Material Safety Data Sheet
Isopropanol, USP, 10%
ACC# 91551
Section 1 - Chemical Product and Company Identification |
MSDS Name: Isopropanol, USP, 10%
Catalog Numbers:
A460-1GAL
Synonyms:
Isopropanol; Dimethylcarbinol; sec-Propyl alcohol; Rubbing alcohol;
Petrohol; 1-Methylethanol; 1-Methylethyl alcohol; 2-Hydroxypropane;
2-Propyl alcohol; Isopropyl alcohol; Propan-2-ol.
Company Identification:
Fisher Scientific
1 Reagent Lane
Fair Lawn, NJ 07410
For information, call: 201-796-7100
Emergency Number: 201-796-7100
For CHEMTREC assistance, call: 800-424-9300
For International CHEMTREC assistance, call: 703-527-3887
Section 2 - Composition, Information on Ingredients
|
CAS# |
Chemical Name |
Percent |
EINECS/ELINCS |
7732-18-5 |
Water |
90 | 231-791-2 |
67-63-0 |
Isopropyl alcohol |
10 | 200-661-7 |
Section 3 - Hazards Identification
|
EMERGENCY OVERVIEW
Appearance: colorless liquid. Flash Point: 41 deg C.
Warning! Flammable liquid and
vapor. May cause severe eye irritation and possible
injury. Causes respiratory tract irritation. Causes mild skin
irritation. Aspiration hazard if swallowed. Can enter lungs and
cause damage. May cause central nervous system depression. May form
explosive peroxides. May cause kidney damage. This substance has
caused adverse reproductive and fetal effects in animals.
Target Organs: Kidneys, central nervous system,
respiratory system, cardiovascular system, eyes, skin.
Potential Health Effects
Eye:
Produces irritation, characterized by a burning sensation, redness,
tearing, inflammation, and possible corneal injury. May cause
transient corneal injury.
Skin:
May cause irritation with pain and stinging, especially if the skin
is abraded. Isopropanol has a low potential to cause allergic skin
reactions; however, rare cases of allergic contact dermatitis have
been reported. May be absorbed through intact skin.
Ingestion:
Causes gastrointestinal irritation with nausea, vomiting and
diarrhea. May cause kidney damage. May cause central nervous system
depression, characterized by excitement, followed by headache,
dizziness, drowsiness, and nausea. Advanced stages may cause
collapse, unconsciousness, coma and possible death due to
respiratory failure. Aspiration of material into the lungs may cause
chemical pneumonitis, which may be fatal.
Inhalation:
Inhalation of high concentrations may cause central nervous system
effects characterized by nausea, headache, dizziness, unconsciousness
and coma. May cause narcotic effects in high concentration. Causes
upper respiratory tract irritation. Inhalation of vapors may cause
drowsiness and dizziness.
Chronic:
Prolonged or repeated skin contact may cause defatting and
dermatitis. May cause reproductive and fetal effects. Laboratory
experiments have resulted in mutagenic effects.
Section 4 - First Aid Measures
|
Eyes:
In case of contact, immediately flush eyes with plenty of water for a
t least 15 minutes. Get medical aid.
Skin:
In case of contact, flush skin with plenty of water. Remove
contaminated clothing and shoes. Get medical aid if irritation
develops and persists. Wash clothing before reuse.
Ingestion:
Potential for aspiration if swallowed. Get medical aid immediately.
Do not induce vomiting unless directed to do so by medical
personnel. Never give anything by mouth to an unconscious person. If
vomiting occurs naturally, have victim lean forward.
Inhalation:
If inhaled, remove to fresh air. If not breathing, give artificial
respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
Urine acetone test may be helpful in diagnosis. Hemodialysis should
be considered in severe intoxication. Treat symptomatically and
supportively.
Section 5 - Fire Fighting Measures
|
General Information:
As in any fire, wear a self-contained breathing apparatus in
pressure-demand, MSHA/NIOSH (approved or equivalent), and full
protective gear. Vapors may form an explosive mixture with air.
Vapors can travel to a source of ignition and flash back. Will burn
if involved in a fire. Use water spray to keep fire-exposed
containers cool. Containers may explode in the heat of a fire.
