Material Safety Data Sheet
Phenyllithium, 2M solution in cyclohexane- ether, 70 to 30

ACC# 88645
Section 1 - Chemical Product and Company Identification
MSDS Name: Phenyllithium, 2M solution in cyclohexane- ether, 70 to 30
Catalog Numbers: AC205680000, AC205680500, AC205681000, AC205685000
Company Identification:

              Acros Organics N.V.
              One Reagent Lane
              Fair Lawn, NJ 07410
For information in North America, call: 800-ACROS-01
For emergencies in the US, call CHEMTREC: 800-424-9300

Section 2 - Composition, Information on Ingredients

CAS# Chemical Name Percent EINECS/ELINCS
110-82-7 Cyclohexane 58 203-806-2
60-29-7 Ethyl ether 25 200-467-2
591-51-5 Phenyllithium 17 209-720-1

Section 3 - Hazards Identification


Appearance: red-brown liquid. Flash Point: -17 deg C.
Danger! Causes eye and skin burns. Produces flammable gases on contact with water. Reacts violently and/or explosively with water, steam or moisture. Extremely flammable liquid and vapor. Vapor may cause flash fire. Causes digestive and respiratory tract burns. May ignite or explode on contact with moist air.
Target Organs: Respiratory system, gastrointestinal system, eyes, skin.

Potential Health Effects
Eye: Causes eye burns.
Skin: Causes skin burns.
Ingestion: Causes gastrointestinal tract burns.
Inhalation: Causes chemical burns to the respiratory tract. Vapors may cause dizziness or suffocation.
Chronic: Chronic exposure to benzene has been associated with an increased incidence of leukemia and multiple myeloma (tumor composed of cells of the type normally found in the bone marrow). Immunodepressive effects have been reported.

Section 4 - First Aid Measures

Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately. Do NOT allow victim to rub eyes or keep eyes closed. Extensive irrigation with water is required (at least 30 minutes).
Skin: Get medical aid immediately. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Destroy contaminated shoes.
Ingestion: Do not induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
Inhalation: Get medical aid immediately. Remove from exposure and move to fresh air immediately. If breathing is difficult, give oxygen. Do NOT use mouth-to-mouth resuscitation. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.
Notes to Physician: Treat symptomatically and supportively.

Section 5 - Fire Fighting Measures

General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Vapors may form an explosive mixture with air. Vapors can travel to a source of ignition and flash back. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Water reactive. Material will react with water and may release a flammable and/or toxic gas. Use water spray to keep fire-exposed containers cool. Extremely flammable liquid and vapor. Containers may explode in the heat of a fire. May ignite or explode on contact with steam or moist air. Will be easily ignited by heat, sparks or flame.
Extinguishing Media: Use dry sand or earth to smother fire. For small fires, use dry chemical, carbon dioxide, water spray or alcohol-resistant foam. For large fires, use water spray, fog, or alcohol-resistant foam. Do NOT use water directly on fire. Use water spray to cool fire-exposed containers. Water may be ineffective. Do NOT use carbon dioxide. DO NOT USE WATER! Do NOT use straight streams of water. Contact professional fire-fighters immediately.
Flash Point: -17 deg C ( 1.40 deg F)
Autoignition Temperature: Not available.
Explosion Limits, Lower:Not available.
Upper: Not available.
NFPA Rating: (estimated) Health: 3; Flammability: 4; Instability: 2; Special Hazard: -W-

Section 6 - Accidental Release Measures

General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks: Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, observing precautions in the Protective Equipment section. Remove all sources of ignition. Use a spark-proof tool. Provide ventilation. Do not expose spill to water. A vapor suppressing foam may be used to reduce vapors.

Section 7 - Handling and Storage

Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Do not allow water to get into the container because of violent reaction. Ground and bond containers when transferring material. Do not get in eyes, on skin, or on clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Keep away from heat, sparks and flame. Do not ingest or inhale. Use with adequate ventilation. Do not allow contact with water. Discard contaminated shoes. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames. Keep from contact with moist air and steam.
Storage: Keep away from water. Refrigerator/flammables. Keep containers tightly closed.

