Material Safety Data Sheet
1-Chloro-2-nitrobenzene, 99+%
ACC# 49254
Section 1 - Chemical Product and Company Identification |
MSDS Name: 1-Chloro-2-nitrobenzene, 99+%
Catalog Numbers:
AC109620000, AC109620010, AC109620050, AC109621000, AC109622500, AC109625000
AC109625000
Synonyms:
o-Chloronitrobenzene, 2-Chloronitrobenzene.
Company Identification:
Acros Organics N.V.
One Reagent Lane
Fair Lawn, NJ 07410
For information in North America, call: 800-ACROS-01
For emergencies in the US, call CHEMTREC: 800-424-9300
Section 2 - Composition, Information on Ingredients
|
CAS# |
Chemical Name |
Percent |
EINECS/ELINCS |
88-73-3 |
1-Chloro-2-nitrobenzene |
>99 | 201-854-9 |
Section 3 - Hazards Identification
|
EMERGENCY OVERVIEW
Appearance: yellow crystals.
Warning! Harmful if swallowed, inhaled, or
absorbed through the skin. May cause eye, skin, and respiratory tract
irritation. Methemoglobin former - can cause cyanosis. Impairs the
oxygen carrying capacity of the blood. May cause liver damage.
Target Organs: Blood, liver.
Potential Health Effects
Eye:
May cause mild eye irritation.
In eye irritation study with rabbits, undiluted test substance was
found to be not irritating at dose of 50 mg/animal. Observation
period was 7 days. (Bayer)
Skin:
May cause skin irritation. Harmful if absorbed through the skin. May
cause skin sensitization, an allergic reaction, which becomes evident
upon re-exposure to this material.
Data from Bayer found o-chloronitrobenzene to be sensitizing in
guinea pigs. The allergenic activity of o-chloronitrobenzene is less
marked than that of p-chloronitrobenzene; 2,4-dinitrochlorobenzene
provokes even stronger sensitization effects than
p-chloronitrobenzene.
Ingestion:
Harmful if swallowed. May cause central nervous system depression.
May form methemoglobin which in sufficient concentration causes
cyanosis (bluish discoloration of skin due to deficient oxygenation
of the blood).
Inhalation:
Harmful if inhaled. May cause respiratory tract irritation.
Methemoglobinemia is characterized by dizziness, drowsiness,
headache, shortness of breath, cyanosis (bluish discoloration of skin
due to deficient oxygenation of the blood), rapid heart rate and
chocolate-brown blood. May cause methemoglobinemia.
Test exposing rats via inhalation to o-chloronitrobenzene for 5
months at conc of 0.000008 mg/l (a conc which has a minimal toxic
effect) found the material to be sensitizing. The allergenic activity
of o-chloronitrobenzene is less marked than that of
p-chloronitobenzene. The state of allergy was investigated at the end
of the experimental period by various methods in vitro and in vivo.
Chronic:
May cause anemia and other blood cell abnormalities. Chronic
exposure may cause liver damage. May cause fatigue, dizziness,
headache, insomnia and weight loss.
Experience with human exposure: in chloronitrobenzene poisoning,
cardiac complications appear to be more frequent and more serious
than in aniline poisoning and gastrointestinal irregularities
(anacidity) also appear to be quite common (no further data,
isomer(s) of chloronitrobenzene not specified). (ECB site from Bayer)
Section 4 - First Aid Measures
|
Eyes:
Flush eyes with plenty of water for at least 15 minutes, occasionally
lifting the upper and lower eyelids. Get medical aid immediately.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15
minutes while removing contaminated clothing and shoes. Wash clothing
before reuse.
Ingestion:
Never give anything by mouth to an unconscious person. Get medical
aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and
drink 2-4 cupfuls of milk or water.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh
air immediately. If breathing is difficult, give oxygen. Do NOT use
mouth-to-mouth resuscitation. If breathing has ceased apply
artificial respiration using oxygen and a suitable mechanical device
such as a bag and a mask.
Notes to Physician:
Treat symptomatically and supportively.
Section 5 - Fire Fighting Measures
|
General Information:
As in any fire, wear a self-contained breathing apparatus in
pressure-demand, MSHA/NIOSH (approved or equivalent), and full
protective gear. During a fire, irritating and highly toxic gases
may be generated by thermal decomposition or combustion. This
material in sufficient quantity and reduced particle size is capable
of creating a dust explosion.