Flammable liquid and vapor. May form explosive peroxides. Vapors may
be heavier than air. They can spread along the ground and collect
in low or confined areas.
Extinguishing Media:
Water may be ineffective. Do NOT use straight streams of water. For
large fires, use dry chemical, carbon dioxide, alcohol-resistant
foam, or water spray. For small fires, use carbon dioxide, dry
chemical, dry sand, or alcohol-resistant foam. Cool containers with
flooding quantities of water until well after fire is out.
Flash Point: 41 deg C ( 105.80 deg F)
Autoignition Temperature: 399 deg C ( 750.20 deg F)
Explosion Limits, Lower:2.0 vol %
Upper: 12.7 @ 93.3°C
NFPA Rating:
(estimated) Health: 1; Flammability: 2; Instability: 0
Section 6 - Accidental Release Measures
|
General Information: Use proper personal protective equipment as indicated
in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth),
then place in suitable container. Clean up spills immediately,
observing precautions in the Protective Equipment section. Remove all
sources of ignition. Use a spark-proof tool. Provide ventilation. A
vapor suppressing foam may be used to reduce vapors.
Section 7 - Handling and Storage
|
Handling:
Wash thoroughly after handling. Remove contaminated clothing and
wash before reuse. Ground and bond containers when transferring
material. Use spark-proof tools and explosion proof equipment. Loosen
closure cautiously before opening. Contents may develop pressure upon
prolonged storage. Avoid contact with eyes, skin, and clothing. Empty
containers retain product residue, (liquid and/or vapor), and can be
dangerous. Take precautionary measures against static discharges.
Keep container tightly closed. Do not ingest or inhale. Use only in
a chemical fume hood. Do not pressurize, cut, weld, braze, solder,
drill, grind, or expose empty containers to heat, sparks or open
flames. Use only with adequate ventilation. Avoid breathing vapor or
mist.
Storage:
Keep away from heat, sparks, and flame. Keep away from sources of
ignition. Do not store in direct sunlight. Store in a tightly closed
container. Keep from contact with oxidizing materials. Store in a
cool, dry, well-ventilated area away from incompatible substances.
Flammables-area. After opening, purge container with nitrogen before
reclosing. Periodically test for peroxide formation on long-term
storage. Addition of water or appropriate reducing materials will
lessen peroxide formation. Store protected from moisture.
Section 8 - Exposure Controls, Personal Protection
|
Engineering Controls:
Use explosion-proof ventilation equipment. Facilities storing or
utilizing this material should be equipped with an eyewash facility
and a safety shower. Use only under a chemical fume hood.
Exposure Limits
Chemical Name |
ACGIH |
NIOSH |
OSHA - Final PELs |
Water
|
none listed
|
none listed
|
none listed
|
Isopropyl alcohol
|
200 ppm TWA; 400 ppm STEL
|
400 ppm TWA; 980 mg/m3 TWA 2000 ppm IDLH
|
400 ppm TWA; 980 mg/m3 TWA
|
OSHA Vacated PELs:
Water:
No OSHA Vacated PELs are listed for this chemical.
Isopropyl alcohol:
400 ppm TWA; 980 mg/m3 TWA
Personal Protective Equipment
Eyes:
Wear chemical splash goggles.
Skin:
Wear appropriate protective gloves to prevent skin
exposure.
Clothing:
Wear appropriate protective clothing to prevent skin
exposure.
Respirators:
A respiratory protection program that meets OSHA's 29
CFR 1910.134 and ANSI Z88.2 requirements or European
Standard EN 149 must be followed whenever workplace
conditions warrant respirator use.
Section 9 - Physical and Chemical Properties
|
Physical State: Liquid
Appearance: colorless
Odor: alcohol-like
pH: Not available.
Vapor Pressure: 33 mm Hg @ 20 deg C
Vapor Density: 2.1 (Air=1)
Evaporation Rate:2.3 (n-butyl acetate=1)
Viscosity: 2.27 mPas @ 20C
Boiling Point: 82 deg C @ 760 mmHg
Freezing/Melting Point:-88 deg C
Decomposition Temperature:Not available.
Solubility: Miscible.