Section 8 - Exposure Controls, Personal Protection

Engineering Controls: Use explosion-proof ventilation equipment. Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits
Chemical Name ACGIH NIOSH OSHA - Final PELs
Cyclohexane 100 ppm TWA 300 ppm TWA; 1050 mg/m3 TWA 1300 ppm IDLH (10% LEL) 300 ppm TWA; 1050 mg/m3 TWA
Ethyl ether 400 ppm TWA; 500 ppm STEL 1900 ppm IDLH (10% LEL) 400 ppm TWA; 1200 mg/m3 TWA
Phenyllithium none listed none listed none listed

OSHA Vacated PELs: Cyclohexane: 300 ppm TWA; 1050 mg/m3 TWA Ethyl ether: 400 ppm TWA; 1200 mg/m3 TWA Phenyllithium: No OSHA Vacated PELs are listed for this chemical.
Personal Protective Equipment
Eyes: Wear chemical splash goggles and face shield.
Skin: Wear appropriate protective gloves to prevent skin exposure.
Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators: A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.

Section 9 - Physical and Chemical Properties

Physical State: Liquid
Appearance: red-brown
Odor: None reported.
pH: Not available.
Vapor Pressure: Not available.
Vapor Density: 2.90
Evaporation Rate:Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point:Not available.
Decomposition Temperature:Not available.
Solubility: Reacts.
Specific Gravity/Density:.7300g/cm3
Molecular Formula:C6H5Li
Molecular Weight:84.05

Section 10 - Stability and Reactivity

Chemical Stability: Stable under normal temperatures and pressures. Combines vigorously or explosively with water.
Conditions to Avoid: Ignition sources, excess heat, exposure to moist air or water.
Incompatibilities with Other Materials: Water, oxidizing agents, acids, alcohols, oxygen, air.
Hazardous Decomposition Products: Carbon monoxide, carbon monoxide, carbon dioxide, lithium hydroxide, benzene, lithium oxide.
Hazardous Polymerization: Has not been reported.

Section 11 - Toxicological Information

CAS# 110-82-7: GU6300000      
CAS# 60-29-7: KI5775000      
CAS# 591-51-5 unlisted.
CAS# 110-82-7:
     Draize test, rabbit, skin: 1548 mg/2D (Intermittent);
     Inhalation, mouse: LC50 = 70000 mg/m3/2H;
     Oral, mouse: LD50 = 813 mg/kg;
     Oral, rat: LD50 = 12705 mg/kg;

CAS# 60-29-7:
     Draize test, rabbit, eye: 100 mg Moderate;
     Inhalation, mouse: LC50 = 31000 ppm/30M;
     Oral, mouse: LD50 = 1760 mg/kg;
     Oral, rat: LD50 = 1215 mg/kg;
     Skin, rabbit: LD50 = >20 mL/kg;

CAS# 591-51-5:

CAS# 110-82-7: Not listed by ACGIH, IARC, NTP, or CA Prop 65.
CAS# 60-29-7: Not listed by ACGIH, IARC, NTP, or CA Prop 65.
CAS# 591-51-5: Not listed by ACGIH, IARC, NTP, or CA Prop 65.

Epidemiology: No information found.
Teratogenicity: No information found.
Reproductive Effects: No information found.
Mutagenicity: No information found.
Neurotoxicity: No information found.
Other Studies:

Section 12 - Ecological Information

No information available.

Section 13 - Disposal Considerations

Chemical waste generators must determine whether a discarded chemical is classified as a hazardous waste. US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3. Additionally, waste generators must consult state and local hazardous waste regulations to ensure complete and accurate classification.
RCRA P-Series: None listed.
RCRA U-Series:
CAS# 110-82-7: waste number U056 (Ignitable waste).
CAS# 60-29-7: waste number U117 (Ignitable waste).

