Material Safety Data Sheet
Section 1 - Chemical Product and Company Identification
MSDS Name: m-Xylene
AC180860000, AC180860010, AC180860025, AC180860100, AC180862500,
AC422660000, AC422665000, 61047-1000, AC18086N219, AC18086NB21, AC18086POPN,
BP2627100, O5078-1, O5079-4
1 Reagent Lane
Fair Lawn, NJ 07410
For information, call: 201-796-7100
Emergency Number: 201-796-7100
For CHEMTREC assistance, call: 800-424-9300
For International CHEMTREC assistance, call: 703-527-3887
Section 2 - Composition, Information on Ingredients
|| > 99 ||203-576-3
Section 3 - Hazards Identification
Appearance: clear, colorless liquid. Flash Point: 25 deg C.
Warning! Flammable liquid and
vapor. Causes eye, skin, and respiratory tract
irritation. Aspiration hazard if swallowed. Can enter lungs and cause
damage. May be harmful if absorbed through skin or if inhaled. May
cause central nervous system depression.
Target Organs: Central nervous system,
respiratory system, eyes, skin.
Potential Health Effects
Splashes of xylene in human eyes generally cause transient
The liquid is probably a mild irritant, based on animal information
for mixed xylene isomers.
May be harmful if absorbed through the skin. Xylene contact causes
defatting of the skin with irritation, dryness, and cracking.
Blistering may occur, particularly if exposure to concentrated xylene
is prolonged and the exposed area of skin is occluded.
Xylene liquid or vapor can be absorbed through the skin, but not as
readily as when inhaled or ingested. Skin absorption has been
reported to be slow and significant harmful effects are not expected
by this route. There is one case report of a person developing an
allergic skin reaction (contact urticaria) following exposure to
xylene (unspecified composition) vapor. The person subsequently
tested positive in a patch test. No information was provided
regarding previous history of allergies. No conclusions can be drawn
regarding the potential for xylene to produce allergic skin
reactions, based on this single case report.
Aspiration hazard. May cause irritation of the digestive tract. May
cause central nervous system depression, characterized by
excitement, followed by headache, dizziness, drowsiness, and nausea.
Advanced stages may cause collapse, unconsciousness, coma and
possible death due to respiratory failure. Aspiration of material
into the lungs may cause chemical pneumonitis, which may be fatal.
Causes respiratory tract irritation. Irritation may lead to chemical
pneumonitis and pulmonary edema. Odor thresholds ranging from 0.07 to
40 ppm have been reported for xylenes. Inhalation overexposure may
lead to central nervous system depression, producing effects such as
dizziness, headache, confusion, incoordination, nausea, weakness, and
loss of consciousness. Extreme exposures may cause other CNS effects
Reversible liver and kidney damage has been reported in cases of
severe xylene exposure. Industrial fatalities due to gross
inhalation exposure have been described.
Chronic exposure to xylene may cause defatting dermatitis,
reversible eye damage, dyspnea (labored breathing), confusion,
dizziness, apprehension, memory loss, headache, tremors, weakness,
anorexia, nausea, ringing in the ears, irritability, thirst, mild
changes in liver function, kidney impairment, anemia, and
hyperplasia, but not destruction, of the bone marrow.
Section 4 - First Aid Measures
In case of contact, immediately flush eyes with plenty of water for a
t least 15 minutes. Get medical aid.
In case of contact, flush skin with plenty of water. Remove
contaminated clothing and shoes. Get medical aid if irritation
develops and persists. Wash clothing before reuse.
Potential for aspiration if swallowed. Get medical aid immediately.
Do not induce vomiting unless directed to do so by medical
personnel. Never give anything by mouth to an unconscious person. If
vomiting occurs naturally, have victim lean forward.
If inhaled, remove to fresh air. If not breathing, give artificial
respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
Treat symptomatically and supportively.
Section 5 - Fire Fighting Measures
As in any fire, wear a self-contained breathing apparatus in
pressure-demand, MSHA/NIOSH (approved or equivalent), and full
protective gear. Use water spray to keep fire-exposed containers
cool. Flammable liquid and vapor. Vapors may form an explosive
mixture with air. Vapors are heavier than air and may travel to a
source of ignition and flash back. Vapors can spread along the
ground and collect in low or confined areas. This liquid floats on
water and may travel to a source of ignition and spread fire. May
accumulate static electricity.
Water may be ineffective. This material is lighter than water and
insoluble in water. The fire could easily be spread by the use of
water in an area where the water cannot be contained. Use water
spray, dry chemical, carbon dioxide, or appropriate foam.