Specific Gravity/Density:0.7850 (water=1)
Molecular Formula:C3H8O
Molecular Weight:60.09
Section 10 - Stability and Reactivity
|
Chemical Stability:
Stable at room temperature in closed containers under normal storage
and handling conditions. Distillation may lead to the formation of
peroxides. This material may be sensitive to peroxide formation.
Conditions to Avoid:
Ignition sources, excess heat.
Incompatibilities with Other Materials:
Strong oxidizing agents, acids.
Hazardous Decomposition Products:
Carbon monoxide, irritating and toxic fumes and gases, carbon
dioxide.
Hazardous Polymerization: Will not occur.
Section 11 - Toxicological Information
|
RTECS#:
CAS# 7732-18-5:
ZC0110000
CAS# 67-63-0:
NT8050000
LD50/LC50:
CAS# 7732-18-5:
Oral, rat: LD50 =
>90 mL/kg;
.
CAS# 67-63-0:
Draize test,
rabbit, eye: 100 mg Severe;
Draize
test, rabbit, eye: 10 mg Moderate;
Draize test, rabbit, eye: 100 mg/24H
Moderate;
Draize test, rabbit,
skin: 500 mg Mild;
Inhalation,
mouse: LC50 = 53000 mg/m3;
Inhalation, rat: LC50 = 16000
ppm/8H;
Inhalation, rat: LC50 =
72600 mg/m3;
Oral, mouse: LD50 =
3600 mg/kg;
Oral, mouse: LD50 =
3600 mg/kg;
Oral, rabbit: LD50 =
6410 mg/kg;
Oral, rat: LD50 = 5045
mg/kg;
Oral, rat: LD50 = 5000
mg/kg;
Skin, rabbit: LD50 = 12800
Carcinogenicity:
CAS# 7732-18-5:
Not listed by ACGIH, IARC, NTP, or CA Prop 65.
CAS# 67-63-0:
Not listed by ACGIH, IARC, NTP, or CA Prop 65.
Epidemiology:
Experimental teratogenic and reproductive effects have been
reported for isopropanol.Early epidemiological studies have
suggested an association between the strong acid
manufacture of isopropyl alcohol and paranasal sinus
cancer in workers.
Teratogenicity:
Oral, rat: TDLo = 8 gm/kg (female 6-15 day(s) after
conception) Effects on Embryo or Fetus - fetotoxicity.;
Oral, rat: TDLo = 32400 ug/kg (female 26 week(s)
pre-mating) Effects on Embryo or Fetus - fetal death.;
Inhalation, rat: TCLo = 7000 ppm/7H (female 1-19 day(s)
after conception) Specific Developmental Abnormalities -
musculoskeletal system.
Reproductive Effects:
Oral, rat: TDLo = 11340 mg/kg (female 45 day(s) pre-mating)
Maternal Effects - menstrual cycle changes or disorders.;
Oral, rat: TDLo = 5040 mg/kg (female 1-20 day(s) after
conception) Fertility - litter size (e.g. # fetuses per
litter; measured before birth).
Mutagenicity:
Cytogenetic analysis: Inhalation, rat = 1030 ug/m3/16W
(Intermittent).
Neurotoxicity:
In rats exposed to isopropanol by inhalation, acute
neurotoxicity was noted at 1 and 6 hours at 5000 ppm, but
only minimal effects were seen at 1500 ppm and the animals
recovered within 5 hours. No toxicity was noted at 500
ppm.
Other Studies:
Section 12 - Ecological Information
|
Ecotoxicity:
Fish: Goldfish: > 5000 mg/L; 24 Hr; Modified ASTM D 1345
bioassayFish: Fathead Minnow: 11,830 mg/L; 1 Hr; Static
bioassay
No data available.
Environmental:
2-Propanol is not expected to adsorb to sediment or bioconcentrate in
fish. In the atmosphere, it will photodegrade primarily by the
reaction with hydroxyl radicals with a half-life of one to several
days. Due to its solubility in water, rainout may be significant.
2-Propanol is expected to evaporate quickly from the soil surface and
leach into the ground. It is predicted to volatilize in aquatic
environments with a half-life of 5.4 days and may biodegrade.
