Leukocyte = 1 pph/72H
(Continuous).; Sister Chromatid Exchange: Human, Lymphocyte
= 500 ppm/72H (Continuous).
Neurotoxicity:
No information found
Other Studies:
Section 12 - Ecological Information
|
Ecotoxicity:
Fish: Rainbow trout: LC50 = 12900-15300 mg/L; 96 Hr; Flow-through @
24-24.3°CFish: Rainbow trout: LC50 = 11200 mg/L; 24 Hr;
Fingerling (Unspecified)Bacteria: Phytobacterium phosphoreum:
EC50 = 34900 mg/L; 5-30 min; Microtox test
CAS# 64-17-5: When spilled on land it is apt to volatilize,
biodegrade, and leach into the ground water, but no data on the rates
of these processes could be found. Its fate in ground water is
unknown. When released into water it will volatilize and probably
biodegrade. It would not be expected to adsorb to sediment or
bioconcentrate in fish.
Environmental:
CAS# 64-17-5: When released to the atmosphere it will photodegrade in
hours (polluted urban atmosphere) to an estimated range of 4 to 6
days in less polluted areas. Rainout should be significant.
Physical:
No information available.
Other:
No information available.
Section 13 - Disposal Considerations
|
Chemical waste generators must determine whether a discarded chemical is classified
as a hazardous waste.
US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3.
Additionally, waste generators must consult state and local hazardous waste regulations to
ensure complete and accurate classification.
RCRA P-Series: None listed.
RCRA U-Series:
CAS# 67-66-3: waste
number U044.
CAS# 141-78-6: waste number U112
(Ignitable waste).
CAS# 67-56-1: waste number U154
(Ignitable waste).
Section 14 - Transport Information
|
|
US DOT |
Canada TDG |
Shipping Name: |
FLAMMABLE LIQUIDS, CORROSIVE, N.O.S. |
ETHANOL SOLUTION |
Hazard Class: |
3 |
3 |
UN Number: |
UN2924 |
UN1170 |
Packing Group: |
II |
II |
Additional Info: | | FLASHPOINT 16C |
Section 15 - Regulatory Information
|
US FEDERAL
TSCA
CAS# 64-17-5 is listed on the TSCA inventory.
CAS# 67-66-3 is listed on the TSCA inventory.
CAS# 64-19-7 is listed on the TSCA inventory.
CAS# 141-78-6 is listed on the TSCA inventory.
CAS# 67-56-1 is listed on the TSCA inventory.
CAS# is not listed on the TSCA inventory.
It is for research and development use only.
Health & Safety Reporting List
CAS# 67-66-3: Effective 6/1/87, Sunset 6/1/97
Chemical Test Rules
CAS# 141-78-6: 40 CFR 799.5000
Section 12b
None of the chemicals are listed under TSCA Section 12b.
TSCA Significant New Use Rule
None of the chemicals in this material have a SNUR under TSCA.
CERCLA Hazardous Substances and corresponding RQs
CAS# 67-66-3: 10 lb final RQ; 4.54 kg final RQ
CAS# 64-19-7: 5000 lb final RQ; 2270 kg final RQ
CAS# 141-78-6: 5000 lb final RQ; 2270 kg final RQ
CAS# 67-56-1: 5000 lb final RQ; 2270 kg final RQ
SARA Section 302 Extremely Hazardous Substances
CAS# 67-66-3: 10000 lb TPQ
SARA Codes
CAS # 64-17-5: immediate, delayed, fire.
CAS # 67-66-3: immediate, delayed.
CAS # 64-19-7: immediate, delayed, fire.
CAS # 141-78-6: fire.
CAS # 67-56-1: immediate, fire.
Section 313
This material contains Chloroform
(CAS# 67-66-3, 30.0%),which is subject to the reporting requirements
of Section 313 of SARA Title III and 40 CFR Part 373.
This material contains Methyl
alcohol (CAS# 67-56-1, 2.1%),which is subject to the reporting
requirements of Section 313 of SARA Title III and 40 CFR Part 373.
