Material Safety Data Sheet
1-Chloro-4-nitrobenzene, 99%
ACC# 86170
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Section 1 - Chemical Product and Company Identification |
MSDS Name: 1-Chloro-4-nitrobenzene, 99%
Catalog Numbers:
AC109630000, AC109630010, AC109630050, AC109631000, AC109635000
Synonyms:
p-Nitrochlorobenzene; PNCB.
Company Identification:
Acros Organics N.V.
One Reagent Lane
Fair Lawn, NJ 07410
For information in North America, call: 800-ACROS-01
For emergencies in the US, call CHEMTREC: 800-424-9300
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Section 2 - Composition, Information on Ingredients
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| CAS# |
Chemical Name |
Percent |
EINECS/ELINCS |
| 100-00-5 |
1-Chloro-4-nitrobenzene |
99 | 202-809-6 |
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Section 3 - Hazards Identification
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EMERGENCY OVERVIEW
Appearance: yellow crystals.
Warning! Harmful if swallowed. May cause allergic
skin reaction. May cause eye, skin, and respiratory tract
irritation. May cause cancer based on animal studies. May cause
central nervous system effects. May cause liver and kidney damage.
May cause methemoglobinemia.
Target Organs: Blood, kidneys, central nervous
system, liver.
Potential Health Effects
Eye:
Causes eye irritation.
Skin:
Causes skin irritation. May cause skin sensitization, an allergic
reaction, which becomes evident upon re-exposure to this material.
Ingestion:
Harmful if swallowed. Methemoglobinemia is characterized by
dizziness, drowsiness, headache, shortness of breath, cyanosis
(bluish discoloration of skin due to deficient oxygenation of the
blood), rapid heart rate and chocolate-brown colored blood. May cause
central nervous system depression.
Inhalation:
May cause effects similar to those described for ingestion.
Methemoglobinemia is characterized by dizziness, drowsiness,
headache, shortness of breath, cyanosis (bluish discoloration of skin
due to deficient oxygenation of the blood), rapid heart rate and
chocolate-brown blood.
Chronic:
May cause liver and kidney damage. Absorption into the body leads to
the formation of methemoglobin which in sufficient concentrations
causes cyanosis (bluish discoloration of skin due to deficient
oxygenation of the blood). May cause anemia and other blood cell
abnormalities. May cause fatigue, dizziness, headache, insomnia and
weight loss.
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Section 4 - First Aid Measures
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Eyes:
Flush eyes with plenty of water for at least 15 minutes, occasionally
lifting the upper and lower eyelids. Get medical aid immediately.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15
minutes while removing contaminated clothing and shoes. Wash clothing
before reuse.
Ingestion:
Never give anything by mouth to an unconscious person. Get medical
aid immediately. Do NOT induce vomiting. If conscious and alert,
rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh
air immediately. If not breathing, give artificial respiration. If
breathing is difficult, give oxygen. Do NOT use mouth-to-mouth
resuscitation.
Notes to Physician:
For methemoglobinemia, administer oxygen alone or with Methylene
Blue depending on the methemoglobin concentration in the blood.
Antidote:
Methylene blue, alone or in combination with oxygen is indicated as
a treatment in nitrite induced methemoglobinemia.
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Section 5 - Fire Fighting Measures
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General Information:
As in any fire, wear a self-contained breathing apparatus in
pressure-demand, MSHA/NIOSH (approved or equivalent), and full
protective gear. During a fire, irritating and highly toxic gases
may be generated by thermal decomposition or combustion. Use water
spray to keep fire-exposed containers cool.
Extinguishing Media:
In case of fire, use water, dry chemical, chemical foam, or
alcohol-resistant foam.
Flash Point: 127 deg C ( 260.60 deg F)
Autoignition Temperature: 510 deg C ( 950.00 deg F)
Explosion Limits, Lower:Not available.
Upper: Not available.