Physical:
Log P(oct) = .05 @ 25°C
Other:
Dangerous to aquatic life in high concentrations.
Section 13 - Disposal Considerations
|
Chemical waste generators must determine whether a discarded chemical is classified
as a hazardous waste.
US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3.
Additionally, waste generators must consult state and local hazardous waste regulations to
ensure complete and accurate classification.
RCRA P-Series: None listed.
RCRA U-Series: None listed.
Section 14 - Transport Information
|
|
US DOT |
Canada TDG |
Shipping Name: |
NOT REGULATED FOR DOMESTIC TRANSPORT |
No information available. |
Hazard Class: |
XCP |
|
UN Number: |
|
|
Packing Group: |
|
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Section 15 - Regulatory Information
|
US FEDERAL
TSCA
CAS# 7732-18-5 is listed on the TSCA inventory.
CAS# 67-63-0 is listed on the TSCA inventory.
Health & Safety Reporting List
CAS# 67-63-0: Effective 12/15/86, Sunset 12/15/96
Chemical Test Rules
CAS# 67-63-0: 40 CFR 799.2325
Section 12b
None of the chemicals are listed under TSCA Section 12b.
TSCA Significant New Use Rule
None of the chemicals in this material have a SNUR under TSCA.
CERCLA Hazardous Substances and corresponding RQs
None of the chemicals in this material have an RQ.
SARA Section 302 Extremely Hazardous Substances
None of the chemicals in this product have a TPQ.
SARA Codes
CAS # 67-63-0: immediate, delayed, fire.
Section 313
This material contains Isopropyl
alcohol (CAS# 67-63-0, 10%),which is subject to the reporting
requirements of Section 313 of SARA Title III and 40 CFR Part 373.
Clean Air Act:
This material does not contain any hazardous air pollutants.
This material does not contain any Class 1 Ozone depletors.
This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
None of the chemicals in this product
are listed as Hazardous Substances under the CWA.
None of the chemicals in this
product are listed as Priority Pollutants under the CWA.
None of the chemicals in this
product are listed as Toxic Pollutants under the CWA.
OSHA:
None of the chemicals in this product
are considered highly hazardous by OSHA.
STATE
CAS# 7732-18-5 is not present on
state lists from CA, PA, MN, MA, FL, or NJ.
CAS# 67-63-0 can be found on the
following state right to know lists: California, New Jersey,
Pennsylvania, Minnesota, Massachusetts.
California Prop 65
California No Significant Risk Level:
None of the chemicals in this product are listed.
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols:
XI
Risk Phrases:
R 10 Flammable.
R 36 Irritating to eyes.
R 67 Vapours may cause drowsiness and dizziness.
Safety Phrases:
S 16 Keep away from sources of ignition - No smoking.
S 24/25 Avoid contact with skin and eyes.
S 26 In case of contact with eyes, rinse immediately with plenty of
water and seek medical advice.
S 7 Keep container tightly closed.
WGK (Water Danger/Protection)
CAS# 7732-18-5: No information available.
CAS# 67-63-0: 1
Canada - DSL/NDSL
CAS# 7732-18-5 is listed on Canada's DSL List.
CAS# 67-63-0 is listed on Canada's DSL List.
Canada - WHMIS
This product has a WHMIS classification of D2B, B3.
This product has been classified in accordance with the hazard
criteria of the Controlled Products Regulations and the MSDS
contains all of the information required by those regulations.
Canadian Ingredient Disclosure List
CAS# 67-63-0 is listed on the Canadian Ingredient Disclosure List.
Section 16 - Additional Information
|
MSDS Creation Date: 5/17/2000
Revision #11 Date: 11/28/2007
The information above is believed to be accurate and represents the best
information currently available to us. However, we make no warranty of
merchantability or any other warranty, express or implied, with respect to
such information, and we assume no liability resulting from its use. Users
should make their own investigations to determine the suitability of the
information for their particular purposes. In no event shall Fisher be liable
for any claims, losses, or damages of any third party or for lost profits
or any special, indirect, incidental, consequential or exemplary
damages, howsoever arising, even if Fisher has been advised of
the possibility of such damages.