Section 2 - Composition, Information on Ingredients

CAS#	Chemical Name	Percent	EINECS/ELINCS
50-14-6	Ergocalciferol	99	200-014-9

Section 3 - Hazards Identification

Appearance: white to yellow white crystalline powder.
Danger! May be fatal if swallowed. Poison! May cause eye and skin irritation. May cause digestive tract irritation with nausea, vomiting, and diarrhea. May cause respiratory tract irritation. Air sensitive. Light sensitive. May cause kidney damage.
Target Organs: Kidneys.


Potential Health Effects
Eye: May cause eye irritation.
Skin: May cause skin irritation.
Ingestion: May be fatal if swallowed. Causes gastrointestinal irritation with nausea, vomiting and diarrhea. May cause weight loss and irritability. Symptoms include weakness, fatigue, lassitude, and headache. Mental dullness and coma may develop. Impairs kidney function, including excessive thirst and urination. Causes calcification in cornea and conjunctiva in form of band keratopathy. Mimics hyperparathyroidism with muscular weakness, nervousness, itching, and hypertension.
Inhalation: May cause effects similar to those described for ingestion. Causes irritation of the mucous membrane and upper respiratory tract.
Chronic: Chronic exposure may cause reproductive disorders and teratogenic effects. Vitamin D ingested in excess results in hypercalcemia, which is caused by excessive absorption of massive quantities of calcium by the intestine and enhanced bone resorption. Causes impairment of kidneys including excessive thirst and urination, nocturia, proteinuria, and decreased urinary concentration

Section 4 - First Aid Measures

Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid imme diately.
Skin: Get medical aid immediately. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Discard contaminated clothing in a manner which limits further exposure. Destroy contaminated shoes.
Ingestion: If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately. Induce vomiting only when instructed to do so by a physician.
Inhalation: Get medical aid immediately. Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Notes to Physician: Treat symptomatically and supportively. Effects may be delayed.

Section 5 - Fire Fighting Measures

General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media: Use agent most appropriate to extinguish fire. Use water spray, dry chemical, carbon dioxide, or appropriate foam.
Flash Point: Not applicable.
Autoignition Temperature: Not applicable.
Explosion Limits, Lower:Not available.
Upper: Not available.
NFPA Rating: (estimated) Health: 3; Flammability: 0; Instability: 0

Section 6 - Accidental Release Measures

General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks: Wash area with soap and water. Clean up spills immediately, observing precautions in the Protective Equipment section. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation.

Section 7 - Handling and Storage

Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use only in a well-ventilated area. Do not get in eyes, on skin, or on clothing. Keep container tightly closed. Do not ingest or inhale. Store protected from light. Store protected from air. Use only in a chemical fume hood.
Storage: Store in a cool, dry, well-ventilated area away from incompatible substances. Poison room locked/refrigerator. Keep containers tightly closed. Store protected from light and air. Store under nitrogen.

Section 8 - Exposure Controls, Personal Protection

Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits. Use only under a chemical fume hood.
Exposure Limits

Chemical Name	ACGIH	NIOSH	OSHA - Final PELs
Ergocalciferol	none listed	none listed	none listed

OSHA Vacated PELs: Ergocalciferol: No OSHA Vacated PELs are listed for this chemical.
Personal Protective Equipment
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin: Wear appropriate protective gloves to prevent skin exposure.
Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators: A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.

Section 9 - Physical and Chemical Properties

Physical State: Crystalline powder
Appearance: white to yellow white
Odor: odorless
pH: Not available.
Vapor Pressure: Not available.
Vapor Density: Not available.
Evaporation Rate:Not available.
Viscosity: Not available.
Boiling Point: Sublimes
Freezing/Melting Point:115 - 119 deg C
Decomposition Temperature:Not available.
Solubility: Insoluble.
Specific Gravity/Density:Not available.
Molecular Formula:C28H44O
Molecular Weight:396.65

Section 10 - Stability and Reactivity

Chemical Stability: Stable under normal temperatures and pressures. Decomposes on exposure to air and light.
Conditions to Avoid: Incompatible materials, light, exposure to air, strong oxidants.
Incompatibilities with Other Materials: Strong oxidizing agents, strong acids, strong bases, air, direct light.
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, carbon dioxide.
Hazardous Polymerization: Has not been reported

Section 11 - Toxicological Information

RTECS#:      
CAS# 50-14-6: KE1050000
LD50/LC50:
CAS# 50-14-6:
     Oral, mouse: LD50 = 23700 ug/kg;
     Oral, rat: LD50 = 10 mg/kg;
.
Oral, woman: TDLo = 12600 ug/kg/72W (Anorexia, nausea, vomiting, weight
Carcinogenicity:
CAS# 50-14-6: Not listed by ACGIH, IARC, NTP, or CA Prop 65.