NFPA Rating:
(estimated) Health: 2; Flammability: 1; Instability: 0
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Section 6 - Accidental Release Measures
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General Information: Use proper personal protective equipment as indicated
in Section 8.
Spills/Leaks:
Clean up spills immediately, observing precautions in the Protective
Equipment section. Sweep up, then place into a suitable container for
disposal. Avoid generating dusty conditions. Remove all sources of
ignition. Provide ventilation.
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Section 7 - Handling and Storage
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Handling:
Wash thoroughly after handling. Remove contaminated clothing and
wash before reuse. Use only in a well-ventilated area. Avoid contact
with skin and eyes. Do not ingest or inhale.
Storage:
Store in a cool, dry place. Store in a cool, dry, well-ventilated
area away from incompatible substances. Keep containers tightly
closed.
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Section 8 - Exposure Controls, Personal Protection
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Engineering Controls:
Use adequate general or local exhaust ventilation to keep airborne
concentrations below the permissible exposure limits.
Exposure Limits
| Chemical Name |
ACGIH |
NIOSH |
OSHA - Final PELs |
| 1-Chloro-4-nitrobenzene
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0.1 ppm TWA; Skin - potential significant contribution to overall exposure by the cutaneous r oute
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100 mg/m3 IDLH
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1 mg/m3 TWA
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OSHA Vacated PELs:
1-Chloro-4-nitrobenzene:
1 mg/m3 TWA
Personal Protective Equipment
Eyes:
Wear appropriate protective eyeglasses or chemical
safety goggles as described by OSHA's eye and face
protection regulations in 29 CFR 1910.133 or European
Standard EN166.
Skin:
Wear appropriate protective gloves and clothing to
prevent skin exposure.
Clothing:
Wear appropriate protective clothing to minimize
contact with skin.
Respirators:
Follow the OSHA respirator regulations found in 29
CFR 1910.134 or European Standard EN 149. Use a
NIOSH/MSHA or European Standard EN 149 approved
respirator if exposure limits are exceeded or if
irritation or other symptoms are experienced.
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Section 9 - Physical and Chemical Properties
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Physical State: Crystals
Appearance: yellow
Odor: sweetish odor
pH: Not available.
Vapor Pressure: 0.019 mbar @ 20 deg C
Vapor Density: 5.4 (air=1)
Evaporation Rate:Not available.
Viscosity: Not available.
Boiling Point: 242 deg C @ 760 mm Hg
Freezing/Melting Point:83 - 84 deg C
Decomposition Temperature:> 300 deg C
Solubility: 0.3 G/L WATER (20°C)
Specific Gravity/Density:1.2980g/cm3
Molecular Formula:C6H4ClNO2
Molecular Weight:157.56
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Section 10 - Stability and Reactivity
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Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Dust generation, excess heat.
Incompatibilities with Other Materials:
Strong oxidizing agents.
Hazardous Decomposition Products:
Hydrogen chloride, nitrogen oxides, carbon monoxide, carbon dioxide.
Hazardous Polymerization: Has not been reported.
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Section 11 - Toxicological Information
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RTECS#:
CAS# 100-00-5:
CZ1050000
LD50/LC50:
CAS# 100-00-5:
Oral, mouse: LD50 =
440 mg/kg;
Oral, rat: LD50 = 420
mg/kg;
Skin, rabbit: LD50 = 3040
mg/kg;
Skin, rat: LD50 = 16
gm/kg;
.
Carcinogenicity:
CAS# 100-00-5:
- ACGIH:
A3 - Confirmed animal carcinogen with unknown relevance to humans
- California:
carcinogen, initial date 10/29/99
- NTP:
Not listed.
- IARC:
Not listed.
Epidemiology:
No information available.
Teratogenicity:
No information available.
Reproductive Effects:
No information available.
Mutagenicity:
No information available.
Neurotoxicity:
No information available.
Other Studies:
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Section 12 - Ecological Information
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Ecotoxicity:
No data available.
No information available.
