Material Safety Data Sheet
Lithium diisopropylamide, 2M solution in THF/n-heptane

ACC# 88153
Section 1 - Chemical Product and Company Identification
MSDS Name: Lithium diisopropylamide, 2M solution in THF/n-heptane
Catalog Numbers: AC268830000, AC268831000, AC268835000, AC268838000
Synonyms: LDA.THF complex.
Company Identification:
              Acros Organics N.V.
              One Reagent Lane
              Fair Lawn, NJ 07410
For information in North America, call: 800-ACROS-01
For emergencies in the US, call CHEMTREC: 800-424-9300

Section 2 - Composition, Information on Ingredients

CAS# Chemical Name Percent EINECS/ELINCS
142-82-5 n-Heptane 29 205-563-8
109-99-9 Tetrahydrofuran 26 203-726-8
4111-54-0 Lithium diisopropylamide 21.4 223-893-0
100-41-4 Ethylbenzene 13 202-849-4
108-18-9 Diisopropylamine 2.8 203-558-5
7439-95-4 Magnesium Balance 231-104-6

Section 3 - Hazards Identification

EMERGENCY OVERVIEW

Appearance: red-orange liquid. Flash Point: -18 deg C.
Danger! Extremely flammable liquid and vapor. Vapor may cause flash fire. Causes eye and skin burns. Causes digestive and respiratory tract burns. Aspiration hazard if swallowed. Can enter lungs and cause damage. May cause central nervous system depression. May form explosive peroxides. Air sensitive. May cause liver and kidney damage. May cause cardiac disturbances. Moisture sensitive. May cause adverse reproductive effects based upon animal studies.
Target Organs: Kidneys, heart, central nervous system, liver, lungs, eyes, skin, mucous membranes.


Potential Health Effects
Eye: Causes eye burns. May cause irreversible eye injury.
Skin: Causes skin burns.
Ingestion: Causes gastrointestinal tract burns. May cause liver and kidney damage. May cause circulatory system failure. May cause central nervous system depression, characterized by excitement, followed by headache, dizziness, drowsiness, and nausea. Advanced stages may cause collapse, unconsciousness, coma and possible death due to respiratory failure. Substance poses serious aspiration hazard.
Inhalation: May cause irritation of the respiratory tract with burning pain in the nose and throat, coughing, wheezing, shortness of breath and pulmonary edema. Causes chemical burns to the respiratory tract.
Chronic: May cause liver and kidney damage. Adverse reproductive effects have been reported in animals.

Section 4 - First Aid Measures


Eyes: In case of contact, immediately flush eyes with plenty of water for a t least 15 minutes. Get medical aid immediately.
Skin: In case of contact, immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid immediately. Wash clothing before reuse.
Ingestion: Potential for aspiration if swallowed. Get medical aid immediately. Do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. If vomiting occurs naturally, have victim lean forward.
Inhalation: If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician: Treat symptomatically and supportively.

Section 5 - Fire Fighting Measures


General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Vapors can travel to a source of ignition and flash back. Water reactive. Material will react with water and may release a flammable and/or toxic gas. Use water spray to keep fire-exposed containers cool. Vapors may be heavier than air. They can spread along the ground and collect in low or confined areas. Extremely flammable liquid and vapor. Vapor may cause flash fire.
Extinguishing Media: Use foam, dry chemical, or carbon dioxide. DO NOT USE WATER!
Flash Point: -18 deg C ( -0.40 deg F)
Autoignition Temperature: Not available.
Explosion Limits, Lower:Not available.
Upper: Not available.
NFPA Rating: (estimated) Health: 3; Flammability: 3; Instability:

Section 6 - Accidental Release Measures


General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks: Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Clean up spills immediately, observing precautions in the Protective Equipment section. Remove all sources of ignition. Use a spark-proof tool. Provide ventilation. Do not expose spill to water. A vapor suppressing foam may be used to reduce vapors.

Section 7 - Handling and Storage


Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Ground and bond containers when transferring material. Use spark-proof tools and explosion proof equipment. Do not get in eyes, on skin, or on clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Do not ingest or inhale. Do not allow contact with water. Store and handle protected from air. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames. Use only with adequate ventilation. Keep away from heat, sparks and flame.
Storage: Keep away from heat, sparks, and flame. Store in a tightly closed container. Keep under a nitrogen blanket. Store in a cool, dry, well-ventilated area away from incompatible substances. Keep away from water. Refrigerator/flammables.