Clean Air Act:
CAS# 67-66-3 is listed as a hazardous air pollutant (HAP).
CAS# 67-56-1 is listed as a hazardous air pollutant (HAP).
This material does not contain any Class 1 Ozone depletors.
This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
CAS# 67-66-3 is listed as a Hazardous Substance under the CWA.
CAS# 64-19-7 is listed as a Hazardous Substance under the CWA.
CAS# 67-66-3 is listed as a Priority Pollutant under the Clean Water
Act.
CAS# 67-66-3 is listed as a Toxic Pollutant under the Clean Water
Act.
OSHA:
None of the chemicals in this product
are considered highly hazardous by OSHA.
STATE
CAS# 64-17-5 can be found on the
following state right to know lists: California, New Jersey,
Pennsylvania, Minnesota, Massachusetts.
CAS# 67-66-3 can be found on the
following state right to know lists: California, New Jersey,
Pennsylvania, Minnesota, Massachusetts.
CAS# 64-19-7 can be found on the
following state right to know lists: California, New Jersey,
Pennsylvania, Minnesota, Massachusetts.
CAS# 141-78-6 can be found on the
following state right to know lists: California, New Jersey,
Pennsylvania, Minnesota, Massachusetts.
CAS# 67-56-1 can be found on the
following state right to know lists: California, New Jersey,
Pennsylvania, Minnesota, Massachusetts.
CAS# is not present on state lists
from CA, PA, MN, MA, FL, or NJ.
California Prop 65
WARNING: This product contains Chloroform, a chemical known to the
state of California to cause cancer.
WARNING: This product contains Ethyl alcohol, a chemical known to the
state of California to cause developmental reproductive toxicity.
California No Significant Risk Level:
CAS# 67-66-3: 20 æg/day NSRL (oral); 40 æg/day NSRL (inhalation)
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols:
F
Risk Phrases:
R 11 Highly flammable.
Safety Phrases:
S 16 Keep away from sources of ignition - No smoking.
S 33 Take precautionary measures against static discharges.
S 7 Keep container tightly closed.
S 9 Keep container in a well-ventilated place.
WGK (Water Danger/Protection)
CAS# 64-17-5: 0
CAS# 67-66-3: 3
CAS# 64-19-7: 1
CAS# 141-78-6: 1
CAS# 67-56-1: 1
CAS# : No information available.
Canada - DSL/NDSL
CAS# 64-17-5 is listed on Canada's DSL List.
CAS# 67-66-3 is listed on Canada's DSL List.
CAS# 64-19-7 is listed on Canada's DSL List.
CAS# 141-78-6 is listed on Canada's DSL List.
CAS# 67-56-1 is listed on Canada's DSL List.
Canada - WHMIS
This product has a WHMIS classification of B2, D2A.
This product has been classified in accordance with the hazard
criteria of the Controlled Products Regulations and the MSDS
contains all of the information required by those regulations.
Canadian Ingredient Disclosure List
CAS# 64-17-5 is listed on the Canadian Ingredient Disclosure List.
CAS# 67-66-3 is listed on the Canadian Ingredient Disclosure List.
CAS# 64-19-7 is listed on the Canadian Ingredient Disclosure List.
CAS# 141-78-6 is listed on the Canadian Ingredient Disclosure List.
CAS# 67-56-1 is listed on the Canadian Ingredient Disclosure List.
Section 16 - Additional Information
|
MSDS Creation Date: 4/26/1999
Revision #6 Date: 10/30/2007
The information above is believed to be accurate and represents the best
information currently available to us. However, we make no warranty of
merchantability or any other warranty, express or implied, with respect to
such information, and we assume no liability resulting from its use. Users
should make their own investigations to determine the suitability of the
information for their particular purposes. In no event shall Fisher be liable
for any claims, losses, or damages of any third party or for lost profits
or any special, indirect, incidental, consequential or exemplary
damages, howsoever arising, even if Fisher has been advised of
the possibility of such damages.