Flash Point: 25 deg C ( 77.00 deg F)
Autoignition Temperature: 527 deg C ( 980.60 deg F)
Explosion Limits, Lower:1.1%
(estimated) Health: 2; Flammability: 3; Instability: 0
Section 6 - Accidental Release Measures
General Information: Use proper personal protective equipment as indicated
in Section 8.
Absorb spill with inert material (e.g. vermiculite, sand or earth),
then place in suitable container. Remove all sources of ignition.
Use a spark-proof tool. Provide ventilation. A vapor suppressing
foam may be used to reduce vapors. Water spray may reduce vapor but
may not prevent ignition in closed spaces. U.S. regulations require
reporting spills and releases to soil, water and air in excess of
reportable quantities. This material creates a fire hazard because it
floats on water. If possible, try to contain floating material.
Section 7 - Handling and Storage
Wash thoroughly after handling. Remove contaminated clothing and
wash before reuse. Ground and bond containers when transferring
material. Avoid contact with eyes, skin, and clothing. Empty
containers retain product residue, (liquid and/or vapor), and can be
dangerous. Do not pressurize, cut, weld, braze, solder, drill, grind,
or expose empty containers to heat, sparks or open flames. Use only
with adequate ventilation. Keep away from heat, sparks and flame.
Avoid breathing vapor or mist.
Keep away from sources of ignition. Keep container closed when not
in use. Keep from contact with oxidizing materials. Store in a cool,
dry, well-ventilated area away from incompatible substances.
Section 8 - Exposure Controls, Personal Protection
Facilities storing or utilizing this material should be equipped
with an eyewash facility and a safety shower. Use adequate general or
local exhaust ventilation to keep airborne concentrations below the
permissible exposure limits. Ventilation fans and other electrical
service must be non-sparking and have an explosion-proof design.
||OSHA - Final PELs|
100 ppm TWA; 150 ppm STEL
100 ppm TWA; 435 mg/m3 TWA 900 ppm IDLH
100 ppm TWA; 435 mg/m3 TWA (listed under Xylenes (o-, m-, p- isomers)).
OSHA Vacated PELs:
No OSHA Vacated PELs are listed for this chemical.
Personal Protective Equipment
Wear chemical splash goggles.
Wear appropriate protective gloves to prevent skin
Wear appropriate protective clothing to prevent skin
Follow the OSHA respirator regulations found in 29
CFR 1910.134 or European Standard EN 149. Use a
NIOSH/MSHA or European Standard EN 149 approved
respirator if exposure limits are exceeded or if
irritation or other symptoms are experienced.
Section 9 - Physical and Chemical Properties
Physical State: Liquid
Appearance: clear, colorless
Odor: aromatic odor
pH: Not applicable.
Vapor Pressure: 8.29 mm Hg @ 25 deg C
Vapor Density: 3.66 (air=1)
Evaporation Rate:0.7 (butyl acetate=1)
Viscosity: <32.6 SUS
Boiling Point: 139 deg C
Freezing/Melting Point:-48 deg C
Decomposition Temperature:Not available.
Specific Gravity/Density:0.86 (water=1)
Section 10 - Stability and Reactivity
Stable under normal temperatures and pressures.
Conditions to Avoid:
High temperatures, ignition sources.
Incompatibilities with Other Materials:
Strong oxidizing agents, nitric acid.
Hazardous Decomposition Products:
Carbon monoxide, carbon dioxide.
Hazardous Polymerization: Will not occur.
Section 11 - Toxicological Information
rabbit, eye: 5 mg/24H Severe;
Draize test, rabbit, skin: 20 mg/24H
Inhalation, mouse: LC50 =
Oral, rat: LD50 = 4988
Skin, rabbit: LD50 = 14100
Not listed by ACGIH, IARC, NTP, or CA Prop 65.
175 workers were exposed to 21 ppm of xylene for 7 years.
Subjective symptoms such as anxiety, forgetfulness,
inability to concentrate and dizziness were reported.
Xylenes accounted for >70% of the total exposure. Liver &
kidney effects were not reported
No increased incidence of birth defects was reported in a
study of lab workers exposed to xylene during early
pregnancy. Exposure to other solvents and chemicals also
occurred. An increased incidence of spontaneous abortions
was reported.Animal information suggests that xylene is
not teratogenic or embryotoxic at exposure levels that are
not harmful to the mother.
An increase in menstrual disorders has been reported in
women exposed to organic solvents such as benzene, toluene,
and xylenes. It is not possible to attribute these effects
to xylenes in particular.
Xylene does not appear to be a mutagen.
Xylene may be ototoxic (damages hearing or enhances
sensitivity to noise) in chronic occupational exposures,
probably from a neurotoxic mechanism.