Extinguishing Media:
In case of fire, use water, dry chemical, chemical foam, or
alcohol-resistant foam.
Flash Point: 124 deg C ( 255.20 deg F)
Autoignition Temperature: 470 deg C ( 878.00 deg F)
Explosion Limits, Lower:1.40 vol %
Upper: 8.70 vol %
NFPA Rating:
(estimated) Health: 2; Flammability: 1; Instability: 0
Section 6 - Accidental Release Measures
|
General Information: Use proper personal protective equipment as indicated
in Section 8.
Spills/Leaks:
Clean up spills immediately, observing precautions in the Protective
Equipment section. Sweep up, then place into a suitable container for
disposal. Avoid generating dusty conditions. Remove all sources of
ignition. Provide ventilation.
Section 7 - Handling and Storage
|
Handling:
Wash thoroughly after handling. Remove contaminated clothing and
wash before reuse. Use only in a well-ventilated area. Minimize dust
generation and accumulation. Avoid contact with skin and eyes. Do
not ingest or inhale.
Storage:
Store in a cool, dry place. Keep container closed when not in use.
Store in a cool, dry, well-ventilated area away from incompatible
substances.
Section 8 - Exposure Controls, Personal Protection
|
Engineering Controls:
Facilities storing or utilizing this material should be equipped
with an eyewash facility and a safety shower. Use adequate general or
local exhaust ventilation to keep airborne concentrations below the
permissible exposure limits.
Exposure Limits
Chemical Name |
ACGIH |
NIOSH |
OSHA - Final PELs |
1-Chloro-2-nitrobenzene
|
none listed
|
none listed
|
none listed
|
OSHA Vacated PELs:
1-Chloro-2-nitrobenzene:
No OSHA Vacated PELs are listed for this chemical.
Personal Protective Equipment
Eyes:
Wear appropriate protective eyeglasses or chemical
safety goggles as described by OSHA's eye and face
protection regulations in 29 CFR 1910.133 or European
Standard EN166.
Skin:
Wear appropriate gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to minimize
contact with skin.
Respirators:
Follow the OSHA respirator regulations found in 29
CFR 1910.134 or European Standard EN 149. Use a
NIOSH/MSHA or European Standard EN 149 approved
respirator if exposure limits are exceeded or if
irritation or other symptoms are experienced.
Section 9 - Physical and Chemical Properties
|
Physical State: Crystals
Appearance: yellow
Odor: None reported.
pH: Not applicable.
Vapor Pressure: 0.04 mm Hg @ 25 deg C
Vapor Density: 5.43 (air=1)
Evaporation Rate:Not available.
Viscosity: Not available.
Boiling Point: 246 deg C @ 760 mm Hg
Freezing/Melting Point:32 - 34 deg C
Decomposition Temperature:> 300 deg C
Solubility: Insoluble.
Specific Gravity/Density:1.3480 g/cm3
Molecular Formula:C6H4ClNO2
Molecular Weight:157.56
Section 10 - Stability and Reactivity
|
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Dust generation, excess heat.
Incompatibilities with Other Materials:
Strong oxidizing agents.
Hazardous Decomposition Products:
Hydrogen chloride, nitrogen oxides, carbon monoxide, carbon dioxide.
Hazardous Polymerization: Has not been reported.
Section 11 - Toxicological Information
|
RTECS#:
CAS# 88-73-3:
CZ0875000
LD50/LC50:
CAS# 88-73-3:
Oral, mouse: LD50 =
135 mg/kg;
Oral, rabbit: LD50 =
280 mg/kg;
Oral, rat: LD50 = 268
mg/kg;
Skin, rabbit: LD50 = 400
mg/kg;
.
Inhalation, 4H, rat, LC50: 3.2 mg/L. (DuPont)
Carcinogenicity:
CAS# 88-73-3:
Not listed by ACGIH, IARC, NTP, or CA Prop 65.
Epidemiology:
o-Chloronitrobenzene has been used for decades, but there
have been no indications of an allergenic potential in man.
(Bayer AG Leverkusen)Dermatitis caused by
chlorodinitrobenzene has been observed in workers who used
the compound to control algae in the coolant water of
air-conditioning systems. The eruption is characterized by
erythema, vesicles, & itching & thus resembles poison ivy.
Teratogenicity:
No information available.
Reproductive Effects:
No information available.
Mutagenicity:
No information available.
Neurotoxicity:
No information available.
Other Studies:
Section 12 - Ecological Information
|
Ecotoxicity:
No data available.