Section 8 - Exposure Controls, Personal Protection


Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use process enclosure, local exhaust ventilation, or other engineering controls to control airborne levels.
Exposure Limits
Chemical Name ACGIH NIOSH OSHA - Final PELs
n-Heptane 400 ppm TWA; 500 ppm STEL 85 ppm TWA; 350 mg/m3 TWA 750 ppm IDLH 500 ppm TWA; 2000 mg/m3 TWA
Tetrahydrofuran 50 ppm TWA; 100 ppm STEL; Skin - potential significant contribution to overall exposure by the cutaneous r oute 200 ppm TWA; 590 mg/m3 TWA 2000 ppm IDLH (10% LEL) 200 ppm TWA; 590 mg/m3 TWA
Lithium diisopropylamide none listed none listed none listed
Ethylbenzene 100 ppm TWA; 125 ppm STEL 100 ppm TWA; 435 mg/m3 TWA 800 ppm IDLH (10% LEL) 100 ppm TWA; 435 mg/m3 TWA
Diisopropylamine 5 ppm TWA; Skin - potential significant contribution to overall exposure by the cutaneous r oute 5 ppm TWA; 20 mg/m3 TWA 200 ppm IDLH 5 ppm TWA; 20 mg/m3 TWA
Magnesium none listed none listed none listed

OSHA Vacated PELs: n-Heptane: 400 ppm TWA; 1600 mg/m3 TWA Tetrahydrofuran: 200 ppm TWA; 590 mg/m3 TWA Lithium diisopropylamide: No OSHA Vacated PELs are listed for this chemical. Ethylbenzene: 100 ppm TWA; 435 mg/m3 TWA Diisopropylamine: 5 ppm TWA; 20 mg/m3 TWA Magnesium: No OSHA Vacated PELs are listed for this chemical.
Personal Protective Equipment
Eyes: Wear chemical splash goggles.
Skin: Wear appropriate protective gloves to prevent skin exposure.
Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Section 9 - Physical and Chemical Properties


Physical State: Liquid
Appearance: red-orange
Odor: Pungent
pH: Not available.
Vapor Pressure: Not available.
Vapor Density: >1.0 (Air=1)
Evaporation Rate:>1.0 (Butyl Acetate=1)
Viscosity: Not available.
Boiling Point: 60 - 136 deg C @ 760 mm Hg
Freezing/Melting Point:Not available.
Decomposition Temperature:Not available.
Solubility: decomposes in water
Specific Gravity/Density:.7900g/cm3
Molecular Formula:C6H14LiN
Molecular Weight:107.12

Section 10 - Stability and Reactivity


Chemical Stability: Stable at room temperature in closed containers under normal storage and handling conditions. Combines vigorously with water with the evolution of heat. May form explosive peroxides.
Conditions to Avoid: Ignition sources, contact with water, excess heat, prolonged exposure to air.
Incompatibilities with Other Materials: Strong oxidizing agents, acids, alcohols.
Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, carbon dioxide, lithium hydroxide, amines, oxides of magnesium, oxides of lithium.
Hazardous Polymerization: Has not been reported.

Section 11 - Toxicological Information


RTECS#:      
CAS# 142-82-5: MI7700000      
CAS# 109-99-9: LU5950000      
CAS# 4111-54-0 unlisted.      
CAS# 100-41-4: DA0700000      
CAS# 108-18-9: IM4025000      
CAS# 7439-95-4: FW6475100
LD50/LC50:
CAS# 142-82-5:
     Inhalation, rat: LC50 = 103 gm/m3/4H;
.

CAS# 109-99-9:
     Inhalation, rat: LC50 = 21000 ppm/3H;
     Oral, rat: LD50 = 1650 mg/kg;
.

CAS# 4111-54-0:
.

CAS# 100-41-4:
     Draize test, rabbit, eye: 500 mg Severe;
     Inhalation, mouse: LC50 = 35500 mg/m3/2H;
     Inhalation, rat: LC50 = 55000 mg/m3/2H;
     Oral, rat: LD50 = 3500 mg/kg;
     Oral, rat: LD50 = 3500 mg/kg;
     Skin, rabbit: LD50 = 17800 uL/kg;
.

