Material Safety Data Sheet
Chloroacetic acid
ACC# 95538
Section 1 - Chemical Product and Company Identification |
MSDS Name: Chloroacetic acid
Catalog Numbers:
AC108510000, AC108510010, AC108510025, AC108510040, AC108512500,
AC220320000, AC220321000, A176-500
Synonyms:
Chloroethanoic acid; Monochloroacetic acid; Monochloroethanoic acid;
MCA; MCAA; alpha-Chloroacetic acid.
Company Identification:
Fisher Scientific
1 Reagent Lane
Fair Lawn, NJ 07410
For information, call: 201-796-7100
Emergency Number: 201-796-7100
For CHEMTREC assistance, call: 800-424-9300
For International CHEMTREC assistance, call: 703-527-3887
Section 2 - Composition, Information on Ingredients
|
CAS# |
Chemical Name |
Percent |
EINECS/ELINCS |
79-11-8 |
Chloroacetic acid |
99 | 201-178-4 |
Section 3 - Hazards Identification
|
EMERGENCY OVERVIEW
Appearance: colorless or white solid.
Danger! Poison! May be fatal if absorbed through
the skin. Causes burns by all exposure routes. Harmful if inhaled or
swallowed. Corrosive to metal. Hygroscopic (absorbs moisture from
the air). Before using this product, make sure that personal
protective equipment and engineering controls are used and operating,
and also that first aid treatments and procedures are available and
understood.
Target Organs: Kidneys, heart, central nervous
system, liver, lungs, respiratory system, eyes, skin.
Potential Health Effects
Eye:
Causes eye burns.
Skin:
May be fatal if absorbed through the skin. Causes skin burns.
Substance is rapidly absorbed through the skin. Not expected to
cause an allergic skin reaction.
In an accident, about 10% of a 24-year-old employee's skin surface
was exposed to warm, liquid MCAA. Prompt & thorough washing with
water for about 1 hour seemed to remove the soluble salt. Skin burns
were considered first degree. The victim's condition suddenly
worsened while under observation at the plant dispensary, & he was
transported to the hospital. On the journey there, he began to
convulse; he died within 10-11 hours of the accident. The autopsy
showed congestion, hemorrhage, & confluent petechia of the heart,
lungs, & thymus. (Doc of TLV)
Ingestion:
Harmful if swallowed. Causes gastrointestinal tract burns.
Inhalation:
Harmful if inhaled. May cause severe irritation of the upper
respiratory tract with pain, burns, and inflammation. Can produce
delayed pulmonary edema.
Chronic:
May cause liver and kidney damage. Effects may be delayed. May cause
lung damage.
Section 4 - First Aid Measures
|
Eyes:
Get medical aid immediately. Extensive irrigation with water is requi
red (at least 30 minutes).
Skin:
POISON material. In case of contact, get medical aid immediately.
Immediately flush eyes or skin with plenty of water for at least 15
minutes while removing contaminated clothing and shoes. Wash
clothing before reuse. Destroy contaminated shoes.
Ingestion:
If swallowed, do NOT induce vomiting. Get medical aid immediately.
If victim is fully conscious, give a cupful of water. Never give
anything by mouth to an unconscious person.
Inhalation:
If inhaled, remove to fresh air. If not breathing, give artificial
respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
Chloroacetic acid causes competitive inhibition of acetate oxidation
and acetylates sulfhydryl residues in the liver and kidney.
Antidote:
Timely administration of intravenous sodium dichloroacetate (SDCA)
may be life saving in cases of serious monochloroacetate
intoxication. SDCA is not approved for medical use in the United
States. Treatment is symptomatic and supportive without it.
Section 5 - Fire Fighting Measures
|
General Information:
During a fire, irritating and highly toxic gases may be generated by
thermal decomposition or combustion. Use water spray to keep
fire-exposed containers cool. Wear appropriate protective clothing
to prevent contact with skin and eyes. Wear a self-contained
breathing apparatus (SCBA) to prevent contact with thermal
decomposition products. Contact with metals may evolve flammable
hydrogen gas.
Extinguishing Media:
Use water spray, dry chemical, "alcohol resistant" foam, or carbon
dioxide.
Flash Point: 126 deg C ( 258.80 deg F)
Autoignition Temperature: 470 deg C ( 878.00 deg F)
Explosion Limits, Lower:8.0.
Upper: Not available.