Section 14 - Transport Information

Hazard Class: 4.2 4.2(4.3)
UN Number: UN2445 UN2445
Packing Group: I I

Section 15 - Regulatory Information


     CAS# 110-82-7 is listed on the TSCA inventory.
     CAS# 60-29-7 is listed on the TSCA inventory.
     CAS# 591-51-5 is listed on the TSCA inventory.
Health & Safety Reporting List
     CAS# 110-82-7: Effective 12/19/85, Sunset 12/19/95
Chemical Test Rules
     CAS# 110-82-7: 40 CFR 799.5000
Section 12b
     None of the chemicals are listed under TSCA Section 12b.
TSCA Significant New Use Rule
     None of the chemicals in this material have a SNUR under TSCA.
CERCLA Hazardous Substances and corresponding RQs
     CAS# 110-82-7: 1000 lb final RQ; 454 kg final RQ      CAS# 60-29-7: 100 lb final RQ; 45.4 kg final RQ
SARA Section 302 Extremely Hazardous Substances
     None of the chemicals in this product have a TPQ.
SARA Codes
     CAS # 110-82-7: immediate, delayed, fire.
     CAS # 60-29-7: immediate, fire, sudden release of pressure, reactive.
Section 313
     This material contains Cyclohexane (CAS# 110-82-7, 58%),which is subject to the reporting requirements of Section 313 of SARA Title III and 40 CFR Part 373.
Clean Air Act:
     This material does not contain any hazardous air pollutants.
     This material does not contain any Class 1 Ozone depletors.
     This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
CAS# 110-82-7 is listed as a Hazardous Substance under the CWA.
     None of the chemicals in this product are listed as Priority Pollutants under the CWA.
     None of the chemicals in this product are listed as Toxic Pollutants under the CWA.
     None of the chemicals in this product are considered highly hazardous by OSHA.
     CAS# 110-82-7 can be found on the following state right to know lists: California, New Jersey, Pennsylvania, Minnesota, Massachusetts.
     CAS# 60-29-7 can be found on the following state right to know lists: California, New Jersey, Pennsylvania, Minnesota, Massachusetts.
     CAS# 591-51-5 is not present on state lists from CA, PA, MN, MA, FL, or NJ.

California Prop 65

California No Significant Risk Level: None of the chemicals in this product are listed.

European/International Regulations

European Labeling in Accordance with EC Directives
Hazard Symbols:
     F+ C
Risk Phrases:

     R 12 Extremely flammable.
     R 15 Contact with water liberates extremely flammable gases.
     R 17 Spontaneously flammable in air.
     R 19 May form explosive peroxides.
     R 34 Causes burns.

Safety Phrases:

     S 16 Keep away from sources of ignition - No smoking.
     S 25 Avoid contact with eyes.
     S 29 Do not empty into drains.
     S 33 Take precautionary measures against static discharges.
     S 45 In case of accident or if you feel unwell, seek medical advice
     immediately (show the label where possible).
     S 9 Keep container in a well-ventilated place.

WGK (Water Danger/Protection)

     CAS# 110-82-7: 1
     CAS# 60-29-7: 1
     CAS# 591-51-5: No information available.
Canada - DSL/NDSL
     CAS# 110-82-7 is listed on Canada's DSL List.
     CAS# 60-29-7 is listed on Canada's DSL List.
     CAS# 591-51-5 is listed on Canada's NDSL List.
Canada - WHMIS
     This product has a WHMIS classification of B6, B2, E.
This product has been classified in accordance with the hazard criteria of the Controlled Products Regulations and the MSDS contains all of the information required by those regulations.
Canadian Ingredient Disclosure List
     CAS# 110-82-7 is listed on the Canadian Ingredient Disclosure List.
     CAS# 60-29-7 is listed on the Canadian Ingredient Disclosure List.

Section 16 - Additional Information

MSDS Creation Date: 11/30/1998
Revision #4 Date: 11/20/2008

The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no event shall Fisher be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if Fisher has been advised of the possibility of such damages.