CAS# 108-18-9:
     Inhalation, mouse: LC50 = 4200 mg/m3/2H;
     Inhalation, rat: LC50 = 4800 mg/m3/2H;
     Oral, mouse: LD50 = 2120 mg/kg;
     Oral, rabbit: LD50 = 4700 mg/kg;
     Oral, rat: LD50 = 770 mg/kg;
     Skin, rabbit: LD50 = >10 gm/kg;
.

CAS# 7439-95-4:
.

Carcinogenicity:
CAS# 142-82-5: Not listed by ACGIH, IARC, NTP, or CA Prop 65.
CAS# 109-99-9:

CAS# 4111-54-0: Not listed by ACGIH, IARC, NTP, or CA Prop 65.
CAS# 100-41-4:
  • ACGIH: A3 - Confirmed Animal Carcinogen with Unknown Relevance to Humans
  • California: carcinogen, initial date 6/11/04
  • NTP: Not listed.
  • IARC: Group 2B carcinogen
CAS# 108-18-9: Not listed by ACGIH, IARC, NTP, or CA Prop 65.
CAS# 7439-95-4: Not listed by ACGIH, IARC, NTP, or CA Prop 65.

Epidemiology: No information available.
Teratogenicity: No information available.
Reproductive Effects: May cause reproductive effects based on animal studies.
Mutagenicity: No information available.
Neurotoxicity: No information available.
Other Studies:

Section 12 - Ecological Information


Ecotoxicity: No data available. Cas# 100-41-4:LC50(96Hr.) rainbow trout = 14.0 mg/L; Static Bioassay.LC50(96Hr.) fathead minnow= 12.1 mg/L; Flow-through Bioassay.LC50(96Hr.) Bluegill =- 150 mg/L; Static Bioassay.EC50(48Hr.)Water Flea = 2.1 mg/L; Static Bioassay.EC50(48Hr.)Water Flea = 2.1 mg/L; Static Bioassay.EC50(30 min.)Photobacterium phosphoreum = 9.68 mg/L; Microtox System.
Environmental: Tetrahydrofuran is expected to biodegrade under aerobic conditions but may be resistant to biodegradation in anaerobic environments.
Physical: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere, tetrahydrofuran, which has a vapor pressure of 162 mm Hg at 25 deg C, determined from experimentally-derived coefficients, will exist solely as a vapor in the ambient atmosphere. Vapor-phase tetrahydrofuran is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals and nitrate radicals; the half-lives for these reactions in air are estimated to be about 1 day and 3 days, respectively.
Other: No information available.

Section 13 - Disposal Considerations

Chemical waste generators must determine whether a discarded chemical is classified as a hazardous waste. US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3. Additionally, waste generators must consult state and local hazardous waste regulations to ensure complete and accurate classification.
RCRA P-Series: None listed.
RCRA U-Series:
CAS# 109-99-9: waste number U213 (Ignitable waste).

Section 14 - Transport Information

US DOT Canada TDG
Shipping Name: ORGANOMETALLIC SUBSTANCE, LIQUID, WATER-REACTIVE, FLAMMABLE WATER-REACTIVE SUBS SOLID FLAMMAB (LITHIUM DIISOPROPYLAMIDE)
Hazard Class: 4.3 4.3(4.1)
UN Number: UN3399 UN3132
Packing Group: I I

Section 15 - Regulatory Information

US FEDERAL
TSCA
     CAS# 142-82-5 is listed on the TSCA inventory.
     CAS# 109-99-9 is listed on the TSCA inventory.
     CAS# 4111-54-0 is listed on the TSCA inventory.
     CAS# 100-41-4 is listed on the TSCA inventory.
     CAS# 108-18-9 is listed on the TSCA inventory.
     CAS# 7439-95-4 is listed on the TSCA inventory.
Health & Safety Reporting List
     CAS# 100-41-4: Effective 6/19/87, Sunset 6/19/97
Chemical Test Rules
     CAS# 142-82-5: 40 CFR 799.5115      CAS# 109-99-9: 40 CFR 799.5000; 40 CFR 799.5115
Section 12b
     CAS# 142-82-5: Section 4, 1 % de minimus concentration      CAS# 109-99-9: Section 4, 1 % de minimus concentration
TSCA Significant New Use Rule
     None of the chemicals in this material have a SNUR under TSCA.
CERCLA Hazardous Substances and corresponding RQs
     CAS# 109-99-9: 1000 lb final RQ; 454 kg final RQ      CAS# 100-41-4: 1000 lb final RQ; 454 kg final RQ
SARA Section 302 Extremely Hazardous Substances
     None of the chemicals in this product have a TPQ.
SARA Codes
     CAS # 142-82-5: immediate, delayed, fire.
     CAS # 109-99-9: immediate, fire, reactive.
     CAS # 100-41-4: immediate, delayed, fire.
     CAS # 108-18-9: immediate, fire, sudden release of pressure.
     CAS # 7439-95-4: immediate, fire, reactive.
Section 313
     This material contains Ethylbenzene (CAS# 100-41-4, 13%),which is subject to the reporting requirements of Section 313 of SARA Title III and 40 CFR Part 373.
Clean Air Act:
     CAS# 100-41-4 is listed as a hazardous air pollutant (HAP).