Epidemiology: No information found
Teratogenicity: Oral, rat: TDLo = 30 mg/kg. (Female, 10-21 days after conception-- Fetotoxicity. Developmental abnormalities: musculoskeletal system.)Oral, rat: TDLo = 45 mg/kg. (Female, 13-21 days after conception-- Developmental abnormalities: endocrine system.)Oral, rat: TDLo = 22500 ug/kg. (Female, 13-21 days after conception-- Effects on embryo- extra-embryotic structures.)Oral, mouse: TDLo = 200 mg/kg. (Female, 4-7 days after conception-- Developmental abnormalities--CNS, craniofacial, musculoskeletal sys.)Intramuscular, rabbit: TDLo =9375 ug/kg. (Female, 2-31 days after conception--Effects on newborn: weaning, growth statistics, delayed effects.)
Reproductive Effects: Subcutaneous, rat: TDLo = 17500 ug/kg (female 1-7 days after conception--female fertility index).Intramuscular, rabbit: TDLo = 17500 ug/kg (female 1-28 days after conception--abortion).Oral, rat: TDLo = 33750 ug/kg (female 9 days pre-mating--Maternal effects: menstrual cycle changes or disorders).
Mutagenicity: No information found
Neurotoxicity: No information found
Other Studies:

Section 12 - Ecological Information

Ecotoxicity: No data available. No information available.
Environmental: No data available.
Physical: No data available.
Other: None.

Section 13 - Disposal Considerations

Chemical waste generators must determine whether a discarded chemical is classified as a hazardous waste. US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3. Additionally, waste generators must consult state and local hazardous waste regulations to ensure complete and accurate classification.
RCRA P-Series: None listed.
RCRA U-Series: None listed.

Section 14 - Transport Information

	US DOT	Canada TDG
Shipping Name:	DOT regulated - small quantity provisions apply (see 49CFR173.4)	No information available.
Hazard Class:
UN Number:
Packing Group:

Section 15 - Regulatory Information

US FEDERAL

TSCA
     CAS# 50-14-6 is listed on the TSCA inventory.
Health & Safety Reporting List
     None of the chemicals are on the Health & Safety Reporting List.
Chemical Test Rules
     None of the chemicals in this product are under a Chemical Test Rule.
Section 12b
     None of the chemicals are listed under TSCA Section 12b.
TSCA Significant New Use Rule
     None of the chemicals in this material have a SNUR under TSCA.
CERCLA Hazardous Substances and corresponding RQs
     None of the chemicals in this material have an RQ.
SARA Section 302 Extremely Hazardous Substances
     CAS# 50-14-6: 1000 lb lower threshold TPQ; 10000 lb upper threshold TP      Q
Section 313      No chemicals are reportable under Section 313.
Clean Air Act:
     This material does not contain any hazardous air pollutants.
     This material does not contain any Class 1 Ozone depletors.
     This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
     None of the chemicals in this product are listed as Hazardous Substances under the CWA.
     None of the chemicals in this product are listed as Priority Pollutants under the CWA.
     None of the chemicals in this product are listed as Toxic Pollutants under the CWA.
OSHA:
     None of the chemicals in this product are considered highly hazardous by OSHA.
STATE
     CAS# 50-14-6 can be found on the following state right to know lists: New Jersey, Pennsylvania, Massachusetts.

California Prop 65

California No Significant Risk Level: None of the chemicals in this product are listed.

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols:
     T+
Risk Phrases:
     R 28 Very toxic if swallowed.

Safety Phrases:
     S 45 In case of accident or if you feel unwell, seek medical advice
     immediately (show the label where possible).

WGK (Water Danger/Protection)
     CAS# 50-14-6: 2
Canada - DSL/NDSL
     CAS# 50-14-6 is listed on Canada's DSL List.
Canada - WHMIS
     This product has a WHMIS classification of D1A, D2A.
This product has been classified in accordance with the hazard criteria of the Controlled Products Regulations and the MSDS contains all of the information required by those regulations.
Canadian Ingredient Disclosure List

Section 16 - Additional Information

MSDS Creation Date: 6/21/1999
Revision #4 Date: 11/20/2008

The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no event shall Fisher be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if Fisher has been advised of the possibility of such damages.