No information available.
Environmental:
Terrestrial: O-Chloronitrobenzene does not contain a readily
hydrolyzable functional group. Therefore, hydrolysis of
O-chloronitrobenzene in soil is not significant. Aquatic:
O-Chloronitrobenzene does not contain any readily hydrolyzable
functional groups and is unlikely to undergo hydrolysis as a major
fate. Atmospheric: Based on a vapor pressure of 0.035 mm Hg at 250C
O-chloronitrobenzene process. Slight biodegradation but significant
bioconcentration.
Physical:
No information available.
Other:
No information available.
Section 13 - Disposal Considerations
|
Chemical waste generators must determine whether a discarded chemical is classified
as a hazardous waste.
US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3.
Additionally, waste generators must consult state and local hazardous waste regulations to
ensure complete and accurate classification.
RCRA P-Series: None listed.
RCRA U-Series: None listed.
Section 14 - Transport Information
|
|
US DOT |
Canada TDG |
Shipping Name: |
CHLORONITROBENZENE, LIQUID |
CHLORONITOBENZENES |
Hazard Class: |
6.1 |
6.1 |
UN Number: |
UN3409 |
UN1578 |
Packing Group: |
II |
II |
Section 15 - Regulatory Information
|
US FEDERAL
TSCA
CAS# 88-73-3 is listed on the TSCA inventory.
Health & Safety Reporting List
None of the chemicals are on the Health & Safety Reporting List.
Chemical Test Rules
None of the chemicals in this product are under a Chemical Test Rule.
Section 12b
None of the chemicals are listed under TSCA Section 12b.
TSCA Significant New Use Rule
None of the chemicals in this material have a SNUR under TSCA.
CERCLA Hazardous Substances and corresponding RQs
None of the chemicals in this material have an RQ.
SARA Section 302 Extremely Hazardous Substances
None of the chemicals in this product have a TPQ.
SARA Codes
CAS # 88-73-3: immediate, delayed.
Section 313
No chemicals are reportable under Section 313.
Clean Air Act:
This material does not contain any hazardous air pollutants.
This material does not contain any Class 1 Ozone depletors.
This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
None of the chemicals in this product
are listed as Hazardous Substances under the CWA.
None of the chemicals in this
product are listed as Priority Pollutants under the CWA.
None of the chemicals in this
product are listed as Toxic Pollutants under the CWA.
OSHA:
None of the chemicals in this product
are considered highly hazardous by OSHA.
STATE
CAS# 88-73-3 can be found on the
following state right to know lists: Pennsylvania, Massachusetts.
California Prop 65
California No Significant Risk Level:
None of the chemicals in this product are listed.
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols:
T
Risk Phrases:
R 20/22 Harmful by inhalation and if swallowed.
R 24 Toxic in contact with skin.
R 52/53 Harmful to aquatic organisms, may cause long-term adverse
effects in the aquatic environment.
Safety Phrases:
S 36/37/39 Wear suitable protective clothing, gloves and eye/face pr
otection.
S 38 In case of insufficient ventilation, wear suitable respiratory
equipment.
S 45 In case of accident or if you feel unwell, seek medical advice
immediately (show the label where possible).
S 60 This material and its container must be disposed of as hazardou
s waste.
S 28A After contact with skin, wash immediately with plenty of water
.
WGK (Water Danger/Protection)
CAS# 88-73-3: 3
Canada - DSL/NDSL
CAS# 88-73-3 is listed on Canada's NDSL List.
Canada - WHMIS
This product has a WHMIS classification of D1B, D2B.
This product has been classified in accordance with the hazard
criteria of the Controlled Products Regulations and the MSDS
contains all of the information required by those regulations.
Canadian Ingredient Disclosure List
CAS# 88-73-3 is listed on the Canadian Ingredient Disclosure List.
Section 16 - Additional Information
|
MSDS Creation Date: 2/09/1999
Revision #5 Date: 11/20/2008
The information above is believed to be accurate and represents the best
information currently available to us. However, we make no warranty of
merchantability or any other warranty, express or implied, with respect to
such information, and we assume no liability resulting from its use. Users
should make their own investigations to determine the suitability of the
information for their particular purposes. In no event shall Fisher be liable
for any claims, losses, or damages of any third party or for lost profits
or any special, indirect, incidental, consequential or exemplary
damages, howsoever arising, even if Fisher has been advised of
the possibility of such damages.