     This material does not contain any Class 1 Ozone depletors.
     This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
CAS# 100-41-4 is listed as a Hazardous Substance under the CWA.      CAS# 100-41-4 is listed as a Priority Pollutant under the Clean Water      Act. CAS# 100-41-4 is listed as a Toxic Pollutant under the Clean Water Act.
OSHA:
     None of the chemicals in this product are considered highly hazardous by OSHA.
STATE
     CAS# 142-82-5 can be found on the following state right to know lists: California, New Jersey, Pennsylvania, Minnesota, Massachusetts.
     CAS# 109-99-9 can be found on the following state right to know lists: California, New Jersey, Pennsylvania, Minnesota, Massachusetts.
     CAS# 4111-54-0 is not present on state lists from CA, PA, MN, MA, FL, or NJ.
     CAS# 100-41-4 can be found on the following state right to know lists: California, New Jersey, Pennsylvania, Minnesota, Massachusetts.
     CAS# 108-18-9 can be found on the following state right to know lists: California, New Jersey, Pennsylvania, Minnesota, Massachusetts.
     CAS# 7439-95-4 can be found on the following state right to know lists: California, New Jersey, Pennsylvania, Massachusetts.

California Prop 65
WARNING: This product contains Ethylbenzene, a chemical known to the state of California to cause cancer.
California No Significant Risk Level: None of the chemicals in this product are listed.

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols:
     F C N
Risk Phrases:
     R 11 Highly flammable.
     R 19 May form explosive peroxides.
     R 34 Causes burns.
     R 50/53 Very toxic to aquatic organisms, may cause long-term
     adverse effects in the aquatic environment.
     R 65 Harmful: may cause lung damage if swallowed.

Safety Phrases:
     S 16 Keep away from sources of ignition - No smoking.
     S 26 In case of contact with eyes, rinse immediately with plenty of
     water and seek medical advice.
     S 36/37/39 Wear suitable protective clothing, gloves and eye/face pr
     otection.
     S 45 In case of accident or if you feel unwell, seek medical advice
     immediately (show the label where possible).
     S 60 This material and its container must be disposed of as hazardou
     s waste.
     S 61 Avoid release to the environment. Refer to special instructions
     /safety data sheets.

WGK (Water Danger/Protection)
     CAS# 142-82-5: 1
     CAS# 109-99-9: 1
     CAS# 4111-54-0: No information available.
     CAS# 100-41-4: 1
     CAS# 108-18-9: 2
     CAS# 7439-95-4: No information available.
Canada - DSL/NDSL
     CAS# 142-82-5 is listed on Canada's DSL List.
     CAS# 109-99-9 is listed on Canada's DSL List.
     CAS# 4111-54-0 is listed on Canada's DSL List.
     CAS# 100-41-4 is listed on Canada's DSL List.
     CAS# 108-18-9 is listed on Canada's DSL List.
     CAS# 7439-95-4 is listed on Canada's DSL List.
Canada - WHMIS
     This product has a WHMIS classification of B2, E.
This product has been classified in accordance with the hazard criteria of the Controlled Products Regulations and the MSDS contains all of the information required by those regulations.
Canadian Ingredient Disclosure List
     CAS# 142-82-5 is listed on the Canadian Ingredient Disclosure List.
     CAS# 109-99-9 is listed on the Canadian Ingredient Disclosure List.
     CAS# 100-41-4 is listed on the Canadian Ingredient Disclosure List.
     CAS# 108-18-9 is listed on the Canadian Ingredient Disclosure List.

Section 16 - Additional Information

MSDS Creation Date: 6/24/1999
Revision #5 Date: 11/20/2008

The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no event shall Fisher be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if Fisher has been advised of the possibility of such damages.