NFPA Rating:
(estimated) Health: 3; Flammability: 1; Instability: 0
Section 6 - Accidental Release Measures
|
General Information: Use proper personal protective equipment as indicated
in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal
container. Avoid runoff into storm sewers and ditches which lead to
waterways. Avoid generating dusty conditions. Provide ventilation.
Evacuate unnecessary personnel. Carefully neutralize the dilute
spill with lime slurry, soda ash, limestone, caustic soda or other
alkaline material. Ensure clean-up is conducted by trained personnel
only.
Section 7 - Handling and Storage
|
Handling:
Wash thoroughly after handling. Remove contaminated clothing and
wash before reuse. Use with adequate ventilation. Minimize dust
generation and accumulation. Do not breathe dust, mist, or vapor. Do
not get in eyes, on skin, or on clothing. Container should be opened
by a technically qualified person. Discard contaminated shoes.
Storage:
Store in a tightly closed container. Keep from contact with
oxidizing materials. Store in a cool, dry, well-ventilated area away
from incompatible substances. Poison room locked. Do not store in
metal containers. Do not store near alkaline substances. Store
protected from moisture.
Section 8 - Exposure Controls, Personal Protection
|
Engineering Controls:
Use process enclosure, local exhaust ventilation, or other
engineering controls to control airborne levels below recommended
exposure limits. Facilities storing or utilizing this material should
be equipped with an eyewash facility and a safety shower.
Exposure Limits
Chemical Name |
ACGIH |
NIOSH |
OSHA - Final PELs |
Chloroacetic acid
|
0.5 ppm TWA (inhalable fraction and vapor); Skin - potential significant contribution to overall exposure by the cutaneous r oute
|
none listed
|
none listed
|
OSHA Vacated PELs:
Chloroacetic acid:
No OSHA Vacated PELs are listed for this chemical.
Personal Protective Equipment
Eyes:
Wear chemical splash goggles and face shield.
Skin:
Wear appropriate protective gloves to prevent skin
exposure.
Clothing:
Wear appropriate protective clothing to prevent skin
exposure.
Respirators:
Follow the OSHA respirator regulations found in 29
CFR 1910.134 or European Standard EN 149. Use a
NIOSH/MSHA or European Standard EN 149 approved
respirator if exposure limits are exceeded or if
irritation or other symptoms are experienced.
Section 9 - Physical and Chemical Properties
|
Physical State: Solid
Appearance: colorless or white
Odor: pungent odor
pH: 1.90 (1% solution)
Vapor Pressure: 0.065 mm Hg @ 25 deg C
Vapor Density: 3.2 (air=1)
Evaporation Rate:Not available.
Viscosity: Not available.
Boiling Point: 189 deg C
Freezing/Melting Point:61-63 deg C
Decomposition Temperature:250 deg C
Solubility: Soluble.
Specific Gravity/Density:1.58 @ 20°C
Molecular Formula:C2H3ClO2
Molecular Weight:94.5
Section 10 - Stability and Reactivity
|
Chemical Stability:
Stable at room temperature in closed containers under normal storage
and handling conditions. Deliquescent (tending to absorb atmospheric
water vapor and become liquid).
Conditions to Avoid:
Dust generation, moisture, excess heat.
Incompatibilities with Other Materials:
Metals, strong oxidizing agents, strong bases, alcohols, amines.
Hazardous Decomposition Products:
Hydrogen chloride, carbon monoxide, carbon dioxide, formaldehyde.
Hazardous Polymerization: Will not occur.
Section 11 - Toxicological Information
|
RTECS#:
CAS# 79-11-8:
AF8575000
LD50/LC50:
CAS# 79-11-8:
Inhalation, rat:
LC50 = 180 mg/m3;
Oral, rat: LD50 =
55 mg/kg;
.
Dermal LD50 rat: 145 mg/kg (ACGIH). Dermal LD50 rabbit: 177.8 mg/kg
(Dow Chemical Company).
Carcinogenicity:
CAS# 79-11-8:
Not listed by ACGIH, IARC, NTP, or CA Prop 65.
Epidemiology:
Accidental dermal exposures of humans to monochloroacetic
acid have resulted in severe chemical burns, acute systemic
toxicity, and death.
Teratogenicity:
No data available.
Reproductive Effects:
No data available.
Mutagenicity:
No data available.
Neurotoxicity:
No data available.