Section 12 - Ecological Information
Fish: Rainbow trout: LC50 = 13.5 mg/L; 96 Hr; UnspecifiedFish:
Goldfish: LD50 = 13 mg/L; 24 Hr; UnspecifiedFish: Fathead
Minnow: LC50 = 46 mg/L; 1 Hr; Static bioassay
Acute and long-term toxicity to fish and invertebrates: LD50 for
goldfish is 13 mg/L/24 Hr.Cas#1330-20-7:LC50(96Hr.) rainbow trout =
8.05 mg/L, Static condition;LC50(96Hr.) fathead minnow = 16.1 mg/L,
flow-through conditions; LC50(96Hr.) bluegill = 16.1 mg/L,
flow-through;EC50 (48 Hr.) water flea = 3.82 mg/L, flow-through
conditions;EC50(24 Hr.) photobacterium phosphoreum = 0.0084 mg/L,
In air, xylenes degrade by reacting with photochemically produced
hydroxyl radicals. In soil it will volatilize and leach into
groundwater. Little bioconcentration is expected.
ATMOSPHERIC FATE: According to a model of gas/particle partitioning
of semivolatile organic compounds in the atmosphere, xylene, which
has an experimental vapor pressure of 7.99 mm Hg at 25 deg C, will
exist solely as a vapor in the ambient atmosphere. Vapor-phase xylene
is degraded in the atmosphere by reaction with
photochemically-produced hydroxyl radicals; the atmospheric lifetime
of xylene is about 14-26 hours. Ambient levels of xylene are detected
in the atmosphere due to large emissions of this compound.
No information available.
Section 13 - Disposal Considerations
Chemical waste generators must determine whether a discarded chemical is classified
as a hazardous waste.
US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3.
Additionally, waste generators must consult state and local hazardous waste regulations to
ensure complete and accurate classification.
RCRA P-Series: None listed.
RCRA U-Series: None listed.
Section 14 - Transport Information
Section 15 - Regulatory Information
CAS# 108-38-3 is listed on the TSCA inventory.
Health & Safety Reporting List
CAS# 108-38-3: Effective 10/4/82, Sunset 10/4/92
Chemical Test Rules
None of the chemicals in this product are under a Chemical Test Rule.
None of the chemicals are listed under TSCA Section 12b.
TSCA Significant New Use Rule
None of the chemicals in this material have a SNUR under TSCA.
CERCLA Hazardous Substances and corresponding RQs
CAS# 108-38-3: 1000 lb final RQ; 454 kg final RQ
SARA Section 302 Extremely Hazardous Substances
None of the chemicals in this product have a TPQ.
CAS # 108-38-3: immediate, delayed, fire.
This material contains m-Xylene
(CAS# 108-38-3, > 99%),which is subject to the reporting requirements
of Section 313 of SARA Title III and 40 CFR Part 373.
Clean Air Act:
CAS# 108-38-3 is listed as a hazardous air pollutant (HAP).
This material does not contain any Class 1 Ozone depletors.
This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
CAS# 108-38-3 is listed as a Hazardous Substance under the CWA.
None of the chemicals in this
product are listed as Priority Pollutants under the CWA.
None of the chemicals in this
product are listed as Toxic Pollutants under the CWA.
None of the chemicals in this product
are considered highly hazardous by OSHA.
CAS# 108-38-3 can be found on the
following state right to know lists: California, New Jersey,
Pennsylvania, Minnesota, (listed as Xylenes (o-, m-, p- isomers)),
California Prop 65
California No Significant Risk Level:
None of the chemicals in this product are listed.
European Labeling in Accordance with EC Directives
R 10 Flammable.
R 20/21 Harmful by inhalation and in contact with skin.
R 36/38 Irritating to eyes and skin.
S 25 Avoid contact with eyes.
WGK (Water Danger/Protection)
CAS# 108-38-3: No information available.
Canada - DSL/NDSL
CAS# 108-38-3 is listed on Canada's DSL List.
Canada - WHMIS
This product has a WHMIS classification of B2, D2B.
This product has been classified in accordance with the hazard
criteria of the Controlled Products Regulations and the MSDS
contains all of the information required by those regulations.
Canadian Ingredient Disclosure List
CAS# 108-38-3 is listed on the Canadian Ingredient Disclosure List.
Section 16 - Additional Information
MSDS Creation Date: 12/09/1997
Revision #13 Date: 7/30/2008
The information above is believed to be accurate and represents the best
information currently available to us. However, we make no warranty of
merchantability or any other warranty, express or implied, with respect to
such information, and we assume no liability resulting from its use. Users
should make their own investigations to determine the suitability of the
information for their particular purposes. In no event shall Fisher be liable
for any claims, losses, or damages of any third party or for lost profits
or any special, indirect, incidental, consequential or exemplary
damages, howsoever arising, even if Fisher has been advised of
the possibility of such damages.