Environmental:
Terrestrial: Leaching may play a significant role. Aquatic: Resistent
to biodegradation, hydrolysis and oxidation. Atmospheric: Exists
mainly in the vapor phase, half-life 1.97 days. Not expected to
biodegrade or bioconcentrate.
Physical:
No information available.
Other:
No information available.
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Section 13 - Disposal Considerations
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Chemical waste generators must determine whether a discarded chemical is classified
as a hazardous waste.
US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3.
Additionally, waste generators must consult state and local hazardous waste regulations to
ensure complete and accurate classification.
RCRA P-Series: None listed.
RCRA U-Series: None listed.
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Section 14 - Transport Information
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| |
US DOT |
Canada TDG |
| Shipping Name: |
CHLORONITROBENZENES, SOLID |
CHLORONITOBENZENES |
| Hazard Class: |
6.1 |
6.1 |
| UN Number: |
UN1578 |
UN1578 |
| Packing Group: |
II |
II |
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Section 15 - Regulatory Information
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US FEDERAL
TSCA
CAS# 100-00-5 is listed on the TSCA inventory.
Health & Safety Reporting List
None of the chemicals are on the Health & Safety Reporting List.
Chemical Test Rules
CAS# 100-00-5: 40 CFR 799.5115
Section 12b
CAS# 100-00-5: Section 4
TSCA Significant New Use Rule
None of the chemicals in this material have a SNUR under TSCA.
CERCLA Hazardous Substances and corresponding RQs
None of the chemicals in this material have an RQ.
SARA Section 302 Extremely Hazardous Substances
None of the chemicals in this product have a TPQ.
Section 313
No chemicals are reportable under Section 313.
Clean Air Act:
This material does not contain any hazardous air pollutants.
This material does not contain any Class 1 Ozone depletors.
This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
None of the chemicals in this product
are listed as Hazardous Substances under the CWA.
None of the chemicals in this
product are listed as Priority Pollutants under the CWA.
None of the chemicals in this
product are listed as Toxic Pollutants under the CWA.
OSHA:
None of the chemicals in this product
are considered highly hazardous by OSHA.
STATE
CAS# 100-00-5 can be found on the
following state right to know lists: California, New Jersey,
Pennsylvania, Minnesota, Massachusetts.
California Prop 65
The following statement(s) is(are) made in order to comply with
the California Safe Drinking Water Act:
WARNING: This product contains 1-Chloro-4-nitrobenzene, a chemical
known to the state of California to cause cancer.
California No Significant Risk Level:
None of the chemicals in this product are listed.
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols:
T
Risk Phrases:
R 25 Toxic if swallowed.
R 33 Danger of cumulative effects.
R 43 May cause sensitization by skin contact.
Safety Phrases:
S 37 Wear suitable gloves.
S 45 In case of accident or if you feel unwell, seek medical advice
immediately (show the label where possible).
S 28A After contact with skin, wash immediately with plenty of water
.
WGK (Water Danger/Protection)
CAS# 100-00-5: 2
Canada - DSL/NDSL
CAS# 100-00-5 is listed on Canada's DSL List.
Canada - WHMIS
This product has a WHMIS classification of D1B, D2B.
This product has been classified in accordance with the hazard
criteria of the Controlled Products Regulations and the MSDS
contains all of the information required by those regulations.
Canadian Ingredient Disclosure List
CAS# 100-00-5 is listed on the Canadian Ingredient Disclosure List.
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Section 16 - Additional Information
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MSDS Creation Date: 12/14/1998
Revision #5 Date: 3/16/2007
The information above is believed to be accurate and represents the best
information currently available to us. However, we make no warranty of
merchantability or any other warranty, express or implied, with respect to
such information, and we assume no liability resulting from its use. Users
should make their own investigations to determine the suitability of the
information for their particular purposes. In no event shall Fisher be liable
for any claims, losses, or damages of any third party or for lost profits
or any special, indirect, incidental, consequential or exemplary
damages, howsoever arising, even if Fisher has been advised of
the possibility of such damages.