Other Studies:
Section 12 - Ecological Information
|
Ecotoxicity:
Daphnia: Daphnia: 88 mg/l; 48h; EC50
Section 13 - Disposal Considerations
|
Chemical waste generators must determine whether a discarded chemical is classified
as a hazardous waste.
US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3.
Additionally, waste generators must consult state and local hazardous waste regulations to
ensure complete and accurate classification.
RCRA P-Series: None listed.
RCRA U-Series: None listed.
Section 14 - Transport Information
|
|
US DOT |
Canada TDG |
Shipping Name: |
CHLOROACETIC ACID, SOLID |
CHLOROACETIC ACID, SOLID |
Hazard Class: |
6.1 |
6.1(8) |
UN Number: |
UN1751 |
UN1751 |
Packing Group: |
II |
II |
Section 15 - Regulatory Information
|
US FEDERAL
TSCA
CAS# 79-11-8 is listed on the TSCA inventory.
Health & Safety Reporting List
None of the chemicals are on the Health & Safety Reporting List.
Chemical Test Rules
None of the chemicals in this product are under a Chemical Test Rule.
Section 12b
None of the chemicals are listed under TSCA Section 12b.
TSCA Significant New Use Rule
None of the chemicals in this material have a SNUR under TSCA.
CERCLA Hazardous Substances and corresponding RQs
CAS# 79-11-8: 100 lb final RQ; 45.4 kg final RQ
SARA Section 302 Extremely Hazardous Substances
CAS# 79-11-8: 100 lb lower threshold TPQ; 10000 lb upper threshold TPQ
SARA Codes
CAS # 79-11-8: immediate.
Section 313
This material contains Chloroacetic
acid (CAS# 79-11-8, 99%),which is subject to the reporting
requirements of Section 313 of SARA Title III and 40 CFR Part 373.
Clean Air Act:
CAS# 79-11-8 is listed as a hazardous air pollutant (HAP).
This material does not contain any Class 1 Ozone depletors.
This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
None of the chemicals in this product
are listed as Hazardous Substances under the CWA.
None of the chemicals in this
product are listed as Priority Pollutants under the CWA.
None of the chemicals in this
product are listed as Toxic Pollutants under the CWA.
OSHA:
None of the chemicals in this product
are considered highly hazardous by OSHA.
STATE
CAS# 79-11-8 can be found on the
following state right to know lists: New Jersey, Pennsylvania,
Minnesota, Massachusetts.
California Prop 65
California No Significant Risk Level:
None of the chemicals in this product are listed.
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols:
T N
Risk Phrases:
R 23/24/25 Toxic by inhalation, in contact with skin and if
swallowed.
R 34 Causes burns.
R 50 Very toxic to aquatic organisms.
Safety Phrases:
S 26 In case of contact with eyes, rinse immediately with plenty of
water and seek medical advice.
S 36/37/39 Wear suitable protective clothing, gloves and eye/face pr
otection.
S 45 In case of accident or if you feel unwell, seek medical advice
immediately (show the label where possible).
S 60 This material and its container must be disposed of as hazardou
s waste.
S 61 Avoid release to the environment. Refer to special instructions
/safety data sheets.
S 63 In case of accident by inhalation: remove casualty to fresh air
and keep at rest.
WGK (Water Danger/Protection)
CAS# 79-11-8: 2
Canada - DSL/NDSL
CAS# 79-11-8 is listed on Canada's DSL List.
Canada - WHMIS
This product has a WHMIS classification of D1A, E.
This product has been classified in accordance with the hazard
criteria of the Controlled Products Regulations and the MSDS
contains all of the information required by those regulations.
Canadian Ingredient Disclosure List
CAS# 79-11-8 is listed on the Canadian Ingredient Disclosure List.
Section 16 - Additional Information
|
MSDS Creation Date: 2/09/1999
Revision #6 Date: 1/03/2007
The information above is believed to be accurate and represents the best
information currently available to us. However, we make no warranty of
merchantability or any other warranty, express or implied, with respect to
such information, and we assume no liability resulting from its use. Users
should make their own investigations to determine the suitability of the
information for their particular purposes. In no event shall Fisher be liable
for any claims, losses, or damages of any third party or for lost profits
or any special, indirect, incidental, consequential or exemplary
damages, howsoever arising, even if Fisher has been advised of
the possibility of such damages.